Lymphoma, and Hyperkeratosis

Diseases related with Lymphoma and Hyperkeratosis

In the following list you will find some of the most common rare diseases related to Lymphoma and Hyperkeratosis that can help you solving undiagnosed cases.

Top matches:

Classical mycosis fungoides is the most common type of mycosis fungoides (MF; see this term), a form of cutaneous T-cell lymphoma, and is characterized by slow progression from patches to more infiltrated plaques and eventually to tumors.

CLASSIC MYCOSIS FUNGOIDES Is also known as mycosis fungoides, alibert-bazin type

Related symptoms:

  • Hepatomegaly
  • Edema
  • Splenomegaly
  • Alopecia
  • Hyperkeratosis


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about CLASSIC MYCOSIS FUNGOIDES

Punctate palmoplantar keratoderma type I (PPKP1), also known as Buschke-Fischer-Brauer syndrome, is a very rare hereditary skin disease characterized by irregularly distributed epidermal hyperkeratosis of the palms and soles with wide variation among patients..

PUNCTATE PALMOPLANTAR KERATODERMA TYPE 1 Is also known as palmoplantar keratoderma, punctate type i|ppkp1|keratodermia palmoplantaris papulosa, buschke-fischer-brauer type|buschke-fischer-brauer syndrome|keratosis palmoplantaris papulosa|kppp1

Related symptoms:

  • Neoplasm
  • Pain
  • Dilatation
  • Depressivity
  • Hyperkeratosis


SOURCES: ORPHANET OMIM MENDELIAN

More info about PUNCTATE PALMOPLANTAR KERATODERMA TYPE 1

Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells).

SÉZARY SYNDROME Is also known as sÉzary lymphoma

Related symptoms:

  • Neoplasm
  • Abnormal facial shape
  • Peripheral neuropathy
  • Hepatomegaly
  • Fever


SOURCES: MESH ORPHANET MENDELIAN

More info about SÉZARY SYNDROME

Other less relevant matches:

Low match EEC SYNDROME

EEC syndrome is a genetic developmental disorder characterized by ectrodactyly, ectodermal dysplasia, and orofacial clefts (cleft lip/palate).

EEC SYNDROME Is also known as eec syndrome 3|ectrodactyly-ectodermal dysplasia-cleft lip/palate syndrome

Related symptoms:

  • Intellectual disability
  • Short stature
  • Hearing impairment
  • Sensorineural hearing impairment
  • Cleft palate


SOURCES: OMIM ORPHANET MENDELIAN

More info about EEC SYNDROME

Dyskeratosis congenita (DC) is a rare ectodermal dysplasia that often presents with the classic triad of nail dysplasia, skin pigmentary changes, and oral leukoplakia associated with a high risk of bone marrow failure (BMF) and cancer.

DYSKERATOSIS CONGENITA Is also known as dkc|dc|dyskeratosis congenita, scoggins type|zinsser-engman-cole syndrome

Related symptoms:

  • Global developmental delay
  • Short stature
  • Hearing impairment
  • Microcephaly
  • Scoliosis


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about DYSKERATOSIS CONGENITA

Low match OMENN SYNDROME

Omenn syndrome (OS) is an inflammatory condition characterized by erythroderma, desquamation, alopecia, chronic diarrhea, failure to thrive, lymphadenopathy, and hepatosplenomegaly, associated with severe combined immunodeficiency (SCID; see this term).

OMENN SYNDROME Is also known as combined immunodeficiency with hypereosinophilia|reticuloendotheliosis, familial, with eosinophilia|severe combined immunodeficiency with hypereosinophilia

Related symptoms:

  • Failure to thrive
  • Anemia
  • Hepatomegaly
  • Fever
  • Edema


SOURCES: ORPHANET OMIM MENDELIAN

More info about OMENN SYNDROME

Microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) is a rare autosomal dominant condition characterized by variable expression of microcephaly, ocular disorders including chorioretinopathy, congenital lymphedema of the lower limbs, and mild to moderate intellectual disability.

MICROCEPHALY-LYMPHEDEMA-CHORIORETINOPATHY SYNDROME Is also known as mlcrd

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Microcephaly
  • Muscular hypotonia


SOURCES: ORPHANET MENDELIAN

More info about MICROCEPHALY-LYMPHEDEMA-CHORIORETINOPATHY SYNDROME

Low match BLOOM SYNDROME

Bloom syndrome (BSyn) is a rare chromosomal breakage syndrome characterized by a marked genetic instability associated with pre- and postnatal growth retardation, facial sun-sensitive telangiectatic erythema, increased susceptibility to infections, and predisposition to cancer.

BLOOM SYNDROME Is also known as bls|microcephaly, growth restriction, and increased sister chromatid exchange 1|bs|bsyn|mgrisce1

Related symptoms:

  • Short stature
  • Microcephaly
  • Growth delay
  • Neoplasm
  • Failure to thrive


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about BLOOM SYNDROME

Growth delay due to IGF-I resistance is characterised by variable intrauterine and postnatal growth retardation and elevated serum IGF-I levels. Addition features include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly, wide-set nipples and pectus excavatum).

GROWTH DELAY DUE TO INSULIN-LIKE GROWTH FACTOR I RESISTANCE Is also known as igf-i resistance|resistance to igf-1|somatomedin, end-organ insensitivity to|somatomedin-c, resistance to

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Microcephaly


SOURCES: ORPHANET OMIM MENDELIAN

More info about GROWTH DELAY DUE TO INSULIN-LIKE GROWTH FACTOR I RESISTANCE

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation is an autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes (summary by Ostergaard et al., 2012). Robitaille et al. (2014) found that MCLMR includes a broader spectrum of ocular disease, including retinal detachment with avascularity of the peripheral retina, and noted phenotypic overlap with familial exudative vitreoretinopathy (FEVR; see EVR1, {133780}).Birtel et al. (2017) observed intrafamilial and intraindividual variability in retinal phenotype, and noted that syndromic manifestations in some patients are too subtle to be detected during a routine ophthalmologic evaluation. Variable expressivity and reduced penetrance have also been observed in some families (Jones et al., 2014; Li et al., 2016).Autosomal recessive forms of microcephaly with chorioretinopathy have been reported (see {251270}).See also Mirhosseini-Holmes-Walton syndrome (autosomal recessive microcephaly with pigmentary retinopathy and mental retardation; {268050}), which has been mapped to chromosome 8q21.3-q22.1.

MICROCEPHALY WITH OR WITHOUT CHORIORETINOPATHY, LYMPHEDEMA, OR MENTAL RETARDATION; MCLMR Is also known as lymphedema, microcephaly, chorioretinopathy syndrome|cdmmr syndrome|mlcrd syndrome|lymphedema and retinal folds with microcephaly and microphthalmos|microcephaly and chorioretinopathy with or without mental retardation, autosomal dominant|microcephaly, ly

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM MESH MENDELIAN

More info about MICROCEPHALY WITH OR WITHOUT CHORIORETINOPATHY, LYMPHEDEMA, OR MENTAL RETARDATION; MCLMR

Top 5 symptoms//phenotypes associated to Lymphoma and Hyperkeratosis

Symptoms // Phenotype % cases
Dry skin Common - Between 50% and 80% cases
Thickened skin Uncommon - Between 30% and 50% cases
Edema Uncommon - Between 30% and 50% cases
Short stature Uncommon - Between 30% and 50% cases
Microcephaly Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Hyperkeratosis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Severe short stature Immunodeficiency Intellectual disability Neoplasm Global developmental delay Scaling skin Specific learning disability Hepatomegaly Skin ulcer Splenomegaly Alopecia Skin rash Leukemia Hearing impairment Abnormal facial shape Abnormal eyelash morphology Nail dystrophy Gangrene Failure to thrive Protruding ear Diabetes mellitus Intrauterine growth retardation Wide nasal bridge Long philtrum Micrognathia Upslanted palpebral fissure Growth delay Cataract Anemia Malar flattening Hypertonia Hypotrichosis Erythroderma Lymphadenopathy Neoplasm of the skin Pruritus Hypopigmented skin patches Abnormal lymphocyte morphology Palmoplantar keratoderma

Rare Symptoms - Less than 30% cases

Erysipelas Blepharitis Broad nasal tip Melanonychia Chorioretinal dysplasia Aplasia/Hypoplasia of the skin Panniculitis Generalized hypotonia Abnormal nasolacrimal system morphology Chylothorax Intellectual disability, mild Leukonychia Abnormality of the nail Retinal dysplasia Agitation Abnormal toenail morphology Diarrhea Pneumonia Underdeveloped supraorbital ridges Cellulitis Reduced number of teeth Delayed skeletal maturation Cellular immunodeficiency Pulmonary fibrosis Irregular hyperpigmentation Hyperhidrosis Recurrent respiratory infections Thrombocytopenia Abnormality of the dentition Abnormal eyelid morphology T-cell lymphoma High pitched voice Squamous cell carcinoma Cafe-au-lait spot Taurodontia Hypoplasia of the corpus callosum Nail pits Urethral stenosis Type II diabetes mellitus Telangiectasia of the skin Thin upper lip vermilion Cutaneous T-cell lymphoma Hypoplasia of the thymus Postnatal growth retardation Anophthalmia Sparse scalp hair Patent foramen ovale Venous thrombosis Visual loss Depressed nasal bridge Anteverted nares Neoplasm of the pancreas Sensorineural hearing impairment Optic atrophy Dilatation Myopia Rigidity Glaucoma Erythema Microphthalmia Syndactyly Papule Seizures Abnormality of the face Hepatosplenomegaly Epidermal acanthosis Epicanthus Muscular hypotonia Abnormality of the skin Spasticity Ptosis Retinopathy Cryptorchidism Wide nose Finger syndactyly Pointed chin Muscle stiffness Blindness Hypodontia Hypoplasia of the maxilla Lymphedema Abnormality of retinal pigmentation Hodgkin lymphoma Amblyopia Carious teeth Polydactyly Subcutaneous nodule Fever Sloping forehead Retinal dystrophy Thick vermilion border Retinal detachment Sparse hair Full cheeks Status epilepticus Atrial septal defect Acute myeloid leukemia IgA deficiency Acute leukemia Myeloid leukemia Exudative vitreoretinopathy Sacral dimple Hypoplasia of the zygomatic bone Hand polydactyly IgG deficiency Hypoplastic pelvis Chromosome breakage Decreased antibody level in blood Azoospermia Clinodactyly of the 5th finger Pleural effusion Abnormality of the hair Myopic astigmatism Chronic obstructive pulmonary disease Abnormality of the optic nerve Cardiomyopathy Short nose Abnormality of the eye Recurrent infections Dolichocephaly Narrow face Infertility Ichthyosis Abnormality of vision Prominent nose Otitis media Cutaneous photosensitivity Hypertrichosis Bronchiectasis Telangiectasia Sinusitis Chronic lung disease Cortical gyral simplification Abnormality of the nose Esodeviation Intellectual disability, severe Downslanted palpebral fissures Nystagmus Increased serum insulin-like growth factor 1 Burkitt lymphoma Hypoplastic facial bones Prominent scalp veins Rieger anomaly Broad finger Perimembranous ventricular septal defect Hyperactivity Abnormality of the rib cage Small face Maternal diabetes Severe failure to thrive Severe intrauterine growth retardation Multiple cafe-au-lait spots Reduced subcutaneous adipose tissue Truncal obesity Delayed cranial suture closure Prominent forehead Reduced visual acuity Lipodystrophy Sleep disturbance Flat occiput Bilateral ptosis Deep philtrum Optic nerve hypoplasia Thick lower lip vermilion Bilateral sensorineural hearing impairment Pigmentary retinopathy Overgrowth Microcornea Astigmatism Mandibular prognathia Hypermetropia Corneal opacity Attention deficit hyperactivity disorder Chorioretinal atrophy Vitreoretinopathy Aggressive behavior Neonatal hypotonia Retinal fold Macrotia Radial deviation of finger Pterygium IgM deficiency Facial telangiectasia in butterfly midface distribution Pectus excavatum Obesity Ventricular septal defect Motor delay Delayed speech and language development High palate Cognitive impairment Low-set ears Strabismus Agenesis of maxillary lateral incisor Narrow mouth Neoplasm of the gastrointestinal tract Congenital microcephaly Spotty hyperpigmentation Spotty hypopigmentation Prominent nasal tip Retinal thinning Female infertility Decreased fertility in females Abnormality of chromosome stability Clinodactyly Retrognathia Acanthosis nigricans Short foot Sandal gap Accelerated skeletal maturation Finger clinodactyly Decreased body weight Blue sclerae Wide intermamillary distance Webbed neck Triangular face Delayed eruption of teeth Highly arched eyebrow Deeply set eye Everted lower lip vermilion Small hand Inability to walk Short distal phalanx of finger Short palm Thin vermilion border Smooth philtrum Synophrys Small for gestational age Anxiety Muscular hypotonia of the trunk Palmar hyperkeratosis Severe B lymphocytopenia Renal hypoplasia/aplasia Ectrodactyly Hypoplastic nipples Aplasia/Hypoplasia of the thumb Hydroureter Keratitis Hypoplastic toenails Proximal placement of thumb Coarse hair Cutaneous syndactyly Xerostomia Sparse eyelashes Abnormality of dental enamel Hypogonadotrophic hypogonadism Sparse and thin eyebrow Hypohidrosis Hypoplasia of dental enamel Recurrent urinary tract infections Renal dysplasia External ear malformation Split foot Choanal atresia Slow-growing hair Abnormality of the nasopharynx Duplicated collecting system Thin nail Selective tooth agenesis Central diabetes insipidus Inflammatory abnormality of the eye Bladder diverticulum Aplasia/Hypoplasia of the nipples Entropion Depressed nasal tip Lacrimation abnormality Anterior hypopituitarism Sparse pubic hair Dysuria Sparse axillary hair Generalized hypopigmentation Corneal erosion Fair hair Blue irides Split hand Fine hair Ureterocele Colon cancer Tremor Skeletal muscle atrophy Peripheral neuropathy Transitional cell carcinoma of the bladder Orthokeratosis Hypergranulosis Parakeratosis Renal cell carcinoma Breast carcinoma Ectropion Carcinoma Depressivity Pain Skin plaque Abnormality of bone marrow cell morphology Poikiloderma Psoriasiform dermatitis Eczema Weight loss Abnormality of the pleura Microdontia Toe syndactyly Renal agenesis Growth hormone deficiency Ectodermal dysplasia Vesicoureteral reflux Nevus Thick eyebrow Oral cleft Cleft upper lip Microtia Lichenification Blepharophimosis Cleft lip Hydronephrosis Photophobia Micropenis Hypospadias Flexion contracture Cleft palate Abnormal immunoglobulin level Abnormality of the middle ear Dacryocystitis Desquamation of skin soon after birth Reticular hyperpigmentation Sepsis Autoimmunity Hypothyroidism Absent lacrimal punctum Esophageal stenosis Displacement of the external urethral meatus Congenital bullous ichthyosiform erythroderma Anorectal anomaly Rough bone trabeculation Inflammatory abnormality of the skin Porokeratosis Aplastic/hypoplastic toenail Interstitial pneumonitis Abnormality of neutrophils Squamous cell carcinoma of the skin Abnormality of the pharynx Testicular atrophy Abnormality of female internal genitalia Nephrotic syndrome Abnormality of the metaphysis Aplastic anemia Hashimoto thyroiditis Generalized lymphadenopathy Protracted diarrhea Recurrent fungal infections B lymphocytopenia Metaphyseal chondrodysplasia Recurrent viral infections Hypoproteinemia Severe combined immunodeficiency Thyroiditis Chronic diarrhea Aplasia/Hypoplasia of the eyebrow Combined immunodeficiency Leukocytosis Eosinophilia Disproportionate short-limb short stature Shock Recurrent bacterial infections Increased body weight Short toe Ridged nail Oral leukoplakia Urethral atresia Cerebellar hypoplasia Abnormal blistering of the skin Nail dysplasia Recurrent fractures Hepatic failure Cirrhosis Abnormality of skin pigmentation Malabsorption Osteoporosis Ataxia Pancytopenia Scoliosis Absence of Stensen duct Generalized microdontia Periorbital hyperpigmentation Transverse vaginal septum Mesoaxial polydactyly Abnormality of the inner ear Aplasia/Hypoplasia of the breasts Megacystis Cerebral calcification Hyperpigmentation of the skin Abnormality of the testis Hypermelanotic macule White hair Periodontitis Abnormal eyebrow morphology Premature loss of teeth Aseptic necrosis Skin vesicle Macule Neurofibromas Abnormality of coagulation Hepatic fibrosis Premature graying of hair Epiphora Tracheoesophageal fistula Myelodysplasia Dermal atrophy Abnormal intestine morphology Abnormality of the fingernails Bone marrow hypocellularity Lymphopenia Chorioretinal lacunae


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