Melanoma, and Carious teeth

Diseases related with Melanoma and Carious teeth

In the following list you will find some of the most common rare diseases related to Melanoma and Carious teeth that can help you solving undiagnosed cases.


Top matches:

High match PAPILLON-LEFÈVRE SYNDROME


Papillon-Lefèvre syndrome (PLS) is a rare ectodermal dysplasia characterized by palmoplantar keratoderma associated with early-onset periodontitis.

PAPILLON-LEFÈVRE SYNDROME Is also known as keratosis palmoplantar-periodontopathy syndrome|pls|keratosis palmoplantaris with periodontopathia

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Abnormality of the dentition
  • Recurrent respiratory infections
  • Hyperhidrosis


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about PAPILLON-LEFÈVRE SYNDROME

High match FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1


Familial adenomatous polyposis-1 is an autosomal dominant disorder characterized by predisposition to cancer. Affected individuals usually develop hundreds to thousands of adenomatous polyps of the colon and rectum, a small proportion of which will progress to colorectal carcinoma if not surgically treated. Gardner syndrome is a variant of FAP in which desmoid tumors, osteomas, and other neoplasms occur together with multiple adenomas of the colon and rectum (Nishisho et al., 1991).Rustgi (2007) reviewed the genetics of hereditary colon cancer, including APC. Genetic Heterogeneity of Familial Adenomatous PolyposisSee also autosomal recessive FAP2 (OMIM ), caused by mutation in the MUTYH gene (OMIM ) on chromosome 1p34; autosomal recessive FAP3 (OMIM ), caused by mutation in the NTHL1 gene (OMIM ) on chromosome 16p13; and autosomal recessive FAP4 (OMIM ), caused by mutation in the MSH3 gene (OMIM ) on chromosome 5q11.

FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1 Is also known as apc|familial polyposis of the colon|fpc|adenomatous polyposis of the colon|polyposis, adenomatous intestinal

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Abnormality of the dentition
  • Kyphoscoliosis
  • Carcinoma


SOURCES: OMIM ORPHANET MENDELIAN

More info about FAMILIAL ADENOMATOUS POLYPOSIS 1; FAP1

High match MUTILATING PALMOPLANTAR KERATODERMA WITH PERIORIFICIAL KERATOTIC PLAQUES


Mutilating palmoplantar keratoderma (PPK) with periorificial keratotic plaques (also known as Olmsted syndrome) is a hereditary palmoplantar keratoderma characterized by the combination of bilateral mutilating transgredient palmoplantar keratoderma and periorificial keratotic plaques.

MUTILATING PALMOPLANTAR KERATODERMA WITH PERIORIFICIAL KERATOTIC PLAQUES Is also known as palmoplantar and periorificial keratoderma|mutilating palmoplantar hyperkeratosis with periorificial keratotic plaques|olms|olmsted syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Hearing impairment
  • Growth delay


SOURCES: ORPHANET OMIM MENDELIAN

More info about MUTILATING PALMOPLANTAR KERATODERMA WITH PERIORIFICIAL KERATOTIC PLAQUES

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Other less relevant matches:

Low match FAMILIAL CUTANEOUS TELANGIECTASIA AND OROPHARYNGEAL CANCER PREDISPOSITION SYNDROME


Familial cutaneous telangiectasia and oropharyngeal cancer predisposition syndrome is a rare, inherited cancer-predisposing syndrome characterized by an early development of cutaneous telangiectasia, mild dental and nail anomalies, patchy alopecia over the affected skin areas and increased lifetime risk for oropharyngeal cancer. Other types of cancer have also been reported.

FAMILIAL CUTANEOUS TELANGIECTASIA AND OROPHARYNGEAL CANCER PREDISPOSITION SYNDROME Is also known as telangiectasia, cutaneous, and cancer syndrome, familial

Related symptoms:

  • Neoplasm
  • Alopecia
  • Carcinoma
  • Carious teeth
  • Convex nasal ridge


SOURCES: ORPHANET OMIM MENDELIAN

More info about FAMILIAL CUTANEOUS TELANGIECTASIA AND OROPHARYNGEAL CANCER PREDISPOSITION SYNDROME

Low match PACHYONYCHIA CONGENITA


Pachyonychia congenita (PC) is a rare genodermatosis predominantly featuring painful palmoplantar keratoderma, thickened nails, cysts and whitish oral mucosa.

PACHYONYCHIA CONGENITA Is also known as pc

Related symptoms:

  • Cataract
  • Cognitive impairment
  • Hepatomegaly
  • Respiratory insufficiency
  • Abnormality of the dentition


SOURCES: ORPHANET OMIM MENDELIAN

More info about PACHYONYCHIA CONGENITA

Low match LEUKONYCHIA TOTALIS


Leukonychia totalis is a rare nail anomaly disorder characterized by complete white discoloration of the nails. Patients typically present white, chalky nails as an isolated finding, although other cutaneous or systemic manifestations could also be present.

LEUKONYCHIA TOTALIS Is also known as leukonychia totalis and/or partialis|porcelain nails

Related symptoms:

  • Diabetes mellitus
  • Photophobia
  • Carious teeth
  • Palmoplantar keratoderma
  • Ectodermal dysplasia


SOURCES: OMIM ORPHANET MENDELIAN

More info about LEUKONYCHIA TOTALIS

Low match OTODENTAL SYNDROME


Otodental syndrome is a very rare inherited condition characterized by grossly enlarged canine and molar teeth (globodontia) associated with sensorineural hearing loss.

OTODENTAL SYNDROME Is also known as globodontia|otodental dysplasia|chromosome 11q13 deletion syndrome|otodental syndrome

Related symptoms:

  • Hearing impairment
  • Micrognathia
  • Sensorineural hearing impairment
  • Cataract
  • Anteverted nares


SOURCES: OMIM ORPHANET MENDELIAN

More info about OTODENTAL SYNDROME

Low match DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 1; DKCB1


Dyskeratosis congenita is a bone marrow failure syndrome classically characterized by the triad of abnormal skin pigmentation, nail dystrophy, and leukoplakia of the oral mucosa. Progressive bone marrow failure occurs in over 80% of cases and is the main cause of early mortality. The phenotype is highly variable, and affected individuals may have multiple additional features, including pulmonary fibrosis, liver cirrhosis, premature hair loss and/or graying, osteoporosis, atresia of the lacrimal ducts, and learning difficulties. Predisposition to malignancy is an important feature. The disorder is caused by defects in the maintenance of telomeres (summary by Kirwan and Dokal, 2008).For a discussion of genetic heterogeneity of dyskeratosis congenita, see DKCA1 (OMIM ).

Related symptoms:

  • Intellectual disability
  • Microcephaly
  • Abnormality of the dentition
  • Thrombocytopenia
  • Alopecia


SOURCES: MESH OMIM MENDELIAN

More info about DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE 1; DKCB1

Low match WHIM SYNDROME


WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).

WHIM SYNDROME Is also known as warts, hypogammaglobulinemia, infections, and myelokathexis syndrome|warts-infections-leukopenia-myelokatexis syndrome|wilm|warts-hypogammaglobulinemia-infections-myelokathexis syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Fever
  • Congestive heart failure
  • Immunodeficiency


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WHIM SYNDROME

Low match MCCUNE-ALBRIGHT SYNDROME


McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), café-au-lait skin spots, and precocious puberty (PP).

MCCUNE-ALBRIGHT SYNDROME Is also known as gonadotropin-independent female-limited sexual precocity

Related symptoms:

  • Optic atrophy
  • Macrocephaly
  • Abnormality of the dentition
  • Kyphosis
  • Mandibular prognathia


SOURCES: ORPHANET MENDELIAN

More info about MCCUNE-ALBRIGHT SYNDROME

Top 5 symptoms//phenotypes associated to Melanoma and Carious teeth

Symptoms // Phenotype % cases
Abnormality of the dentition Common - Between 50% and 80% cases
Carcinoma Common - Between 50% and 80% cases
Nail dystrophy Uncommon - Between 30% and 50% cases
Alopecia Uncommon - Between 30% and 50% cases
Abnormality of the fingernails Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Melanoma and Carious teeth. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Neoplasm Palmoplantar keratoderma Intellectual disability Oral leukoplakia Hearing impairment Squamous cell carcinoma Hyperkeratosis Ectodermal dysplasia Periodontitis Hyperhidrosis Neoplasm of the skin

Rare Symptoms - Less than 30% cases


Hypoplasia of dental enamel Plantar hyperkeratosis Nail dysplasia Agenesis of premolar Telangiectasia Sarcoma Hyperpigmentation of the skin Epidermoid cyst Precocious puberty Abnormality of dental enamel Parakeratosis Ankylosis Increased number of teeth Neoplasm of the lung Hypodontia Onycholysis Ichthyosis Epiphora Sensorineural hearing impairment Erythema Papule Hypotrichosis Abnormality of the nail Odontoma Osteolysis Increased circulating cortisol level Cataract Osteoporosis Microcephaly Lens coloboma Abnormality of skin pigmentation Cirrhosis Microdontia Pancytopenia Bone marrow hypocellularity High-frequency sensorineural hearing impairment Sparse scalp hair Hepatic fibrosis Abnormality of the dental pulp Otitis media with effusion Thrombocytopenia Pulp stones Small nail Abnormality of canine Abnormality of molar morphology Abnormality of the maxilla Microcornea Macrodontia Micrognathia Steatocystoma multiplex Diabetes mellitus Photophobia Type II diabetes mellitus Nephrolithiasis Psoriasiform dermatitis Blepharitis Abnormal eyelash morphology Abnormal toenail morphology Concave nail Leukonychia Adenoma sebaceum Short eyelashes Anteverted nares High-frequency hearing impairment Long philtrum Microphthalmia Coloboma Long face Iris coloboma Delayed eruption of teeth Full cheeks Bilateral sensorineural hearing impairment Gingival overgrowth Progressive hearing impairment Progressive sensorineural hearing impairment Taurodontia Retinal coloboma Sparse eyelashes Respiratory failure Pterygium Mandibular prognathia Tall stature Abnormality of the face Recurrent fractures Abnormality of the eye Elevated hepatic transaminase Skeletal dysplasia Kyphosis Abnormal palate morphology Macrocephaly Optic atrophy Myelokathexis Bone marrow hypercellularity Hypersegmentation of neutrophil nuclei Tonsillitis Bone pain Reduced bone mineral density Folliculitis Hyperthyroidism Testicular neoplasm Neoplasm of the breast Long penis Macroorchidism Hearing abnormality Generalized hyperpigmentation Multiple cafe-au-lait spots Abnormality of vision Hyperparathyroidism Prolonged bleeding time Hypophosphatemia Open bite Polycystic ovaries Goiter Septic arthritis Abnormality of bone marrow cell morphology Pulmonary fibrosis Congestive heart failure Neutropenia Respiratory tract infection Arthritis Skin plaque Pneumonia Immunodeficiency Fever Decreased antibody level in blood Pterygium of nails Decreased mean platelet volume Esophageal stricture Nasolacrimal duct obstruction Poikiloderma Aplastic anemia Lymphoma Otitis media Abnormality of female external genitalia Osteomyelitis Abnormality of female internal genitalia Atelectasis Verrucae B-cell lymphoma IgG deficiency Cellulitis Combined immunodeficiency Recurrent urinary tract infections Leukocytosis Recurrent upper respiratory tract infections Recurrent bacterial infections Meningitis Sinusitis Bronchiectasis Abnormality of nail color Convex nasal ridge Thick nail Stomach cancer Intestinal obstruction Colon cancer Chorioretinal atrophy Agenesis of permanent teeth Neurofibromas Multiple lipomas Brain neoplasm Astrocytoma Thyroid carcinoma Intestinal polyposis Medulloblastoma Glioma Adrenocortical adenoma Horseshoe kidney Papillary thyroid carcinoma Hepatoblastoma Keloids Thoracic kyphoscoliosis Chondrosarcoma Absent gallbladder Intestinal polyp Adrenocortical carcinoma Multiple impacted teeth Colorectal polyposis Cholangiocarcinoma Fibroadenoma of the breast Osteoma Hyperextensible skin Infertility Multiple gastric polyps Pustule Recurrent respiratory infections Arachnodactyly Cerebral calcification Hypertrichosis Generalized hirsutism Hypopigmented skin patches Recurrent skin infections Palmoplantar hyperkeratosis Reduced number of teeth Scaling skin Keratitis Sparse body hair Premature loss of teeth Gingivitis Leukemia Fragile nails Stomatitis Premature loss of primary teeth Liver abscess Cigarette-paper scars Recurrent cutaneous abscess formation Choroid plexus calcification Severe periodontitis Chronic furunculosis Halitosis Atrophy of alveolar ridges Kyphoscoliosis Intellectual disability, moderate Abdominal mass Unerupted tooth Hamartoma Basal cell carcinoma Alopecia universalis Abnormal cornea morphology Abnormal oral mucosa morphology Abnormality of the gingiva Palmoplantar hyperhidrosis Hidrotic ectodermal dysplasia Autoamputation Foot pain Ainhum Circumungual hyperkeratosis Skin fissure Anal fissure Breast carcinoma Ridged nail Trichorrhexis nodosa Thin nail Patchy alopecia Onychomycosis Sebaceous gland carcinoma Cognitive impairment Hepatomegaly Respiratory insufficiency Abnormal blistering of the skin Abnormality of the hair Corneal dystrophy Laryngomalacia Anonychia Natal tooth Abnormality of the tongue Amniotic constriction ring Adenomatous colonic polyposis Sparse hair Duodenal adenocarcinoma Small intestine carcinoid Desmoid tumors Duodenal polyposis Congenital hypertrophy of retinal pigment epithelium Seizures Global developmental delay Growth delay Pain Flexion contracture Delayed skeletal maturation Severe short stature Joint laxity Corneal opacity Subungual hyperkeratosis Pruritus Epidermal acanthosis Inflammatory abnormality of the skin Thickened skin Skin ulcer Opacification of the corneal stroma Cutis laxa Mutism Anhidrosis Curly hair Pili torti Hypergranulosis Generalized osteoporosis Neoplasm of the thyroid gland



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