Lymphoma, and Tachycardia

Diseases related with Lymphoma and Tachycardia

In the following list you will find some of the most common rare diseases related to Lymphoma and Tachycardia that can help you solving undiagnosed cases.


Top matches:

Low match RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISEASE


RAS-associated autoimmune leukoproliferative disease (RALD) is a rare genetic disorder characterized by monocytosis, autoimmune cytopenias, lymphoproliferation, hepatosplenomegaly, and hypergammaglobulinemia.

RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISEASE Is also known as alps4|rald|autoimmune lymphoproliferative syndrome, type iv

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Recurrent infections


SOURCES: ORPHANET OMIM MENDELIAN

More info about RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISEASE

Low match HEREDITARY NEUTROPHILIA


Related symptoms:

  • Anemia
  • Fever
  • Weight loss
  • Dyspnea
  • Hepatosplenomegaly


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about HEREDITARY NEUTROPHILIA

Low match PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1; PNH1


Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon acquired hemolytic anemia that often manifests with hemoglobinuria, abdominal pain, smooth muscle dystonias, fatigue, and thrombosis. The disease results from the expansion of hematopoietic stem cells harboring a mutation in the PIGA gene, which encodes a protein required for the biosynthesis of glycosylphosphatidylinositol (GPI), a lipid moiety that attaches dozens of proteins to the cell surface. Thus, PNH cells are deficient in cell surface GPI-anchored proteins. This deficiency on erythrocytes leads to intravascular hemolysis, since certain GPI-anchored proteins (i.e., CD55 (OMIM ) and CD59 (OMIM )) normally function as complement regulators. Free hemoglobin released from intravascular hemolysis leads to circulating nitrous oxide depletion and is responsible for many of the clinical manifestations of PNH, including fatigue, erectile dysfunction, esophageal spasm, and thrombosis (review by Brodsky, 2008). Genetic Heterogeneity of Paroxysmal Nocturnal HemoglobinuriaSee also PNH2 (OMIM ), which may be caused by germline and somatic mutation in the PIGT gene (OMIM ) on chromosome 20q13.

Related symptoms:

  • Pain
  • Anemia
  • Fatigue
  • Respiratory distress
  • Thrombocytopenia


SOURCES: OMIM MENDELIAN

More info about PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1; PNH1

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Other less relevant matches:

Low match WISKOTT-ALDRICH SYNDROME


Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

Low match MASTOCYTOSIS, CUTANEOUS; MASTC


Mastocytosis, or mast cell disease, is a heterogeneous group of clinical disorders characterized by the abnormal accumulation of mast cells in various tissues, especially in the skin and hematopoietic organs. Mastocytosis usually appears in infancy or early adulthood. In most pediatric cases, the disease is limited to the skin, but it can be associated with systemic symptoms due to the release of mediators from mast cells, even when there is no systemic infiltration. It usually has a good prognosis, with substantial improvement or spontaneous resolution before puberty. In rare cases, the disease may remain active through adolescence as a systemic adult mastocytosis. Cutaneous mastocytosis is characterized by macules, papules, nodules, or diffuse infiltration of the skin, often associated with localized hyperpigmentation. Gentle rubbing of the lesions induces histamine release from mechanically activated mast cells, causing local wheals, erythema, and often pruritus, a phenomenon termed the 'Darier sign.' In contrast to childhood-onset mastocytosis, adult-onset mastocytosis often persists for the lifetime of the patient and is also more likely to be a severe and systemic disease involving numerous organs. In some cases, it is associated with a clonal hematologic non-mast-cell lineage disease, such as a myelodysplastic or myeloproliferative disorder. Adult-onset mastocytosis can also lead to the rare mast cell leukemia, which carries a high risk of mortality (summary by Bodemer et al., 2010 and Kambe et al., 2010).

MASTOCYTOSIS, CUTANEOUS; MASTC Is also known as mastocytosis, maculopapular cutaneous|mastocytosis, diffuse cutaneous|urticaria pigmentosa

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hypertension
  • Hepatomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about MASTOCYTOSIS, CUTANEOUS; MASTC

Low match THIAMINE-RESPONSIVE MEGALOBLASTIC ANEMIA SYNDROME


Thiamine-responsive megaloblastic anemia (TRMA) is characterized by a triad of megaloblastic anemia, non-type I diabetes mellitus, and sensorineural deafness.

THIAMINE-RESPONSIVE MEGALOBLASTIC ANEMIA SYNDROME Is also known as thmd1|trma|thiamine-responsive megaloblastic anemia with diabetes mellitus and sensorineural deafness|rogers syndrome|thiamine-responsive myelodysplasia|thiamine metabolism dysfunction syndrome 1 (megaloblastic anemia, diabetes mellitus, and deafness type

Related symptoms:

  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment
  • Microcephaly


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about THIAMINE-RESPONSIVE MEGALOBLASTIC ANEMIA SYNDROME

Low match BLOOD GROUP, MN; MN


MN antigens reside on GYPA, one of the most abundant red-cell glycoproteins. The M and N antigens are 2 autosomal codominant antigens encoded by the first 5 amino acids of GYPA and include 3 O-linked glycans as part of the epitope. M and N differ at amino acids 1 and 5, where M is ser-ser-thr-thr-gly, and N is leu-ser-thr-thr-glu. M is the ancestral GYPA allele and is common in all human populations and Old World apes. GYPA, glycophorin B (GYPB ), and glycophorin E (GYPE ) are closely linked on chromosome 4q31. The N terminus of GYPB is essentially identical to that of GYPA except that it always expresses the N antigen, denoted 'N' or N-prime. Antigens of the Ss blood group (OMIM ) reside on GYPB, and recombination and gene conversion between GYPA, GYPB, and GYPE lead to hybrid glycophorin molecules and generation of low-incidence antigens. Thus, the MN and Ss blood groups are together referred to as the MNSs or MNS blood group system. The U antigen refers to a short extracellular sequence in GYPB located near the membrane. Recombination results in 3 glycophorin-null phenotypes: En(a-) cells lack GYPA due to recombination between GYPA and GYPB; GYPB-negative (S-s-U-) cells lack GYPB due to recombination in GYPB; and M(k) cells (M-N-S-s-U-) lack both GYPA and GYPB due to recombination between GYPA and GYPE. Individuals with glycophorin-null phenotypes have decreased sialic acid content and increased resistance to malarial infection (see {611162}). GYPA and GYPB are not essential for red-cell development or survival, and GYPA- and GYPB-null phenotypes are not associated with anemia or altered red-cell function (review by Cooling, 2015).

BLOOD GROUP, MN; MN Is also known as mn blood group

Related symptoms:

  • Neoplasm
  • Anemia
  • Leukemia


SOURCES: OMIM MENDELIAN

More info about BLOOD GROUP, MN; MN

Low match CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II


Congenital dyserythropoietic anemia type II (CDA II) is the most common form of CDA (see this term) characterized by anemia, jaundice and splenomegaly and often leading to liver iron overload and gallstones.

CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II Is also known as dyserythropoietic anemia, congenital, type ii|cda ii|sec23b-cdg|hempas|hereditary erythroblastic multinuclearity with positive acidified-serum test|cda type ii|cda type 2|hereditary erythroblastic multinuclearity with a positive acidified-serum test (hemp

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Congestive heart failure
  • Splenomegaly
  • Arrhythmia


SOURCES: ORPHANET OMIM MENDELIAN

More info about CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II

Low match COMBINED IMMUNODEFICIENCY DUE TO STK4 DEFICIENCY


Combined immunodeficiency due to STK4 deficiency is a rare, genetic combined T and B cell immunodeficiency characterized by T- and B-cell lymphopenia, hypergammaglobulinemia and intermittent neutropenia. It presents with recurrent opportunistic viral, bacterial and fungal infections involving skin (cutaneous papillomatosis, molluscum contagiosum, skin abscesses, mucocutaneous candidiasis), upper and lower respiratory tract or septicemia. Other clinical features include autoimmune manifestations (autoimmune hemolytic anemia) and congenital heart defects (atrial septal defects, patent foramen ovale, mitral, triscupid and pulmonary valve insufficiency).

COMBINED IMMUNODEFICIENCY DUE TO STK4 DEFICIENCY Is also known as mst1 deficiency|cid due to stk4 deficiency|stk4 deficiency

Related symptoms:

  • Anemia
  • Atrial septal defect
  • Immunodeficiency
  • Lymphadenopathy
  • Hemolytic anemia


SOURCES: OMIM ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY DUE TO STK4 DEFICIENCY

Top 5 symptoms//phenotypes associated to Lymphoma and Tachycardia

Symptoms // Phenotype % cases
Anemia Very Common - Between 80% and 100% cases
Leukemia Common - Between 50% and 80% cases
Thrombocytopenia Uncommon - Between 30% and 50% cases
Arrhythmia Uncommon - Between 30% and 50% cases
Splenomegaly Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Lymphoma and Tachycardia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Hepatosplenomegaly Lymphadenopathy Hemolytic anemia Neutropenia Pancytopenia Hepatomegaly Diarrhea Neoplasm Acute leukemia Fatigue Myelodysplasia Fever

Rare Symptoms - Less than 30% cases


Vasculitis Skin rash Pain Purpura Abdominal pain Pallor Sarcoma Chronic leukemia Headache Respiratory tract infection Lymphopenia Recurrent respiratory infections Recurrent infections Immunodeficiency Cirrhosis Urticaria Abnormal eosinophil morphology Atrial septal defect Combined immunodeficiency Autoimmune hemolytic anemia Congestive heart failure Gastroesophageal reflux Increased antibody level in blood Recurrent upper respiratory tract infections Lymphoproliferative disorder Weight loss Dyspnea Cardiac arrest Sudden cardiac death Seizures Global developmental delay Anaphylactic shock Cutaneous mastocytosis Dermatographic urticaria Telangiectasia macularis eruptiva perstans Sensorineural hearing impairment Visual loss Short stature Hearing impairment Cardiomyopathy Microcephaly Ataxia Ventricular septal defect Optic atrophy Cryptorchidism Nystagmus Abnormality of blood and blood-forming tissues Mastocytosis Loss of consciousness Asthma Gastrointestinal hemorrhage Hypotension Abnormal blistering of the skin Telangiectasia Bone pain Bone marrow hypocellularity Osteolysis Leukopenia Shock Portal hypertension Hypermelanotic macule Abnormality of the gastric mucosa Diabetes mellitus Flushing Allergy Generalized osteosclerosis Myeloproliferative disorder Hypersplenism Gastrointestinal stroma tumor Immunologic hypersensitivity Asthenia Impaired temperature sensation Food intolerance Abnormal heart morphology Cone/cone-rod dystrophy Hypoglycemia Increased red cell osmotic fragility Hyperbilirubinemia Cholelithiasis Prolonged neonatal jaundice Reticulocytosis Gout Anemia of inadequate production Chronic myelogenous leukemia Congenital hypoplastic anemia Increased total bilirubin Increased hemoglobin Endopolyploidy on chromosome studies of bone marrow Jaundice Reduced activity of N-acetylglucosaminyltransferase II Ventricular hypertrophy Inflammatory abnormality of the skin Recurrent bacterial infections Patent foramen ovale Right ventricular hypertrophy Chronic mucocutaneous candidiasis B-cell lymphoma Recurrent viral infections Verrucae Pulmonary insufficiency Abnormality of the liver Thiamine-responsive megaloblastic anemia Abnormal cardiac septum morphology Anorexia Stroke Lethargy Paresthesia Retinal degeneration Retinal dystrophy Polyneuropathy Aciduria Abnormality of the skin Amenorrhea Bilateral sensorineural hearing impairment Situs inversus totalis Paroxysmal atrial tachycardia Hoarse voice Aminoaciduria Polycystic ovaries Hyperglycemia Secondary amenorrhea Macrocytic anemia Megaloblastic anemia Abdominal situs inversus Abnormality of the basal ganglia Sideroblastic anemia Progressive peripheral neuropathy Ascites Small vessel vasculitis Recurrent fractures Chronic diarrhea Bruising susceptibility Nephropathy Sepsis Abnormal bleeding Chest pain Otitis media Specific learning disability Eczema Epistaxis Recurrent otitis media Sinusitis Autoimmunity Skin ulcer Meningitis Conjunctivitis Chronic kidney disease Intracranial hemorrhage Glomerulosclerosis Rheumatoid arthritis Glomerulonephritis Chronic otitis media Inflammation of the large intestine Cough Proteinuria Keratitis Megakaryocyte dysplasia Autoimmune thrombocytopenia Lymphocytosis Follicular hyperplasia Monocytosis Decreased lymphocyte apoptosis Eosinophilia Pericardial effusion Thickened calvaria Neutrophilia Refractory anemia Elevated leukocyte alkaline phosphatase Arthritis Respiratory distress Venous thrombosis Impotence Abnormality of coagulation Aplastic anemia Hemoglobinuria Paroxysmal nocturnal hemoglobinuria Peripheral neuropathy Renal insufficiency Pneumonia Hyperostosis Focal segmental glomerulosclerosis Nausea Oral bleeding Decreased mean platelet volume Abnormal platelet morphology Congenital thrombocytopenia Reduced delayed hypersensitivity Large vessel vasculitis Recurrent intrapulmonary hemorrhage Absent microvilli on the surface of peripheral blood lymphocytes Abnormal delayed hypersensitivity skin test Reduced lymphocyte surface expression of CD43 Specific anti-polysaccharide antibody deficiency Hypertension Internal hemorrhage Edema Osteoporosis Arthralgia Myalgia Erythema Papule Pruritus Malabsorption Nausea and vomiting Ichthyosis Abnormal platelet function Generalized lymphadenopathy Petechiae Chronic obstructive pulmonary disease Prolonged bleeding time Cellulitis Microcytic anemia Glomerulopathy Iron deficiency anemia Hodgkin lymphoma Gingival bleeding Blepharitis Recurrent lower respiratory tract infections Hematochezia Hypoplasia of the thymus Bloody diarrhea IgM deficiency Recurrent ear infections Increased IgE level Abnormality of the menstrual cycle Membranoproliferative glomerulonephritis Interstitial pneumonitis Increased IgA level Hematemesis Melena Spontaneous hematomas Recurrent fungal infections



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