Lymphoma, and Lymphedema

Diseases related with Lymphoma and Lymphedema

In the following list you will find some of the most common rare diseases related to Lymphoma and Lymphedema that can help you solving undiagnosed cases.

Top matches:

Medium match FOLLICULAR LYMPHOMA

Follicular lymphoma is a form of non-Hodgkin lymphoma (see this term) characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.

FOLLICULAR LYMPHOMA Is also known as oncogene b-cell leukemia 2

Related symptoms:

  • Neoplasm
  • Fever
  • Fatigue
  • Diarrhea
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about FOLLICULAR LYMPHOMA

Medium match KAPOSI SARCOMA

Kaposi sarcoma (KS) is a rare human herpes virus 8 (HHV-8)-induced endothelial inflammatory neoplasm that develops is various clinically distinct settings, manifesting mostly as cutaneous lesions, or mucosal or visceral involvement.

KAPOSI SARCOMA Is also known as multiple idiopathic pigmented hemangiosarcoma, susceptibility to

Related symptoms:

  • Neoplasm
  • Hypertension
  • Fever
  • Fatigue
  • Edema


SOURCES: OMIM ORPHANET MENDELIAN

More info about KAPOSI SARCOMA

Microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) is a rare autosomal dominant condition characterized by variable expression of microcephaly, ocular disorders including chorioretinopathy, congenital lymphedema of the lower limbs, and mild to moderate intellectual disability.

MICROCEPHALY-LYMPHEDEMA-CHORIORETINOPATHY SYNDROME Is also known as mlcrd

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Microcephaly
  • Muscular hypotonia


SOURCES: ORPHANET MENDELIAN

More info about MICROCEPHALY-LYMPHEDEMA-CHORIORETINOPATHY SYNDROME

Other less relevant matches:

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation is an autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes (summary by Ostergaard et al., 2012). Robitaille et al. (2014) found that MCLMR includes a broader spectrum of ocular disease, including retinal detachment with avascularity of the peripheral retina, and noted phenotypic overlap with familial exudative vitreoretinopathy (FEVR; see EVR1, {133780}).Birtel et al. (2017) observed intrafamilial and intraindividual variability in retinal phenotype, and noted that syndromic manifestations in some patients are too subtle to be detected during a routine ophthalmologic evaluation. Variable expressivity and reduced penetrance have also been observed in some families (Jones et al., 2014; Li et al., 2016).Autosomal recessive forms of microcephaly with chorioretinopathy have been reported (see {251270}).See also Mirhosseini-Holmes-Walton syndrome (autosomal recessive microcephaly with pigmentary retinopathy and mental retardation; {268050}), which has been mapped to chromosome 8q21.3-q22.1.

MICROCEPHALY WITH OR WITHOUT CHORIORETINOPATHY, LYMPHEDEMA, OR MENTAL RETARDATION; MCLMR Is also known as lymphedema, microcephaly, chorioretinopathy syndrome|cdmmr syndrome|mlcrd syndrome|lymphedema and retinal folds with microcephaly and microphthalmos|microcephaly and chorioretinopathy with or without mental retardation, autosomal dominant|microcephaly, ly

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM MESH MENDELIAN

More info about MICROCEPHALY WITH OR WITHOUT CHORIORETINOPATHY, LYMPHEDEMA, OR MENTAL RETARDATION; MCLMR

Bannayan-Riley-Ruvalcaba syndrome (BRRS) is a rare congenital disorder characterized by hamartomatous intestinal polyposis, lipomas, macrocephaly and genital lentiginosis.

BANNAYAN-RILEY-RUVALCABA SYNDROME Is also known as brrs|myhre-riley-smith syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Scoliosis


SOURCES: ORPHANET MENDELIAN

More info about BANNAYAN-RILEY-RUVALCABA SYNDROME

Medium match WEAVER SYNDROME; WVS

Weaver syndrome comprises pre- and postnatal overgrowth, accelerated osseous maturation, characteristic craniofacial appearance, and developmental delay. Most cases are sporadic, although autosomal dominant inheritance has been reported. Although there is phenotypic overlap between Weaver syndrome and Sotos syndrome (OMIM ), distinguishing features of Weaver syndrome include broad forehead and face, ocular hypertelorism, prominent wide philtrum, micrognathia, deep horizontal chin groove, and deep-set nails. In addition, carpal bone development is advanced over the rest of the hand in Weaver syndrome, whereas in Sotos syndrome carpal bone development is at or behind that of the rest of the hand (summary by Basel-Vanagaite, 2010).The 'Weaver-like' syndrome reported by Stoll et al. (1985) in a mother and son may be a separate entity.Sotos syndrome (OMIM ), which shows considerable phenotypic overlap with Weaver syndrome, is caused by mutation in the NSD1 gene (OMIM ) on chromosome 5q35.

WEAVER SYNDROME; WVS Is also known as weaver-smith syndrome|wss

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Scoliosis


SOURCES: OMIM MENDELIAN

More info about WEAVER SYNDROME; WVS

Noonan syndrome-like disorder with juvenile myelomonocytic leukemia is a rare, genetic, polymalformative syndrome with increased risk of developing cancer characterized by a Noonan-like phenotype, including typical dysmorphic facial features (i.e. high forehead, hypertelorism, downslanting palpebral fissures, ptosis, low-set ears, prominent philtrum and short neck with or without pterygium colli), thoracic abnormalities, congenital heart defects and short stature, associated with a very frequent ocurrence of juvenile myelomonocytic leukemia. Developmental delay, ectodermal anomalies, joint laxity, and hypotonia may also be associated.

NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA Is also known as cbl mutation-associated syndrome|noonan syndrome-like disorder with jmml|cbl syndrome

Related symptoms:

  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Microcephaly
  • Growth delay


SOURCES: ORPHANET OMIM MENDELIAN

More info about NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA

Cardiofaciocutaneous (CFC) syndrome is a RASopathy characterized by craniofacial dysmorphology, congenital heart disease, dermatological abnormalities (most commonly hyperkeratotic skin and sparse, curly hair), growth retardation and intellectual disability.

CARDIOFACIOCUTANEOUS SYNDROME Is also known as cfcs|cfc syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about CARDIOFACIOCUTANEOUS SYNDROME

Monocytopenia with susceptibility to infections is a rare, genetic, primary immunodeficiency disorder characterized by profound circulating monocytopenia, B- and NK-cell lymphopenia and severe dentritic cell decrease, which manifests clinically with disseminated mycobacterial and viral infections, as well as opportunistic fungal and parasitic infections and frequent pulmonary alveolar proteinosis. Predisposition to developping myeloid neoplasms is associated.

MONOCYTOPENIA WITH SUSCEPTIBILITY TO INFECTIONS Is also known as dendritic cell, monocyte, b and nk lymphoid deficiency|dcml|dendritic cell, monocyte, b lymphocyte, and natural killer lymphocyte deficiency|monocytopenia with susceptibility to mycobacterial, fungal, and papillomavirus infections and myelodysplasia|monoc

Related symptoms:

  • Hearing impairment
  • Sensorineural hearing impairment
  • Anemia
  • Hypertension
  • Immunodeficiency


SOURCES: OMIM ORPHANET MENDELIAN

More info about MONOCYTOPENIA WITH SUSCEPTIBILITY TO INFECTIONS

Deafness - lymphedema - leukemia is a very rare, serious syndromic genetic disorder characterized by primary lymphedema, immunodeficiency, and hematological disorders.

DEAFNESS-LYMPHEDEMA-LEUKEMIA SYNDROME Is also known as emberger syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Sensorineural hearing impairment
  • Anemia
  • Epicanthus


SOURCES: OMIM ORPHANET MENDELIAN

More info about DEAFNESS-LYMPHEDEMA-LEUKEMIA SYNDROME

Top 5 symptoms//phenotypes associated to Lymphoma and Lymphedema

Symptoms // Phenotype % cases
Leukemia Common - Between 50% and 80% cases
Neoplasm Common - Between 50% and 80% cases
Epicanthus Common - Between 50% and 80% cases
Muscular hypotonia Common - Between 50% and 80% cases
Global developmental delay Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Lymphoma and Lymphedema. may also develop some of the following symptoms:

Common Symptoms - More than 50% cases

Edema

Uncommon Symptoms - Between 30% and 50% cases

Long philtrum Intellectual disability Macrotia Anteverted nares Seizures Downslanted palpebral fissures Micrognathia Atrial septal defect Depressed nasal bridge Splenomegaly Hearing impairment Generalized hypotonia Short stature Optic atrophy Hypertonia Thick vermilion border Prominent forehead Abnormality of the optic nerve Macrocephaly Ptosis Pleural effusion Fatigue Venous thrombosis Spasticity Cataract Blindness Myopia Delayed skeletal maturation Bruising susceptibility Visual loss Webbed neck Thickened skin Abnormal eyelash morphology Underdeveloped supraorbital ridges Cellulitis Dry skin Wide nose Retinal dystrophy Full cheeks Scaling skin Neurological speech impairment Pectus excavatum Subcutaneous nodule Scoliosis Hypermetropia Microcephaly Cryptorchidism Lymphadenopathy Fever Astigmatism Fine hair Sparse hair Hypertension Weight loss Immunodeficiency Inguinal hernia Sensorineural hearing impairment Delayed speech and language development Abnormal facial shape Pointed chin Frontal bossing Chylothorax Hypertelorism Erysipelas Deep philtrum Thrombocytopenia Bilateral ptosis Strabismus Panniculitis

Rare Symptoms - Less than 30% cases

Leukopenia Pancytopenia Sleep disturbance Myelodysplasia Anemia Overgrowth Low posterior hairline Bone marrow hypocellularity Poor suck Optic nerve hypoplasia Recurrent infections Hyperpigmentation of the skin Cafe-au-lait spot Flat occiput Prominent fingertip pads Myopathy Hyperhidrosis Abnormality of cardiovascular system morphology Cardiomyopathy Dysarthria Short neck Behavioral abnormality Kyphosis Hernia Feeding difficulties Polyhydramnios Umbilical hernia Joint laxity Low-set ears Broad forehead Failure to thrive Growth delay Large for gestational age Posteriorly rotated ears Gastroesophageal reflux Short nose Cutis laxa Dolichocephaly Nevus Broad thumb Tall stature Narrow palate Delayed gross motor development Intracranial hemorrhage Multiple cafe-au-lait spots High forehead Myeloid leukemia Falls Chronic otitis media Joint hypermobility Pulmonic stenosis Pectus carinatum Feeding difficulties in infancy Low-set, posteriorly rotated ears Abnormal bleeding Hydrocele testis Acute myeloid leukemia Neurodevelopmental delay Status epilepticus Sloping forehead Specific learning disability Retinal detachment Retinopathy Protruding ear Abnormality of the eye Rigidity Glaucoma Upslanted palpebral fissure Severe short stature Microphthalmia Wide nasal bridge Aggressive behavior Abnormality of retinal pigmentation Abnormality of the spleen Abnormality of the gastrointestinal tract Scarring Hemangioma Pulmonary arterial hypertension Pneumonia Encephalopathy Hepatomegaly Skin nodule B-cell lymphoma Neutropenia Respiratory tract infection Diarrhea Amblyopia Short attention span Skin ulcer Neonatal hypotonia Verrucae Cubitus valgus Nystagmus Melanonychia Chorioretinal dysplasia Abnormal nasolacrimal system morphology Mandibular prognathia Leukonychia Retinal dysplasia Failure to thrive in infancy Intellectual disability, severe Abnormal toenail morphology Gangrene Anophthalmia Abnormality of vision Muscle stiffness Bulbous nose Abnormality of the nail Hydroureter Autism Hyperkeratosis Alopecia Proptosis Aplasia/Hypoplasia of the eyebrow Cerebral cortical atrophy Sparse eyelashes Malnutrition Oculomotor apraxia Abnormal palate morphology Constipation Open bite Clinodactyly of the 5th finger Obsessive-compulsive behavior Absent eyebrow Melanocytic nevus Ectropion Sparse eyebrow Brittle hair Redundant skin Heart murmur Aspiration Relative macrocephaly Palmoplantar hyperkeratosis Abnormality of the genitourinary system Sleep apnea Aplasia/Hypoplasia of the corpus callosum Hyperextensible skin Abnormality of skin pigmentation Osteopenia Cardiomegaly High, narrow palate Palmoplantar keratoderma Abdominal distention Myocardial infarction Coarctation of aorta Vesicoureteral reflux Intestinal malrotation Genu valgum Narrow forehead Peripheral axonal neuropathy Abnormality of the cardiovascular system Premature birth Progressive visual loss Dental malocclusion Growth hormone deficiency Hemiparesis Hypotrichosis Cerebral visual impairment Abnormality of the kidney Coarse facial features EEG abnormality Hydronephrosis Ichthyosis Hypertrophic cardiomyopathy Telecanthus Decreased body weight Irritability Inflammatory abnormality of the skin Erythema Hepatic steatosis Abnormal cardiac septum morphology Pruritus Nail dystrophy Open mouth Abnormality of the cerebral white matter Long face Abnormality of the hairline Neurofibromas Decreased antibody level in blood Recurrent fungal infections B lymphocytopenia Recurrent viral infections Aplastic anemia Severe sensorineural hearing impairment Spontaneous abortion Lymphopenia Recurrent otitis media Nephrotic syndrome Otitis media Hypothyroidism Severe viral infections Oral aversion Multiple plantar creases Eyelid fasciculation Multiple palmar creases Abnormality of the auditory canal Inappropriate crying Cutaneous T-cell lymphoma Morphological abnormality of the gastrointestinal tract Puberty and gonadal disorders Abnormal location of ears Alveolar proteinosis Chronic myelomonocytic leukemia Hyperkeratosis pilaris Hematuria Macronodular cirrhosis Granulocytopenia Myeloproliferative disorder Hypercoagulability Acute leukemia Prolonged bleeding time Leukocytosis Hypotelorism Migraine Tapered finger Hemolytic anemia Monocytopenia Cirrhosis Vertigo Nausea and vomiting Pallor Respiratory failure Recurrent respiratory infections Syndactyly Cerebellar atrophy Respiratory insufficiency Abnormal natural killer cell morphology Recurrent mycobacterium avium complex infections Depressivity Tongue thrusting Infantile spasms Enlarged kidney Delayed CNS myelination Abnormality of the testis Dystrophic fingernails Abnormal hair pattern Thick upper lip vermilion Woolly hair Abnormality of the ulna Premature skin wrinkling Hypoplasia of the zygomatic bone Absent eyelashes Arnold-Chiari type I malformation Abnormality of refraction Alopecia of scalp Atopic dermatitis Poor appetite Anal stenosis Submucous cleft hard palate Generalized hyperpigmentation Curly hair Biparietal narrowing Abnormal heart valve morphology Long palpebral fissure Abnormality of the sternum Abnormal myocardium morphology Deep palmar crease Functional abnormality of the gastrointestinal tract Increased nuchal translucency Laryngeal cleft Generalized ichthyosis Hypoplasia of the frontal lobes Optic nerve dysplasia Patchy alopecia Abnormal tricuspid valve morphology Abnormality of the optic disc Anterior creases of earlobe Frontal balding Endocarditis Sparse or absent eyelashes Gastrointestinal dysmotility Multiple lentigines Cavernous hemangioma Abnormality of hair texture Excessive wrinkled skin Abnormality of the pulmonary artery Hyperextensibility of the finger joints Abnormal aortic valve morphology Subvalvular aortic stenosis Thickened helices Slow-growing hair Abnormal mitral valve morphology Abnormal heart morphology Limited knee extension Cerebral atrophy Aortic aneurysm Meningioma Capillary hemangioma Lipoma Hashimoto thyroiditis Irregular hyperpigmentation Hamartoma Multiple lipomas Cutis marmorata Cachexia Angina pectoris Telangiectasia Joint hyperflexibility Hypoglycemia Skeletal muscle atrophy Muscle weakness Chorioretinal lacunae Myopic astigmatism Exudative vitreoretinopathy Retinal thinning Arteriovenous malformation Thyroid carcinoma Congenital microcephaly Talipes equinovarus Nail dysplasia Round face Talipes Platyspondyly Abnormality of the pinna Camptodactyly Retrognathia Pes cavus Clinodactyly Flexion contracture Intestinal polyposis Pain Neoplasm of the adrenal cortex Abnormal large intestine morphology Uterine neoplasm Abdominal wall muscle weakness Subcutaneous hemorrhage Hamartomatous polyposis Neoplasm of the breast Visceral angiomatosis Prominent nasal tip Retinal fold Hypertrichosis Papule Lymphoproliferative disorder Abnormality of the lower limb Macule Abnormal retinal morphology Hypermelanotic macule Sarcoma Neoplasm of the skin Abnormal lung morphology Gastrointestinal hemorrhage Skin rash Venous insufficiency Abnormality of the liver Abnormality of the peritoneum Mediastinal lymphadenopathy Night sweats Chronic lymphatic leukemia Glucose intolerance Meningitis Insulin resistance Nausea Cellular immunodeficiency Generalized lymphadenopathy Vitreoretinopathy Corneal opacity Chorioretinal atrophy Cortical gyral simplification Agitation Patent foramen ovale Thick lower lip vermilion Bilateral sensorineural hearing impairment Pigmentary retinopathy Broad nasal tip Microcornea Attention deficit hyperactivity disorder Skin plaque Thin upper lip vermilion Reduced visual acuity Hyperactivity Intellectual disability, mild Hypoplasia of the corpus callosum Abnormal eyelid morphology Abnormality of the hair Neoplasm by anatomical site Susceptibility to herpesvirus Amenorrhea Pachygyria Malar flattening Aortic valve stenosis Decreased muscle mass Proximal placement of thumb Overfolded helix Abnormality of the thorax Cholelithiasis Bicuspid aortic valve Torticollis Vasculitis Bilateral single transverse palmar creases Hydrops fetalis Facial hypotonia Mitral regurgitation Epistaxis Cyanosis Hip dysplasia Wide intermamillary distance Esotropia Triangular face Ascites Highly arched eyebrow Abnormal eyebrow morphology Hypochromic microcytic anemia Postnatal growth retardation Abnormality of the subarachnoid space Congestive heart failure Abnormality of the dentition Vomiting Hydrocephalus Ventriculomegaly Ventricular septal defect Dysphagia High palate Ataxia Reduced factor X activity Broad toe Reduced prothrombin activity Juvenile myelomonocytic leukemia Reduced factor XII activity Hypoplasia of olfactory tract Reduced factor IX activity Abnormality of the mediastinum Arteritis Pulmonary lymphangiectasia Monocytosis Abnormality of the foot Hepatosplenomegaly Joint contracture of the hand Bilateral talipes equinovarus Hypoplastic iliac wing Diastasis recti Down-sloping shoulders Prolactin excess Acute lymphoblastic leukemia Inverted nipples Secondary amenorrhea Absent septum pellucidum Limited elbow extension Overlapping toe Broad face Metatarsus adductus Radial deviation of finger Large hands Back pain Slurred speech Accelerated skeletal maturation Coxa valga Short ribs Hoarse voice Large earlobe Dilation of lateral ventricles Respiratory distress Deep-set nails Gait disturbance Motor delay Cognitive impairment Dysharmonic bone age Flared humeral metaphysis Abnormally low-pitched voice Flared femoral metaphysis Lumbar kyphosis Sacrococcygeal teratoma Horizontal eyebrow Broad philtrum Vertebral wedging Short fourth metatarsal Galactorrhea Teratoma Thin nail Thoracolumbar kyphosis Calcaneovalgus deformity Poor fine motor coordination Dimple chin Abnormal neutrophil count


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