Lymphoma, and Myalgia

Diseases related with Lymphoma and Myalgia

In the following list you will find some of the most common rare diseases related to Lymphoma and Myalgia that can help you solving undiagnosed cases.

Top matches:

G6PD deficiency is the most common genetic cause of chronic and drug-, food-, or infection-induced hemolytic anemia. G6PD catalyzes the first reaction in the pentose phosphate pathway, which is the only NADPH-generation process in mature red cells; therefore, defense against oxidative damage is dependent on G6PD. Most G6PD-deficient patients are asymptomatic throughout their life, but G6PD deficiency can be life-threatening. The most common clinical manifestations of G6PD deficiency are neonatal jaundice and acute hemolytic anemia, which in most patients is triggered by an exogenous agent, e.g., primaquine or fava beans. Acute hemolysis is characterized by fatigue, back pain, anemia, and jaundice. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. The striking similarity between the areas where G6PD deficiency is common and Plasmodium falciparum malaria (see {611162}) is endemic provided evidence that G6PD deficiency confers resistance against malaria (summary by Cappellini and Fiorelli, 2008).

ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY Is also known as favism, susceptibility to

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Muscle weakness
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY

Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

Related symptoms:

  • Hepatomegaly
  • Splenomegaly
  • Myalgia
  • Abnormality of the nervous system
  • Pruritus


SOURCES: ORPHANET OMIM MENDELIAN

More info about CHRONIC EOSINOPHILIC LEUKEMIA

Other less relevant matches:

Primary familial polycythemia is an inherited hematological disorder resulting from mutations in the erythropoietin (EPO) receptor and is characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production in the presence of low EPO levels.

PRIMARY FAMILIAL POLYCYTHEMIA Is also known as polycythemia, primary familial and congenital|primary familial and congenital polycythemia|familial erythrocytosis|erythrocytosis, autosomal dominant benign|pfcp|congenital polycythemia due to erythropoietin receptor mutation|congenital erythrocytosis due

Related symptoms:

  • Pain
  • Hypertension
  • Fatigue
  • Respiratory distress
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about PRIMARY FAMILIAL POLYCYTHEMIA

Dopamine beta-hydroxylase deficiency is an extremely rare genetic metabolic disorder characterized by autonomic dysregulation leading mainly to orthostatic hypotension.

DOPAMINE BETA-HYDROXYLASE DEFICIENCY Is also known as norepinephrine deficiency|noradrenaline deficiency

Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Muscular hypotonia
  • Pain
  • Ptosis


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about DOPAMINE BETA-HYDROXYLASE DEFICIENCY

Mastocytosis, or mast cell disease, is a heterogeneous group of clinical disorders characterized by the abnormal accumulation of mast cells in various tissues, especially in the skin and hematopoietic organs. Mastocytosis usually appears in infancy or early adulthood. In most pediatric cases, the disease is limited to the skin, but it can be associated with systemic symptoms due to the release of mediators from mast cells, even when there is no systemic infiltration. It usually has a good prognosis, with substantial improvement or spontaneous resolution before puberty. In rare cases, the disease may remain active through adolescence as a systemic adult mastocytosis. Cutaneous mastocytosis is characterized by macules, papules, nodules, or diffuse infiltration of the skin, often associated with localized hyperpigmentation. Gentle rubbing of the lesions induces histamine release from mechanically activated mast cells, causing local wheals, erythema, and often pruritus, a phenomenon termed the 'Darier sign.' In contrast to childhood-onset mastocytosis, adult-onset mastocytosis often persists for the lifetime of the patient and is also more likely to be a severe and systemic disease involving numerous organs. In some cases, it is associated with a clonal hematologic non-mast-cell lineage disease, such as a myelodysplastic or myeloproliferative disorder. Adult-onset mastocytosis can also lead to the rare mast cell leukemia, which carries a high risk of mortality (summary by Bodemer et al., 2010 and Kambe et al., 2010).

MASTOCYTOSIS, CUTANEOUS; MASTC Is also known as mastocytosis, maculopapular cutaneous|mastocytosis, diffuse cutaneous|urticaria pigmentosa

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hypertension
  • Hepatomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about MASTOCYTOSIS, CUTANEOUS; MASTC

Complete deficiency of erythrocyte AMP deaminase is a clinically benign disorder (Ogasawara et al., 1987; Zydowo et al., 1989).

Related symptoms:

  • Pain
  • Fatigue
  • Myalgia


SOURCES: OMIM MENDELIAN

More info about ERYTHROCYTE AMP DEAMINASE DEFICIENCY

Low match EWING SARCOMA

Ewing's sarcoma is a malignant small round cell bone tumor with strong metastatic potential.

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Fever
  • Weight loss


SOURCES: OMIM ORPHANET MENDELIAN

More info about EWING SARCOMA

Low match OVARIAN CANCER

Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases (Chi et al., 2001). These typical features relate to the biology of the disease, which is a principal determinant of outcome (Auersperg et al., 2001). Epithelial ovarian cancer is the most common form and encompasses 5 major histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Epithelial ovarian cancer arises as a result of genetic alterations sustained by the ovarian surface epithelium (Stany et al., 2008; Soslow, 2008).

Related symptoms:

  • Neoplasm
  • Pain
  • Fatigue
  • Respiratory distress
  • Vomiting


SOURCES: OMIM ORPHANET MENDELIAN

More info about OVARIAN CANCER

Top 5 symptoms//phenotypes associated to Lymphoma and Myalgia

Symptoms // Phenotype % cases
Pain Common - Between 50% and 80% cases
Fatigue Uncommon - Between 30% and 50% cases
Splenomegaly Uncommon - Between 30% and 50% cases
Abdominal pain Uncommon - Between 30% and 50% cases
Pruritus Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Myalgia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Neoplasm Arthralgia Weight loss Nausea and vomiting Ascites Leukemia Hepatomegaly Hypertension Anemia

Rare Symptoms - Less than 30% cases

Nausea Diarrhea Sarcoma Abnormality of the nervous system Dyspnea Venous thrombosis Respiratory distress Headache Cough Myeloproliferative disorder Pleural effusion Lymphadenopathy Mastocytosis Vertigo Skin rash Urticaria Peripheral neuropathy Hodgkin lymphoma Fever Cirrhosis Hypotension Meningitis Leukocytosis Vomiting Back pain Gastroesophageal reflux Immunologic hypersensitivity Seizures Papule Shock Leukopenia Osteolysis Recurrent hypoglycemia Bone marrow hypocellularity Bone pain Telangiectasia Multiple myeloma Nocturia Abnormal blistering of the skin Tachycardia Ichthyosis Recurrent fractures Erythema Gastrointestinal hemorrhage Retrograde ejaculation Malabsorption Hepatosplenomegaly Asthma Sudden cardiac death Edema Osteoporosis Thrombocytopenia Arrhythmia Intermittent hypothermia Intellectual disability Portal hypertension Abnormality of metabolism/homeostasis Acute lymphoblastic leukemia Meningioma Chronic myelogenous leukemia Burkitt lymphoma Primitive neuroectodermal tumor Ewing sarcoma Peripheral neuroepithelioma Neoplasm of the peripheral nervous system Constipation Myeloid leukemia Carcinoma Abdominal distention Increased body weight Melanoma Breast carcinoma Ovarian neoplasm Ovarian carcinoma Dysgerminoma Non-Hodgkin lymphoma Neuroblastoma Paraplegia Loss of consciousness Asthenia Hypermelanotic macule Abnormality of blood and blood-forming tissues Acute leukemia Flushing Allergy Generalized osteosclerosis Hypersplenism Gastrointestinal stroma tumor Impaired temperature sensation Paralysis Neonatal hypoglycemia Abnormal eosinophil morphology Food intolerance Abnormality of the gastric mucosa Dermatographic urticaria Cutaneous mastocytosis Anaphylactic shock Chronic leukemia Telangiectasia macularis eruptiva perstans Hypothermia Thromboembolism Amyloidosis Conjunctivitis Proteinuria Autoimmunity Hematuria Sensory neuropathy Vasculitis Recurrent bacterial infections Joint dislocation Renal insufficiency Cranial nerve paralysis Cerebral palsy Reduced tendon reflexes Nephritis Hemiplegia/hemiparesis Emphysema Restrictive ventilatory defect Arthritis Sensorineural hearing impairment Abnormal heart valve morphology Prolonged neonatal jaundice Muscle weakness Jaundice Pallor Hemolytic anemia Abnormality of the cardiovascular system Hyperbilirubinemia Osteomyelitis Reticulocytosis Ataxia Anisocytosis Poikilocytosis Hemoglobinuria Nonspherocytic hemolytic anemia Unconjugated hyperbilirubinemia Kernicterus Fava bean-induced hemolytic anemia Pericardial effusion Glomerulopathy Orthostatic hypotension Muscular hypotonia Increased hemoglobin Increased hematocrit Plethora Increased red blood cell mass Peripheral thrombosis Generalized hypotonia Ptosis Polycythemia High palate Hypoglycemia Syncope Dehydration Abnormal autonomic nervous system physiology Epiphora Blurred vision Abnormal hemoglobin Exertional dyspnea Hemoptysis Small vessel vasculitis Irregular hyperpigmentation Uveitis Inflammatory abnormality of the eye Angioedema Complement deficiency Episcleritis Obstructive lung disease Eosinophilia Cerebral hemorrhage Pulmonary infiltrates Restrictive cardiomyopathy Endocardial fibrosis Stroke Abnormal bleeding Epistaxis Myocardial infarction Ovarian papillary adenocarcinoma


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