Lymphoma, and Respiratory tract infection

Diseases related with Lymphoma and Respiratory tract infection

In the following list you will find some of the most common rare diseases related to Lymphoma and Respiratory tract infection that can help you solving undiagnosed cases.


Top matches:

Low match ACTIVATED PI3K-DELTA SYNDROME


Activated PI3K-delta syndrome is a rare, genetic, primary immunodeficiency disease characterized by increased susceptibility to recurrent and/or severe bacterial and viral infections (in particular, sinopulmonary bacterial and herpesvirus infections), chronic benign lymphoproliferation (manifesting as lympadenopathy, hepatosplenomegaly and focal nodular lymphoid hyperplasia), and/or autoimmune disease (including immune cytopenias, juvenile arthritis, glomerulonephritis and sclerosing cholangitis). Immunophenotypically, variable degrees of agammaglobulinemia with increased IgM levels, increased circulating transitional B cells, decreased naïve CD4 and CD8 T-cells with increased CD8 effector/memory T cells are observed.

ACTIVATED PI3K-DELTA SYNDROME Is also known as activated pi3k-delta syndrome|senescent t-cells-lymphadenopathy-immunodeficiency syndrome due to p110delta-activating mutation|apds|p110-delta-activating mutation causing senescent t cells, lymphadenopathy, and immunodeficiency|pasli

Related symptoms:

  • Splenomegaly
  • Immunodeficiency
  • Recurrent infections
  • Recurrent respiratory infections
  • Respiratory tract infection


SOURCES: ORPHANET OMIM MENDELIAN

More info about ACTIVATED PI3K-DELTA SYNDROME

Low match SEVERE COMBINED IMMUNODEFICIENCY DUE TO CORO1A DEFICIENCY


SEVERE COMBINED IMMUNODEFICIENCY DUE TO CORO1A DEFICIENCY Is also known as severe combined immunodeficiency due to coronin-1a deficiency|scid due to coro1a deficiency|scid due to coronin-1a deficiency

Related symptoms:

  • Seizures
  • Global developmental delay
  • Anemia
  • Immunodeficiency
  • Recurrent infections


SOURCES: ORPHANET OMIM MENDELIAN

More info about SEVERE COMBINED IMMUNODEFICIENCY DUE TO CORO1A DEFICIENCY

Low match IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B


IMD11B is an autosomal dominant disorder of immune dysfunction characterized by onset of moderate to severe atopic dermatitis in early childhood. Some patients may have recurrent infections and other variable immune abnormalities. Laboratory studies show defects in T-cell activation, increased IgE, and eosinophilia (summary by Ma et al., 2017).

IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B Is also known as atopic dermatitis, elevated ige, and eosinophilia

Related symptoms:

  • Recurrent infections
  • Pneumonia
  • Asthma
  • Lymphoma
  • Decreased antibody level in blood


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B

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Other less relevant matches:

Low match IDIOPATHIC CD4 LYMPHOCYTOPENIA


Idiopathic CD4 lymphocytopenia is a rare primary immunodeficiency disorder characterized by persistent CD4 T-cell lymphopenia (less than 300 cells/µL on multiple occasions) not associated with any other underlying primary or secondary immune deficiency. Patients typically present opportunistic infections (with cryptococcal, mycobacterial, candidal, varicella zoster virus infections and progressive multifocal leukoencephalopathy being the most prevalent), malignancies (mainly lymphoproliferative disorders), or autoimmune disorders. Some individuals are asymptomatic and incidentally diagnosed.

IDIOPATHIC CD4 LYMPHOCYTOPENIA Is also known as icl|idiopathic cd4 lymphopenia

Related symptoms:

  • Neoplasm
  • Anemia
  • Immunodeficiency
  • Pneumonia
  • Carcinoma


SOURCES: OMIM ORPHANET MENDELIAN

More info about IDIOPATHIC CD4 LYMPHOCYTOPENIA

Low match IMMUNODEFICIENCY, COMMON VARIABLE, 12; CVID12


Common variable immunodeficiency-12 is an autosomal dominant primary immunodeficiency characterized by recurrent infections, mainly respiratory, associated with hypogammaglobulinemia. The disorder shows a highly variable age at onset and highly variable disease severity, even within the same family. Some patients have features of autoimmunity (summary by Fliegauf et al., 2015).For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (OMIM ).

IMMUNODEFICIENCY, COMMON VARIABLE, 12; CVID12 Is also known as nfkb1 deficiency

Related symptoms:

  • Anemia
  • Immunodeficiency
  • Recurrent infections
  • Thrombocytopenia
  • Alopecia


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY, COMMON VARIABLE, 12; CVID12

Low match FOLLICULAR LYMPHOMA


Follicular lymphoma is a form of non-Hodgkin lymphoma (see this term) characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.

FOLLICULAR LYMPHOMA Is also known as oncogene b-cell leukemia 2

Related symptoms:

  • Neoplasm
  • Fever
  • Fatigue
  • Diarrhea
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about FOLLICULAR LYMPHOMA

Low match COMBINED IMMUNODEFICIENCY WITH GRANULOMATOSIS


COMBINED IMMUNODEFICIENCY WITH GRANULOMATOSIS Is also known as cid due to rag 1/2 deficiency|combined immunodeficiency due to rag 1/2 deficiency

Related symptoms:

  • Splenomegaly
  • Immunodeficiency
  • Recurrent respiratory infections
  • Respiratory tract infection
  • Lymphoma


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about COMBINED IMMUNODEFICIENCY WITH GRANULOMATOSIS

Low match MALT LYMPHOMA


MALT (mucosa-associated lymphoid tissue) lymphoma is a rare form of malignant non-Hodgkin lymphoma (see this term) that affects B cells and grows at the expense of lymphoid tissue associated with mucous membranes, but also occurs, more rarely, in lymph nodes.

MALT LYMPHOMA Is also known as maltoma|mucosa-associated lymphatic tissue lymphoma|extranodal marginal zone b-cell lymphoma|mucosa-associated lymphoid tissue lymphoma

Related symptoms:

  • Anemia
  • Visual impairment
  • Fever
  • Fatigue
  • Constipation


SOURCES: ORPHANET MENDELIAN

More info about MALT LYMPHOMA

Low match LYMPHOPROLIFERATIVE SYNDROME 1; LPFS1


Lymphoproliferative syndrome-1 is an autosomal recessive primary immunodeficiency characterized by onset in early childhood of Epstein-Barr virus (EBV)-associated immune dysregulation, manifest as lymphoma, lymphomatoid granulomatosis, hemophagocytic lymphohistiocytosis, Hodgkin disease, and/or hypogammaglobulinemia. Autoimmune disorders, such as autoimmune hemolytic anemia or renal disease, may also occur. Patients show a high EBV viral load and decreased invariant natural killer T cells. It is unknown whether patients with ITK mutations are intrinsically susceptible to development of lymphoma or dysgammaglobulinemia in the absence of EBV infection (summary by Stepensky et al., 2011; Linka et al., 2012).For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (OMIM ).

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Immunodeficiency


SOURCES: OMIM MESH MENDELIAN

More info about LYMPHOPROLIFERATIVE SYNDROME 1; LPFS1

Low match IMMUNODEFICIENCY 36; IMD36


IMD36 is a primary immunodeficiency with a highly heterogeneous clinical phenotype, characterized primarily by recurrent respiratory tract infections, lymphoproliferation, and antibody deficiency. Other features include growth retardation, mild neurodevelopmental delay, and autoimmunity. The major complication is development of B-cell lymphoma (Elkaim et al., 2016).

Related symptoms:

  • Growth delay
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency
  • Recurrent respiratory infections


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY 36; IMD36

Top 5 symptoms//phenotypes associated to Lymphoma and Respiratory tract infection

Symptoms // Phenotype % cases
Immunodeficiency Common - Between 50% and 80% cases
Lymphadenopathy Common - Between 50% and 80% cases
Decreased antibody level in blood Common - Between 50% and 80% cases
Lymphopenia Common - Between 50% and 80% cases
Splenomegaly Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Lymphoma and Respiratory tract infection. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Anemia Recurrent infections Recurrent respiratory infections B-cell lymphoma Recurrent sinopulmonary infections Fever Hodgkin lymphoma Pneumonia Hemolytic anemia Autoimmunity Autoimmune hemolytic anemia Bronchiectasis

Rare Symptoms - Less than 30% cases


Dysgammaglobulinemia Inflammation of the large intestine Thrombocytopenia Chronic lymphatic leukemia Diarrhea Weight loss Pleural effusion Mediastinal lymphadenopathy IgG deficiency Granulomatosis Pulmonary infiltrates Psoriasiform dermatitis Fatigue Inflammatory abnormality of the skin Neoplasm Papilloma Lymphoproliferative disorder T-cell lymphoma Nausea and vomiting Posterior uveitis Abnormal nasolacrimal system morphology Cellulitis Abnormality of the thyroid gland Hyperhidrosis Abdominal pain Hepatosplenomegaly Constipation Visual impairment Iritis Recurrent ear infections B lymphocytopenia Decrease in T cell count Hepatomegaly Carcinoma Seizures Generalized lymphadenopathy Allergy Neurodevelopmental delay Recurrent upper respiratory tract infections Recurrent bacterial infections Chronic diarrhea Arthritis Growth delay Hemophagocytosis Ascites Histiocytosis Recurrent aphthous stomatitis Stomatitis Immune dysregulation Pericardial effusion Elevated erythrocyte sedimentation rate Pancytopenia Recurrent viral infections Combined immunodeficiency Vitiligo Bronchiolitis obliterans Recurrent skin infections Colitis Alopecia Atopic dermatitis Bronchiolitis obliterans organizing pneumonia Opportunistic infection Bronchiolitis IgA deficiency Recurrent sinusitis Ulcerative colitis Squamous cell carcinoma Sinusitis Recurrent otitis media Otitis media Eosinophilia Chronic obstructive pulmonary disease Fatigable weakness Attention deficit hyperactivity disorder Abnormality of the peritoneum Global developmental delay Skin nodule Night sweats Hyperactivity Glucose intolerance Meningitis Asthma Lymphedema Insulin resistance Neutropenia Nausea Leukemia Decreased proportion of CD4-positive T cells Enlarged tonsils



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