Lymphoma, and Paralysis

Diseases related with Lymphoma and Paralysis

In the following list you will find some of the most common rare diseases related to Lymphoma and Paralysis that can help you solving undiagnosed cases.

Top matches:

Low match EWING SARCOMA

Ewing's sarcoma is a malignant small round cell bone tumor with strong metastatic potential.

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Fever
  • Weight loss


SOURCES: OMIM ORPHANET MENDELIAN

More info about EWING SARCOMA

Hereditary neuropathy with liability to pressure palsies (HNPP) is an inherited peripheral nerve disorder characterized by recurrent mononeuropathy usually triggered by minor physical activities.

HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES Is also known as hnpp|potato-grubbing palsy|polyneuropathy, familial recurrent|current pressure-sensitive neuropathy|heterozygous microdeletion 17p11.2p12|tulip-bulb digger's palsy|tomaculous neuropathy

Related symptoms:

  • Hearing impairment
  • Scoliosis
  • Muscle weakness
  • Pain
  • Peripheral neuropathy


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES

Neurofibromatosis type I is an autosomal dominant disorder characterized by cafe-au-lait spots, Lisch nodules in the eye, and fibromatous tumors of the skin. Individuals with the disorder have increased susceptibility to the development of benign and malignant tumors. NF1 is sometimes referred to as 'peripheral neurofibromatosis.' The worldwide incidence of NF1 is 1 in 2,500 to 1 in 3,000 individuals (reviews by Shen et al., 1996 and Williams et al., 2009).Type II neurofibromatosis (NF2 ) is a genetically distinct disorder caused by mutation in the gene encoding merlin (NF2 ) on chromosome 22q12. NF2, sometimes known as 'central neurofibromatosis,' is characterized by bilateral acoustic neuroma and meningioma, but few skin lesions or neurofibromas (Rouleau et al., 1993).Some patients with homozygous or compound heterozygous mutations in mismatch repair genes (see, e.g., MLH1; {120436} and MSH2; {609309}) have a phenotype characterized by early onset malignancies and mild features of NF1, especially cafe-au-lait spots; this is known as the mismatch repair cancer syndrome (OMIM ), sometimes referred to as brain tumor-polyposis syndrome-1 or Turcot syndrome. These patients typically do not have germline mutations in the NF1 gene, although a study by Wang et al. (2003) suggested that biallelic mutations in mismatch repair genes may cause somatic mutations in the NF1 gene, perhaps resulting in isolated features resembling NF1.See also Legius syndrome (OMIM ), a genetically distinct disorder with a similar phenotype to NF1.

NEUROFIBROMATOSIS TYPE 1 DUE TO NF1 MUTATION OR INTRAGENIC DELETION Is also known as von recklinghausen disease due to nf1 mutation or intragenic deletion|neurofibromatosis, peripheral type|von recklinghausen disease

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Scoliosis
  • Hypertelorism


SOURCES: ORPHANET OMIM MENDELIAN

More info about NEUROFIBROMATOSIS TYPE 1 DUE TO NF1 MUTATION OR INTRAGENIC DELETION

Other less relevant matches:

Low match N SYNDROME

N syndrome is characterised by intellectual deficit, deafness, ocular anomalies, T-cell leukaemia, cryptorchidism, hypospadias and spasticity.

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Hearing impairment
  • Neoplasm
  • Cryptorchidism


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about N SYNDROME

Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).

LYMPHOMA, HODGKIN, CLASSIC; CHL Is also known as hodgkin disease

Related symptoms:

  • Ataxia
  • Neoplasm
  • Peripheral neuropathy
  • Hepatomegaly
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about LYMPHOMA, HODGKIN, CLASSIC; CHL

X-linked lymphoproliferative disease is a hereditary immunodeficiency characterized, in the majority of cases, by an inadequate immune response to infection with the Epstein-Barr virus (EBV).

X-LINKED LYMPHOPROLIFERATIVE DISEASE Is also known as xlpd|duncan disease|xlp|immunodeficiency 5|infectious mononucleosis, severe, susceptibility to|purtilo syndrome|imd5|ebvs|lymphoproliferative disease, x-linked|epstein-barr virus infection, familial fatal|lyp|ebv infection, severe, susceptibility to|immun

Related symptoms:

  • Seizures
  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Fever


SOURCES: ORPHANET OMIM MENDELIAN

More info about X-LINKED LYMPHOPROLIFERATIVE DISEASE

Purine nucleoside phosphorylase (PNP) deficiency is a disorder of purine metabolism characterized by progressive immunodeficiency leading to recurrent and opportunistic infections, autoimmunity and malignancy as well as neurologic manifestations.

PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY Is also known as pnp deficiency|pnpase deficiency|nucleoside phosphorylase deficiency

Related symptoms:

  • Intellectual disability
  • Generalized hypotonia
  • Ataxia
  • Failure to thrive
  • Muscular hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY

Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

Dyskeratosis congenita is an inherited bone marrow failure syndrome classically characterized by the triad of mucosal leukoplakia, nail dysplasia, and abnormal skin pigmentation. Affected individuals have an increased risk of aplastic anemia and malignancy. Less common features include epiphora, premature gray hair, microcephaly, developmental delay, and pulmonary fibrosis, among others. The phenotype is highly variable. All affected individuals have shortened telomeres due to a defect in telomere maintenance (summary by Savage et al., 2008).For a discussion of genetic heterogeneity of dyskeratosis congenita, see DCKA1 (OMIM ).

Related symptoms:

  • Global developmental delay
  • Short stature
  • Hearing impairment
  • Microcephaly
  • Ataxia


SOURCES: OMIM MENDELIAN

More info about DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 3; DKCA3

Zur Stadt et al. (2005) summarized the clinical features of hemophagocytic lymphohistiocytosis (HLH), a rare autosomal recessive disorder characterized by massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently central nervous system involvement. In FHL, the familial form of the disease, first episodes occur mostly during infancy, with a rapidly fatal outcome if untreated. Diagnostic criteria also include low fibrinogen and high triglyceride and ferritin levels. Chemoimmunotherapy based on corticosteroids, epipodophyllotoxins, and cyclosporin succeeds in controlling the disease in the majority of patients, although remission is rarely obtained (Henter et al., 2002). Most patients suffer an early death unless they are treated by hematopoietic stem cell transplantation (Durken et al., 1999). Genetic Heterogeneity of Familial Hemophagocytic LymphohistiocytosisFamilial hemophagocytic lymphohistiocytosis exhibits genetic heterogeneity. In some families, familial hemophagocytic lymphohistiocytosis has been found to be linked to chromosome 9q (HPLH1, FHL1). FHL2 (OMIM ) is caused by mutation in the PRF1 gene (OMIM ) on chromosome 10q22; FHL3 (OMIM ) is caused by mutation in the UNC13D gene (OMIM ) on chromosome 17q25; FHL4 (OMIM ) is caused by mutation in the syntaxin-11 gene (STX11 ) on chromosome 6q24; and FHL5 (OMIM ) is caused by mutation in the syntaxin-binding protein-2 (STXBP2 ), which is an interaction partner of STX11, on chromosome 19p13.Furthermore, before the identification of mutations in the RAG1 (OMIM ) and RAG2 (OMIM ) genes, both of which map to 11p, Omenn syndrome (familial reticuloendotheliosis with eosinophilia; {603554}) was not thought to be clearly distinct from other reported cases of hemophagocytic lymphohistiocytosis.

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1 Is also known as hemophagocytic reticulosis, familial|hlh1|hemophagocytic lymphohistiocytosis, familial|erythrophagocytic lymphohistiocytosis, familial|reticulosis, familial histiocytic|hplh1|fhl|fhlh|hplh|fel

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia
  • Neoplasm


SOURCES: OMIM MENDELIAN

More info about HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1

Top 5 symptoms//phenotypes associated to Lymphoma and Paralysis

Symptoms // Phenotype % cases
Neoplasm Common - Between 50% and 80% cases
Anemia Common - Between 50% and 80% cases
Splenomegaly Uncommon - Between 30% and 50% cases
Ataxia Uncommon - Between 30% and 50% cases
Leukemia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Paralysis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Pain Hodgkin lymphoma Lymphadenopathy Seizures Peripheral neuropathy Hepatomegaly Weight loss Fever Hearing impairment Meningitis Intellectual disability Sarcoma Pancytopenia Delayed speech and language development Bone marrow hypocellularity Cellular immunodeficiency Immunodeficiency Thrombocytopenia Skin rash Global developmental delay Pruritus Respiratory insufficiency

Rare Symptoms - Less than 30% cases

Gastrointestinal hemorrhage Cryptorchidism Spasticity Pulmonary fibrosis Histiocytosis Pure red cell aplasia Failure to thrive Visual impairment Hypertension Generalized hypotonia Muscular hypotonia Behavioral abnormality Bone pain Tetraplegia Osteoporosis Recurrent bacterial infections Osteopenia Leukopenia Abnormality of skin pigmentation Dilatation Short stature Back pain Confusion Chronic myelogenous leukemia Pneumonia Burkitt lymphoma Vasculitis Cranial nerve paralysis Hepatosplenomegaly Encephalitis Scoliosis Increased antibody level in blood Fatigue Hemoptysis Pleural effusion Abnormality of the nervous system Meningioma Paresthesia Sensory neuropathy Tetraparesis Cough Hepatic failure Peripheral demyelination Aplastic anemia Diarrhea Recurrent viral infections Impaired T cell function Ascites Abdominal pain Renal insufficiency Arthralgia Hematuria Hypouricemia Nausea and vomiting Autoimmunity Autoimmune neutropenia Abnormal T cell morphology Proteinuria Recurrent opportunistic infections Dyspnea Cerebral vasculitis Bronchiectasis Brain abscess Lymph node hypoplasia Arthritis Abnormality of B cell physiology Myalgia Recurrent lower respiratory tract infections Sensorineural hearing impairment Lymphopenia Autoimmune thrombocytopenia Reduced natural killer cell activity Lymphocytosis Hepatic encephalopathy Granulomatosis Chorioretinitis Increased IgM level Dysgammaglobulinemia Recurrent pharyngitis Immune dysregulation Joint dislocation Hepatic necrosis Non-Hodgkin lymphoma Pharyngitis B-cell lymphoma Fulminant hepatitis Autoimmune hemolytic anemia Agammaglobulinemia Motor delay IgG deficiency Tremor Babinski sign Abnormal pyramidal sign Otitis media Spastic tetraplegia Recurrent urinary tract infections Sinusitis Spastic tetraparesis Recurrent upper respiratory tract infections Spastic diplegia Conjunctivitis Microcephaly Cerebral palsy Purpura Combined immunodeficiency Abnormality of the coagulation cascade Albinism Hyponatremia Hemiplegia Hypoalbuminemia Eosinophilia Increased intracranial pressure Hyperbilirubinemia Severe combined immunodeficiency Aspiration Hypertriglyceridemia Gliosis Sepsis Coma Hemolytic anemia Abnormality of the liver Irritability Episodic fever Pulmonary infiltrates Jaundice Increased total bilirubin Lipogranulomatosis Plasmacytosis Polyneuritis CSF pleocytosis Hypofibrinogenemia Increased VLDL cholesterol concentration T-cell lymphoma Granulocytopenia Partial albinism Increased CSF protein Increased LDL cholesterol concentration Hemophagocytosis Prolonged prothrombin time Decreased HDL cholesterol concentration Generalized edema Prolonged partial thromboplastin time Hypoproteinemia Acute leukemia Increased serum ferritin Elevated hepatic transaminase Encephalopathy Reduced tendon reflexes Uveitis Growth delay Small vessel vasculitis Obstructive lung disease Episcleritis Immunologic hypersensitivity Complement deficiency Angioedema Inflammatory abnormality of the eye Irregular hyperpigmentation Alopecia Glomerulopathy Abnormal heart valve morphology Pericardial effusion Restrictive ventilatory defect Emphysema Hemiplegia/hemiparesis Nephritis Urticaria Intrauterine growth retardation Cerebellar hypoplasia Recurrent infections Premature graying of hair Hypertonia Pulmonary hemorrhage Reticulated skin pigmentation Phimosis Esophageal stricture Oral leukoplakia Aseptic necrosis Interstitial pulmonary abnormality Epiphora Retinopathy Portal hypertension Abnormal intestine morphology Hyperpigmentation of the skin Abnormal lung morphology Fine hair Cerebral calcification Nail dysplasia Dry skin Nail dystrophy Hemiparesis Abnormal eye morphology Memory impairment Depressivity Hypoglycemia Kyphoscoliosis Autism Glaucoma Hyperactivity Abnormal heart morphology Visual loss Abnormality of cardiovascular system morphology Autistic behavior Headache Intellectual disability, mild Blindness Cardiomyopathy Hydrocephalus Abnormality of the skeletal system Macrocephaly Hypertrophic cardiomyopathy Attention deficit hyperactivity disorder Cognitive impairment Abnormality of the cardiovascular system Spina bifida Sensorimotor neuropathy Cafe-au-lait spot Aganglionic megacolon Hypsarrhythmia Coarctation of aorta Mitral valve prolapse Tetralogy of Fallot Pulmonic stenosis Overgrowth Specific learning disability Recurrent fractures Peripheral axonal neuropathy Facial asymmetry Genu valgum Malabsorption Dysarthria Ptosis Venous thrombosis Neoplasm of the peripheral nervous system Abnormality of movement Myoclonus Pes cavus Hyporeflexia Areflexia Skeletal muscle atrophy Muscle weakness Peripheral neuroepithelioma Polyneuropathy Ewing sarcoma Primitive neuroectodermal tumor Acute lymphoblastic leukemia Neuroblastoma Myeloid leukemia Leukocytosis Paraplegia Inability to walk Muscle cramps Abnormal facial shape Constrictive median neuropathy Hypertelorism Brachial plexus neuropathy Myelin tomacula Segmental peripheral demyelination/remyelination Vocal cord paresis Abnormal myelination Low back pain Vocal cord paralysis Generalized muscle weakness Axonal loss Axonal degeneration Decreased motor nerve conduction velocity Hammertoe Abnormality of the voice Foot dorsiflexor weakness Hoarse voice Hypotelorism Atherosclerosis Reduced bone mineral density Decreased antibody level in blood Optic nerve glioma Cerebral artery stenosis Arterial fibromuscular dysplasia Spinal neurofibromas Inguinal freckling Plexiform neurofibroma Acute promyelocytic leukemia Subcutaneous neurofibromas Neurofibrosarcoma Brow ptosis Neuroma Vestibular Schwannoma Embryonal rhabdomyosarcoma Axillary freckling Renovascular hypertension Renal artery stenosis Single ventricle Tibial pseudoarthrosis Hypospadias Soft tissue sarcoma Osteolysis Falls Respiratory failure Polyclonal elevation of IgM Impaired lymphocyte transformation with phytohemagglutinin Monoclonal immunoglobulin M proteinemia Lung adenocarcinoma Poor appetite Anorexia Bilateral sensorineural hearing impairment Migraine Chest pain Hyperhidrosis T-cell lymphoma/leukemia Abnormality of chromosome stability Chromosome breakage Abnormal eyelid morphology Megalocornea Pseudoarthrosis Epigastric pain Breast carcinoma Multiple cafe-au-lait spots Neoplasm of the endocrine system Gangrene Increased reactive oxygen species production Overweight Severe vision loss Renal cell carcinoma Osteomalacia Freckling Brain neoplasm Tibial bowing Neurofibromas Hypophosphatemia Sensory axonal neuropathy Clitoral hypertrophy Precocious puberty Incoordination Myocardial fibrosis Astrocytoma Dural ectasia Glioma Leiomyosarcoma Fibular bowing Gastrointestinal stroma tumor Neoplasm of the central nervous system Lisch nodules Renal phosphate wasting Schwannoma Nasolacrimal duct obstruction Aqueductal stenosis Rhabdomyosarcoma Carcinoid tumor Paraganglioma Night sweats Anomalous pulmonary venous return Complete atrioventricular canal defect Pheochromocytoma Parathyroid adenoma Abnormal natural killer cell physiology


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