Peripheral neuropathy, and Lymphoma

Diseases related with Peripheral neuropathy and Lymphoma

In the following list you will find some of the most common rare diseases related to Peripheral neuropathy and Lymphoma that can help you solving undiagnosed cases.


Top matches:

Low match CHARCOT-MARIE-TOOTH DISEASE, DEMYELINATING, TYPE 1A; CMT1A


For a general phenotypic description and a discussion of genetic heterogeneity of Charcot-Marie-Tooth disease type 1, see CMT1B (OMIM ).CMT1A is the most common form of CMT. The average age of onset of clinical symptoms is 12.2 +/- 7.3 years. Slow nerve conduction velocity (NCV) less than 38 m/s is highly diagnostic and is a 100% penetrant phenotype independent of age ({36,39:Lupski et al., 1991, 1992}).

CHARCOT-MARIE-TOOTH DISEASE, DEMYELINATING, TYPE 1A; CMT1A Is also known as hereditary motor and sensory neuropathy ia|hmsn ia|charcot-marie-tooth neuropathy, type 1a|hmsn1a|charcot-marie-tooth disease, autosomal dominant, with focally folded myelin sheaths, type 1a

Related symptoms:

  • Global developmental delay
  • Hearing impairment
  • Muscle weakness
  • Motor delay
  • Peripheral neuropathy


SOURCES: OMIM MENDELIAN

More info about CHARCOT-MARIE-TOOTH DISEASE, DEMYELINATING, TYPE 1A; CMT1A

Low match HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES


Hereditary neuropathy with liability to pressure palsies (HNPP) is an inherited peripheral nerve disorder characterized by recurrent mononeuropathy usually triggered by minor physical activities.

HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES Is also known as hnpp|potato-grubbing palsy|polyneuropathy, familial recurrent|current pressure-sensitive neuropathy|heterozygous microdeletion 17p11.2p12|tulip-bulb digger's palsy|tomaculous neuropathy

Related symptoms:

  • Hearing impairment
  • Scoliosis
  • Muscle weakness
  • Pain
  • Peripheral neuropathy


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES

Low match LYMPHOMA, HODGKIN, CLASSIC; CHL


Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).

LYMPHOMA, HODGKIN, CLASSIC; CHL Is also known as hodgkin disease

Related symptoms:

  • Ataxia
  • Neoplasm
  • Peripheral neuropathy
  • Hepatomegaly
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about LYMPHOMA, HODGKIN, CLASSIC; CHL

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Other less relevant matches:

Low match ESSENTIAL THROMBOCYTHEMIA


Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN, see this term) characterized by a sustained elevation of platelet number (> 450 x 109/L) with a tendency for thrombosis and hemorrhage.

ESSENTIAL THROMBOCYTHEMIA Is also known as thrombocytosis 1|essential thrombocytosis|et

Related symptoms:

  • Pain
  • Hypertension
  • Hepatomegaly
  • Abnormality of the skeletal system
  • Respiratory distress


SOURCES: ORPHANET OMIM MENDELIAN

More info about ESSENTIAL THROMBOCYTHEMIA

Low match SÉZARY SYNDROME


Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells).

SÉZARY SYNDROME Is also known as sÉzary lymphoma

Related symptoms:

  • Neoplasm
  • Abnormal facial shape
  • Peripheral neuropathy
  • Hepatomegaly
  • Fever


SOURCES: MESH ORPHANET MENDELIAN

More info about SÉZARY SYNDROME

Low match HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS


Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

Low match PGM3-CDG


PGM3-CDG is a rare congenital disorder of glycosylation caused by mutations in the PGM3 gene and characterized by neonatal to childhood onset of recurrent bacterial and viral infections, inflammatory skin diseases, atopic dermatitis and atopic diatheses, and marked serum IgE elevation. Early neurologic impairment is evident including developmental delay, intellectual disability, ataxia, dysarthria, sensorineural hearing loss, myoclonus and seizures.

PGM3-CDG Is also known as cid due to pgm3 deficiency|immunodeficiency with hyper ige and cognitive impairment|pgm3-related congenital disorder of glycosylation|combined immunodeficiency due to pgm3 deficiency|immunodeficiency-vasculitis-myoclonus syndrome|ivms

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM ORPHANET MENDELIAN

More info about PGM3-CDG

Low match CELIAC DISEASE, SUSCEPTIBILITY TO, 1; CELIAC1


Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy (GSE), is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). Long regarded as gastrointestinal disorder of childhood, the disease is now considered to be a chronic systemic autoimmune disease and is more often diagnosed in adults than in children (Monsuur et al., 2005).For a discussion of genetic heterogeneity of celiac disease, see MAPPING.

CELIAC DISEASE, SUSCEPTIBILITY TO, 1; CELIAC1 Is also known as celiac sprue, susceptibility to, 1|gluten-sensitive enteropathy, susceptibility to, 1

Related symptoms:

  • Seizures
  • Short stature
  • Ataxia
  • Failure to thrive
  • Anemia


SOURCES: OMIM MENDELIAN

More info about CELIAC DISEASE, SUSCEPTIBILITY TO, 1; CELIAC1

Low match WALDENSTRÖM MACROGLOBULINEMIA


Waldenström macroglobulinemia (WM) is an indolent B-cell lymphoproliferative disorder characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein.

Related symptoms:

  • Hearing impairment
  • Ataxia
  • Neoplasm
  • Anemia
  • Peripheral neuropathy


SOURCES: OMIM ORPHANET MENDELIAN

More info about WALDENSTRÖM MACROGLOBULINEMIA

Low match WISKOTT-ALDRICH SYNDROME


Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

Top 5 symptoms//phenotypes associated to Peripheral neuropathy and Lymphoma

Symptoms // Phenotype % cases
Splenomegaly Common - Between 50% and 80% cases
Hepatomegaly Uncommon - Between 30% and 50% cases
Weight loss Uncommon - Between 30% and 50% cases
Fatigue Uncommon - Between 30% and 50% cases
Ataxia Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Peripheral neuropathy and Lymphoma. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Lymphadenopathy Anemia Hodgkin lymphoma Polyneuropathy Diarrhea Neoplasm Hearing impairment Vasculitis Fever Leukemia Autoimmunity Seizures Immunodeficiency Pain Respiratory insufficiency Renal insufficiency Cranial nerve paralysis Dyspnea Pruritus Recurrent infections Chest pain Urticaria Cough Skeletal muscle atrophy Eczema Hyporeflexia Skin rash Sensory neuropathy

Rare Symptoms - Less than 30% cases


Gangrene Thrombocytosis Prolonged bleeding time Glomerulonephritis Gingival bleeding Bruising susceptibility Polyclonal elevation of IgM Vertigo Migraine Anorexia Hemoptysis Hepatosplenomegaly Monoclonal immunoglobulin M proteinemia Headache Impaired lymphocyte transformation with phytohemagglutinin Abnormality of the skeletal system Acute leukemia Global developmental delay Purpura Chronic diarrhea Lymphopenia Inflammatory abnormality of the skin Membranoproliferative glomerulonephritis Neutropenia Hemolytic anemia Respiratory tract infection Recurrent respiratory infections Failure to thrive Short stature Small vessel vasculitis Malabsorption Glomerulopathy Pleural effusion Bloody diarrhea Conjunctivitis Meningitis Proteinuria Arthritis Arthralgia Abdominal pain Sensorineural hearing impairment Iron deficiency anemia Alopecia Abnormal facial shape Epistaxis Decreased mean platelet volume Abnormal platelet morphology Irregular hyperpigmentation Combined immunodeficiency Foot dorsiflexor weakness Myoclonus Segmental peripheral demyelination/remyelination Hammertoe Muscle weakness Paresthesia Areflexia Pes cavus Axonal loss Scoliosis Decreased motor nerve conduction velocity Abnormality of the nervous system Peripheral demyelination Rickets Spontaneous abortion Abnormal intestine morphology Generalized lymphadenopathy Type I diabetes mellitus Hypocalcemia Abnormal eosinophil morphology Otitis media Spontaneous hematomas Abnormality of the coagulation cascade Malnutrition Internal hemorrhage Melena Celiac disease Macrocytic anemia IgA deficiency Hematemesis Increased IgA level Thyroiditis Interstitial pneumonitis Abnormality of the menstrual cycle Steatorrhea Nevus Hypoplasia of dental enamel Recurrent intrapulmonary hemorrhage Atopic dermatitis Severe combined immunodeficiency Allergic rhinitis Specific anti-polysaccharide antibody deficiency Vasculitis in the skin Reduced lymphocyte surface expression of CD43 Abnormal delayed hypersensitivity skin test Autoimmune neutropenia Absent microvilli on the surface of peripheral blood lymphocytes Cortical myoclonus Vomiting Chronic leukemia Depressivity Cerebral calcification Osteoporosis Elevated hepatic transaminase Large vessel vasculitis Anxiety Reduced delayed hypersensitivity Irritability Congenital thrombocytopenia Postnatal growth retardation Abnormal platelet function Delayed puberty Infertility Abdominal distention Recurrent ear infections Increased IgE level Chronic fatigue IgM deficiency Sarcoma Abnormality of the retinal vasculature Keratitis Reduced consciousness/confusion Periorbital edema Hyperostosis Normocytic anemia Inflammation of the large intestine Retinal hemorrhage Multifocal epileptiform discharges Chronic otitis media Rheumatoid arthritis Glomerulosclerosis Intracranial hemorrhage Cryoglobulinemia Focal segmental glomerulosclerosis Chronic kidney disease Thrombocytopenia Recurrent upper respiratory tract infections Skin ulcer Sinusitis Arrhythmia Pneumonia Nephropathy Recurrent otitis media Sepsis Abnormal bleeding Sudden cardiac death Pancytopenia Lymphoproliferative disorder Hypercoagulability Hypoplasia of the thymus Proptosis Specific learning disability Prolonged partial thromboplastin time Stomatitis Recurrent aphthous stomatitis Prolonged prothrombin time Chronic obstructive pulmonary disease Abnormality of the abdominal wall Folate deficiency Vitamin D deficiency Vitamin K deficiency Vitamin B12 deficiency Congestive heart failure Visual loss Pallor Edema of the lower limbs Hematochezia Recurrent lower respiratory tract infections Stroke Gastrointestinal hemorrhage Blepharitis Memory impairment Microcytic anemia Cellulitis Cutis marmorata Elevated erythrocyte sedimentation rate Petechiae Pulmonary infiltrates Raynaud phenomenon Abnormality of neutrophils Reduced tendon reflexes Recurrent skin infections Myelin tomacula Generalized muscle weakness Hypotelorism Tetraparesis Hoarse voice Back pain Abnormality of the voice Axonal degeneration Vocal cord paralysis Constrictive median neuropathy Low back pain Abnormal myelination Vocal cord paresis Brachial plexus neuropathy Inability to walk Hyperhidrosis Bone pain Bone marrow hypocellularity Osteolysis Poor appetite Cellular immunodeficiency Lung adenocarcinoma Hypertension Respiratory distress Myocardial infarction Venous thrombosis Myelodysplasia Leukocytosis Muscle cramps Confusion Pulmonary embolism Decreased nerve conduction velocity Motor delay Kyphoscoliosis Apnea Distal muscle weakness Limb muscle weakness Abnormality of the foot Distal amyotrophy Distal sensory impairment Delayed myelination Split hand Progressive muscle weakness Sleep apnea Delayed gross motor development Steppage gait Abnormality of movement Neurofibromas Decreased number of peripheral myelinated nerve fibers Onion bulb formation Demyelinating peripheral neuropathy Hypopnea Axonal regeneration Ulnar claw Hypertrophic nerve changes Myelin outfoldings Abnormal nervous system electrophysiology Progressive distal muscular atrophy Cold-induced muscle cramps Paralysis Myeloid leukemia Transient ischemic attack Leukopenia Episcleritis Joint dislocation Cerebral palsy Nephritis Hemiplegia/hemiparesis Emphysema Restrictive ventilatory defect Pericardial effusion Abnormal heart valve morphology Uveitis Inflammatory abnormality of the eye Angioedema Complement deficiency Immunologic hypersensitivity Obstructive lung disease Ascites Intellectual disability Generalized hypotonia Cognitive impairment High palate Dysarthria Brachydactyly Gastroesophageal reflux Conductive hearing impairment Erythema Asthma Sensory impairment Bronchiectasis Narrow palpebral fissure Recurrent bacterial infections Hematuria Acrocyanosis Hypotrichosis Abnormality of the cerebral vasculature Arterial thrombosis Abnormal thrombocyte morphology Impaired platelet aggregation Myeloproliferative disorder Amaurosis fugax Abnormality of bone marrow cell morphology Myelofibrosis Abnormal platelet aggregation Increased megakaryocyte count Tremor Edema Nail dystrophy Dry skin Nausea and vomiting Palmoplantar keratoderma Abnormality of the face Thickened skin Neoplasm of the skin Ectropion Erythroderma Abnormality of the pleura Lichenification T-cell lymphoma Abnormal lymphocyte morphology Abnormal immunoglobulin level Cutaneous T-cell lymphoma Myalgia Oral bleeding



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