Lymphoma, and Sudden cardiac death

Diseases related with Lymphoma and Sudden cardiac death

In the following list you will find some of the most common rare diseases related to Lymphoma and Sudden cardiac death that can help you solving undiagnosed cases.

Top matches:

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

RAS-associated autoimmune leukoproliferative disease (RALD) is a rare genetic disorder characterized by monocytosis, autoimmune cytopenias, lymphoproliferation, hepatosplenomegaly, and hypergammaglobulinemia.

RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISEASE Is also known as alps4|rald|autoimmune lymphoproliferative syndrome, type iv

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Recurrent infections


SOURCES: ORPHANET OMIM MENDELIAN

More info about RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISEASE

Mastocytosis, or mast cell disease, is a heterogeneous group of clinical disorders characterized by the abnormal accumulation of mast cells in various tissues, especially in the skin and hematopoietic organs. Mastocytosis usually appears in infancy or early adulthood. In most pediatric cases, the disease is limited to the skin, but it can be associated with systemic symptoms due to the release of mediators from mast cells, even when there is no systemic infiltration. It usually has a good prognosis, with substantial improvement or spontaneous resolution before puberty. In rare cases, the disease may remain active through adolescence as a systemic adult mastocytosis. Cutaneous mastocytosis is characterized by macules, papules, nodules, or diffuse infiltration of the skin, often associated with localized hyperpigmentation. Gentle rubbing of the lesions induces histamine release from mechanically activated mast cells, causing local wheals, erythema, and often pruritus, a phenomenon termed the 'Darier sign.' In contrast to childhood-onset mastocytosis, adult-onset mastocytosis often persists for the lifetime of the patient and is also more likely to be a severe and systemic disease involving numerous organs. In some cases, it is associated with a clonal hematologic non-mast-cell lineage disease, such as a myelodysplastic or myeloproliferative disorder. Adult-onset mastocytosis can also lead to the rare mast cell leukemia, which carries a high risk of mortality (summary by Bodemer et al., 2010 and Kambe et al., 2010).

MASTOCYTOSIS, CUTANEOUS; MASTC Is also known as mastocytosis, maculopapular cutaneous|mastocytosis, diffuse cutaneous|urticaria pigmentosa

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hypertension
  • Hepatomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about MASTOCYTOSIS, CUTANEOUS; MASTC

Other less relevant matches:

Thiamine-responsive megaloblastic anemia (TRMA) is characterized by a triad of megaloblastic anemia, non-type I diabetes mellitus, and sensorineural deafness.

THIAMINE-RESPONSIVE MEGALOBLASTIC ANEMIA SYNDROME Is also known as thmd1|trma|thiamine-responsive megaloblastic anemia with diabetes mellitus and sensorineural deafness|rogers syndrome|thiamine-responsive myelodysplasia|thiamine metabolism dysfunction syndrome 1 (megaloblastic anemia, diabetes mellitus, and deafness type

Related symptoms:

  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment
  • Microcephaly


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about THIAMINE-RESPONSIVE MEGALOBLASTIC ANEMIA SYNDROME

Gaucher disease type 2 is the acute neurological form of Gaucher disease (GD; see this term). It is characterized by early-onset and severe neurological involvement of the brainstem, associated with an organomegaly and generally leading to death before the age of 2.

GAUCHER DISEASE TYPE 2 Is also known as infantile cerebral gaucher disease|acute neuronopathic gaucher disease

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly
  • Scoliosis


SOURCES: ORPHANET MENDELIAN

More info about GAUCHER DISEASE TYPE 2

Brugada Syndrome 7Brugada syndrome is characterized by an ST segment elevation in the right precordial electrocardiogram leads (so-called type 1 ECG) and a high incidence of sudden death in patients with structurally normal hearts. The syndrome typically manifests during adulthood, with a mean age of sudden death of 41 +/- 15 years, but also occurs in infants and children (summary by Antzelevitch et al., 2005).For a discussion of genetic heterogeneity of Brugada syndrome, see BRGDA1 (OMIM ). Atrial Fibrillation 16Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinical setting, with a prevalence of 1% in the general population; prevalence increases with age and reaches more than 8% in the ninth decade of life. AF accounts for more than 15% of strokes, and is associated with worsening heart failure and increased mortality. More than 30% of cases of AF are considered to be 'lone AF,' unassociated with coronary artery disease, hypertension, valvular heart disease, hyperthyroidism, heart failure, or structural heart disease (summary by Wang et al., 2010).For a discussion of genetic heterogeneity of atrial fibrillation, see ATFB1 (OMIM ).

Related symptoms:

  • Neoplasm
  • Hypertension
  • Congestive heart failure
  • Arrhythmia
  • Sudden cardiac death


SOURCES: MESH OMIM MENDELIAN

More info about BRUGADA SYNDROME 7; BRGDA7

Jervell and Lange-Nielsen syndrome (JLNS) is an autosomal recessive variant of familial long QT syndrome (see this term) characterized by congenital profound bilateral sensorineural hearing loss, a long QT interval on electrocardiogram and ventricular tachyarrhythmias.

JERVELL AND LANGE-NIELSEN SYNDROME Is also known as long qt interval-deafness syndrome

Related symptoms:

  • Seizures
  • Hearing impairment
  • Diarrhea
  • Sudden cardiac death
  • Syncope


SOURCES: OMIM ORPHANET MENDELIAN

More info about JERVELL AND LANGE-NIELSEN SYNDROME

The Jervell and Lange-Nielsen syndrome is an autosomal recessive disorder characterized by congenital deafness, prolongation of the QT interval, syncopal attacks due to ventricular arrhythmias, and a high risk of sudden death (Jervell and Lange-Nielsen, 1957).

JERVELL AND LANGE-NIELSEN SYNDROME 1; JLNS1 Is also known as prolonged qt interval in ekg and sudden death|deafness, congenital, and functional heart disease|surdo-cardiac syndrome|cardioauditory syndrome of jervell and lange-nielsen

Related symptoms:

  • Seizures
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about JERVELL AND LANGE-NIELSEN SYNDROME 1; JLNS1

Arrhythmogenic right ventricular dysplasia (ARVD) is a clinical and pathologic entity for which the diagnosis rests on electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. It is inherited in an autosomal dominant manner with reduced penetrance and is one of the major genetic causes of juvenile sudden death. When the dysplasia is extensive, it may represent the Uhl anomaly ('parchment right ventricle'). The presenting finding is usually recurrent, sustained ventricular tachycardia with left bundle branch block configuration. Basso et al. (2009) provided a detailed review of ARVD, including diagnosis, pathogenesis, treatment options, and genetics. Genetic Heterogeneity of Familial Arrhythmogenic Right Ventricular DysplasiaOther forms of ARVD include ARVD2 (OMIM ), caused by mutation in the RYR2 gene (OMIM ) on chromosome 1q42-q43; ARVD3 (OMIM ), on chromosome 14q12-q22; ARVD4 (OMIM ), on chromosome 2q32.1-q32.3; ARVD5 (OMIM ), caused by mutation in the TMEM43 gene (OMIM ) on chromosome 3p23; ARVD6 (OMIM ), on chromosome 10p14-p12; ARVD8 (OMIM ), caused by mutation in the DSP gene (OMIM ) on chromosome 6p24; ARVD9 (OMIM ), caused by mutation in the PKP2 gene (OMIM ) on chromosome 12p11; ARVD10 (OMIM ), caused by mutation in the DSG2 (OMIM ) on chromosome 18q12.1; ARVD11 (OMIM ), caused by mutation in the DSC2 gene (OMIM ) on chromosome 18q12.1; ARVD12 (OMIM ), caused by mutation in the JUP gene (OMIM ) on chromosome 17q21; and ARVD13 (OMIM ), caused by mutation in the CTNNA3 gene (OMIM ) on chromosome 10q21.ARVD7 is a former designation for a form of myopathy and ARVD mapped to chromosome 10q22, which was later found to be a form of myofibrillar myopathy (MFM1 ) caused by mutation in the DES gene (OMIM ) on chromosome 2q35.Christensen et al. (2010) screened 65 ARVD probands for mutations in 5 desmosomal genes as well as the TGFB3 gene (OMIM ), and identified 19 different mutations in the desmosomal genes in 12 of the families, including 7 with more than 1 mutation. In 6 families, digenic mutation carriers were identified, with at least 1 of the mutations being absent in the control population. The authors stated that their findings partially supported a gene dosage effect, although phenotypic variation was large.Nitoiu et al. (2014) reviewed desmosome biology in cardiocutaneous syndromes and inherited skin disease, including discussion of the involvement of the DSP, PKP2, DSG2, DSC2, and JUP genes.

ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 1; ARVD1 Is also known as arvc1|arrhythmogenic right ventricular cardiomyopathy 1

Related symptoms:

  • Fever
  • Cardiomyopathy
  • Edema
  • Myopathy
  • Congestive heart failure


SOURCES: ORPHANET OMIM MENDELIAN

More info about ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 1; ARVD1

Familial atrial fibrillation is a rare, genetically heterogenous cardiac disease characterized by erratic activation of the atria with an irregular ventricular response, in various members of a single family. It may be asymptomatic or associated with palpitations, dyspnea and light-headedness. Concomitant rhythm disorders and cardiomyopathies are frequently reported.

FAMILIAL ATRIAL FIBRILLATION Is also known as atrial fibrillation, autosomal dominant

Related symptoms:

  • Pain
  • Respiratory distress
  • Arrhythmia
  • Stroke
  • Dilated cardiomyopathy


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about FAMILIAL ATRIAL FIBRILLATION

Top 5 symptoms//phenotypes associated to Lymphoma and Sudden cardiac death

Symptoms // Phenotype % cases
Arrhythmia Common - Between 50% and 80% cases
Cardiac arrest Common - Between 50% and 80% cases
Anemia Common - Between 50% and 80% cases
Syncope Uncommon - Between 30% and 50% cases
Diarrhea Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Sudden cardiac death. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Thrombocytopenia Lymphadenopathy Pancytopenia Congestive heart failure Seizures Tachycardia Fever Splenomegaly Gastroesophageal reflux Neutropenia Edema Hearing impairment Purpura Pain Hepatomegaly Chest pain Hepatosplenomegaly Neoplasm Dyspnea Ventricular arrhythmia Atrioventricular block Leukemia ST segment elevation Fatigue Ventricular fibrillation Recurrent respiratory infections Ventricular tachycardia

Rare Symptoms - Less than 30% cases

Bone pain Ascites Cirrhosis Nausea Prolonged QT interval T-wave inversion Abdominal pain Headache Leukopenia Hypertension Torsade de pointes Dilated cardiomyopathy Skin rash Palpitations Chronic leukemia Osteolysis Atrial fibrillation Portal hypertension Stroke Epileptic spasms Atrial flutter Respiratory distress Anorexia Bilateral sensorineural hearing impairment Abnormality of the skin Spontaneous hematomas Pallor Loss of consciousness Hypoglycemia Cardiomyopathy Sensorineural hearing impairment Ataxia Microcephaly Congenital sensorineural hearing impairment Global developmental delay Generalized osteosclerosis Abnormal eosinophil morphology Lethargy Abnormal bleeding Intracranial hemorrhage Urticaria Sarcoma Recurrent upper respiratory tract infections Vasculitis Hemolytic anemia Petechiae Epistaxis Cough Recurrent infections Iron deficiency anemia Respiratory tract infection Acute leukemia Congenital ichthyosiform erythroderma Jaundice Hyponatremia Clubbing Akinesia Heart murmur Athetosis Menorrhagia Opisthotonus Abnormality of coagulation Interstitial pulmonary abnormality Hypokinesia Exertional dyspnea Bulbar palsy Umbilical hernia Osteopenia Abnormality of the thorax Poor eye contact Atrophy/Degeneration affecting the brainstem Polyhydramnios Protuberant abdomen Limb hypertonia Sepsis Hepatocellular carcinoma Increased serum ferritin Myoclonus Aspiration pneumonia Fetal akinesia sequence Hypomagnesemia Bulbar signs Dementia Ectropion Rigidity Corneal opacity Hydrops fetalis Ophthalmoplegia Abnormality of eye movement Hepatic failure Pulmonary hypoplasia Generalized myoclonic seizures Irritability Brain atrophy Cyanosis Decreased fetal movement Pulmonary arterial hypertension Progressive neurologic deterioration Cholestasis Decreased body weight Thickened skin Progressive microcephaly Bilateral ptosis Aspiration Feeding difficulties in infancy Elbow flexion contracture Developmental regression Hypocalcemia Knee flexion contracture Hyperbilirubinemia Oculomotor apraxia Slow saccadic eye movements Hyperammonemia Poor suck Cholelithiasis Apnea Elevated hepatic transaminase Trismus Multiple myeloma Nonimmune hydrops fetalis Dilatation Multiple lipomas Elevated erythrocyte sedimentation rate Coronary artery atherosclerosis Bundle branch block Peripheral neuropathy Renal insufficiency Myopathy Myocarditis Subarachnoid hemorrhage Confusion Generalized tonic-clonic seizures T-wave alternans Immunodeficiency Pneumonia Left bundle branch block Abnormal myocardium morphology Arthritis Vertigo Abnormal electrophysiology of sinoatrial node origin Permanent atrial fibrillation Thromboembolic stroke Abnormal atrioventricular conduction Paroxysmal atrial fibrillation Ventricular extrasystoles Sinoatrial block Myofibrillar myopathy Abnormality of the left ventricular outflow tract Abnormal right ventricle morphology T-wave inversion in the right precordial leads Dilatation of the ventricular cavity Peripheral edema Right ventricular cardiomyopathy Vestibular dysfunction Proteinuria Supranuclear gaze palsy Histiocytosis Subcutaneous hemorrhage Abducens palsy Axial dystonia Hemophagocytosis Eclabion Abnormal pattern of respiration Restrictive deficit on pulmonary function testing Giant cell hepatitis Avascular necrosis of the capital femoral epiphysis Abnormality of the spleen Hypoxemia Abnormality of the larynx Encephalopathy Congenital nonbullous ichthyosiform erythroderma Intestinal bleeding Laryngeal stridor Delayed gross motor development Nephropathy Abnormal intestine morphology Autoimmunity Bruising susceptibility Neoplasm of the lung Hyperthyroidism Abnormal heart valve morphology EEG with temporal sharp waves Orthopnea Slowed horizontal saccades Cardiac valve calcification Abnormal platelet aggregation Hematological neoplasm Decreased beta-glucocerebrosidase protein and activity Erlenmeyer flask deformity of the femurs CSF pleocytosis Delayed skeletal maturation Chronic obstructive pulmonary disease Kyphosis Combined immunodeficiency Malabsorption Pruritus Papule Erythema Myalgia Arthralgia Weight loss Ichthyosis Osteoporosis Prolonged bleeding time Cellulitis Microcytic anemia Glomerulopathy Decreased lymphocyte apoptosis Nausea and vomiting Focal segmental glomerulosclerosis Follicular hyperplasia Telangiectasia Glomerulosclerosis Shock Rheumatoid arthritis Glomerulonephritis Bone marrow hypocellularity Chronic otitis media Abnormal blistering of the skin Keratitis Hypotension Gastrointestinal hemorrhage Asthma Inflammation of the large intestine Recurrent fractures Hyperostosis Monocytosis Lymphocytosis Abnormality of blood and blood-forming tissues Hematemesis Abnormal platelet function Internal hemorrhage Generalized lymphadenopathy Bloody diarrhea Hematochezia Melena Increased IgA level Abnormal platelet morphology Interstitial pneumonitis Membranoproliferative glomerulonephritis Abnormality of the menstrual cycle Increased IgE level Recurrent ear infections IgM deficiency Decreased mean platelet volume Congenital thrombocytopenia Lymphoproliferative disorder Oral bleeding Autoimmune thrombocytopenia Autoimmune hemolytic anemia Increased antibody level in blood Hodgkin lymphoma Gingival bleeding Blepharitis Specific anti-polysaccharide antibody deficiency Reduced delayed hypersensitivity Reduced lymphocyte surface expression of CD43 Abnormal delayed hypersensitivity skin test Absent microvilli on the surface of peripheral blood lymphocytes Recurrent lower respiratory tract infections Recurrent intrapulmonary hemorrhage Small vessel vasculitis Large vessel vasculitis Hypermelanotic macule Flushing Dystonia Polycystic ovaries Abdominal situs inversus Megaloblastic anemia Macrocytic anemia Secondary amenorrhea Hyperglycemia Myelodysplasia Cone/cone-rod dystrophy Sideroblastic anemia Aminoaciduria Hoarse voice Situs inversus totalis Otitis media Specific learning disability Amenorrhea Abnormality of the basal ganglia Progressive peripheral neuropathy Aciduria Flexion contracture Hypertonia Vomiting Hypoplasia of the thymus Dysphagia Intrauterine growth retardation Motor delay Spasticity Paroxysmal atrial tachycardia Abnormal facial shape Strabismus Failure to thrive Scoliosis Generalized hypotonia Thiamine-responsive megaloblastic anemia Eczema Polyneuropathy Allergy Abnormality of the gastric mucosa Chronic kidney disease Telangiectasia macularis eruptiva perstans Anaphylactic shock Cutaneous mastocytosis Dermatographic urticaria Mastocytosis Food intolerance Conjunctivitis Impaired temperature sensation Asthenia Immunologic hypersensitivity Gastrointestinal stroma tumor Hypersplenism Myeloproliferative disorder Short stature Nystagmus Retinal dystrophy Diabetes mellitus Retinal degeneration Paresthesia Recurrent otitis media Abnormal cardiac septum morphology Chronic diarrhea Sinusitis Abnormal heart morphology Meningitis Visual loss Lymphopenia Atrial septal defect Skin ulcer Ventricular septal defect Optic atrophy Cryptorchidism AV nodal tachycardia


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