Lymphoma, and Encephalitis

Diseases related with Lymphoma and Encephalitis

In the following list you will find some of the most common rare diseases related to Lymphoma and Encephalitis that can help you solving undiagnosed cases.

Top matches:

X-linked lymphoproliferative disease is a hereditary immunodeficiency characterized, in the majority of cases, by an inadequate immune response to infection with the Epstein-Barr virus (EBV).

X-LINKED LYMPHOPROLIFERATIVE DISEASE Is also known as xlpd|duncan disease|xlp|immunodeficiency 5|infectious mononucleosis, severe, susceptibility to|purtilo syndrome|imd5|ebvs|lymphoproliferative disease, x-linked|epstein-barr virus infection, familial fatal|lyp|ebv infection, severe, susceptibility to|immun

Related symptoms:

  • Seizures
  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Fever


SOURCES: ORPHANET OMIM MENDELIAN

More info about X-LINKED LYMPHOPROLIFERATIVE DISEASE

Zur Stadt et al. (2005) summarized the clinical features of hemophagocytic lymphohistiocytosis (HLH), a rare autosomal recessive disorder characterized by massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently central nervous system involvement. In FHL, the familial form of the disease, first episodes occur mostly during infancy, with a rapidly fatal outcome if untreated. Diagnostic criteria also include low fibrinogen and high triglyceride and ferritin levels. Chemoimmunotherapy based on corticosteroids, epipodophyllotoxins, and cyclosporin succeeds in controlling the disease in the majority of patients, although remission is rarely obtained (Henter et al., 2002). Most patients suffer an early death unless they are treated by hematopoietic stem cell transplantation (Durken et al., 1999). Genetic Heterogeneity of Familial Hemophagocytic LymphohistiocytosisFamilial hemophagocytic lymphohistiocytosis exhibits genetic heterogeneity. In some families, familial hemophagocytic lymphohistiocytosis has been found to be linked to chromosome 9q (HPLH1, FHL1). FHL2 (OMIM ) is caused by mutation in the PRF1 gene (OMIM ) on chromosome 10q22; FHL3 (OMIM ) is caused by mutation in the UNC13D gene (OMIM ) on chromosome 17q25; FHL4 (OMIM ) is caused by mutation in the syntaxin-11 gene (STX11 ) on chromosome 6q24; and FHL5 (OMIM ) is caused by mutation in the syntaxin-binding protein-2 (STXBP2 ), which is an interaction partner of STX11, on chromosome 19p13.Furthermore, before the identification of mutations in the RAG1 (OMIM ) and RAG2 (OMIM ) genes, both of which map to 11p, Omenn syndrome (familial reticuloendotheliosis with eosinophilia; {603554}) was not thought to be clearly distinct from other reported cases of hemophagocytic lymphohistiocytosis.

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1 Is also known as hemophagocytic reticulosis, familial|hlh1|hemophagocytic lymphohistiocytosis, familial|erythrophagocytic lymphohistiocytosis, familial|reticulosis, familial histiocytic|hplh1|fhl|fhlh|hplh|fel

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia
  • Neoplasm


SOURCES: OMIM MENDELIAN

More info about HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1

Schimke immuno-osseous dysplasia (SIOD) is a multisystem disorder characterized by spondyloepiphyseal dysplasia and disproportionate short stature, facial dysmorphism, T-cell immunodeficiency, and glomerulonephritis with nephrotic syndrome.

SCHIMKE IMMUNO-OSSEOUS DYSPLASIA Is also known as immunoosseous dysplasia, schimke type|schimke syndrome|spondyloepiphyseal dysplasia-nephrotic syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Scoliosis
  • Growth delay


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about SCHIMKE IMMUNO-OSSEOUS DYSPLASIA

Other less relevant matches:

Follicular lymphoma is a form of non-Hodgkin lymphoma (see this term) characterized by a proliferation of B cells whose nodular structure of follicular architecture is preserved.

FOLLICULAR LYMPHOMA Is also known as oncogene b-cell leukemia 2

Related symptoms:

  • Neoplasm
  • Fever
  • Fatigue
  • Diarrhea
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about FOLLICULAR LYMPHOMA

G6PD deficiency is the most common genetic cause of chronic and drug-, food-, or infection-induced hemolytic anemia. G6PD catalyzes the first reaction in the pentose phosphate pathway, which is the only NADPH-generation process in mature red cells; therefore, defense against oxidative damage is dependent on G6PD. Most G6PD-deficient patients are asymptomatic throughout their life, but G6PD deficiency can be life-threatening. The most common clinical manifestations of G6PD deficiency are neonatal jaundice and acute hemolytic anemia, which in most patients is triggered by an exogenous agent, e.g., primaquine or fava beans. Acute hemolysis is characterized by fatigue, back pain, anemia, and jaundice. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. The striking similarity between the areas where G6PD deficiency is common and Plasmodium falciparum malaria (see {611162}) is endemic provided evidence that G6PD deficiency confers resistance against malaria (summary by Cappellini and Fiorelli, 2008).

ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY Is also known as favism, susceptibility to

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Muscle weakness
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY

IMMUNODEFICIENCY, COMMON VARIABLE, 2; CVID2 Is also known as antibody deficiency due to taci defect|hypogammaglobulinemia due to taci deficiency

Related symptoms:

  • Neoplasm
  • Hepatomegaly
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY, COMMON VARIABLE, 2; CVID2

Low match WHIM SYNDROME

WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a congenital autosomal dominant immune deficiency characterized by abnormal retention of mature neutrophils in the bone marrow (myelokathexis) and occasional hypogammaglobulinemia, associated with an increased risk for bacterial infections and a susceptibility to human papillomavirus (HPV) induced lesions (cutaneous warts, genital dysplasia and invasive mucosal carcinoma).

WHIM SYNDROME Is also known as warts, hypogammaglobulinemia, infections, and myelokathexis syndrome|warts-infections-leukopenia-myelokatexis syndrome|wilm|warts-hypogammaglobulinemia-infections-myelokathexis syndrome

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Fever
  • Congestive heart failure
  • Immunodeficiency


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about WHIM SYNDROME

Purine nucleoside phosphorylase (PNP) deficiency is a disorder of purine metabolism characterized by progressive immunodeficiency leading to recurrent and opportunistic infections, autoimmunity and malignancy as well as neurologic manifestations.

PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY Is also known as pnp deficiency|pnpase deficiency|nucleoside phosphorylase deficiency

Related symptoms:

  • Intellectual disability
  • Generalized hypotonia
  • Ataxia
  • Failure to thrive
  • Muscular hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY

Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

Top 5 symptoms//phenotypes associated to Lymphoma and Encephalitis

Symptoms // Phenotype % cases
Meningitis Common - Between 50% and 80% cases
Fever Common - Between 50% and 80% cases
Splenomegaly Common - Between 50% and 80% cases
Immunodeficiency Common - Between 50% and 80% cases
Neoplasm Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Lymphoma and Encephalitis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Anemia Diarrhea Pneumonia Lymphadenopathy Seizures Autoimmunity Recurrent infections Recurrent bacterial infections B-cell lymphoma Otitis media Neutropenia Combined immunodeficiency Hepatomegaly Thrombocytopenia Intellectual disability Conjunctivitis Lymphopenia Recurrent upper respiratory tract infections Sinusitis Proteinuria Arthritis Renal insufficiency Glomerulopathy Pancytopenia Cellular immunodeficiency Leukemia Vasculitis Hemolytic anemia IgG deficiency Hodgkin lymphoma Bronchiectasis Decreased antibody level in blood Fatigue Ataxia Respiratory tract infection

Rare Symptoms - Less than 30% cases

Nephropathy Recurrent lower respiratory tract infections Small vessel vasculitis Motor delay Dyspnea Congestive heart failure Cough Acute leukemia Peripheral neuropathy IgM deficiency Cellulitis Recurrent otitis media Pleural effusion Pain Myalgia Leukocytosis Osteomyelitis Abnormal T cell morphology Carcinoma Hyperbilirubinemia Chronic kidney disease Impaired T cell function Emphysema Focal segmental glomerulosclerosis Nephritis Glomerulonephritis Recurrent urinary tract infections Glomerulosclerosis Purpura Urticaria Increased antibody level in blood Jaundice Sepsis Pure red cell aplasia Muscular hypotonia Sarcoma Skin rash Gliosis Hepatic failure Histiocytosis Hepatosplenomegaly Respiratory failure Tetraplegia Failure to thrive Generalized hypotonia Bone marrow hypocellularity Spontaneous hematomas Hematemesis Melena Microcytic anemia Bloody diarrhea Generalized lymphadenopathy Carious teeth Internal hemorrhage Abnormal platelet function Abnormal eosinophil morphology Interstitial pneumonitis Increased IgA level Septic arthritis Delayed speech and language development Spasticity Myelokathexis Bone marrow hypercellularity Hypersegmentation of neutrophil nuclei Tonsillitis Folliculitis Periodontitis Abnormality of bone marrow cell morphology Abnormality of female external genitalia Abnormality of female internal genitalia Hearing impairment Atelectasis Verrucae Decreased mean platelet volume Recurrent sinopulmonary infections Gastrointestinal carcinoma Hemoglobinuria Abnormality of the peritoneum Specific anti-polysaccharide antibody deficiency Muscle weakness Reduced lymphocyte surface expression of CD43 Pallor Cirrhosis Abnormality of the cardiovascular system Back pain Abnormal delayed hypersensitivity skin test Absent microvilli on the surface of peripheral blood lymphocytes Prolonged neonatal jaundice Reticulocytosis Anisocytosis Poikilocytosis Nonspherocytic hemolytic anemia Follicular hyperplasia Reduced delayed hypersensitivity Abnormal platelet morphology Congenital thrombocytopenia Behavioral abnormality Recurrent bronchitis Thyroiditis IgA deficiency Recurrent sinusitis Unconjugated hyperbilirubinemia Large vessel vasculitis Recurrent intrapulmonary hemorrhage Recurrent pneumonia Chronic leukemia Fava bean-induced hemolytic anemia Kernicterus Tremor Spastic tetraplegia Babinski sign Angioedema Recurrent respiratory infections Arrhythmia Obstructive lung disease Episcleritis Immunologic hypersensitivity Complement deficiency Inflammatory abnormality of the eye Abnormal bleeding Uveitis Irregular hyperpigmentation Hemoptysis Abnormal heart valve morphology Pericardial effusion Blepharitis Bruising susceptibility Chest pain Hemiplegia/hemiparesis Chronic otitis media Gingival bleeding Prolonged bleeding time Petechiae Keratitis Hyperostosis Inflammation of the large intestine Rheumatoid arthritis Sudden cardiac death Intracranial hemorrhage Skin ulcer Chronic diarrhea Epistaxis Eczema Specific learning disability Restrictive ventilatory defect Skin nodule Abnormal pyramidal sign Hypouricemia Abnormality of the menstrual cycle Brain abscess Cerebral vasculitis Recurrent opportunistic infections Autoimmune neutropenia Membranoproliferative glomerulonephritis Recurrent viral infections Abnormality of B cell physiology Autoimmune thrombocytopenia Autoimmune hemolytic anemia Spastic diplegia Spastic tetraparesis Tetraparesis Iron deficiency anemia Lymph node hypoplasia Sensorineural hearing impairment Reduced tendon reflexes Hematuria Cerebral palsy Cranial nerve paralysis Hematochezia Joint dislocation Ascites Sensory neuropathy Nausea and vomiting Abdominal pain Pruritus Chronic obstructive pulmonary disease Hypoplasia of the thymus Arthralgia Recurrent ear infections Increased IgE level Mediastinal lymphadenopathy Disproportionate short-trunk short stature Night sweats Decreased HDL cholesterol concentration Granulocytopenia Increased total bilirubin Partial albinism Increased LDL cholesterol concentration Hemophagocytosis Prolonged prothrombin time Generalized edema Increased VLDL cholesterol concentration Prolonged partial thromboplastin time Hypoproteinemia Increased serum ferritin Increased CSF protein Pulmonary infiltrates Severe combined immunodeficiency Episodic fever T-cell lymphoma Hypofibrinogenemia Albinism Cognitive impairment Cerebellar atrophy Cardiomyopathy Short neck Intrauterine growth retardation Myopia Hypertension Depressed nasal bridge Abnormal facial shape CSF pleocytosis Growth delay Scoliosis Short stature Abnormal natural killer cell physiology Lipogranulomatosis Plasmacytosis Polyneuritis Abnormality of the coagulation cascade Hyponatremia Abnormality of the dentition Lymphocytosis Burkitt lymphoma Hepatic necrosis Dysgammaglobulinemia Increased IgM level Chorioretinitis Granulomatosis Hepatic encephalopathy Recurrent pharyngitis Pharyngitis Immune dysregulation Aplastic anemia Agammaglobulinemia Hemiparesis Memory impairment Falls Dilatation Non-Hodgkin lymphoma Reduced natural killer cell activity Hemiplegia Coma Hypoalbuminemia Eosinophilia Increased intracranial pressure Leukopenia Aspiration Hypertriglyceridemia Peripheral demyelination Confusion Fulminant hepatitis Abnormality of the liver Irritability Abnormality of the nervous system Elevated hepatic transaminase Encephalopathy Hypertonia Global developmental delay Vomiting Kyphosis Chronic lymphatic leukemia Thoracic kyphosis Dentinogenesis imperfecta Subvalvular aortic stenosis Precocious atherosclerosis Cerebral ischemia Villous atrophy Lymphoproliferative disorder Ovoid vertebral bodies Transient ischemic attack Arteriosclerosis Abnormality of the vasculature Protuberant abdomen Multiple cafe-au-lait spots Steatorrhea Hypermelanotic macule High pitched voice Spondyloepiphyseal dysplasia Right ventricular cardiomyopathy Hypoplasia of the capital femoral epiphysis Epiphyseal dysplasia Anterior pituitary dysgenesis Glucose intolerance Lymphedema Insulin resistance Nausea Weight loss Lateral displacement of the femoral head Nephrosclerosis Premature arteriosclerosis Mucopolysacchariduria Moyamoya phenomenon Abnormal immunoglobulin level Encephalomalacia Increased thyroid-stimulating hormone level Shallow acetabular fossae Steroid-resistant nephrotic syndrome Multiple lentigines Melanocytic nevus Coarse hair Headache Stroke Abnormality of skin pigmentation Stage 5 chronic kidney disease Astigmatism Malabsorption Platyspondyly Hip dislocation Corneal opacity Scarring Abnormal cerebellum morphology Hyperlordosis Developmental regression Abnormality of the kidney Thin upper lip vermilion Osteopenia Hypothyroidism Dementia Bulbous nose Brain atrophy Reduced bone mineral density Abnormal lung morphology Azoospermia Hyperlipidemia Atherosclerosis Opacification of the corneal stroma Abnormality of epiphysis morphology Heterotopia Abnormal form of the vertebral bodies Fine hair Migraine Intellectual disability, profound Lumbar hyperlordosis Nephrotic syndrome Microdontia Decreased testicular size Waddling gait Premature birth Oral bleeding


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Myopia and Optic disc pallor, related diseases and genetic alterations Intellectual disability, severe and Sinusitis, related diseases and genetic alterations