Obesity, and Vertigo

Diseases related with Obesity and Vertigo

In the following list you will find some of the most common rare diseases related to Obesity and Vertigo that can help you solving undiagnosed cases.


Top matches:

Medium match FAMILIAL PRIMARY HYPOMAGNESEMIA WITH NORMOCALCIURIA AND NORMOCALCEMIA


Familial primary hypomagnesemia with normocalciuria and normocalcemia (FPHNN) is a form of familial primary hypomagnesemia (FPH), characterized by low serum magnesium (Mg) values but inappropriate normal urinary Mg values (i.e. renal hypomagnesemia). The typical symptoms are weakness of the limbs, vertigo, headaches, seizures, brisk tendon reflexes and mild to moderate psychomotor delay.

Related symptoms:

  • Seizures
  • Microcephaly
  • Ventriculomegaly
  • Headache
  • Obesity


SOURCES: ORPHANET MENDELIAN

More info about FAMILIAL PRIMARY HYPOMAGNESEMIA WITH NORMOCALCIURIA AND NORMOCALCEMIA

Medium match AUTOSOMAL RECESSIVE EMERY-DREIFUSS MUSCULAR DYSTROPHY


Emery-Dreifuss muscular dystrophy is characterized classically by the triad of weakness of the shoulder and pelvic girdle muscles, contractures of the elbows, neck, and Achilles tendon, and cardiac involvement, most commonly arrhythmias (summary by Jimenez-Escrig et al., 2012).For a discussion of genetic heterogeneity of EDMD, see {310300}.

AUTOSOMAL RECESSIVE EMERY-DREIFUSS MUSCULAR DYSTROPHY Is also known as edmd3

Related symptoms:

  • Intellectual disability
  • Scoliosis
  • Micrognathia
  • Muscle weakness
  • Abnormal facial shape


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about AUTOSOMAL RECESSIVE EMERY-DREIFUSS MUSCULAR DYSTROPHY

Medium match CRANIOPHARYNGIOMA


Craniopharyngiomas are benign slow growing tumours that are located within the sellar and parasellar regions of the central nervous system.

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Hearing impairment
  • Growth delay


SOURCES: ORPHANET MENDELIAN

More info about CRANIOPHARYNGIOMA

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Other less relevant matches:

Medium match AUTOSOMAL DOMINANT EMERY-DREIFUSS MUSCULAR DYSTROPHY


EDMD is characterized by myopathic changes in certain skeletal muscles and early contractures at the neck, elbows, and Achilles tendons, as well as cardiac conduction defects. 'Classic' Emery-Dreifuss muscular dystrophy (EDMD1 ) is an X-linked disorder caused by mutation in the emerin gene (EMD ) on Xq28 (Emery, 1989).For a discussion of genetic heterogeneity of EDMD, see {310300}.

AUTOSOMAL DOMINANT EMERY-DREIFUSS MUSCULAR DYSTROPHY Is also known as scapuloilioperoneal atrophy with cardiopathy|emd2|muscular dystrophy, limb-girdle, type 1b, formerly|emery-dreifuss muscular dystrophy, autosomal dominant|edmd2|cardiomyopathy, dilated, with quadriceps myopathy|muscular dystrophy, proximal, type 1b, forme

Related symptoms:

  • Intellectual disability
  • Generalized hypotonia
  • Scoliosis
  • Muscle weakness
  • Muscular hypotonia


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOSOMAL DOMINANT EMERY-DREIFUSS MUSCULAR DYSTROPHY

Medium match ARTERIAL TORTUOSITY SYNDROME; ATS


ARTERIAL TORTUOSITY SYNDROME; ATS Is also known as arterial tortuosity

Related symptoms:

  • Intellectual disability
  • Seizures
  • Generalized hypotonia
  • Scoliosis
  • Hypertelorism


SOURCES: OMIM MENDELIAN

More info about ARTERIAL TORTUOSITY SYNDROME; ATS

Medium match CORNELIA DE LANGE SYNDROME 1; CDLS1


The Cornelia de Lange syndrome (CDLS) is a multisystem malformation syndrome recognized primarily on the basis of characteristic facial dysmorphism, including low anterior hairline, arched eyebrows, synophrys, anteverted nares, maxillary prognathism, long philtrum, thin lips, and 'carp' mouth, in association with prenatal and postnatal growth retardation, mental retardation and, in many cases, upper limb anomalies. However, there is wide clinical variability in this disorder, with milder phenotypes that may be difficult to ascertain on the basis of physical features (summary by Rohatgi et al., 2010).Boyle et al. (2015) provided a detailed review of CDLS, including clinical features, diagnosis, and genetic counseling. Genetic Heterogeneity of Cornelia de Lange SyndromeAbout 50 to 60% of the cases of CDLS are due to mutation in the NIPBL gene (Musio et al., 2006; Rohatgi et al., 2010).One X-linked form of CDLS (CDLS2 ) is caused by mutation in the SMC1A gene (OMIM ), which accounts for about 5% of cases. Two milder variants of Cornelia de Lange syndrome have been identified: CDLS3 (OMIM ), caused by mutation in the SMC3 gene (OMIM ), and CDLS4 (OMIM ), caused by mutation in the RAD21 gene (OMIM ). All 4 genes, NIPBL, SMC1A, SMC3, and RAD21, encode components of the cohesin complex. Another X-linked form, CDLS5 (OMIM ), is caused by mutation in the HDAC8 gene (OMIM ), the vertebrate histone deacetylase of SMC3.

CORNELIA DE LANGE SYNDROME 1; CDLS1 Is also known as typus degenerativus amstelodamensis|brachmann-de lange syndrome|cdl|de lange syndrome|cdls|bdls

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM MENDELIAN

More info about CORNELIA DE LANGE SYNDROME 1; CDLS1

Medium match VARIANT ABETA2M AMYLOIDOSIS


Autosomal dominant beta 2-microglobulinic amyloidosis is a form of amyloidosis (see this term), characterized by accumulation and extensive visceral deposition of anamyloidogenic variant of beta 2 microglobulin (D76N variant β2M) leading to progressive gastrointestinal dysfunction, Sjögren syndrome (see this term) and autonomic neuropathy.

VARIANT ABETA2M AMYLOIDOSIS Is also known as autosomal dominant beta2-microglobulinic amyloidosis

Related symptoms:

  • Constipation
  • Weight loss
  • Malabsorption
  • Vertigo
  • Gastrointestinal hemorrhage


SOURCES: ORPHANET MENDELIAN

More info about VARIANT ABETA2M AMYLOIDOSIS

Medium match FAMILIAL THROMBOCYTOSIS


Familial thrombocytosis is a type of thrombocytosis, a sustained elevation of platelet numbers, which affects the platelet/megakaryocyte lineage and may create a tendency for thrombosis and hemorrhage but does not cause myeloproliferation.

FAMILIAL THROMBOCYTOSIS Is also known as familial thrombocythemia|hereditary thrombocythemia

Related symptoms:

  • Seizures
  • Dysarthria
  • Splenomegaly
  • Headache
  • Hyperhidrosis


SOURCES: ORPHANET MENDELIAN

More info about FAMILIAL THROMBOCYTOSIS

Medium match POLYCYTHEMIA VERA


Polycythemia vera (PV) is an acquired myeloproliferative disorder characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production, frequently associated with uncontrolled white blood cell and platelet production.

POLYCYTHEMIA VERA Is also known as polycythemia rubra vera|acquired primary erythrocytosis|prv|vaquez disease|osler-vaquez disease|pv

Related symptoms:

  • Neoplasm
  • Visual impairment
  • Hypertension
  • Hepatomegaly
  • Fatigue


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about POLYCYTHEMIA VERA

Medium match DIABETES INSIPIDUS, NEUROHYPOPHYSEAL


Neurohypophyseal diabetes insipidus is an autosomal dominant disorder of free water conservation characterized by childhood onset of polyuria and polydipsia. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopression deficiency during childhood (summary by Wahlstrom et al., 2004).

DIABETES INSIPIDUS, NEUROHYPOPHYSEAL Is also known as diabetes insipidus, cranial type|diabetes insipidus, primary central|cdi

Related symptoms:

  • Intellectual disability
  • Seizures
  • Growth delay
  • Hypertelorism
  • Neoplasm


SOURCES: OMIM MENDELIAN

More info about DIABETES INSIPIDUS, NEUROHYPOPHYSEAL

Top 5 symptoms//phenotypes associated to Obesity and Vertigo

Symptoms // Phenotype % cases
Seizures Common - Between 50% and 80% cases
Intellectual disability Common - Between 50% and 80% cases
Headache Common - Between 50% and 80% cases
Ptosis Uncommon - Between 30% and 50% cases
Weight loss Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Obesity and Vertigo. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Neoplasm Hypertension Fatigue Scoliosis Vomiting Arrhythmia Long philtrum Hypertelorism Syncope Hypotension Myocardial infarction Increased body weight High palate Generalized hypotonia Elbow flexion contracture Pectus excavatum Cerebral ischemia Growth delay Flexion contracture Muscular hypotonia Constipation Micrognathia

Rare Symptoms - Less than 30% cases


Hypoglycemia Decreased cervical spine flexion due to contractures of posterior cervical muscles Restricted neck movement due to contractures Global developmental delay Pituitary hypothyroidism Orthostatic hypotension Impotence Diabetes insipidus Hypogonadotrophic hypogonadism Hearing impairment Optic atrophy Amenorrhea Central diabetes insipidus Hydrocephalus Coma Sleep disturbance Behavioral abnormality Confusion Delayed puberty Lethargy Postnatal growth retardation Thrombocytosis Sudden loss of visual acuity Osteoporosis Hyperhidrosis Thrombocytopenia Fever Spontaneous abortion Microcephaly Abnormal thrombosis Hiatus hernia Congenital diaphragmatic hernia Bruising susceptibility Pulmonic stenosis Stroke Pallor Osteopenia Inguinal hernia Bitemporal hemianopia Hernia Macrocephaly Gastrointestinal hemorrhage Splenomegaly Pruritus Venous thrombosis Hypertrophic cardiomyopathy Myelodysplasia Type 1 muscle fiber atrophy Arterial thrombosis Respiratory insufficiency Wide nasal bridge Feeding difficulties Absent muscle fiber emerin Cardiomyopathy Proximal upper limb amyotrophy Ichthyosis Limb-girdle muscular dystrophy Lipodystrophy Back pain Atrioventricular block EMG: myopathic abnormalities Reduced tendon reflexes Scapular winging Diplopia Palpitations Atrial fibrillation Hypertriglyceridemia Waddling gait Sudden cardiac death Paresthesia Congenital muscular dystrophy Lower limb muscle weakness Limb muscle weakness Dilated cardiomyopathy Muscular dystrophy Joint stiffness Hyperlordosis Proximal muscle weakness Elevated serum creatine phosphokinase Myopathy Gait disturbance Skeletal muscle atrophy Abnormal facial shape Muscle weakness Autistic behavior Myotonia Kyphosis Toe walking Rimmed vacuoles Proximal muscle weakness in lower limbs Achilles tendon contracture Supraventricular arrhythmia Limb-girdle muscle weakness Shoulder girdle muscle weakness Ventricular escape rhythm Increased LDL cholesterol concentration Proximal lower limb amyotrophy Proximal muscle weakness in upper limbs Ankle contracture Limb-girdle muscle atrophy Sprengel anomaly Shoulder girdle muscle atrophy Spinal rigidity Optic nerve coloboma Histiocytosis Self-injurious behavior Pollakisuria Pyloric stenosis Short metatarsal Abnormality of the gastrointestinal tract Deep philtrum Proximal placement of thumb Incoordination Abnormality of the urinary system Hypoplasia of the radius Relative macrocephaly Widely spaced teeth Torticollis Nocturia Hypoplastic labia majora Esophagitis Abnormality of digit Short middle phalanx of finger Limited elbow extension Weak cry Dislocated radial head Opisthotonus Ectopic kidney Hypoplastic nipples 2-3 toe syndactyly Oligodactyly Aspiration pneumonia Aspiration Cutis marmorata Enuresis Ectrodactyly Tricuspid regurgitation Clubbing Poor appetite Low anterior hairline Low posterior hairline Long eyelashes Small for gestational age Thin vermilion border Cleft upper lip Astigmatism Micromelia Hypertonic dehydration Toe syndactyly Synophrys Hip dislocation Prominent nasal bridge Pulmonary hypoplasia Craniosynostosis Respiratory tract infection Abnormality of the pinna Abnormality of the anterior pituitary Camptodactyly Telecanthus Aggressive behavior Proteinuria Conductive hearing impairment Thick eyebrow Hirsutism Recurrent urinary tract infections Vesicoureteral reflux Choanal atresia Hypertrichosis Recurrent hypoglycemia Renal hypoplasia Blue sclerae High myopia Microdontia Otitis media Webbed neck Sepsis Downturned corners of mouth Triangular face Renal cyst Microcornea Delayed eruption of teeth Tapered finger Single transverse palmar crease Highly arched eyebrow Small hand High, narrow palate Thick upper lip vermilion Polydipsia Volvulus Peripheral arterial stenosis Visual impairment Chronic myelogenous leukemia Autoimmunity Gliosis Portal vein thrombosis Retrognathia Growth hormone deficiency Transient ischemic attack Abdominal pain Increased hemoglobin Acute myeloid leukemia Visual field defect Increased hematocrit Budd-Chiari syndrome Pulmonary arterial hypertension Irritability Chest pain Hepatomegaly Arthralgia Increased red blood cell mass Pulmonary embolism Myeloproliferative disorder Angina pectoris Deep venous thrombosis Myelofibrosis Intermittent claudication Acute leukemia Dry skin Gingival bleeding Thromboembolism Erythema Polycythemia Leukocytosis Cerebral hemorrhage Erythroid hyperplasia Portal hypertension Tinnitus Epistaxis Leukemia Abnormal bleeding Diabetes mellitus Panhypopituitarism Gastroparesis Increased megakaryocyte count Left-to-right shunt Hypertropia Esophageal stenosis Hypoplastic male external genitalia Curly eyelashes Absent hand Elevated leukocyte alkaline phosphatase Dehydration Duplication of internal organs Supernumerary ribs Phocomelia Wide nose Hand oligodactyly Perimembranous ventricular septal defect Polyuria Short sternum Peters anomaly Projectile vomiting Malrotation of colon Dysarthria Bowel incontinence Autonomic bladder dysfunction Chronic axonal neuropathy Orthostatic hypotension due to autonomic dysfunction Intermittent diarrhea Gastrointestinal dysmotility Chronic constipation Xerostomia Keratoconjunctivitis sicca Abnormal autonomic nervous system physiology Otitis media with effusion Chronic diarrhea Abnormality of metabolism/homeostasis Malabsorption Dysplastic tricuspid valve Hypoplastic radial head Abnormality of the umbilicus Reduced renal corticomedullary differentiation Short nose Thin upper lip vermilion Oculomotor nerve palsy Gastroesophageal reflux Facial palsy Spinal muscular atrophy Ventricular arrhythmia Respiratory insufficiency due to muscle weakness Knee flexion contracture Bradycardia Progressive muscle weakness Frequent falls Falls Neonatal hypotonia Mildly elevated creatine phosphokinase Rigidity Difficulty walking Dyspnea Pes cavus Midface retrusion Congestive heart failure Abnormality of the frontal bone Abnormality of the nasal bone Calf muscle hypertrophy Difficulty climbing stairs Neoplasm of the anterior pituitary Scapuloperoneal amyotrophy Umbilical hernia Macrotia Respiratory failure Dilatation Blindness Respiratory distress Downslanted palpebral fissures Proximal spinal muscular atrophy Peroneal muscle weakness Heart block Left anterior fascicular block Peroneal muscle atrophy Atrial arrhythmia Abnormal atrioventricular conduction Distal lower limb muscle weakness Distal lower limb amyotrophy Proximal amyotrophy Vocal cord paralysis Progressive proximal muscle weakness Abnormal hypothalamus morphology Intracranial cystic lesion Blepharophimosis Abnormal lung morphology Permanent atrial fibrillation Pelvic girdle muscle weakness Hyporeflexia of lower limbs Increased connective tissue Decreased HDL cholesterol concentration Progeroid facial appearance Restrictive ventilatory defect Generalized amyotrophy Lumbar hyperlordosis Recurrent infections Hypermagnesiuria Abnormal myelination Moderate global developmental delay Hypomagnesemia Hyperactive deep tendon reflexes Generalized muscle weakness Poor speech Intellectual disability, moderate Ventriculomegaly Pelvic girdle muscle atrophy Hypogonadism Abnormal visual field test Proportionate short stature Craniopharyngioma Progressive visual field defects Enlarged pituitary gland Slow decrease in visual acuity Central adrenal insufficiency Excessive daytime somnolence Prolactin excess Papilledema Hypopituitarism Hypothyroidism Polyphagia Increased susceptibility to fractures Increased intracranial pressure Sleep apnea Type II diabetes mellitus Cerebral calcification Nausea Nausea and vomiting Anxiety Joint laxity Scarring Mandibular prognathia Cleft palate Abnormality of the skeletal system Intrauterine growth retardation Myopia Depressed nasal bridge Delayed speech and language development Anemia Low-set ears Cryptorchidism Sensorineural hearing impairment Talipes equinovarus Strabismus Failure to thrive Nystagmus Short stature Aortic tortuosity Abnormality of hair density Telangiectases of the cheeks Internal ophthalmoplegia Curved fingers Ventricular septal defect Anteverted nares Soft, doughy skin Pneumonia Proptosis Autism Narrow mouth Glaucoma Hyperactivity Brachycephaly Prominent forehead Severe short stature Clinodactyly of the 5th finger Short neck Delayed skeletal maturation Abnormal heart morphology Clinodactyly Hypospadias Syndactyly Hypertonia Abnormality of the dentition Intellectual disability, severe Atrial septal defect Generalized arterial tortuosity Fourth cranial nerve palsy Pectus carinatum Short chin Hyperglycemia Heart murmur Hyperinsulinemia Hyperextensible skin Easy fatigability Ischemic stroke Cutis laxa Aortic regurgitation Recurrent pneumonia Blurred vision Aortic valve stenosis Gynecomastia Telangiectasia Thin skin Ventricular hypertrophy Progressive visual loss Convex nasal ridge Long face Arachnodactyly Epiphora Atrophic scars Cranial nerve VI palsy Secondary growth hormone deficiency Decreased fertility in males Adrenocorticotropin deficient adrenal insufficiency Dyspareunia Female hypogonadism Decreased circulating ACTH level Decreased female libido Arterial tortuosity Decreased fertility in females Galactorrhea Keratoconus Rectal prolapse Bladder diverticulum Adrenocorticotropic hormone deficiency Male hypogonadism Soft skin Pulmonary artery stenosis Growth hormone excess Tracheomalacia Aortic root aneurysm Germinoma



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