Muscle weakness, and Arrhythmia

Diseases related with Muscle weakness and Arrhythmia

In the following list you will find some of the most common rare diseases related to Muscle weakness and Arrhythmia that can help you solving undiagnosed cases.

Top matches:

Autosomal dominant Charcot-Marie-Tooth disease, type 2K (CMT2K) is an axonal CMT peripheral sensorimotor polyneuropathy.

AUTOSOMAL DOMINANT CHARCOT-MARIE-TOOTH DISEASE TYPE 2K Is also known as cmt2k

Related symptoms:

  • Motor delay
  • Skeletal muscle atrophy
  • Gait disturbance
  • Arrhythmia
  • Proximal muscle weakness


SOURCES: ORPHANET MENDELIAN

More info about AUTOSOMAL DOMINANT CHARCOT-MARIE-TOOTH DISEASE TYPE 2K

Emery-Dreifuss muscular dystrophy is a genetically heterogeneous muscular disease that presents with muscular dystrophy, joint contractures, and cardiomyopathy with conduction defects (summary by Liang et al., 2011).For a discussion of genetic heterogeneity of EDMD, see {310300}.

Related symptoms:

  • Muscle weakness
  • Flexion contracture
  • Cardiomyopathy
  • Arrhythmia
  • Proximal muscle weakness


SOURCES: OMIM MENDELIAN

More info about EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7

Other less relevant matches:

Autosomal recessive limb-girdle muscular dystrophy type 2X is a rare subtype of autosomal recessive limb-girdle muscular dystrophy characterized by atrioventricular block resulting in repeated syncope episodes, elevated creatine kinase serum levels and adult-onset of slowly progressive proximal limb skeletal muscle weakness and atrophy. Muscular dystrophic changes observed in muscle biopsy include diameter variability, increased central nuclei, and presence of necrotic and regenerating fibers.

AUTOSOMAL RECESSIVE LIMB-GIRDLE MUSCULAR DYSTROPHY TYPE 2X Is also known as autosomal recessive limb-girdle muscular dystrophy-cardiac arrhythmia syndrome|lgmd2x|muscular dystrophy, limb-girdle, type 2x

Related symptoms:

  • Muscle weakness
  • Cardiomyopathy
  • Arrhythmia
  • Elevated serum creatine phosphokinase
  • Proximal muscle weakness


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOSOMAL RECESSIVE LIMB-GIRDLE MUSCULAR DYSTROPHY TYPE 2X

Related symptoms:

  • Muscle weakness
  • Fatigue
  • Cardiomyopathy
  • Myopathy
  • Congestive heart failure


SOURCES: OMIM MESH MENDELIAN

More info about CARDIOMYOPATHY, DILATED, 1I; CMD1I

Late-onset distal myopathy, Markesbery-Griggs type is a rare, genetic, non-dystrophic myofibrillar myopathy disorder characterized by late-adult onset of distal and/or proximal limb muscle weakness with initial involvement of posterior lower leg muscles, medial gastrocnemius and soleus. Patients present with ankle weakness followed by weakness of finger and wrist extensors and later on of proximal muscles. Ambulation is usually preserved. Late-onset associated cardiomyopathy and/or neuropathy has been reported in a minority of cases.

LATE-ONSET DISTAL MYOPATHY, MARKESBERY-GRIGGS TYPE Is also known as zasp-related myofibrillar myopathy

Related symptoms:

  • Muscle weakness
  • Cardiomyopathy
  • Myopathy
  • Elevated serum creatine phosphokinase
  • Irritability


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about LATE-ONSET DISTAL MYOPATHY, MARKESBERY-GRIGGS TYPE

Atrial fibrillation is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997).For a discussion of genetic heterogeneity of atrial fibrillation, see {608583}.

Related symptoms:

  • Short stature
  • Muscle weakness
  • Cleft palate
  • Low-set ears
  • Brachydactyly


SOURCES: OMIM MENDELIAN

More info about ATRIAL FIBRILLATION, FAMILIAL, 9; ATFB9

Glycogen storage disease due to muscle and heart glycogen synthase deficiency is characterised by muscle and heart glycogen deficiency. It has been described in three siblings (two brothers and their younger sister). The older brother died at 10.5 years of age as a result of sudden cardiac arrest and the younger brother presented with hypertrophic cardiomyopathy, abnormal heart rate and blood pressure during exercise, and muscle fatigability. The sister showed no symptoms but a lack of glycogen was identified through muscle biopsy. The syndrome is caused by homozygous missense mutations in the gene encoding muscle glycogen synthase.

GLYCOGEN STORAGE DISEASE DUE TO MUSCLE AND HEART GLYCOGEN SYNTHASE DEFICIENCY Is also known as glycogen storage disease type 0b|gsd due to muscle and heart glycogen synthase deficiency|gsd type 0b|muscle glycogen synthase deficiency|glycogenosis due to muscle and heart glycogen synthase deficiency|muscle glycogen storage disease 0|gsd 0b|glycogenos

Related symptoms:

  • Seizures
  • Muscle weakness
  • Cardiomyopathy
  • Arrhythmia
  • Myalgia


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about GLYCOGEN STORAGE DISEASE DUE TO MUSCLE AND HEART GLYCOGEN SYNTHASE DEFICIENCY

Related symptoms:

  • Muscle weakness
  • Ptosis
  • Respiratory insufficiency
  • Cardiomyopathy
  • Congestive heart failure


SOURCES: OMIM MENDELIAN

More info about EMERY-DREIFUSS MUSCULAR DYSTROPHY 5, AUTOSOMAL DOMINANT; EDMD5

Top 5 symptoms//phenotypes associated to Muscle weakness and Arrhythmia

Symptoms // Phenotype % cases
Cardiomyopathy Common - Between 50% and 80% cases
Proximal muscle weakness Uncommon - Between 30% and 50% cases
Syncope Uncommon - Between 30% and 50% cases
Muscular dystrophy Uncommon - Between 30% and 50% cases
Elevated serum creatine phosphokinase Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Muscle weakness and Arrhythmia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Left ventricular hypertrophy Tachycardia Atrial fibrillation

Rare Symptoms - Less than 30% cases

Palpitations Myopathy Ventricular tachycardia Cardiac arrest Congestive heart failure Proximal amyotrophy Limb muscle weakness Dilated cardiomyopathy Progressive muscle weakness Stroke Ventricular hypertrophy Ventricular extrasystoles Progressive distal muscle weakness Short stature Cleft palate Low-set ears Motor delay Autophagic vacuoles Brachydactyly Muscle fiber splitting Myofibrillar myopathy EMG: neuropathic changes Progressive proximal muscle weakness Mildly elevated creatine phosphokinase Hyporeflexia of lower limbs Seizures Syndactyly Loss of consciousness Respiratory insufficiency Ptosis Decreased muscle glycogen content Left atrial enlargement Type 2 muscle fiber atrophy Prolonged QT interval Ragged-red muscle fibers Clinodactyly Exercise intolerance Generalized tonic-clonic seizures Hypertrophic cardiomyopathy Myalgia Polyneuropathy Thromboembolic stroke Paroxysmal atrial fibrillation EMG: myopathic abnormalities Dyspnea Irritability Hypokalemia Gait disturbance Distal muscle weakness Distal sensory impairment Peripheral demyelination Decreased nerve conduction velocity Hand muscle atrophy Flexion contracture Bradycardia Neck muscle weakness Coma Shock Polymorphic ventricular tachycardia Paralysis Goiter Hyperthyroidism Mildly reduced ejection fraction Skeletal muscle atrophy Ventricular escape rhythm Reduced systolic function Atrial flutter Cardiomegaly Hypotension Sudden cardiac death Fatigue Periodic paralysis Late-onset proximal muscle weakness Loss of ability to walk Sinus bradycardia Limb-girdle muscle weakness Centrally nucleated skeletal muscle fibers Atrioventricular block Scapular winging


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