Lymphoma, and Hematuria

Diseases related with Lymphoma and Hematuria

In the following list you will find some of the most common rare diseases related to Lymphoma and Hematuria that can help you solving undiagnosed cases.

Top matches:

Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH MCP/CD46 ANOMALY Is also known as ahus with mcp/cd46 anomaly|hemolytic-uremic syndrome without diarrhea with mcp/cd46 anomaly|ahus, susceptibility to, 2|atypical hus with mcp/cd46 anomaly|d-hus with mcp/cd46 anomaly

Related symptoms:

  • Hypertension
  • Renal insufficiency
  • Thrombocytopenia
  • Proteinuria
  • Stage 5 chronic kidney disease


SOURCES: OMIM ORPHANET MENDELIAN

More info about ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH MCP/CD46 ANOMALY

Hereditary leiomyomatosis and renal cell cancer is an autosomal dominant tumor predisposition syndrome characterized by the variable development of 3 tumors: cutaneous piloleiomyomata that develop in essentially all patients by age 40 years; leiomyomata (fibroids) of the uterus, and rarely leiomyosarcomas, at a mean age of 30 years (range, 18 to 52 years); and type 2 papillary renal cell carcinoma at a mean age of 46 years (range, 17 to 75 years), which occurs in about 20% of patients. Type 2 papillary renal cell carcinoma is a pathologic subtype characterized by large tumor cells with eosinophilic cytoplasm and pseudostratified nuclei; it shows an aggressive clinical course. Some patients with FH mutations may develop collecting duct renal cell carcinoma. The main focus of management in HLRCC is prevention of disease and death due to renal cancer (summary by Gardie et al., 2011; Smit et al., 2011; and Lehtonen, 2011).For a general discussion of papillary renal cell carcinoma, see RCCP1 (OMIM ).

HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER; HLRCC Is also known as mcl|multiple cutaneous and uterine leiomyomata 1, with or without renal cell carcinoma|mcul1|lrcc|leiomyoma, multiple cutaneous|leiomyomatosis and renal cell cancer, hereditary

Related symptoms:

  • Neoplasm
  • Pain
  • Cataract
  • Carcinoma
  • Skin rash


SOURCES: MESH OMIM MENDELIAN

More info about HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CANCER; HLRCC

Other less relevant matches:

The gray platelet syndrome (GPS) is a rare inherited disorder characterized by mild to moderate bleeding tendency, moderate thrombocytopenia, and a marked decrease or absence of platelet alpha-granules and of the proteins contained in alpha-granules. The platelets are enlarged, but not giant, and have a gray appearance on light microscopy of Wright-stained peripheral blood smears due to decreased granules. Many patients with gray platelet syndrome develop a stable myelofibrosis (summary by Nurden and Nurden, 2007).Cases suggesting autosomal dominant and autosomal recessive inheritance have been described, indicating that GPS is probably a genetically heterogeneous disorder with more than one molecular cause.

GRAY PLATELET SYNDROME; GPS Is also known as bleeding disorder, platelet-type, 4|bdplt4|platelet alpha-granule deficiency

Related symptoms:

  • Anemia
  • Splenomegaly
  • Thrombocytopenia
  • Skin rash
  • Bruising susceptibility


SOURCES: OMIM MESH MENDELIAN

More info about GRAY PLATELET SYNDROME; GPS

Hemophilia B due to factor IX deficiency is phenotypically indistinguishable from hemophilia A (OMIM ), which results from deficiency of coagulation factor VIII (F8 ). The classic laboratory findings in hemophilia B include a prolonged activated partial thromboplastin time (aPTT) and a normal prothrombin time (PT) (Lefkowitz et al., 1993).Early studies made a distinction between cross-reactive-material (CRM)-negative and CRM-positive hemophilia B mutants. This classification referred to detection of the F9 antigen in plasma, even in the presence of decreased F9 activity. Detection of the antigen indicated the presence of a dysfunctional F9 protein. Roberts et al. (1968) found that about 90% of patients with hemophilia B were CRM-negative, whereas about 10% were CRM-positive. However, Bertina and Veltkamp (1978) found that a rather large proportion of the hemophilia B patients could be characterized as hemophilia B CRM+. They identified 14 cases of hemophilia B CRM+ from 11 families among a group of 33 patients. After immunologic and activity comparisons, they found at least 7 different factor IX variants. Bertina and Veltkamp (1978) noted the high heterogeneity within this group. In an editorial on variants of vitamin K-dependent coagulation factors, Bertina et al. (1979) stated that 9 defective variants of factor II, 5 variants of factor X, and many variants (about 180 pedigrees) of factor IX had been identified. At least one variant of factor VII (Padua) was also known.

HEMOPHILIA B; HEMB Is also known as christmas disease|factor ix deficiency|f9 deficiency|plasma thromboplastin component deficiency

Related symptoms:

  • Immunodeficiency
  • Leukemia
  • Hematuria
  • Abnormal bleeding
  • Gastrointestinal hemorrhage


SOURCES: OMIM ORPHANET MENDELIAN

More info about HEMOPHILIA B; HEMB

Deafness - lymphedema - leukemia is a very rare, serious syndromic genetic disorder characterized by primary lymphedema, immunodeficiency, and hematological disorders.

DEAFNESS-LYMPHEDEMA-LEUKEMIA SYNDROME Is also known as emberger syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Sensorineural hearing impairment
  • Anemia
  • Epicanthus


SOURCES: OMIM ORPHANET MENDELIAN

More info about DEAFNESS-LYMPHEDEMA-LEUKEMIA SYNDROME

Sickle cell anemias are chronic hemolytic diseases that may induce three types of acute accidents: severe anemia, severe bacterial infections, and ischemic vasoocclusive accidents (VOA) caused by sickle-shaped red blood cells obstructing small blood vessels and capillaries. Many diverse complications can occur.

SICKLE CELL ANEMIA Is also known as sickle cell disease

Related symptoms:

  • Intellectual disability
  • Pain
  • Anemia
  • Hypertension
  • Hepatomegaly


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about SICKLE CELL ANEMIA

Gaucher disease is an autosomal recessive lysosomal storage disorder due to deficient activity of beta-glucocerebrosidase. As a result of this deficiency, there is intracellular accumulation of glucosylceramide (GlcCer, glucosylcerebroside) primarily within cells of mononuclear phagocyte origin, which are the characteristic 'Gaucher cells' identified in most tissues (Jmoudiak and Futerman, 2005).Gaucher disease is classically categorized phenotypically into 3 main subtypes: nonneuronopathic type I, acute neuronopathic type II (OMIM ), and subacute neuronopathic type III (OMIM ). Type I is the most common form of Gaucher disease and lacks primary central nervous system involvement. Types II and III have central nervous system involvement and neurologic manifestations (Knudson and Kaplan, 1962; Jmoudiak and Futerman, 2005).All 3 forms of Gaucher disease are caused by mutation in the GBA gene. There are 2 additional phenotypes which may be distinguished: perinatal lethal Gaucher disease (OMIM ), which is a severe form of type II, and Gaucher disease type IIIC (OMIM ), which also has cardiovascular calcifications.See also {610539} for a form of atypical Gaucher disease caused by mutation in the gene encoding saposin C (PSAP ), which is an activator of beta-glucosidase.

GAUCHER DISEASE, TYPE I Is also known as gd i|glucocerebrosidase deficiency|acid beta-glucosidase deficiency|gba deficiency|gaucher disease, noncerebral juvenile

Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Failure to thrive
  • Strabismus


SOURCES: OMIM MENDELIAN

More info about GAUCHER DISEASE, TYPE I

Gaucher disease type 1 is the chronic non-neurological form of Gaucher disease (GD; see this term) characterized by organomegaly, bone involvement and cytopenia.

GAUCHER DISEASE TYPE 1 Is also known as gaucher disease, juvenile and adult, cerebral|gd iii|gaucher disease, chronic neuronopathic type|non-cerebral juvenile gaucher disease|gaucher disease, subacute neuronopathic type

Related symptoms:

  • Seizures
  • Global developmental delay
  • Short stature
  • Scoliosis
  • Ataxia


SOURCES: ORPHANET OMIM MENDELIAN

More info about GAUCHER DISEASE TYPE 1

Gaucher disease type 3 is the subacute neurological form of Gaucher disease (GD; see this term) characterized by progressive encephalopathy and associated with the systemic manifestations (organomegaly, bone involvement, cytopenia) of GD type 1 (see this term).

GAUCHER DISEASE TYPE 3 Is also known as chronic neuronopathic gaucher disease|cerebral juvenile and adult form of gaucher disease|gaucher disease, subacute neuronopathic type

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Scoliosis


SOURCES: ORPHANET MENDELIAN

More info about GAUCHER DISEASE TYPE 3

Top 5 symptoms//phenotypes associated to Lymphoma and Hematuria

Symptoms // Phenotype % cases
Splenomegaly Common - Between 50% and 80% cases
Thrombocytopenia Common - Between 50% and 80% cases
Hepatomegaly Common - Between 50% and 80% cases
Anemia Common - Between 50% and 80% cases
Fatigue Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Hematuria. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Epistaxis Proteinuria Seizures Pericardial effusion Osteoporosis Ataxia Pancytopenia Bone pain Recurrent respiratory infections Leukemia Lymphadenopathy Aseptic necrosis Bruising susceptibility Abnormal bleeding Dyspnea Pain Abdominal pain Erlenmeyer flask deformity of the femurs Hypertension Prolonged bleeding time Increased susceptibility to fractures Leukocytosis Petechiae Increased antibody level in blood Leukopenia Portal hypertension Menorrhagia Edema Cirrhosis Vertebral compression fractures Neurological speech impairment Multiple myeloma Abnormal myocardium morphology Increased bone mineral density Osteolysis Interstitial pulmonary abnormality Hepatosplenomegaly Generalized myoclonic seizures Delayed skeletal maturation Dementia Cholelithiasis Strabismus Ascites Delayed puberty Renal insufficiency Pulmonary arterial hypertension Diarrhea Failure to thrive Abnormality of the spleen Skin rash

Rare Symptoms - Less than 30% cases

Congestive heart failure Myopia Kyphosis Depressivity Arrhythmia Myoclonus Osteopenia Corneal opacity Hydrops fetalis Intracranial hemorrhage Osteoarthritis Scoliosis Abnormality of eye movement Immunodeficiency Gait disturbance Spasticity Abdominal distention Syncope Cyanosis Growth delay Fever Short stature Hemolytic anemia Hypercoagulability Respiratory distress Myeloid leukemia Pneumonia Rigidity Bone marrow hypocellularity Myeloproliferative disorder Ophthalmoplegia Pathologic fracture Mental deterioration Abnormality of the eye Global developmental delay Pallor Respiratory failure Encephalopathy Recurrent infections Hypersplenism Osteomyelitis Aortic valve calcification Dysphagia Intellectual disability Mitral valve calcification Progressive neurologic deterioration Decreased body weight Decreased beta-glucocerebrosidase protein and activity Spontaneous hematomas Avascular necrosis of the capital femoral epiphysis Generalized osteosclerosis Cough Elevated serum creatinine Pruritus Nausea and vomiting Meningitis Neoplasm Cerebral palsy Orthopnea Recurrent bacterial infections Horizontal supranuclear gaze palsy Cardiac valve calcification Hematological neoplasm Supranuclear gaze palsy Arthritis Hepatocellular carcinoma Restrictive ventilatory defect Oculomotor apraxia Sensorineural hearing impairment Abnormality of the thorax Abnormal heart valve morphology Clubbing Gastrointestinal hemorrhage Exertional dyspnea Hepatic failure Abnormal lung morphology Hypoalbuminemia Opisthotonus Hyperpigmentation of the skin Lower limb hyperreflexia Abnormality of the sternum Lymphopenia Abnormal retinal morphology Aspiration Pulmonary fibrosis Intention tremor Progressive cerebellar ataxia Hepatic fibrosis Astrocytosis Bulbar palsy Abnormality of the acoustic reflex Pure red cell aplasia Persistence of hemoglobin F Abnormal lactate dehydrogenase activity Increased lactate dehydrogenase activity Priapism Pigment gallstones Increased red cell sickling tendency Generalized hypotonia Abnormality of ion homeostasis Thoracic kyphosis Abnormal saccadic eye movements Feeding difficulties Abnormal thrombosis Abnormality of the skeletal system Neurodegeneration Protein-losing enteropathy Restrictive deficit on pulmonary function testing Slow saccadic eye movements Shock Hypertonia Hyperkinesis EEG abnormality Fractures of the long bones Esodeviation Periorbital edema Cognitive impairment Motor delay Edema of the lower limbs Increased serum ferritin Bipolar affective disorder Gingival bleeding Flank pain Protuberant abdomen Abnormality of coagulation Abnormality of skin pigmentation Parkinsonism Reduced bone mineral density Abnormality of the cardiovascular system Apraxia Chronic hemolytic anemia Spastic paraparesis Abnormality of bone marrow cell morphology Arthralgia of the hip Malabsorption Macular atrophy Generalized tonic-clonic seizures Stridor Abnormal pyramidal sign Oral-pharyngeal dysphagia Aggressive behavior Difficulty walking Dystonia Anorexia Vomiting Pulmonary infiltrates Abnormal platelet function Aspiration pneumonia Hydrocephalus Tremor Nystagmus Chronic fatigue Puberty and gonadal disorders Biliary tract obstruction Vertical supranuclear gaze palsy Vascular calcification Unconjugated hyperbilirubinemia Jaundice Hypochromic anemia Renal cell carcinoma Papillary renal cell carcinoma Gastrointestinal stroma tumor Bladder neoplasm Leiomyosarcoma Low back pain Renal neoplasm Abnormality of the musculature Barrett esophagus Basal cell carcinoma Nephroblastoma Back pain Breast carcinoma Neoplasm of the skin Papule Uterine leiomyoma Vaginal neoplasm Cataract Deep venous thrombosis Decreased platelet glycoprotein IIb-IIIa Internal hemorrhage Myelofibrosis Extramedullary hematopoiesis Abnormal thrombocyte morphology Ecchymosis Autoimmune thrombocytopenia Uterine leiomyosarcoma Purpura Cutaneous leiomyosarcoma Decreased fumarate hydratase activity Papillary renal cell carcinoma type 2 Multiple cutaneous leiomyomas Cutaneous leiomyoma Carcinoma Monoclonal immunoglobulin M proteinemia Platelet antibody positive Conjunctivitis Nephritis Pleural effusion Urticaria Reduced tendon reflexes Cranial nerve paralysis Joint dislocation Vasculitis Emphysema Sensory neuropathy Autoimmunity Myalgia Arthralgia Peripheral neuropathy Hemiplegia/hemiparesis Glomerulopathy Microangiopathic hemolytic anemia Obstructive lung disease Anuria Increased blood urea nitrogen Hemolytic-uremic syndrome Acute kidney injury Stage 5 chronic kidney disease Small vessel vasculitis Episcleritis Hemoptysis Immunologic hypersensitivity Complement deficiency Angioedema Inflammatory abnormality of the eye Uveitis Irregular hyperpigmentation Impaired collagen-induced platelet aggregation Absence of alpha granules Chronic myelogenous leukemia Irritability Chest pain Sepsis Nephropathy Confusion Stroke Retinopathy Abnormality of the nervous system Cholestasis Abnormal neutrophil count Macronodular cirrhosis Erysipelas Granulocytopenia Abnormality of the optic nerve Verrucae Cardiomegaly Tachypnea Acute myeloid leukemia Atelectasis Microalbuminuria Abnormal hemoglobin Night sweats Left ventricular failure Hypoxemia Increased mean corpuscular volume Asplenia Microcytic anemia Abnormality of the vasculature Thrombocytosis Reticulocytosis Poor appetite Iron deficiency anemia Wheezing Acute leukemia Cellulitis Reduced von Willebrand factor activity Poor wound healing Reduced factor IX activity Prolonged bleeding after surgery Intramuscular hematoma Persistent bleeding after trauma Menometrorrhagia Spontaneous, recurrent epistaxis Joint hemorrhage Prolonged bleeding after dental extraction Prolonged prothrombin time Prolonged partial thromboplastin time Abnormality of the coagulation cascade Hepatitis Reduced quantity of Von Willebrand factor Impaired thrombin-induced platelet aggregation Prolonged whole-blood clotting time Delayed onset bleeding Chronic otitis media Vertigo Myelodysplasia Lymphedema Hypotelorism Webbed neck Migraine Tapered finger Scarring Cephalohematoma Weight loss Visual loss Syndactyly Cerebellar atrophy Respiratory insufficiency Epicanthus Hearing impairment Sleep myoclonus


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