TRIM27 gene related symptoms and diseases

All the information presented here about the TRIM27 gene and its related diseases, symptoms, and test panels has been aggregated from the following public sources: HGNC,OMIM,ORPHANET,NCBIGENE.

Top 5 symptoms associated to TRIM27 gene



Symptoms // Phenotype % Cases
Autosomal dominant inheritance 100%
Milia 100%
Neoplasm 100%
Tics 100%
Carcinoma 100%

Other less frequent symptoms

Patients with TRIM27 gene alterations may also develop some of the following symptoms and phenotypes:

100% Goiter 100% Colon cancer 100% Thyroiditis 100% Thyroid carcinoma 100% Nodular goiter 100% Multinodular goiter 100% Papillary thyroid carcinoma 100% Medullary thyroid carcinoma

And 3 more phenotypes.
View the complete list

Rare diseases associated to TRIM27 gene

Here you will find a list of rare diseases related to the TRIM27. You can also use our tool to get a more accurate diagnosis based on your current symptoms.


THYROID CANCER, NONMEDULLARY, 1; NMTC1

Alternate names

THYROID CANCER, NONMEDULLARY, 1; NMTC1 Is also known as papillary carcinoma of thyroid;pact;ptc;tpc, familial nonmedullary thyroid cancer, papillary, nonmedullary thyroid carcinoma, papillary;differentiated thyroid carcinoma (dtc), also known as papillary or follicular thyroid carcinoma, is a slow-growing malignancy usually presenting in adults as an asymptomatic thyroid mass.

Description

Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; {155240}). NMTC is classified into 4 groups: papillary, follicular (OMIM ), Hurthle cell (OMIM ), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a component of a familial cancer syndrome (e.g., familial adenomatous polyposis, {175100}; Carney complex, {160980}) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009).PTC is characterized by distinctive nuclear alterations including pseudoinclusions, grooves, and chromatin clearing. PTCs smaller than 1 cm are referred to as papillary microcarcinomas. These tumors have been identified in up to 35% of individuals at autopsy, suggesting that they may be extremely common although rarely clinically relevant. PTC can also be multifocal but is typically slow-growing with a tendency to spread to lymph nodes and usually has an excellent prognosis (summary by Bonora et al., 2010). Genetic Heterogeneity of Susceptibility to Nonmedullary Thyroid CancerOther susceptibilities to nonmedullary thyroid cancer include NMTC2 (OMIM ), caused by mutation in the SRGAP1 gene (OMIM ); NMTC3 (OMIM ), mapped to chromosome 2q21; NMTC4 (OMIM ), caused by mutation in the FOXE1 gene (OMIM ); and NMTC5 (OMIM ), caused by mutation in the HABP2 gene (OMIM ).A susceptibility locus for familial nonmedullary thyroid carcinoma with or without cell oxyphilia (TCO ) has been mapped to chromosome 19p.

Most common symptoms of THYROID CANCER, NONMEDULLARY, 1; NMTC1

  • Autosomal dominant inheritance
  • Milia
  • Neoplasm
  • Tics
  • Carcinoma


More info about THYROID CANCER, NONMEDULLARY, 1; NMTC1

SOURCES: ORPHANET SCTID OMIM UMLS MONDO

Potential gene panels for TRIM27 gene

TRIM27 Panel

By Fulgent Genetics Fulgent Genetics in United States.

This panel specifically test the TRIM27 gene.

More info about this panel

Caris MI TumorSeek 592-Gene NGS Panel Panel

By Caris Life Sciences in United States. Caris MI TumorSeek 592-Gene NGS Panel that also includes the following genes: BRCA1 BRCA2 VHL APC MSH2 PMS2 MSH6 MLH1 MUTYH PTEN

More info about this panel


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