Lymphoma, and Sinusitis

Diseases related with Lymphoma and Sinusitis

In the following list you will find some of the most common rare diseases related to Lymphoma and Sinusitis that can help you solving undiagnosed cases.


Top matches:

Medium match IDIOPATHIC CD4 LYMPHOCYTOPENIA


Idiopathic CD4 lymphocytopenia is a rare primary immunodeficiency disorder characterized by persistent CD4 T-cell lymphopenia (less than 300 cells/µL on multiple occasions) not associated with any other underlying primary or secondary immune deficiency. Patients typically present opportunistic infections (with cryptococcal, mycobacterial, candidal, varicella zoster virus infections and progressive multifocal leukoencephalopathy being the most prevalent), malignancies (mainly lymphoproliferative disorders), or autoimmune disorders. Some individuals are asymptomatic and incidentally diagnosed.

IDIOPATHIC CD4 LYMPHOCYTOPENIA Is also known as icl|idiopathic cd4 lymphopenia

Related symptoms:

  • Neoplasm
  • Anemia
  • Immunodeficiency
  • Pneumonia
  • Carcinoma


SOURCES: OMIM ORPHANET MENDELIAN

More info about IDIOPATHIC CD4 LYMPHOCYTOPENIA

Medium match CHRONIC EPSTEIN-BARR VIRUS INFECTION SYNDROME


Chronic Epstein-Barr virus infection syndrome is a rare infectious disease characterized by familial, primary, chronic Epstein-Barr virus infection which typically manifests with persistent mononucleosis-like signs and symptoms, in the absence of secondary immunodeficiency.

CHRONIC EPSTEIN-BARR VIRUS INFECTION SYNDROME Is also known as irf8 deficiency, autosomal recessive|epstein-barr virus, susceptibility to chronic infection by|immunodeficiency 32b, monocyte, dendritic cell, and natural killer cell deficiency, autosomal recessive|caebv syndrome|chronic ebv infection syndrome

Related symptoms:

  • Global developmental delay
  • Neoplasm
  • Failure to thrive
  • Anemia
  • Hepatomegaly


SOURCES: ORPHANET OMIM MENDELIAN

More info about CHRONIC EPSTEIN-BARR VIRUS INFECTION SYNDROME

Medium match IMMUNODEFICIENCY, COMMON VARIABLE, 2; CVID2


IMMUNODEFICIENCY, COMMON VARIABLE, 2; CVID2 Is also known as antibody deficiency due to taci defect|hypogammaglobulinemia due to taci deficiency

Related symptoms:

  • Neoplasm
  • Hepatomegaly
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY, COMMON VARIABLE, 2; CVID2

Mendelian

Too many results?
We can help you with your rare disease diagnosis.

Learn more

Other less relevant matches:

Medium match WHIM SYNDROME


WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).

WHIM SYNDROME Is also known as warts, hypogammaglobulinemia, infections, and myelokathexis syndrome|warts-infections-leukopenia-myelokatexis syndrome|wilm|warts-hypogammaglobulinemia-infections-myelokathexis syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Fever
  • Congestive heart failure
  • Immunodeficiency


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WHIM SYNDROME

Medium match PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY


Purine nucleoside phosphorylase (PNP) deficiency is a disorder of purine metabolism characterized by progressive immunodeficiency leading to recurrent and opportunistic infections, autoimmunity and malignancy as well as neurologic manifestations.

PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY Is also known as pnp deficiency|pnpase deficiency|nucleoside phosphorylase deficiency

Related symptoms:

  • Intellectual disability
  • Generalized hypotonia
  • Ataxia
  • Failure to thrive
  • Muscular hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY

Medium match COMMON VARIABLE IMMUNODEFICIENCY


Common variable immunodeficiency (CVID) comprises a heterogeneous group of diseases characterized by a significant hypogammaglobulinemia of unknown cause, failure to produce specific antibodies after immunizations and susceptibility to bacterial infections, predominantly caused by encapsulated bacteria.

COMMON VARIABLE IMMUNODEFICIENCY Is also known as primary antibody deficiency|cvid|antibody deficiency due to icos defect|idiopathic immunoglobulin deficiency|primary hypogammaglobulinemia

Related symptoms:

  • Hepatomegaly
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency
  • Recurrent infections


SOURCES: ORPHANET OMIM MENDELIAN

More info about COMMON VARIABLE IMMUNODEFICIENCY

Medium match SEVERE COMBINED IMMUNODEFICIENCY DUE TO ADENOSINE DEAMINASE DEFICIENCY


Severe combined immunodeficiency (SCID) due to adenosine deaminase (ADA) deficiency is a form of SCID characterized by profound lymphopenia and very low immunoglobulin levels of all isotypes resulting in severe and recurrent opportunistic infections.

SEVERE COMBINED IMMUNODEFICIENCY DUE TO ADENOSINE DEAMINASE DEFICIENCY Is also known as ada deficiency|ada-scid|scid due to adenosine deaminase deficiency|scid due to ada deficiency|scid due to ada deficiency, early-onset

Related symptoms:

  • Global developmental delay
  • Failure to thrive
  • Hypertension
  • Hepatomegaly
  • Abnormality of the skeletal system


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about SEVERE COMBINED IMMUNODEFICIENCY DUE TO ADENOSINE DEAMINASE DEFICIENCY

Medium match COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY


Common variable immunodeficiency-8 with autoimmunity is an autosomal recessive disorder of immune dysregulation. Affected individuals have early childhood onset of recurrent infections, particularly respiratory infections, and also develop variable autoimmune disorders, including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and inflammatory bowel disease. The presentation and phenotype are highly variable, even within families (summary by Lopez-Herrera et al., 2012 and Alangari et al., 2012). Immunologic findings are also variable and may include decreased B cells, hypogammaglobulinemia, and deficiency of CD4+ T regulatory (Treg) cells (Charbonnier et al., 2015).For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (OMIM ).

COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY Is also known as cid due to lrba deficiency

Related symptoms:

  • Growth delay
  • Neoplasm
  • Failure to thrive
  • Anemia
  • Diarrhea


SOURCES: OMIM ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY DUE TO LRBA DEFICIENCY

Medium match HYPER-IGE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT


Hyper-IgE recurrent infection syndrome is a primary immunodeficiency disorder characterized by chronic eczema, recurrent Staphylococcal infections, increased serum IgE, and eosinophilia. Patients have a distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures (Buckley et al., 1972; Grimbacher et al., 1999).

HYPER-IGE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT Is also known as hies, autosomal dominant|hyper-ige syndrome, autosomal dominant|job syndrome

Related symptoms:

  • Scoliosis
  • Hypertelorism
  • Strabismus
  • High palate
  • Wide nasal bridge


SOURCES: OMIM MENDELIAN

More info about HYPER-IGE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT

Medium match BLOOM SYNDROME


Bloom syndrome (BSyn) is a rare chromosomal breakage syndrome characterized by a marked genetic instability associated with pre- and postnatal growth retardation, facial sun-sensitive telangiectatic erythema, increased susceptibility to infections, and predisposition to cancer.

BLOOM SYNDROME Is also known as bls|microcephaly, growth restriction, and increased sister chromatid exchange 1|bs|bsyn|mgrisce1

Related symptoms:

  • Short stature
  • Microcephaly
  • Growth delay
  • Neoplasm
  • Failure to thrive


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about BLOOM SYNDROME

Top 5 symptoms//phenotypes associated to Lymphoma and Sinusitis

Symptoms // Phenotype % cases
Immunodeficiency Very Common - Between 80% and 100% cases
Pneumonia Very Common - Between 80% and 100% cases
Otitis media Common - Between 50% and 80% cases
Recurrent infections Common - Between 50% and 80% cases
Neoplasm Common - Between 50% and 80% cases
Mendelian

Accelerate your rare disease diagnosis with us

Learn more

Other less frequent symptoms

Patients with Lymphoma and Sinusitis. may also develop some of the following symptoms:

Common Symptoms - More than 50% cases


Bronchiectasis

Uncommon Symptoms - Between 30% and 50% cases


Splenomegaly

Common Symptoms - More than 50% cases


Recurrent bacterial infections

Uncommon Symptoms - Between 30% and 50% cases


Recurrent sinusitis Diarrhea Recurrent respiratory infections Decreased antibody level in blood Failure to thrive IgA deficiency IgM deficiency Recurrent otitis media Recurrent pneumonia Lymphopenia Verrucae Respiratory tract infection Autoimmunity Recurrent upper respiratory tract infections Inflammatory abnormality of the skin Autoimmune thrombocytopenia Anemia Hepatomegaly Neutropenia Autoimmune hemolytic anemia IgG deficiency Purpura B lymphocytopenia Conjunctivitis Recurrent bronchitis Impaired T cell function Respiratory failure Combined immunodeficiency Carcinoma Skin rash Hemolytic anemia Asthma Squamous cell carcinoma Lymphadenopathy

Rare Symptoms - Less than 30% cases


Abnormal intestine morphology Prominent nose Recurrent lower respiratory tract infections Recurrent viral infections Autoimmune neutropenia Recurrent opportunistic infections Erythema Hepatosplenomegaly Abnormality of the dentition Chronic lung disease Diabetes mellitus Growth delay Bronchitis Recurrent fungal infections Decrease in T cell count Eosinophilia Chronic diarrhea B-cell lymphoma Abnormality of the skeletal system Chronic otitis media Increased IgE level Meningitis Follicular hyperplasia Recurrent urinary tract infections Fever Opportunistic infection Global developmental delay Hodgkin lymphoma Recurrent sinopulmonary infections Thrombocytopenia Congestive heart failure Arthritis Persistence of primary teeth Hemihypertrophy Red hair Atopic dermatitis Urticaria Chronic mucocutaneous candidiasis T-cell lymphoma Fractures of the long bones Eczematoid dermatitis Recurrent bacterial skin infections Onychomycosis Severe viral infections Recurrent Staphylococcus aureus infections Recurrent candida infections Lung abscess Anal canal squamous carcinoma Squamous cell carcinoma of the vulva Impaired neutrophil chemotaxis Recurrent skin infections Hemivertebrae Microcephaly Osteopenia Hypertelorism Strabismus High palate Wide nasal bridge Frontal bossing Dysphagia Bronchiolitis Constipation Prominent forehead Osteoporosis Mandibular prognathia Coarse facial features Skin ulcer Deeply set eye Craniosynostosis Cough Pruritus Facial asymmetry Joint hypermobility Wide nose Recurrent fractures Psoriasiform dermatitis Eczema Thick lower lip vermilion Short stature Cellulitis Micrognathia Acute leukemia Azoospermia Sacral dimple Hypopigmented skin patches Reduced number of teeth Hand polydactyly High pitched voice Pulmonary fibrosis Telangiectasia of the skin Myeloid leukemia Acute myeloid leukemia Hypoplasia of the zygomatic bone Cafe-au-lait spot Chromosome breakage Hypoplastic pelvis Chronic obstructive pulmonary disease Abnormality of the nose Abnormality of chromosome stability Decreased fertility in females Female infertility Spotty hypopigmentation Spotty hyperpigmentation Neoplasm of the gastrointestinal tract Agenesis of maxillary lateral incisor Narrow face Telangiectasia Cryptorchidism Polydactyly Intrauterine growth retardation Burkitt lymphoma Cardiomyopathy Intellectual disability, mild Short nose Malar flattening Syndactyly Delayed skeletal maturation Clinodactyly of the 5th finger Severe short stature Hyperhidrosis Postnatal growth retardation Abnormality of the face Protruding ear Finger syndactyly Leukemia Dolichocephaly Infertility Ichthyosis Abnormality of the skin Specific learning disability Type II diabetes mellitus Cutaneous photosensitivity Hypertrichosis Scoliosis Brain neoplasm Generalized lymphadenopathy Abnormality of B cell physiology Spastic tetraparesis Spastic diplegia Carious teeth Hypouricemia Pure red cell aplasia Abnormal T cell morphology Hearing impairment Cerebral vasculitis Brain abscess Lymph node hypoplasia Brachycephaly Spastic tetraplegia Arthralgia Elevated hepatic transaminase Abnormality of the liver Anal atresia Vasculitis Gastrointestinal carcinoma Failure to thrive in infancy Emphysema Restrictive ventilatory defect Thyroiditis Tetraparesis Tetraplegia Gastrointestinal stroma tumor Bone marrow hypercellularity Osteomyelitis Leukocytosis Atelectasis Abnormality of female internal genitalia Abnormality of female external genitalia Abnormality of bone marrow cell morphology Folliculitis Septic arthritis Tonsillitis Hypersegmentation of neutrophil nuclei Myelokathexis Abnormal pyramidal sign Intellectual disability Generalized hypotonia Ataxia Muscular hypotonia Spasticity Delayed speech and language development Motor delay Tremor Behavioral abnormality Babinski sign Lymphoproliferative disorder Recurrent infection of the gastrointestinal tract Interstitial pneumonitis Inflammation of the large intestine Lack of T cell function Anti-thyroid peroxidase antibody positivity Reduced red cell adenosine deaminase activity Absent specific antibody response Bronchiolitis obliterans Hypothyroidism Pancytopenia Abnormal lung morphology Type I diabetes mellitus Clubbing Interstitial pulmonary abnormality Abnormality of humoral immunity Colitis Fatigable weakness Exocrine pancreatic insufficiency Papilloma Clubbing of fingers Villous atrophy Periodontitis Cor pulmonale Immune dysregulation Gastritis Severe B lymphocytopenia Absent tonsils Humoral immunodeficiency Abnormality of pelvic girdle bone morphology Posterior pharyngeal cleft Hypertension Chronic infection Hepatic failure Platyspondyly Sepsis Hepatitis Dilatation Leukoencephalopathy Fatigue Malnutrition Absence of lymph node germinal center Severe combined immunodeficiency Allergy Cellular immunodeficiency Pulmonary insufficiency Diffuse mesangial sclerosis Bronchiolitis obliterans organizing pneumonia Anterior rib cupping Aplasia of the thymus Cortical sclerosis Immunoglobulin IgG2 deficiency Facial telangiectasia in butterfly midface distribution



If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Rod-cone dystrophy and Fatigue, related diseases and genetic alterations Ventricular septal defect and Malar flattening, related diseases and genetic alterations

Need help with a diagnosis?

Learn more about how to achieve it with Mendelian


Learn more