Muscle weakness, and Migraine

Diseases related with Muscle weakness and Migraine

In the following list you will find some of the most common rare diseases related to Muscle weakness and Migraine that can help you solving undiagnosed cases.

Top matches:

Paroxysmal kinesigenic dyskinesia (PKD) is a form of paroxysmal dyskinesia (see this term), characterized by recurrent brief involuntary hyperkinesias, such as choreoathetosis, ballism, athetosis or dystonia, triggered by sudden movements.

PAROXYSMAL KINESIGENIC DYSKINESIA Is also known as dystonia 10|pkd|paroxysmal kinesigenic choreathetosis|dystonia, familial paroxysmal|pkc|familial paroxysmal kinesigenic dyskinesia|familial pkd|paroxysmal kinesigenic dyskinesia|dyt10|paroxysmal kinesigenic choreoathetosis

Related symptoms:

  • Seizures
  • Neoplasm
  • Muscle weakness
  • Dystonia
  • Myoclonus


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about PAROXYSMAL KINESIGENIC DYSKINESIA

Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. Rare menstrual cycle-dependent febrile episodes have been reported, some of which have shown a luteal-phase-dependent pattern (summary by Jiang et al., 2012).

Related symptoms:

  • Ataxia
  • Fever
  • Tremor
  • Myalgia
  • Lower limb muscle weakness


SOURCES: OMIM MENDELIAN

More info about PERIODIC FEVER, MENSTRUAL CYCLE-DEPENDENT

Atypical teratoid rhabdoid tumor (ATRT) is a highly malignant central nervous system (CNS) rhabdoid tumor (RT; see this term) found almost exclusively in children.

ATYPICAL TERATOID RHABDOID TUMOR Is also known as atrt

Related symptoms:

  • Seizures
  • Ataxia
  • Muscle weakness
  • Macrocephaly
  • Hydrocephalus


SOURCES: ORPHANET MENDELIAN

More info about ATYPICAL TERATOID RHABDOID TUMOR

Other less relevant matches:

Paroxysmal non-kinesigenic dyskinesia (PNKD) is a form of paroxysmal dyskinesia (see this term), characterized by attacks of dystonic or choreathetotic movements precipitated by stress, fatigue, coffee or alcohol intake or menstruation.

PAROXYSMAL NON-KINESIGENIC DYSKINESIA Is also known as paroxysmal dystonic choreoathetosis|choreoathetosis, nonkinesigenic|pdc|dystonia 8|paroxystic non-kinesigenic choreoathetosis|dyt8|choreoathetosis, familial paroxysmal|mount-reback syndrome|fpd1

Related symptoms:

  • Seizures
  • Ataxia
  • Spasticity
  • Dysarthria
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about PAROXYSMAL NON-KINESIGENIC DYSKINESIA

Paroxysmal exertion-induced dyskinesia (PED) is a form of paroxysmal dyskinesia (see this term), characterized by painless attacks of dystonia of the extremities triggered by prolonged physical activities.

PAROXYSMAL EXERTION-INDUCED DYSKINESIA Is also known as ped with or without epilepsy and/or hemolytic anemia|paroxysmal exertion-induced dystonia with or without epilepsy and/or hemolytic anemia|dyt18|dystonia 18|ped|paroxysmal exercise-induced dyskinesia with or without epilepsy and/or hemolytic anemia

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about PAROXYSMAL EXERTION-INDUCED DYSKINESIA

PBD14B is an autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy (Ebberink et al., 2012), all of which had been observed in patients with mild peroxisomal biogenesis disorders (e.g., Kelley et al., 1986; Poll-The et al., 1987). Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, was reported.Thoms and Gartner (2012) classified the disorder described by Ebberink et al. (2012) in their patient as a mild 'Zellweger syndrome (OMIM ) spectrum' (ZSS) disorder. See PBD1B (OMIM ) for a phenotypic description and discussion of genetic heterogeneity of less severe phenotypes on the Zellweger syndrome spectrum. See PBD9B (OMIM ) for another atypical peroxisome biogenesis disorder.

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Nystagmus
  • Sensorineural hearing impairment
  • Muscle weakness


SOURCES: OMIM MENDELIAN

More info about PEROXISOME BIOGENESIS DISORDER 14B; PEX14B

Cerebral cavernous angiomas are relatively rare vascular malformations that may involve any part of the central nervous system. Cerebral cavernous angiomas are to be distinguished from cerebral arteriovenous malformations ({106070}, {108010}). CCMs are venous and not demonstrable by arteriography; hence they are referred to as angiographically silent.Capillary hemangiomas (OMIM ) are classified as distinct from vascular malformations in that hemangiomas are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. Hemangiomas develop shortly after birth. In contrast, vascular malformations are present from birth, tend to grow with the individual, do not regress, and show normal rates of endothelial cell turnover (Mulliken and Young, 1988). Genetic Heterogeneity of CCMCCM2 (OMIM ) is caused by mutation in the CCM2/malcavernin gene (OMIM ), and CCM3 (OMIM ) is caused by mutation in the PDCD10 gene (OMIM ).Evidence suggests that a 2-hit mechanism involving biallelic germline and somatic mutations is responsible for CCM1 pathogenesis, see PATHOGENESIS and MOLECULAR GENETICS sections.

CEREBRAL CAVERNOUS MALFORMATIONS; CCM Is also known as cam|cerebral capillary malformations|cavernous angiomatous malformations|cavernous angioma, familial

Related symptoms:

  • Seizures
  • Muscle weakness
  • Hepatomegaly
  • Congestive heart failure
  • Headache


SOURCES: ORPHANET OMIM MENDELIAN

More info about CEREBRAL CAVERNOUS MALFORMATIONS; CCM

Neurofibromatosis type 2 (NF2) is a tumor-prone disorder characterized by the development of multiple schwannomas and meningiomas.

NEUROFIBROMATOSIS TYPE 2 Is also known as nf2|bilateral acoustic neurofibromatosis|central neurofibromatosis

Related symptoms:

  • Ataxia
  • Sensorineural hearing impairment
  • Cataract
  • Visual impairment
  • Gait disturbance


SOURCES: ORPHANET MENDELIAN

More info about NEUROFIBROMATOSIS TYPE 2

Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome is characterised by adult-onset severe sensory ataxic neuropathy, dysarthria and chronic progressive external ophthalmoplegia.

SENSORY ATAXIC NEUROPATHY-DYSARTHRIA-OPHTHALMOPARESIS SYNDROME Is also known as sando

Related symptoms:


SOURCES: ORPHANET MENDELIAN

More info about SENSORY ATAXIC NEUROPATHY-DYSARTHRIA-OPHTHALMOPARESIS SYNDROME

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Hearing impairment


SOURCES: OMIM MENDELIAN

More info about CYCLIC VOMITING SYNDROME; CVS

Top 5 symptoms//phenotypes associated to Muscle weakness and Migraine

Symptoms // Phenotype % cases
Seizures Common - Between 50% and 80% cases
Ataxia Common - Between 50% and 80% cases
Headache Uncommon - Between 30% and 50% cases
Intellectual disability Uncommon - Between 30% and 50% cases
Involuntary movements Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Muscle weakness and Migraine. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Paroxysmal dystonia Focal-onset seizure Choreoathetosis Chorea Dyskinesia Abnormality of movement Myoclonus Dystonia Paroxysmal dyskinesia

Rare Symptoms - Less than 30% cases

Cerebral calcification Cranial nerve paralysis Spasticity Dysarthria Fatigue Hearing impairment Episodic ataxia Nystagmus Vertigo Global developmental delay Generalized hypotonia Microcephaly Irritability Cognitive impairment Intellectual disability, mild Photophobia Vomiting Cataract Nausea and vomiting Sensorineural hearing impairment Lower limb muscle weakness Paresthesia Fever Cerebral palsy Paroxysmal choreoathetosis Tremor Capillary hemangioma Hemangioma Intracranial hemorrhage Cerebral hemorrhage Abnormality of the musculature Cardiomyopathy Cavernous hemangioma Abnormality of the skin Neuritis Venous malformation Varicocele Retrobulbar optic neuritis Retinal vascular malformation Hepatic vascular malformations Telangiectasia Congestive heart failure Stroke Paralysis Gait disturbance Hepatomegaly Hydrocele testis Arnold-Chiari type I malformation Progressive sensorineural hearing impairment Progressive hearing impairment Bilateral sensorineural hearing impairment Urinary incontinence Polyneuropathy Dry skin Congenital cataract Areflexia Abnormality of mitochondrial metabolism Visual impairment Corneal opacity Exercise intolerance Abnormality of the retinal vasculature Motor delay Diarrhea Behavioral abnormality Pain Muscular hypotonia Strabismus Growth delay Hyperhidrosis Abdominal pain Occasional neurofibromas Benign neoplasm of the central nervous system Pseudoepiphyses of the metacarpals Neoplasm of the central nervous system Dysgraphia Meningioma Facial palsy Pallor Myopathy Abnormal autonomic nervous system physiology Anorexia Nausea Lethargy Attention deficit hyperactivity disorder Papule Multiple cafe-au-lait spots Autism Sensory neuropathy Subcutaneous nodule Neoplasm of the skin Increased intracranial pressure Tinnitus Astrocytoma Absence seizures Generalized tonic-clonic seizures without focal onset Spastic paraplegia Malignant neoplasm of the central nervous system Dysphagia Dyspnea Rigidity Joint stiffness Neurological speech impairment Paraplegia Hemiplegia/hemiparesis Generalized muscle weakness Torticollis Hyperkinesis Encephalitis Trismus Myokymia Facial grimacing Reduced consciousness/confusion Apathy Staring gaze Orofacial dyskinesia Abnormality of the face Athetosis Loss of consciousness Hyperventilation Hypoparathyroidism Neoplasm of the endocrine system Writer's cramp Limitation of joint mobility Focal sensory seizure Myalgia Hepatitis Increased circulating cortisol level Recurrent spontaneous abortion Macrocephaly Hydrocephalus Kernicterus Anemia Hypoglycorrhachia Hand tremor Hemiplegia Focal impaired awareness seizure Impulsivity Atonic seizures Hyperactive deep tendon reflexes Reticulocytosis Action tremor Neoplasm Torsion dystonia Abnormality of the head Migraine without aura Limb dysmetria Jerky head movements Focal aware seizure Upper limb dysmetria Slurred speech Horizontal nystagmus Hyperreflexia Generalized tonic-clonic seizures Cerebral atrophy Gait ataxia EEG abnormality Aggressive behavior Intellectual disability, moderate Mental deterioration Dysmetria Progressive microcephaly Falls Hemolytic anemia Specific learning disability Generalized-onset seizure Frequent falls Lower limb spasticity Limb ataxia Gastrointestinal dysmotility


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