Hypertension, Essential

Description

The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution (Pickering, 1978). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait (Platt, 1963). McDonough et al. (1964) defended the monogenic idea. See McKusick (1960) and Kurtz and Spence (1993) for reviews. Swales (1985) reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.

Clinical Features

Top most frequent phenotypes and symptoms related to Hypertension, Essential

  • Hypertension
  • Hypertonia
  • Small for gestational age
  • Hypotension
  • Malnutrition
  • Hyperaldosteronism
  • Pseudohypoaldosteronism
  • Large placenta
  • Elevated systolic blood pressure
  • Elevated diastolic blood pressure

And another 1 symptoms. If you need more information about this disease we can help you.

Click here to know more about Mendelian.

Incidence and onset information

Not enough data available about incidence and published cases.
No data available about the known clinical features onset.

Researches and researchers

Currently, we don't have any information about doctors, researches or researchers related to this disease. Please contact us if you would like to appear here.


Mendelian

Accelerate your rare disease diagnosis with us

Learn more

Hypertension, Essential Recommended genes panels

Panel Name, Specifity and genes Tested/covered
Hirschsprung disease, cardiac defects, and autonomic dysfunction (sequence analysis of ECE1 gene).

By CGC Genetics (Portugal).

ECE1
Specificity
100 %
Genes
12 %
Hirschsprung Disease (Non-syndromic) Sequencing Panel with CNV Detection.

By PreventionGenetics PreventionGenetics (United States).

ECE1, EDN3, EDNRB, GDNF, NRTN, RET
Specificity
17 %
Genes
12 %
Hirschsprung Disease, Cardiac Defects and Autonomic Dysfunction via ECE1 Gene Sequencing with CNV Detection.

By PreventionGenetics PreventionGenetics (United States).

ECE1
Specificity
100 %
Genes
12 %
Central hypoventilation syndrome, congenital.

By Centogene AG - the Rare Disease Company (Germany).

ECE1
Specificity
100 %
Genes
12 %
Hirschsprung disease.

By Centogene AG - the Rare Disease Company (Germany).

ECE1
Specificity
100 %
Genes
12 %
Hirschsprung Disease NGS Panel.

By Fulgent Genetics Fulgent Genetics (United States).

ECE1, EDN3, EDNRB, GDNF, RET
Specificity
20 %
Genes
12 %
ECE1.

By Fulgent Genetics Fulgent Genetics (United States).

ECE1
Specificity
100 %
Genes
12 %
Study of Molecular Markers Of Essential Hypertension and Associated Cardiovascular Events (37 genes - 57 genetic variants).

By HeartGenetics, Genetics and Biotechnology, SA (Portugal).

SCNN1A, SCNN1B, SLC12A3, CALCA, WNK1, STK39, CLCNKA, CLCNKB, ADD1, ADRA1A, ECE1, AGTR1, AGTR2, GNB3, GRK4, HSD11B2, NEDD4L, NOS2, NPPA, NR3C2 , (...)

View the complete list with 1 more genes
Specificity
24 %
Genes
56 %

We have 61 more panels available in our App

Get the app

Sources and references

You can check the following sources for additional information.

OMIM Rare Disease Symptoms Checker

If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like NEMALINE MYOPATHY 7; NEM7 GILBERT SYNDROME GM2-GANGLIOSIDOSIS, AB VARIANT CHRONIC ATRIAL AND INTESTINAL DYSRHYTHMIA; CAID CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION; CMAVM LEUKODYSTROPHY, HYPOMYELINATING, 9; HLD9 ASPARTYLGLUCOSAMINURIA

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more