Muscle weakness, and Atrial fibrillation

Diseases related with Muscle weakness and Atrial fibrillation

In the following list you will find some of the most common rare diseases related to Muscle weakness and Atrial fibrillation that can help you solving undiagnosed cases.


Top matches:

Medium match EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7


Emery-Dreifuss muscular dystrophy is a genetically heterogeneous muscular disease that presents with muscular dystrophy, joint contractures, and cardiomyopathy with conduction defects (summary by Liang et al., 2011).For a discussion of genetic heterogeneity of EDMD, see {310300}.

Related symptoms:

  • Muscle weakness
  • Flexion contracture
  • Cardiomyopathy
  • Arrhythmia
  • Proximal muscle weakness


SOURCES: OMIM MENDELIAN

More info about EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7

Low match CARDIOMYOPATHY, DILATED, 1I; CMD1I


Related symptoms:

  • Muscle weakness
  • Fatigue
  • Cardiomyopathy
  • Myopathy
  • Congestive heart failure


SOURCES: OMIM MESH MENDELIAN

More info about CARDIOMYOPATHY, DILATED, 1I; CMD1I

Low match ATRIAL FIBRILLATION, FAMILIAL, 9; ATFB9


Atrial fibrillation is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997).For a discussion of genetic heterogeneity of atrial fibrillation, see {608583}.

Related symptoms:

  • Short stature
  • Muscle weakness
  • Cleft palate
  • Low-set ears
  • Brachydactyly


SOURCES: OMIM MENDELIAN

More info about ATRIAL FIBRILLATION, FAMILIAL, 9; ATFB9

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Other less relevant matches:

Low match DESMINOPATHY


Desminopathy is a rare genetic skeletal muscle disease characterized by abnormal chimeric aggregates of desmin and other cytoskeletal proteins and granulofilamentous material at the ultrastructural level in muscle biopsies and variable clinical/ myopathological features, age of disease onset and rate of disease progression. Patients present with bilateral skeletal muscle weakness that starts in distal leg muscles and spreads proximally, sometimes involving trunk, neck flexors and facial muscles and often cardiomyopathy manifested by conduction blocks, arrhythmias, chronic heart failure, and sometimes tachyarrhythmia. Weakness eventually leads to wheelchair dependence. Respiratory insufficiency can be a major cause of disability and death, beginning with nocturnal hyperventilation with oxygen desaturation and progressing to daytime respiratory failure.

DESMINOPATHY Is also known as desmin-related myofibrillar myopathy

Related symptoms:

  • Cardiomyopathy
  • Diarrhea
  • Arrhythmia
  • Constipation
  • Proximal muscle weakness


SOURCES: ORPHANET MENDELIAN

More info about DESMINOPATHY

Low match CARDIOMYOPATHY, DILATED, 1S; CMD1S


Related symptoms:

  • Muscle weakness
  • Ventriculomegaly
  • Cardiomyopathy
  • Myopathy
  • Congestive heart failure


SOURCES: OMIM MESH MENDELIAN

More info about CARDIOMYOPATHY, DILATED, 1S; CMD1S

Low match ATTRV122I AMYLOIDOSIS


Transthyretin (TTR)-related familial amyloidotic cardiomyopathy is a hereditary TTR-related systemic amyloidosis (ATTR) with predominant cardiac involvement resulting from myocardial infiltration of abnormal amyloid protein.

ATTRV122I AMYLOIDOSIS Is also known as attr cardiomyopathy|attrv122i-related amyloidosis|transthyretin-related familial amyloid cardiomyopathy|transthyretin amyloid cardiopathy|ttr-related amyloid cardiomyopathy|ttr-related cardiac amyloidosis

Related symptoms:

  • Muscle weakness
  • Cardiomyopathy
  • Diarrhea
  • Congestive heart failure
  • Arrhythmia


SOURCES: ORPHANET MENDELIAN

More info about ATTRV122I AMYLOIDOSIS

Low match HYALINE BODY MYOPATHY


Myosin storage myopathy, also known as hyaline body myopathy, is a congenital myopathy characterized by the accumulation of ATPase and antibody positive myosin in hyaline subsarcolemmal bodies in type I muscle fibers. The clinical features are variable, with different patients displaying proximal, scapuloperoneal, or generalized weakness and progressive or nonprogressive courses (summary by Dye et al., 2006).

HYALINE BODY MYOPATHY Is also known as myopathy, hyaline body, autosomal dominant|myopathy with lysis of type i myofibrils

Related symptoms:

  • Scoliosis
  • Muscle weakness
  • Flexion contracture
  • Skeletal muscle atrophy
  • Cardiomyopathy


SOURCES: ORPHANET OMIM MENDELIAN

More info about HYALINE BODY MYOPATHY

Low match AUTOSOMAL DOMINANT LIMB-GIRDLE MUSCULAR DYSTROPHY TYPE 1B


Autosomal dominant limb-girdle muscular dystrophy type 1B (LGMD1B) is a subtype of autosomal dominant limb girdle muscular dystrophy characterized by a variable age of onset of progressive shoulder and hip girdle weakness, with inferior limbs usually being affected prior to upper limbs, and mild joint contractures. LGMD1B is also associated with cardiac dysrhythmias, including atrioventricular conduction blocks, and late-onset dilated cardiomyopathy, that may lead to sudden death.

AUTOSOMAL DOMINANT LIMB-GIRDLE MUSCULAR DYSTROPHY TYPE 1B Is also known as lgmd1b|limb-girdle muscular dystrophy due to lamin a/c deficiency

Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Scoliosis
  • Muscle weakness
  • Flexion contracture


SOURCES: ORPHANET MESH MENDELIAN

More info about AUTOSOMAL DOMINANT LIMB-GIRDLE MUSCULAR DYSTROPHY TYPE 1B

Low match MCLEOD SYNDROME; MCLDS


Hematologically, McLeod syndrome is characterized by the absence of red blood cell Kx antigen, weak expression of Kell red blood cell antigens, acanthocytosis, and compensated hemolysis. Most carriers of this McLeod blood group phenotype have acanthocytosis and elevated serum creatine kinase levels and are prone to develop a severe neurologic disorder resembling Huntington disease (OMIM ). Onset of neurologic symptoms ranges between 25 and 60 years (mean onset 30-40 years), and penetrance appears to be high. Additional symptoms include generalized seizures, neuromuscular symptoms leading to weakness and atrophy, and cardiomyopathy mainly manifesting with atrial fibrillation, malignant arrhythmias, and dilated cardiomyopathy (summary by Jung et al., 2007).The cooccurrence of McLeod syndrome and chronic granulomatous disease (CGD ) results from a contiguous gene deletion (Francke et al., 1985).

MCLEOD SYNDROME; MCLDS Is also known as mcleod phenotype|neuroacanthocytosis, mcleod type

Related symptoms:

  • Seizures
  • Muscle weakness
  • Cognitive impairment
  • Anemia
  • Peripheral neuropathy


SOURCES: MESH OMIM MENDELIAN

More info about MCLEOD SYNDROME; MCLDS

Low match X-LINKED EMERY-DREIFUSS MUSCULAR DYSTROPHY


Related symptoms:

  • Intellectual disability
  • Scoliosis
  • Muscular hypotonia
  • Ptosis
  • Gait disturbance


SOURCES: ORPHANET MENDELIAN

More info about X-LINKED EMERY-DREIFUSS MUSCULAR DYSTROPHY

Top 5 symptoms//phenotypes associated to Muscle weakness and Atrial fibrillation

Symptoms // Phenotype % cases
Cardiomyopathy Common - Between 50% and 80% cases
Arrhythmia Common - Between 50% and 80% cases
Dilated cardiomyopathy Common - Between 50% and 80% cases
Myopathy Uncommon - Between 30% and 50% cases
Proximal muscle weakness Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Muscle weakness and Atrial fibrillation. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


EMG: myopathic abnormalities Muscular dystrophy Sudden cardiac death Elevated serum creatine phosphokinase Skeletal muscle atrophy Exertional dyspnea Scoliosis Ventricular tachycardia Flexion contracture Atrioventricular block Waddling gait Hypertrophic cardiomyopathy Ventricular hypertrophy Bradycardia Congestive heart failure

Rare Symptoms - Less than 30% cases


Atrial arrhythmia Ichthyosis Left bundle branch block Ventriculomegaly Proximal muscle weakness in upper limbs Proximal lower limb amyotrophy Reduced ejection fraction Abnormal echocardiogram Pelvic girdle muscle weakness Respiratory insufficiency due to muscle weakness Achilles tendon contracture Limb-girdle muscle weakness Ankle contracture Seizures Gait disturbance Hyperlordosis Elbow flexion contracture Lipodystrophy Limb-girdle muscular dystrophy Scapular winging Distal muscle weakness Syncope Cardiomegaly Reduced systolic function Ventricular escape rhythm Proximal amyotrophy Neck muscle weakness Progressive muscle weakness Stroke Left ventricular hypertrophy Constipation Diarrhea Peroneal muscle weakness Pneumonia Dysarthria Behavioral abnormality Dystonia Splenomegaly Depressivity Areflexia Hepatosplenomegaly Myoclonus Peripheral neuropathy Anxiety Pelvic girdle muscle atrophy Dyskinesia Chorea Generalized-onset seizure Hepatomegaly Cognitive impairment Anemia Sick sinus syndrome Difficulty running Weakness of facial musculature Hypotension Dyspnea Fatigue Abnormal atrioventricular conduction Decreased cervical spine flexion due to contractures of posterior cervical muscles Aspiration Absent muscle fiber emerin Limb-girdle muscle atrophy Paroxysmal supraventricular tachycardia Fatiguable weakness of proximal limb muscles Pelvic girdle amyotrophy Abnormal muscle fiber lamin A/C Type 1 muscle fiber atrophy Proximal upper limb amyotrophy Tip-toe gait Sprengel anomaly Reduced tendon reflexes Back pain Myotonia Toe walking Spinal rigidity Rimmed vacuoles Vocal cord paralysis Hypertriglyceridemia Distal lower limb amyotrophy Sinus bradycardia Distal lower limb muscle weakness Proximal muscle weakness in lower limbs Supraventricular arrhythmia Increased LDL cholesterol concentration Peroneal muscle atrophy Palpitations Joint stiffness EMG abnormality Personality disorder Obsessive-compulsive behavior Abnormality of the musculature Rhabdomyolysis Difficulty climbing stairs Motor axonal neuropathy Acanthocytosis Tics Abetalipoproteinemia Pectus excavatum Phonic tics Intellectual disability Muscular hypotonia Ptosis Short neck Kyphosis Obesity Aspiration pneumonia Knee flexion contracture Calf muscle hypertrophy Cardiogenic shock Coronary artery atherosclerosis Pulmonary embolism Pulmonary artery stenosis Left ventricular noncompaction T-wave inversion Abnormal left ventricle morphology First degree atrioventricular block Aortic arch aneurysm Ventricular arrhythmia Left ventricular noncompaction cardiomyopathy Pulmonary artery hypoplasia ST segment depression Ebstein anomaly of the tricuspid valve Abnormal cardiac septum morphology Paresthesia Peripheral axonal neuropathy Tricuspid regurgitation Bicuspid aortic valve Impotence Left anterior fascicular block Right bundle branch block Bulbar palsy Thromboembolic stroke Skeletal myopathy Right ventricular cardiomyopathy Hyporeflexia of lower limbs Abnormal levels of creatine kinase in blood Late-onset proximal muscle weakness Shock Restrictive heart failure Trifascicular block Paroxysmal atrial fibrillation Dilatation Pulmonic stenosis Coarctation of aorta Pulmonary arterial hypertension Exercise intolerance Pericardial effusion Atrial flutter Generalized hypotonia Reduced vital capacity Calf muscle pseudohypertrophy Generalized limb muscle atrophy Scapuloperoneal amyotrophy Civatte bodies Scapuloperoneal weakness Short stature Feeding difficulties Shoulder girdle muscle weakness Wide nasal bridge Mildly reduced ejection fraction Respiratory insufficiency Midface retrusion Difficulty walking Neonatal hypotonia Facial palsy Type 1 muscle fiber predominance Centrally nucleated skeletal muscle fibers Orthostatic hypotension Cardiac amyloidosis Ventricular extrasystoles Heart block Edema of the lower limbs Right ventricular hypertrophy Tachycardia Biventricular hypertrophy Peripheral edema Abnormal ventricular filling Cleft palate Orthostatic syncope Clinodactyly Syndactyly Brachydactyly Generalized muscle weakness Low-set ears Abnormality of the cardiovascular system Restricted neck movement due to contractures



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