Muscular Dystrophy, Becker Type; Bmd

Description

The muscular dystrophy that carries the Becker eponym is similar to Duchenne muscular dystrophy in the distribution of muscle wasting and weakness, which is mainly proximal, but the course is more benign, with age of onset around 12 years; some patients have no symptoms until much later in life. Loss of ambulation also varies from adolescence onward, with death usually in the fourth or fifth decade. In some cases, as in Duchenne muscular dystrophy, a degree of mental impairment is present (Emery, 2002).As in DMD, about 5 to 10% of female carriers of this X-linked disorder show muscle weakness, and frequently enlarged calves--so-called manifesting heterozygotes. Such weakness is often asymmetric; it can develop in childhood or not become evident until adult life, and can be slowly progressive or remain static. Because weakness is essentially proximal, differentiation from limb-girdle muscular dystrophy is essential for genetic counseling. In both DMD and BMD, female carriers may develop dilated cardiomyopathy in the absence of apparent weakness (Grain et al., 2001).

Clinical Features

Top most frequent phenotypes and symptoms related to Muscular Dystrophy, Becker Type; Bmd

  • Muscle weakness
  • Cognitive impairment
  • Skeletal muscle atrophy
  • Cardiomyopathy
  • Myopathy
  • Behavioral abnormality
  • Arrhythmia
  • Hyporeflexia
  • Elevated serum creatine phosphokinase
  • Myalgia

And another 14 symptoms. If you need more information about this disease we can help you.

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Incidence and onset information

— Currently we don't have prevalence information about this disease (Not enough data available about incidence and published cases.)
— The onset for some of the known clinical features related to this disease may vary, including late onset .

Alternative names

Muscular Dystrophy, Becker Type; Bmd Is also known as muscular dystrophy, pseudohypertrophic progressive, becker type, becker muscular dystrophy.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


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Muscular Dystrophy, Becker Type; Bmd Recommended genes panels

Panel Name, Specifity and genes Tested/covered
DMD Deletion/Duplication Analysis.

By Baylor Miraca Genetics Laboratories (United States).

DMD
Specificity
100 %
Genes
100 %
DMD Deletion/Duplication Analysis - Prenatal.

By Baylor Miraca Genetics Laboratories (United States).

DMD
Specificity
100 %
Genes
100 %
DMD Familial Mutation/Variant Analysis.

By Baylor Miraca Genetics Laboratories (United States).

DMD
Specificity
100 %
Genes
100 %
DMD Prenatal Sequence Analysis.

By Baylor Miraca Genetics Laboratories (United States).

DMD
Specificity
100 %
Genes
100 %
GeneAware Complete Panel Version 2 (Female).

By Baylor Miraca Genetics Laboratories (United States).

RMRP, BCS1L, SACS, BLM, SGCA, SGCB, SGCG, SGSH, SLC12A6, SLC17A5, SLC22A5, SLC25A13, SLC25A15, SLC26A2, SLC35A3, SLC7A7, SMN1, SMPD1, BTD, BTK , (...)

View the complete list with 139 more genes
Specificity
1 %
Genes
100 %
GeneAware Basic Panel Version 2 (Female).

By Baylor Miraca Genetics Laboratories (United States).

SMN1, CFTR, DMD, FMR1, HBA1, HBA2, HBB
Specificity
15 %
Genes
100 %
GeneAware Ashkenazi Jewish Panel Version 2 (Female).

By Baylor Miraca Genetics Laboratories (United States).

BLM, SLC35A3, SMN1, SMPD1, CLRN1, MCOLN1, PCDH15, RTEL1, CFTR, SUMF1, DHDDS, ADAMTS2, COL4A3, CPT2, TMEM216, DHCR7, DLD, DMD, FAH, FANCC , (...)

View the complete list with 19 more genes
Specificity
3 %
Genes
100 %
GeneAware ACMG/ACOG Panel Version 2 (Female).

By Baylor Miraca Genetics Laboratories (United States).

BLM, SMN1, SMPD1, MCOLN1, CFTR, DMD, FANCC, FMR1, GBA, HBA1, HBA2, HBB, HEXA, ELP1, ASPA
Specificity
7 %
Genes
100 %

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Sources and references

You can check the following sources for additional information.

OMIM Genetic Syndrome Finder

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