Lymphoma, and Jaundice

Diseases related with Lymphoma and Jaundice

In the following list you will find some of the most common rare diseases related to Lymphoma and Jaundice that can help you solving undiagnosed cases.

Top matches:

G6PD deficiency is the most common genetic cause of chronic and drug-, food-, or infection-induced hemolytic anemia. G6PD catalyzes the first reaction in the pentose phosphate pathway, which is the only NADPH-generation process in mature red cells; therefore, defense against oxidative damage is dependent on G6PD. Most G6PD-deficient patients are asymptomatic throughout their life, but G6PD deficiency can be life-threatening. The most common clinical manifestations of G6PD deficiency are neonatal jaundice and acute hemolytic anemia, which in most patients is triggered by an exogenous agent, e.g., primaquine or fava beans. Acute hemolysis is characterized by fatigue, back pain, anemia, and jaundice. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. The striking similarity between the areas where G6PD deficiency is common and Plasmodium falciparum malaria (see {611162}) is endemic provided evidence that G6PD deficiency confers resistance against malaria (summary by Cappellini and Fiorelli, 2008).

ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY Is also known as favism, susceptibility to

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Muscle weakness
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY

Zur Stadt et al. (2005) summarized the clinical features of hemophagocytic lymphohistiocytosis (HLH), a rare autosomal recessive disorder characterized by massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently central nervous system involvement. In FHL, the familial form of the disease, first episodes occur mostly during infancy, with a rapidly fatal outcome if untreated. Diagnostic criteria also include low fibrinogen and high triglyceride and ferritin levels. Chemoimmunotherapy based on corticosteroids, epipodophyllotoxins, and cyclosporin succeeds in controlling the disease in the majority of patients, although remission is rarely obtained (Henter et al., 2002). Most patients suffer an early death unless they are treated by hematopoietic stem cell transplantation (Durken et al., 1999). Genetic Heterogeneity of Familial Hemophagocytic LymphohistiocytosisFamilial hemophagocytic lymphohistiocytosis exhibits genetic heterogeneity. In some families, familial hemophagocytic lymphohistiocytosis has been found to be linked to chromosome 9q (HPLH1, FHL1). FHL2 (OMIM ) is caused by mutation in the PRF1 gene (OMIM ) on chromosome 10q22; FHL3 (OMIM ) is caused by mutation in the UNC13D gene (OMIM ) on chromosome 17q25; FHL4 (OMIM ) is caused by mutation in the syntaxin-11 gene (STX11 ) on chromosome 6q24; and FHL5 (OMIM ) is caused by mutation in the syntaxin-binding protein-2 (STXBP2 ), which is an interaction partner of STX11, on chromosome 19p13.Furthermore, before the identification of mutations in the RAG1 (OMIM ) and RAG2 (OMIM ) genes, both of which map to 11p, Omenn syndrome (familial reticuloendotheliosis with eosinophilia; {603554}) was not thought to be clearly distinct from other reported cases of hemophagocytic lymphohistiocytosis.

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1 Is also known as hemophagocytic reticulosis, familial|hlh1|hemophagocytic lymphohistiocytosis, familial|erythrophagocytic lymphohistiocytosis, familial|reticulosis, familial histiocytic|hplh1|fhl|fhlh|hplh|fel

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia
  • Neoplasm


SOURCES: OMIM MENDELIAN

More info about HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1

Chédiak-Higashi syndrome (CHS) is a rare severe genetic disorder generally characterized by partial oculocutaneous albinism (OCA, see this term), severe immunodeficiency, mild bleeding, neurological dysfunction and lymphoproliferative disorder. A classic, early-onset form and an attenuated, later-onset form (Atypical CHS; see this term) have been described.

CHÉDIAK-HIGASHI SYNDROME Is also known as chÉdiak-higashi-steinbrink syndrome|chÉdiak-higashi disease

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about CHÉDIAK-HIGASHI SYNDROME

Other less relevant matches:

Li-Fraumeni syndrome (LFS) is a rare cancer predisposition syndrome characterized by the early-onset of multiple primary cancers such as breast cancer, soft tissue and bone sarcomas (see these terms), brain tumors and adrenal cortical carcinoma (ACC) (see this term).

LI-FRAUMENI SYNDROME Is also known as sarcoma family syndrome of li and fraumeni|sbla syndrome

Related symptoms:

  • Neoplasm
  • Carcinoma
  • Leukemia
  • Lymphoma
  • Neoplasm of the skin


SOURCES: OMIM ORPHANET MENDELIAN

More info about LI-FRAUMENI SYNDROME

Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN, see this term) characterized by a sustained elevation of platelet number (> 450 x 109/L) with a tendency for thrombosis and hemorrhage.

ESSENTIAL THROMBOCYTHEMIA Is also known as thrombocytosis 1|essential thrombocytosis|et

Related symptoms:

  • Pain
  • Hypertension
  • Hepatomegaly
  • Abnormality of the skeletal system
  • Respiratory distress


SOURCES: ORPHANET OMIM MENDELIAN

More info about ESSENTIAL THROMBOCYTHEMIA

Hemoglobin H disease is a subtype of alpha-thalassemia (see {604131}) in which patients have compound heterozygosity for alpha(+)-thalassemia, caused by deletion of one alpha-globin gene, and for alpha(0)-thalassemia, caused by deletion in cis of 2 alpha-globin genes (summary by Lal et al., 2011). When 3 alpha-globin genes become inactive because of deletions with or without concomitant nondeletional mutations, the affected individual has only 1 functional alpha-globin gene. These people usually have moderate anemia and marked microcytosis and hypochromia. In affected adults, there is an excess of beta-globin chains within erythrocytes that will form beta-4 tetramers, also known as hemoglobin H (summary by Chui et al., 2003).Hb H disease is usually caused by the combination of alpha(0)-thalassemia with deletional alpha(+)-thalassemia, a combination referred to as 'deletional' Hb H disease. In a smaller proportion of patients, Hb H disease is caused by an alpha(0)-thalassemia plus an alpha(+)-thalassemia point mutation or small insertion/deletion. Such a situation is labeled 'nondeletional' Hb H disease. Patients with nondeletional Hb H disease are usually more anemic, more symptomatic, more prone to have significant hepatosplenomegaly, and more likely to require transfusions (summary by Lal et al., 2011).While most thalassemia-related hydrops fetalis is caused by the lack of all alpha-globin genes, there are reports of fetuses with Hb H disease that developed the hydrops fetalis syndrome; see {236750}.

HEMOGLOBIN H DISEASE; HBH Is also known as alpha-thalassemia, hemoglobin h type|hemoglobin h disease, deletional

Related symptoms:

  • Cognitive impairment
  • Anemia
  • Hepatomegaly
  • Edema
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about HEMOGLOBIN H DISEASE; HBH

Congenital dyserythropoietic anemia type II (CDA II) is the most common form of CDA (see this term) characterized by anemia, jaundice and splenomegaly and often leading to liver iron overload and gallstones.

CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II Is also known as dyserythropoietic anemia, congenital, type ii|cda ii|sec23b-cdg|hempas|hereditary erythroblastic multinuclearity with positive acidified-serum test|cda type ii|cda type 2|hereditary erythroblastic multinuclearity with a positive acidified-serum test (hemp

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Congestive heart failure
  • Splenomegaly
  • Arrhythmia


SOURCES: ORPHANET OMIM MENDELIAN

More info about CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II

Congenital dyserythropoietic anemia type III (CDA III) is a rare form of CDA (see this term) characterized by dyserythropoiesis, with big multinucleated erythroblasts in the bone marrow, and manifesting with mild to moderate anemia.

CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE III Is also known as anemia with multinucleated erythroblasts|erythroreticulosis, hereditary benign|congenital dyserythropoietic anemia type 3|cda type 3|dyserythropoietic anemia, congenital, type iii|cda iii|cda type iii

Related symptoms:

  • Short stature
  • Neoplasm
  • Anemia
  • Fatigue
  • Headache


SOURCES: ORPHANET OMIM MENDELIAN

More info about CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE III

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

SICKLE CELL ANEMIA Is also known as sickle cell disease

Related symptoms:

  • Intellectual disability
  • Pain
  • Anemia
  • Hypertension
  • Hepatomegaly


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about SICKLE CELL ANEMIA

Pitt-Hopkins syndrome (PHS) is characterized by the association of intellectual deficit, characteristic facial dysmorphism and problems of abnormal and irregular breathing.

PITT-HOPKINS SYNDROME Is also known as encephalopathy, severe epileptic, with autonomic dysfunction|mental retardation, syndromal, with intermittent hyperventilation

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Hearing impairment


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about PITT-HOPKINS SYNDROME

Top 5 symptoms//phenotypes associated to Lymphoma and Jaundice

Symptoms // Phenotype % cases
Anemia Common - Between 50% and 80% cases
Splenomegaly Common - Between 50% and 80% cases
Hepatomegaly Common - Between 50% and 80% cases
Leukemia Common - Between 50% and 80% cases
Hemolytic anemia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Jaundice. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Neoplasm Hepatosplenomegaly Hyperbilirubinemia Intellectual disability Fatigue Fever Global developmental delay Reticulocytosis Seizures Ataxia Recurrent infections Generalized hypotonia Pneumonia Hodgkin lymphoma Pain Leukocytosis Cholelithiasis Acute leukemia

Rare Symptoms - Less than 30% cases

Hemophagocytosis Leukopenia Bruising susceptibility Albinism Paresthesia Partial albinism Increased total bilirubin Rigidity Edema Strabismus Hypofibrinogenemia Hypopigmentation of the skin Respiratory distress Gingival bleeding Acrocyanosis Increased mean corpuscular volume Congenital hypoplastic anemia Chronic myelogenous leukemia Anemia of inadequate production Abnormal hemoglobin Microcytic anemia Thrombocytosis Hypersplenism Myeloid leukemia Myelodysplasia Headache Pancytopenia Abnormality of the skeletal system Hypertension Hypertriglyceridemia Chest pain Peripheral demyelination Immunodeficiency Confusion Abnormality of the liver Irritability Abnormality of the nervous system Elevated hepatic transaminase Encephalopathy Thrombocytopenia Muscular hypotonia Hepatic failure Failure to thrive Unconjugated hyperbilirubinemia Poikilocytosis Anisocytosis Prolonged neonatal jaundice Osteomyelitis Cirrhosis Pallor Lymphadenopathy Meningitis Sepsis Hypochromic anemia Pigment gallstones Priapism Increased lactate dehydrogenase activity Abnormal lactate dehydrogenase activity Persistence of hemoglobin F Pure red cell aplasia Chronic hemolytic anemia Microalbuminuria Hearing impairment Night sweats Abnormality of the spleen Left ventricular failure Hypoxemia Atelectasis Asplenia Elevated serum creatinine Increased red cell sickling tendency Microcephaly Aseptic necrosis Talipes equinovarus Constipation Clinodactyly Absent speech Intellectual disability, severe Hypoplasia of the corpus callosum Short neck Anteverted nares Myopia Scoliosis Wide nasal bridge Depressed nasal bridge Motor delay Feeding difficulties Cryptorchidism Abnormal facial shape Hypertelorism Growth delay Abnormality of the vasculature Poor appetite Upslanted palpebral fissure Multiple myeloma Oral cavity bleeding Post-partum hemorrhage Abnormal cellular phenotype Abnormal erythrocyte morphology Increased serum iron Erythroid hyperplasia Melena Muscle weakness Abnormal proerythroblast morphology Macrocytic anemia Heterotopia Proptosis Short stature Reduced activity of N-acetylglucosaminyltransferase II Endopolyploidy on chromosome studies of bone marrow Increased red cell osmotic fragility Increased total iron binding capacity Abnormal erythroid lineage cell morphology Iron deficiency anemia Cardiomegaly Wheezing Tachypnea Cerebral palsy Recurrent bacterial infections Bone marrow hypocellularity Bone pain Cholestasis Nephropathy Hemosiderinuria Hematuria Cough Stroke Retinopathy Respiratory failure Abdominal pain Osteoporosis Renal insufficiency Pes cavus Micropenis Myalgia Incoordination Aphasia Supernumerary nipple Overlapping toe Cupped ear Clubbing Self-injurious behavior Short metatarsal Coarse hair Hyperventilation Hypopigmented skin patches Mutism Sleep apnea Aplasia/Hypoplasia of the corpus callosum Widely spaced teeth Abnormal palate morphology Intellectual disability, progressive Dysphasia Hiatus hernia Abnormal autonomic nervous system physiology Large beaked nose Triangular nasal tip Broad fingertip Intermittent hyperventilation Narrow foot Failure of eruption of permanent teeth Small cerebral cortex Square face Happy demeanor Esophagitis Pes valgus Abnormal pattern of respiration Thickened helices Breathing dysregulation Abnormality of the helix Clubbing of fingers Echolalia Misalignment of teeth Finger clinodactyly Truncal ataxia Gait ataxia Intellectual disability, moderate Short philtrum Wide mouth Autistic behavior Protruding ear Abnormality of the pinna Postnatal growth retardation Apnea Aggressive behavior Neurological speech impairment Anxiety Deeply set eye Pes planus Coarse facial features Gastroesophageal reflux Mandibular prognathia Autism Prominent nasal bridge Severe global developmental delay Postnatal microcephaly Wide intermamillary distance Aganglionic megacolon Open mouth Thick lower lip vermilion Narrow forehead Cyanosis Specific learning disability Convex nasal ridge Prominent nose Astigmatism Full cheeks Abdominal distention Sleep disturbance Single transverse palmar crease Tapered finger Small hand Thick vermilion border Thick eyebrow Increased hemoglobin Increased serum ferritin Hypoproteinemia Hyponatremia Epistaxis Abnormality of extrapyramidal motor function Bradykinesia Gastrointestinal hemorrhage Brain atrophy Parkinsonism Abnormal bleeding Neutropenia Amblyopia Neurodegeneration Sensory neuropathy Coma Falls Peripheral axonal neuropathy Abnormality of the coagulation cascade Paraplegia Cutaneous photosensitivity Hyperpigmentation of the skin Spastic paraplegia Hypopigmentation of hair White hair Generalized hypopigmentation Fair hair Periodontitis Gingivitis Iris hypopigmentation Hypertonia Generalized hyperpigmentation Skin ulcer Resting tremor Sensory axonal neuropathy Cerebral hemorrhage Melanocytic nevus Decreased nerve conduction velocity Abnormality of vision Cranial nerve paralysis Foot dorsiflexor weakness Abnormality of movement Developmental regression Progressive peripheral neuropathy Pulmonary infiltrates Polyneuritis CSF pleocytosis Severe combined immunodeficiency Increased VLDL cholesterol concentration T-cell lymphoma Granulocytopenia Skin rash Increased LDL cholesterol concentration Lipogranulomatosis Increased CSF protein Histiocytosis Cellular immunodeficiency Prolonged prothrombin time Decreased HDL cholesterol concentration Generalized edema Prolonged partial thromboplastin time Plasmacytosis Abnormal natural killer cell physiology Abnormality of the eye Areflexia Mental deterioration Combined immunodeficiency Photophobia Difficulty walking Reduced visual acuity Recurrent respiratory infections Hyporeflexia Cerebellar atrophy Nystagmus Atrial septal defect Increased antibody level in blood Gait disturbance Tremor Skeletal muscle atrophy Peripheral neuropathy Visual impairment Episodic fever Spinocerebellar tract degeneration Hemiplegia Aspiration Transient ischemic attack Myeloproliferative disorder Impaired platelet aggregation Abnormal thrombocyte morphology Arterial thrombosis Abnormality of the cerebral vasculature Gangrene Tetraplegia Increased intracranial pressure Abnormality of bone marrow cell morphology Pulmonary embolism Eosinophilia Prolonged bleeding time Hemoglobinuria Venous thrombosis Myocardial infarction Nonspherocytic hemolytic anemia Amaurosis fugax Myelofibrosis Dyspnea Abnormality of immune system physiology Gout Arrhythmia Congestive heart failure Hemoglobin H Reduced alpha/beta synthesis ratio Abnormality of the cardiovascular system Decreased mean corpuscular volume Gliosis Bloody diarrhea Back pain Hydrops fetalis Purpura Cognitive impairment Increased megakaryocyte count Abnormal platelet aggregation Decreased mean platelet volume Abnormal platelet morphology Vertigo Encephalitis Macular hypoplasia Carcinoma Acute lymphoblastic leukemia Colon cancer Nephroblastoma Sarcoma Breast carcinoma Melanoma Neoplasm of the skin Generalized hypopigmentation of hair Progressive encephalopathy Recurrent systemic pyogenic infections Abnormality of multiple cell lineages in the bone marrow Giant melanosomes in melanocytes Recurrent cutaneous abscess formation Abnormal leukocyte morphology Oculogyric crisis Recurrent bacterial skin infections Neoplasm of the lung Neoplasm of the pancreas Kernicterus Monoclonal immunoglobulin M proteinemia Fava bean-induced hemolytic anemia Hypoalbuminemia Prostate neoplasm Neoplasm of the adrenal cortex Neoplasm of the colon Impaired lymphocyte transformation with phytohemagglutinin Plethora Neoplasm of the nervous system Osteosarcoma Lung adenocarcinoma Adrenocortical carcinoma Soft tissue sarcoma Stomach cancer Rhabdomyosarcoma Prostate cancer Medulloblastoma Brain neoplasm Overhanging nasal tip


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