Lymphoma, and Lymphopenia

Diseases related with Lymphoma and Lymphopenia

In the following list you will find some of the most common rare diseases related to Lymphoma and Lymphopenia that can help you solving undiagnosed cases.

Top matches:

Polyagglutination refers to red blood cells that agglutinate upon exposure to almost all human sera, but not to autologous serum or the sera of newborns. The condition becomes apparent during blood typing and cross-matching in the laboratory (summary by Beck, 2000).Tn polyagglutination syndrome is an acquired clonal disorder characterized by the polyagglutination of red blood cells by naturally occurring anti-Tn antibodies following exposure of the Tn antigen on the surface of erythrocytes. Only a subset of red cells express the antigen, which can also be expressed on platelets and leukocytes. This condition may occur in healthy individuals who manifest asymptomatic anemia, leukopenia, or thrombocytopenia; however, there is also an association between the Tn antigen and leukemia or myelodysplastic disorders. The Tn antigen is an incompletely glycosylated membrane glycoprotein with an exposed N-acetylgalactosamine residue. The Tn antigen results from inactivation of C1GALT1C1, which encodes a chaperone required for the correct functioning of T-synthetase (C1GALT1 ), an enzyme essential for the correct biosynthesis of O-glycans. Absence of active T-synthetase results in exposure of GalNAc residues, with a proportion of these residues becoming sialylated and forming a sialyl-Tn antigen (summary by Vainchenker et al., 1985 and Crew et al., 2008).

TN POLYAGGLUTINATION SYNDROME; TNPS Is also known as galactosyltransferase deficiency

Related symptoms:

  • Anemia
  • Thrombocytopenia
  • Autoimmunity
  • Leukemia
  • Hemolytic anemia


SOURCES: MESH OMIM MENDELIAN

More info about TN POLYAGGLUTINATION SYNDROME; TNPS

X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia is a rare combined T and B cell immunodeficiency characterized by recurrent sinopulmonary and viral infections, persistent elevated Epstein-Barr virus (EBV) viremia and increased susceptibility to EBV-associated B-cell lymphoproliferative disorders. Immunological analyses show normal lymphocyte count or mild to moderate lymphopenia, inverted CD4:CD8 T-cell ratio and hypogammaglobulinemias.

X-LINKED IMMUNODEFICIENCY WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION AND NEOPLASIA Is also known as combined immunodeficiency due to magt1 deficiency|cid due to magt1 deficiency|xmen

Related symptoms:

  • Neoplasm
  • Immunodeficiency
  • Recurrent infections
  • Lymphoma
  • Lymphopenia


SOURCES: ORPHANET OMIM MENDELIAN

More info about X-LINKED IMMUNODEFICIENCY WITH MAGNESIUM DEFECT, EPSTEIN-BARR VIRUS INFECTION AND NEOPLASIA

Severe combined immunodeficiency (SCID) due to CTPS1 deficiency is a rare primary immunodeficiency disorder due to impaired capacity of activated T- and B-cells to proliferate in response to antigen receptor-mediated activation characterized by early-onset, severe, persistent and/or recurrent viral infections due to Epstein-Barr virus (EBV) and Varicella Zoster virus (VZV, including generalized varicella)), as well as recurrent sino-pulmonary bacterial infections due to encapsulated pathogens.

SEVERE COMBINED IMMUNODEFICIENCY DUE TO CTPS1 DEFICIENCY Is also known as scid due to ctps1 deficiency

Related symptoms:

  • Immunodeficiency
  • Lymphoma
  • Lymphopenia
  • Hodgkin lymphoma
  • Decreased proportion of CD4-positive T cells


SOURCES: ORPHANET OMIM MENDELIAN

More info about SEVERE COMBINED IMMUNODEFICIENCY DUE TO CTPS1 DEFICIENCY

Other less relevant matches:

SEVERE COMBINED IMMUNODEFICIENCY DUE TO CORO1A DEFICIENCY Is also known as severe combined immunodeficiency due to coronin-1a deficiency|scid due to coro1a deficiency|scid due to coronin-1a deficiency

Related symptoms:

  • Seizures
  • Global developmental delay
  • Anemia
  • Immunodeficiency
  • Recurrent infections


SOURCES: ORPHANET OMIM MENDELIAN

More info about SEVERE COMBINED IMMUNODEFICIENCY DUE TO CORO1A DEFICIENCY

IMD11B is an autosomal dominant disorder of immune dysfunction characterized by onset of moderate to severe atopic dermatitis in early childhood. Some patients may have recurrent infections and other variable immune abnormalities. Laboratory studies show defects in T-cell activation, increased IgE, and eosinophilia (summary by Ma et al., 2017).

IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B Is also known as atopic dermatitis, elevated ige, and eosinophilia

Related symptoms:

  • Recurrent infections
  • Pneumonia
  • Asthma
  • Lymphoma
  • Decreased antibody level in blood


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B

Combined immunodeficiency due to STK4 deficiency is a rare, genetic combined T and B cell immunodeficiency characterized by T- and B-cell lymphopenia, hypergammaglobulinemia and intermittent neutropenia. It presents with recurrent opportunistic viral, bacterial and fungal infections involving skin (cutaneous papillomatosis, molluscum contagiosum, skin abscesses, mucocutaneous candidiasis), upper and lower respiratory tract or septicemia. Other clinical features include autoimmune manifestations (autoimmune hemolytic anemia) and congenital heart defects (atrial septal defects, patent foramen ovale, mitral, triscupid and pulmonary valve insufficiency).

COMBINED IMMUNODEFICIENCY DUE TO STK4 DEFICIENCY Is also known as mst1 deficiency|cid due to stk4 deficiency|stk4 deficiency

Related symptoms:

  • Anemia
  • Atrial septal defect
  • Immunodeficiency
  • Lymphadenopathy
  • Hemolytic anemia


SOURCES: OMIM ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY DUE TO STK4 DEFICIENCY

Idiopathic CD4 lymphocytopenia is a rare primary immunodeficiency disorder characterized by persistent CD4 T-cell lymphopenia (less than 300 cells/µL on multiple occasions) not associated with any other underlying primary or secondary immune deficiency. Patients typically present opportunistic infections (with cryptococcal, mycobacterial, candidal, varicella zoster virus infections and progressive multifocal leukoencephalopathy being the most prevalent), malignancies (mainly lymphoproliferative disorders), or autoimmune disorders. Some individuals are asymptomatic and incidentally diagnosed.

IDIOPATHIC CD4 LYMPHOCYTOPENIA Is also known as icl|idiopathic cd4 lymphopenia

Related symptoms:

  • Neoplasm
  • Anemia
  • Immunodeficiency
  • Pneumonia
  • Carcinoma


SOURCES: OMIM ORPHANET MENDELIAN

More info about IDIOPATHIC CD4 LYMPHOCYTOPENIA

Burkitt lymphoma is a rare form of malignant mature B-cell non-Hodgkin lymphoma.

BURKITT LYMPHOMA Is also known as small non-cleaved cell lymphoma

Related symptoms:

  • Neoplasm
  • Immunodeficiency
  • Abdominal pain
  • Abnormality of the liver
  • Nausea and vomiting


SOURCES: OMIM ORPHANET MENDELIAN

More info about BURKITT LYMPHOMA

COMBINED IMMUNODEFICIENCY WITH GRANULOMATOSIS Is also known as cid due to rag 1/2 deficiency|combined immunodeficiency due to rag 1/2 deficiency

Related symptoms:

  • Splenomegaly
  • Immunodeficiency
  • Recurrent respiratory infections
  • Respiratory tract infection
  • Lymphoma


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about COMBINED IMMUNODEFICIENCY WITH GRANULOMATOSIS

Familial myeloproliferative/lymphoproliferative neoplasms is an autosomal dominant cancer predisposition syndrome characterized by adult-onset of hematologic malignancies mainly affecting the myeloid line. Most patients present with myelodysplastic syndrome (MDS ) and/or acute myeloid leukemia (AML ). Rare lymphoid malignancies, including lymphoma, can also occur. Some mutation carriers, even if unaffected by a hematologic malignancy, may have evidence of immune dysregulation disorders, including asthma, eczema, or juvenile arthritis. The disorder shows incomplete penetrance (summary by Lewinsohn et al., 2016). Patients may show a favorable response to treatment with lenalidomide (summary by Polprasert et al., 2015).

Related symptoms:

  • Neoplasm
  • Anemia
  • Arthritis
  • Leukemia
  • Asthma


SOURCES: ORPHANET OMIM MENDELIAN

More info about DDX41-RELATED HEMATOLOGIC MALIGNANCY PREDISPOSITION SYNDROME

Top 5 symptoms//phenotypes associated to Lymphoma and Lymphopenia

Symptoms // Phenotype % cases
Immunodeficiency Common - Between 50% and 80% cases
Anemia Uncommon - Between 30% and 50% cases
Decreased proportion of CD4-positive T cells Uncommon - Between 30% and 50% cases
Neoplasm Uncommon - Between 30% and 50% cases
Recurrent viral infections Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Lymphopenia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

B-cell lymphoma Hodgkin lymphoma Inflammatory abnormality of the skin Hemolytic anemia Recurrent infections

Rare Symptoms - Less than 30% cases

Respiratory tract infection Psoriasiform dermatitis Combined immunodeficiency Autoimmune hemolytic anemia Decreased antibody level in blood Asthma Papilloma Lymphoproliferative disorder T-cell lymphoma Lymphadenopathy Pneumonia Leukopenia Recurrent respiratory infections Leukemia Abnormality of the spleen Neoplasm of the oral cavity Increased lactate dehydrogenase activity Burkitt lymphoma Abnormality of the lymph nodes Abnormality of bone marrow cell morphology Systemic lupus erythematosus Abnormality of the ovary Splenomegaly Hyperuricemia Intestinal obstruction Chronic myelomonocytic leukemia Gastrointestinal hemorrhage Nausea and vomiting Abnormality of the liver Abnormality of the pancreas Vitiligo Fatigable weakness Acute monocytic leukemia Bone marrow hypocellularity Myelodysplasia Myeloid leukemia Eczema Acute myeloid leukemia Bronchiolitis obliterans organizing pneumonia Immune dysregulation Refractory anemia Melanoma Arthritis Iritis Granulomatosis B lymphocytopenia Monocytosis Decrease in T cell count IgG deficiency Abdominal pain Verrucae Opportunistic infection Hyperactivity Atopic dermatitis Colitis Eosinophilia Recurrent sinopulmonary infections Bronchiectasis Attention deficit hyperactivity disorder Global developmental delay Atrial septal defect Seizures Defective T cell proliferation Immunoglobulin IgG2 deficiency Severe viral infections Decreased T cell activation Abnormal erythrocyte morphology Autoimmunity Ulcerative colitis Neutropenia Bronchiolitis obliterans Carcinoma Bronchiolitis Recurrent sinusitis Squamous cell carcinoma Sinusitis Recurrent otitis media Otitis media Recurrent fungal infections Ventricular hypertrophy Pulmonary insufficiency Thrombocytopenia Chronic mucocutaneous candidiasis Right ventricular hypertrophy Increased antibody level in blood Patent foramen ovale Recurrent bacterial infections Erythroid dysplasia


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