Lymphoma, and Downturned corners of mouth

Diseases related with Lymphoma and Downturned corners of mouth

In the following list you will find some of the most common rare diseases related to Lymphoma and Downturned corners of mouth that can help you solving undiagnosed cases.

Top matches:

X-linked intellectual disability, Nascimento type is a rare X-linked intellectual disability syndrome characterized by intellectual disability (with severe speech impairment), a myxedematous appearance, dysmorphic facial features (including large head, synophrys, prominent supraorbital ridges, almond-shaped and deep-set eyes, large ears, wide mouth with everted lower lip and downturned lip corners), low posterior hairline, short, broad neck, marked general hirsutism and abnormal hair whorls, skin changes (e.g. dry skin or hypopigmented spots), widely spaced nipples, obesity, micropenis, onychodystrophy and seizures.

X-LINKED INTELLECTUAL DISABILITY, NASCIMENTO TYPE Is also known as mrxs30|mental retardation, x-linked, syndromic 30|x-linked intellectual disability-nail dystrophy-seizures syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Depressed nasal bridge
  • Macrocephaly
  • Short neck


SOURCES: ORPHANET OMIM MENDELIAN

More info about X-LINKED INTELLECTUAL DISABILITY, NASCIMENTO TYPE

Low match DOWN SYNDROME

Down syndrome is a chromosomal abnormality caused by the presence of a third (partial or total) copy of chromosome 21 and that is characterized by variable intellectual disability, muscular hypotonia, and joint laxity, often associated with a characteristic facial dysmorphism and various anomalies such as cardiac, gastrointestinal, or endocrine defects.

DOWN SYNDROME Is also known as trisomy 21

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Hearing impairment


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about DOWN SYNDROME

Prader-Willi syndrome is characterized by diminished fetal activity, obesity, muscular hypotonia, mental retardation, short stature, hypogonadotropic hypogonadism, and small hands and feet. It can be considered to be an autosomal dominant disorder and is caused by deletion or disruption of a gene or several genes on the proximal long arm of the paternal chromosome 15 or maternal uniparental disomy 15, because the gene(s) on the maternal chromosome(s) 15 are virtually inactive through imprinting. Horsthemke and Wagstaff (2008) provided a detailed review of the mechanisms of imprinting of the Prader-Willi/Angelman syndrome (OMIM ) region.See also the chromosome 15q11-q13 duplication syndrome (OMIM ), which shows overlapping clinical features.

PRADER-WILLI SYNDROME; PWS Is also known as prader-labhart-willi syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM MENDELIAN

More info about PRADER-WILLI SYNDROME; PWS

Other less relevant matches:

Pitt-Hopkins syndrome (PHS) is characterized by the association of intellectual deficit, characteristic facial dysmorphism and problems of abnormal and irregular breathing.

PITT-HOPKINS SYNDROME Is also known as encephalopathy, severe epileptic, with autonomic dysfunction|mental retardation, syndromal, with intermittent hyperventilation

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Hearing impairment


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about PITT-HOPKINS SYNDROME

Cardiofaciocutaneous (CFC) syndrome is a RASopathy characterized by craniofacial dysmorphology, congenital heart disease, dermatological abnormalities (most commonly hyperkeratotic skin and sparse, curly hair), growth retardation and intellectual disability.

CARDIOFACIOCUTANEOUS SYNDROME Is also known as cfcs|cfc syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about CARDIOFACIOCUTANEOUS SYNDROME

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Hypertelorism


SOURCES: OMIM MENDELIAN

More info about EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 66; EIEE66

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Hypertelorism


SOURCES: OMIM MENDELIAN

More info about MENTAL RETARDATION, AUTOSOMAL DOMINANT 49; MRD49

Familial lambdoid synostosis is a rare, genetic cranial malformation characterized by unilateral or bilateral synostosis of the lambdoid suture in multiple members of a single family. Unilateral cases typically present ipsilateral occipitomastoid bulge, compensatory contralateral parietal and frontal bossing, displacement of one ear, lateral deviation of jaw and compensatory deformation of cervical spine while bilateral cases usually manifest with flat and widened occiput, displacement of both ears and frequent occurrence of raised intracranial pressure.

Related symptoms:

  • Intellectual disability
  • Hypertelorism
  • Muscular hypotonia
  • Spasticity
  • Low-set ears


SOURCES: OMIM ORPHANET MENDELIAN

More info about FAMILIAL LAMBDOID SYNOSTOSIS

MENTAL RETARDATION, AUTOSOMAL DOMINANT 38; MRD38 Is also known as psychomotor retardation, epilepsy, and language disability syndrome|prelds

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly


SOURCES: OMIM MENDELIAN

More info about MENTAL RETARDATION, AUTOSOMAL DOMINANT 38; MRD38

Transient neonatal diabetes mellitus (TNDM) is a genetically heterogeneous form of neonatal diabetes (NDM, see this term) characterized by hyperglycemia presenting in the neonatal period that remits during infancy but recurs in later life in most patients.

TRANSIENT NEONATAL DIABETES MELLITUS Is also known as tndm3|tndm

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Hearing impairment
  • Failure to thrive


SOURCES: ORPHANET OMIM MENDELIAN

More info about TRANSIENT NEONATAL DIABETES MELLITUS

Top 5 symptoms//phenotypes associated to Lymphoma and Downturned corners of mouth

Symptoms // Phenotype % cases
Intellectual disability Very Common - Between 80% and 100% cases
Depressed nasal bridge Common - Between 50% and 80% cases
Global developmental delay Common - Between 50% and 80% cases
Seizures Common - Between 50% and 80% cases
Generalized hypotonia Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Lymphoma and Downturned corners of mouth. may also develop some of the following symptoms:

Common Symptoms - More than 50% cases

Muscular hypotonia

Uncommon Symptoms - Between 30% and 50% cases

Strabismus Short nose Aggressive behavior Myopia Hypertelorism Abnormal facial shape Upslanted palpebral fissure Epicanthus Delayed speech and language development Intellectual disability, severe Autism Hearing impairment Short neck Leukemia Malar flattening Wide mouth Absent speech Failure to thrive Cryptorchidism Motor delay High palate Growth delay Nystagmus Anteverted nares Edema Abnormality of the dentition Abnormal heart morphology Obesity Behavioral abnormality Sleep apnea Narrow forehead Full cheeks Sleep disturbance Small hand Hypermetropia Open mouth Feeding difficulties Clinodactyly Prominent forehead Hydrocephalus Neoplasm Low-set ears Macrocephaly Micropenis Generalized tonic-clonic seizures Deeply set eye Hypopigmentation of the skin Short stature Downslanted palpebral fissures Scoliosis Astigmatism

Rare Symptoms - Less than 30% cases

Round ear Optic nerve hypoplasia Proptosis Weight loss Autistic behavior Hyperactivity Diabetes mellitus Telecanthus Abnormal cardiac septum morphology Kyphosis Cerebral visual impairment Congestive heart failure Vomiting Talipes equinovarus Ventriculomegaly Thin upper lip vermilion Intrauterine growth retardation Bilateral ptosis Obsessive-compulsive behavior Neurodevelopmental delay Protruding ear Arnold-Chiari type I malformation Encephalopathy Micrognathia Constipation Generalized myoclonic seizures Gastroesophageal reflux Osteopenia Neonatal hypotonia Thick vermilion border Neurological speech impairment Abdominal distention Abnormal palate morphology Ataxia Microcephaly Acrocyanosis Aplasia/Hypoplasia of the corpus callosum Thickened helices Failure to thrive in infancy Poor suck Narrow palpebral fissure Insulin resistance Abnormality of the cardiovascular system Apnea Specific learning disability Growth hormone deficiency Frontal bossing Hypertonia Tapered finger Long philtrum Genu valgum Cerebral atrophy Wide nasal bridge Dolichocephaly Respiratory tract infection Abnormality of the pinna Pruritus Coarse facial features Pes planus Hydronephrosis Narrow palate Midface retrusion Aganglionic megacolon Macrotia Thick lower lip vermilion Type II diabetes mellitus Single transverse palmar crease Echolalia Short palm Hypotrichosis Almond-shaped palpebral fissure Cataract Hydroureter Umbilical hernia Cognitive impairment Anemia Dry skin Hypertension Narrow mouth Abnormality of cardiovascular system morphology Clinodactyly of the 5th finger Synophrys Nail dystrophy Increased body weight Thrombocytopenia Sandal gap Neutropenia Short foot Low posterior hairline Myeloid leukemia Impaired pain sensation Wide intermamillary distance Scarring Inguinal hernia Deep philtrum Hyperextensible skin Relative macrocephaly Delayed skeletal maturation Abnormality of vision Palmoplantar hyperkeratosis Alopecia Posteriorly rotated ears Cerebral cortical atrophy Hyperhidrosis Brittle hair Delayed gross motor development Hyperkeratosis Abnormality of the genitourinary system Hemangioma Cutis laxa Nail dysplasia Polyhydramnios Oculomotor apraxia Redundant skin Scaling skin Poor speech Large for gestational age Abnormal heart valve morphology Long palpebral fissure Abnormality of the sternum Infantile spasms Neurofibromas Hernia Aplasia/Hypoplasia of the eyebrow Malnutrition Open bite Absent eyebrow Sparse eyebrow Depressivity Heart murmur Chronic otitis media Cubitus valgus Melanocytic nevus Pectus excavatum Ectropion Pleural effusion Abnormality of the nail Sparse eyelashes Thin vermilion border Aspiration Bruising susceptibility Vesicoureteral reflux Nevus Erythema Abnormal bleeding Palmoplantar keratoderma Sparse hair High, narrow palate Hepatic steatosis Retinal dystrophy Bulbous nose Feeding difficulties in infancy Falls Joint hypermobility Long face Abnormality of skin pigmentation Peripheral axonal neuropathy Ichthyosis Pulmonic stenosis Abnormality of the cerebral white matter Pectus carinatum Irritability Intestinal malrotation Hirsutism Hypertrophic cardiomyopathy High forehead EEG abnormality Hyperpigmentation of the skin Lymphedema Cafe-au-lait spot Thickened skin Decreased body weight Inflammatory abnormality of the skin Hemiparesis Myocardial infarction Abnormality of the kidney Fine hair Low-set, posteriorly rotated ears Biparietal narrowing Coarctation of aorta Cardiomegaly Progressive visual loss Webbed neck Dental malocclusion Premature birth Abnormality of the eye Multiple cafe-au-lait spots Double outlet right ventricle Curly hair Pointed chin Anterior plagiocephaly External ear malformation Flat occiput Increased intracranial pressure Plagiocephaly Microretrognathia Facial asymmetry Blepharophimosis Craniosynostosis Retrognathia Spasticity Enlarged cisterna magna Dimple chin Delayed ability to walk Broad-based gait Status epilepticus Hypsarrhythmia Epileptic encephalopathy Hyperreflexia Visual impairment Oral aversion Multiple plantar creases Eyelid fasciculation Multiple palmar creases Stomatocytosis Lambdoidal craniosynostosis Inappropriate crying Steatorrhea Abnormality of the pancreatic islet cells Contractures of the joints of the lower limbs Transient neonatal diabetes mellitus Hypovolemia Abnormality of the upper urinary tract Autoimmune antibody positivity Ketonuria Maternal diabetes Renal tubular dysfunction Prominent metopic ridge Glycosuria Hyperglycemia Craniofacial dysostosis Apraxia Dehydration Coma Arthrogryposis multiplex congenita Tented upper lip vermilion Everted lower lip vermilion Posterior plagiocephaly Pansynostosis Diminished ability to concentrate Prominent scalp veins Ectopic posterior pituitary Abnormality of the auditory canal Cutaneous T-cell lymphoma Generalized hyperpigmentation Abnormality of the gastrointestinal tract Deep palmar crease Abnormality of refraction Abnormal myocardium morphology Delayed CNS myelination Abnormality of the testis Abnormality of the optic nerve Dystrophic fingernails Abnormal hair pattern Thick upper lip vermilion Woolly hair Short attention span Abnormality of the ulna Abnormal mitral valve morphology Premature skin wrinkling Hypoplasia of the zygomatic bone Absent eyelashes Enlarged kidney Abnormal eyelash morphology Alopecia of scalp Atopic dermatitis Poor appetite Underdeveloped supraorbital ridges Anal stenosis Submucous cleft hard palate Gastrointestinal dysmotility Slow-growing hair Morphological abnormality of the gastrointestinal tract Abnormal tricuspid valve morphology Puberty and gonadal disorders Abnormal location of ears Abnormality of the hairline Hyperkeratosis pilaris Tongue thrusting Functional abnormality of the gastrointestinal tract Laryngeal cleft Generalized ichthyosis Hypoplasia of the frontal lobes Optic nerve dysplasia Patchy alopecia Abnormality of the optic disc Subvalvular aortic stenosis Anterior creases of earlobe Frontal balding Endocarditis Increased nuchal translucency Sparse or absent eyelashes Multiple lentigines Cavernous hemangioma Abnormality of hair texture Excessive wrinkled skin Abnormality of the pulmonary artery Hyperextensibility of the finger joints Abnormal aortic valve morphology Splenomegaly Ptosis Blindness Sepsis Decreased fetal movement Oligohydramnios Hypothyroidism Amenorrhea Conductive hearing impairment Hip dysplasia Febrile seizures Esotropia Gastrointestinal hemorrhage Joint laxity Developmental regression Cutaneous photosensitivity Microtia Polymicrogyria Arachnodactyly Infertility Anal atresia Delayed puberty Carious teeth Flat face Postaxial polydactyly Stroke Attention deficit hyperactivity disorder Psychosis Primary amenorrhea Abnormality of the nervous system Hyperinsulinemia Truncal obesity Decreased muscle mass Adrenal insufficiency Skeletal muscle hypertrophy Albinism Glucose intolerance Inflammation of the large intestine Large hands Emotional lability Radial deviation of finger Precocious puberty Clumsiness Nasal speech Dementia Infantile muscular hypotonia Scrotal hypoplasia Brachycephaly Bicuspid aortic valve Polydactyly Spontaneous abortion Hypogonadotrophic hypogonadism Aortic valve stenosis Bradycardia Postural instability Macroglossia Polyphagia Atlantoaxial instability Polycythemia Protruding tongue Thrombocytosis Acute lymphoblastic leukemia Acute megakaryocytic leukemia Left-to-right shunt Thickened nuchal skin fold Brushfield spots Transient myeloproliferative syndrome Crackles Neutrophilia Congenital hypothyroidism Abnormality of the fontanelles or cranial sutures Shallow acetabular fossae Duodenal stenosis Abnormality of the lymphatic system Myeloproliferative disorder Short middle phalanx of the 5th finger Complete atrioventricular canal defect Pulmonary edema Hypoxemia Acute monocytic leukemia Senile plaques Neurofibrillary tangles Pain Hypoglycemia Renal hypoplasia/aplasia Photophobia Microdontia Depressed nasal ridge Respiratory failure Bilateral single transverse palmar creases Hypogonadism Osteoporosis Recurrent respiratory infections Hyporeflexia Dilatation Syndactyly Intellectual disability, mild Abnormality of immune system physiology Breast carcinoma Cholelithiasis Alzheimer disease Myopathy Decreased fertility Atrioventricular canal defect Broad palm Fever Transposition of the great arteries Prematurely aged appearance Abnormality of blood and blood-forming tissues External genital hypoplasia Narrow nasal bridge Atrial septal defect Short metatarsal Hiatus hernia Hyperventilation Hodgkin lymphoma Dysphasia Aphasia Supernumerary nipple Overlapping toe Cupped ear Clubbing Self-injurious behavior Incoordination Misalignment of teeth Coarse hair Hypopigmented skin patches Mutism Acute myeloid leukemia Widely spaced teeth Broad neck Intellectual disability, progressive Finger clinodactyly Abnormal autonomic nervous system physiology Truncal ataxia Postnatal microcephaly Esophagitis Clubbing of fingers Convex nasal ridge Overhanging nasal tip Cardiomyopathy Ventricular septal defect Dysphagia Generalized hirsutism Prominent supraorbital ridges Optic atrophy Dysarthria Hepatomegaly Broad hallux Hypoplastic iliac wing Triangular nasal tip Abnormality of the helix Broad fingertip Intermittent hyperventilation Narrow foot Failure of eruption of permanent teeth Small cerebral cortex Square face Large beaked nose Happy demeanor Pes valgus Abnormal pattern of respiration Breathing dysregulation Cyanosis Prominent nose Striae distensae Generalized hypopigmentation Temperature instability Triangular mouth Disseminated intravascular coagulation Erysipelas Frontal upsweep of hair Clitoral hypoplasia Anteverted ears Poor fine motor coordination Abdominal obesity Cor pulmonale Hypothermia Hypoplastic labia minora Ocular albinism Chromosome breakage Hypoplasia of the fovea Oligomenorrhea Overweight Central hypotonia Abnormality of lipid metabolism Iris hypopigmentation Hypoventilation Hypopigmentation of hair Pulmonary embolism Central adrenal insufficiency Psychotic episodes Broad face Mandibular prognathia Thick eyebrow Spotty hypopigmentation Severe global developmental delay Abnormal hair whorl Prominent nasal bridge Short philtrum Regional abnormality of skin Postnatal growth retardation Intellectual disability, moderate Anxiety Hypointensity of cerebral white matter on MRI Gait ataxia Narrow palm Pes cavus Pneumonia Hypoplasia of the corpus callosum Abnormality of the skeletal system Fatigue Brachydactyly Gait disturbance Recurrent infections Acromicria Poor gross motor coordination Hypopnea Elevated hemoglobin A1c


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