Lymphoma, and Bruising susceptibility

Diseases related with Lymphoma and Bruising susceptibility

In the following list you will find some of the most common rare diseases related to Lymphoma and Bruising susceptibility that can help you solving undiagnosed cases.

Top matches:

PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY; FPDMM Is also known as platelet disorder, aspirin-like|thrombocytopenia, familial, with propensity to acute myelogenous leukemia|fpd/aml

Related symptoms:

  • Anemia
  • Thrombocytopenia
  • Hernia
  • Hypospadias
  • Umbilical hernia


SOURCES: OMIM MENDELIAN

More info about PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY; FPDMM

Related symptoms:

  • Scoliosis
  • Neoplasm
  • Fever
  • Inguinal hernia
  • Arthralgia


SOURCES: OMIM MENDELIAN

More info about EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2; EDSPD2

Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN, see this term) characterized by a sustained elevation of platelet number (> 450 x 109/L) with a tendency for thrombosis and hemorrhage.

ESSENTIAL THROMBOCYTHEMIA Is also known as thrombocytosis 1|essential thrombocytosis|et

Related symptoms:

  • Pain
  • Hypertension
  • Hepatomegaly
  • Abnormality of the skeletal system
  • Respiratory distress


SOURCES: ORPHANET OMIM MENDELIAN

More info about ESSENTIAL THROMBOCYTHEMIA

Other less relevant matches:

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

Chédiak-Higashi syndrome (CHS) is a rare severe genetic disorder generally characterized by partial oculocutaneous albinism (OCA, see this term), severe immunodeficiency, mild bleeding, neurological dysfunction and lymphoproliferative disorder. A classic, early-onset form and an attenuated, later-onset form (Atypical CHS; see this term) have been described.

CHÉDIAK-HIGASHI SYNDROME Is also known as chÉdiak-higashi-steinbrink syndrome|chÉdiak-higashi disease

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about CHÉDIAK-HIGASHI SYNDROME

Noonan syndrome-like disorder with juvenile myelomonocytic leukemia is a rare, genetic, polymalformative syndrome with increased risk of developing cancer characterized by a Noonan-like phenotype, including typical dysmorphic facial features (i.e. high forehead, hypertelorism, downslanting palpebral fissures, ptosis, low-set ears, prominent philtrum and short neck with or without pterygium colli), thoracic abnormalities, congenital heart defects and short stature, associated with a very frequent ocurrence of juvenile myelomonocytic leukemia. Developmental delay, ectodermal anomalies, joint laxity, and hypotonia may also be associated.

NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA Is also known as cbl mutation-associated syndrome|noonan syndrome-like disorder with jmml|cbl syndrome

Related symptoms:

  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Microcephaly
  • Growth delay


SOURCES: ORPHANET OMIM MENDELIAN

More info about NOONAN SYNDROME-LIKE DISORDER WITH JUVENILE MYELOMONOCYTIC LEUKEMIA

Medium match FANCONI ANEMIA

Fanconi anemia (FA) is a hereditary DNA repair disorder characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors.

FANCONI ANEMIA Is also known as fanconi pancytopenia|fanconi anemia|fa

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Short stature
  • Hearing impairment
  • Microcephaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about FANCONI ANEMIA

Cardiofaciocutaneous (CFC) syndrome is a RASopathy characterized by craniofacial dysmorphology, congenital heart disease, dermatological abnormalities (most commonly hyperkeratotic skin and sparse, curly hair), growth retardation and intellectual disability.

CARDIOFACIOCUTANEOUS SYNDROME Is also known as cfcs|cfc syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about CARDIOFACIOCUTANEOUS SYNDROME

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic LeukemiaA susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (OMIM ), which has been mapped to chromosome 7p12.2; and ALL3 (OMIM ), which is caused by mutation in the PAX5 gene (OMIM ) on chromosome 9p.

Related symptoms:

  • Neoplasm
  • Pain
  • Fever
  • Fatigue
  • Arthralgia


SOURCES: OMIM ORPHANET MENDELIAN

More info about LEUKEMIA, ACUTE LYMPHOBLASTIC; ALL

Disorder characterized by a decrease or lack of platelet dense bodies in which the releasable pool of adenine nucleotides and 5HT are normally stored.

ALPHA DELTA GRANULE DEFICIENCY Is also known as combined alpha-delta platelet storage pool deficiency|alpha dense granule deficiency

Related symptoms:

  • Anemia
  • Thrombocytopenia
  • Bruising susceptibility
  • Abnormal bleeding
  • Epistaxis


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about ALPHA DELTA GRANULE DEFICIENCY

Top 5 symptoms//phenotypes associated to Lymphoma and Bruising susceptibility

Symptoms // Phenotype % cases
Leukemia Common - Between 50% and 80% cases
Thrombocytopenia Common - Between 50% and 80% cases
Neoplasm Common - Between 50% and 80% cases
Abnormal bleeding Common - Between 50% and 80% cases
Anemia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Bruising susceptibility. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Splenomegaly Fever Acute leukemia Epistaxis Hepatomegaly Global developmental delay Umbilical hernia Strabismus Neutropenia Myelodysplasia Prolonged bleeding time Atrial septal defect Edema Abnormality of cardiovascular system morphology Abnormality of the eye Cafe-au-lait spot Abnormality of vision Hepatosplenomegaly Astigmatism Intellectual disability Hyperpigmentation of the skin Fatigue Generalized hypotonia Ataxia Nystagmus Falls Respiratory distress Frontal bossing Pancytopenia Joint hypermobility Growth delay Hypertelorism Failure to thrive Short stature Cryptorchidism Ptosis Scoliosis Inguinal hernia Irritability Decreased mean platelet volume Gingival bleeding Epicanthus

Rare Symptoms - Less than 30% cases

Low posterior hairline Poor suck Deep philtrum Abnormality of the foot Thick vermilion border Webbed neck Chronic otitis media Lymphedema Visual impairment Gait disturbance Fine hair Bilateral ptosis B-cell lymphoma Short attention span Pleural effusion Cubitus valgus Failure to thrive in infancy Neurodevelopmental delay Seizures Posteriorly rotated ears Pulmonic stenosis Long philtrum Abnormal facial shape Muscular hypotonia Low-set ears Feeding difficulties Delayed speech and language development Depressed nasal bridge Macrocephaly Optic atrophy Downslanted palpebral fissures Generalized hyperpigmentation Anteverted nares Short neck Cardiomyopathy Melanocytic nevus Cranial nerve paralysis Hypermetropia Low-set, posteriorly rotated ears Pectus carinatum Sparse hair Peripheral axonal neuropathy Postnatal growth retardation Feeding difficulties in infancy Hypopigmentation of the skin Macrotia Leukopenia High forehead Gastroesophageal reflux Polyhydramnios Prominent forehead Micrognathia Pectus excavatum Hearing impairment Microcephaly Abnormal aortic valve morphology Peripheral neuropathy Abnormality of skin pigmentation Multiple cafe-au-lait spots Absent radius Dolichocephaly Bloody diarrhea Abnormal platelet morphology Abnormal cardiac septum morphology Abnormality of the kidney Myeloid leukemia Renal insufficiency Cataract Recurrent infections Hypertrophic cardiomyopathy Recurrent respiratory infections Abnormality of the ulna Respiratory tract infection Hydroureter Myocardial infarction Lymphadenopathy Arthralgia Hernia Hypospadias Purpura Acute myeloid leukemia Acute lymphoblastic leukemia Acute monocytic leukemia Impaired platelet aggregation Hyperextensible skin Chest pain Periodontitis Pain Hypertension Abnormality of the skeletal system Headache Dyspnea Paresthesia Vertigo Proptosis Immunodeficiency Abnormality of the testis Congestive heart failure Skin ulcer High palate Abnormal heart morphology Ventriculomegaly Vasculitis Clinodactyly of the 5th finger Hydrocephalus Aplasia/Hypoplasia of the iris Low-grade fever Hypertonia Clubbing of toes Complete duplication of thumb phalanx Partial duplication of thumb phalanx Tracheoesophageal fistula Decreased fertility in males Abnormality of femur morphology Glucose intolerance Hypoplasia of the ulna Meckel diverticulum Hyperinsulinemia Duplicated collecting system Kyphosis Abnormal renal morphology Abnormal localization of kidney Abnormality of chromosome stability Azoospermia Reticulocytopenia Abnormality of the hypothalamus-pituitary axis Abnormality of nervous system morphology Renal hypoplasia/aplasia Triphalangeal thumb Primary hypothyroidism Hypopigmented skin patches Behavioral abnormality Duodenal stenosis Reduced bone mineral density Abnormality of the urinary system Squamous cell carcinoma Chromosomal breakage induced by crosslinking agents Abnormality of the dentition Ectopic kidney Neoplasm of head and neck Myopia Dysarthria Chromosome breakage Anemic pallor Abnormal eyelid morphology Deficient excision of UV-induced pyrimidine dimers in DNA Aplasia/Hypoplasia of the uvula Dysphagia Arteriovenous malformation Aplasia/Hypoplasia of fingers Abnormality of the preputium Abnormality of the upper limb Aplastic anemia Pyridoxine-responsive sideroblastic anemia Prolonged G2 phase of cell cycle Abnormality of the thumb Hypoplastic anemia Irregular hyperpigmentation Absent thumb Abnormality of the uterus Absent testis Abnormality of blood and blood-forming tissues Compensated hypothyroidism Aplasia/Hypoplasia of the radius External ear malformation Ventricular septal defect Vomiting Almond-shaped palpebral fissure Abnormal carotid artery morphology Hearing abnormality Bicornuate uterus Blindness Intellectual disability, severe Abnormal aortic morphology Sleep disturbance Short nose Woolly hair Arnold-Chiari type I malformation Enlarged kidney Absent eyelashes Hypoplasia of the zygomatic bone Premature skin wrinkling Abnormality of the gastrointestinal tract Thick upper lip vermilion Alopecia of scalp Abnormal hair pattern Dystrophic fingernails Abnormality of the optic nerve Delayed CNS myelination Abnormal myocardium morphology Abnormality of refraction Abnormal eyelash morphology Atopic dermatitis Gastrointestinal dysmotility Infantile spasms Absent eyebrow Large for gestational age Open bite Malnutrition Aplasia/Hypoplasia of the eyebrow Neurofibromas Abnormality of the sternum Poor appetite Long palpebral fissure Abnormal heart valve morphology Biparietal narrowing Curly hair Submucous cleft hard palate Anal stenosis Underdeveloped supraorbital ridges Deep palmar crease Abnormal mitral valve morphology Heart murmur Puberty and gonadal disorders Laryngeal cleft Functional abnormality of the gastrointestinal tract Tongue thrusting Hyperkeratosis pilaris Abnormality of the hairline Abnormal location of ears Morphological abnormality of the gastrointestinal tract Hypoplasia of the frontal lobes Cutaneous T-cell lymphoma Inappropriate crying Abnormality of the auditory canal Multiple palmar creases Eyelid fasciculation Multiple plantar creases Generalized ichthyosis Optic nerve dysplasia Slow-growing hair Cavernous hemangioma Thickened helices Subvalvular aortic stenosis Hyperextensibility of the finger joints Abnormality of the pulmonary artery Excessive wrinkled skin Abnormality of hair texture Multiple lentigines Patchy alopecia Sparse or absent eyelashes Increased nuchal translucency Endocarditis Frontal balding Anterior creases of earlobe Abnormality of the optic disc Abnormal tricuspid valve morphology Obsessive-compulsive behavior Ectropion Malar flattening Ichthyosis Pruritus Nail dystrophy Abnormality of the cerebral white matter Hypotrichosis Genu valgum Dry skin Long face Scarring Bulbous nose Retinal dystrophy Hepatic steatosis High, narrow palate Horseshoe kidney Palmoplantar keratoderma Neurological speech impairment Erythema Full cheeks Hyperhidrosis Cerebral atrophy Depressivity Encephalopathy Delayed skeletal maturation Constipation Alopecia Cerebral cortical atrophy Telecanthus Hyperkeratosis Autism Osteopenia Coarse facial features EEG abnormality Hydronephrosis Aggressive behavior Abdominal distention Nevus Scaling skin Abnormality of the genitourinary system Oculomotor apraxia Cutis laxa Abnormal palate morphology Aplasia/Hypoplasia of the corpus callosum Hemangioma Sleep apnea Delayed gross motor development Narrow palate Optic nerve hypoplasia Palmoplantar hyperkeratosis Relative macrocephaly Redundant skin Brittle hair Sparse eyebrow Sparse eyelashes Abnormality of the nail Vesicoureteral reflux Narrow forehead Intestinal malrotation Premature birth Dental malocclusion Growth hormone deficiency Progressive visual loss Abnormality of the cardiovascular system Cardiomegaly Aspiration Coarctation of aorta Hemiparesis Inflammatory abnormality of the skin Open mouth Decreased body weight Thickened skin Cerebral visual impairment Type I diabetes mellitus Decreased muscle mass Bone marrow hypocellularity IgM deficiency Abnormal eosinophil morphology Generalized lymphadenopathy Spontaneous hematomas Melena Hematemesis Increased IgA level Interstitial pneumonitis Membranoproliferative glomerulonephritis Abnormality of the menstrual cycle Increased IgE level Recurrent ear infections Hypoplasia of the thymus Abnormal platelet function Chronic obstructive pulmonary disease Hematochezia Recurrent lower respiratory tract infections Blepharitis Hodgkin lymphoma Iron deficiency anemia Glomerulopathy Microcytic anemia Cellulitis Petechiae Combined immunodeficiency Internal hemorrhage Congenital thrombocytopenia Keratitis Areflexia Paraplegia Abnormality of movement Spastic paraplegia Developmental regression Mental deterioration Rigidity Photophobia Difficulty walking Jaundice Reduced visual acuity Hyporeflexia Cerebellar atrophy Reduced delayed hypersensitivity Tremor Skeletal muscle atrophy Oral bleeding Specific anti-polysaccharide antibody deficiency Reduced lymphocyte surface expression of CD43 Abnormal delayed hypersensitivity skin test Absent microvilli on the surface of peripheral blood lymphocytes Chronic leukemia Recurrent intrapulmonary hemorrhage Small vessel vasculitis Large vessel vasculitis Focal segmental glomerulosclerosis Hyperostosis Neurodegeneration Transient ischemic attack Increased megakaryocyte count Abnormal platelet aggregation Myelofibrosis Abnormality of bone marrow cell morphology Amaurosis fugax Myeloproliferative disorder Abnormal thrombocyte morphology Arterial thrombosis Abnormality of the cerebral vasculature Gangrene Acrocyanosis Thrombocytosis Arrhythmia Pulmonary embolism Leukocytosis Venous thrombosis Gingival recession Premature loss of teeth Fragile skin Atrophic scars Nephroblastoma Osteoarthritis Refractory anemia Neuroblastoma Diarrhea Pneumonia Inflammation of the large intestine Sinusitis Glomerulonephritis Rheumatoid arthritis Glomerulosclerosis Urticaria Intracranial hemorrhage Sarcoma Chronic kidney disease Recurrent upper respiratory tract infections Conjunctivitis Meningitis Lymphopenia Chronic diarrhea Arthritis Recurrent otitis media Eczema Specific learning disability Otitis media Sudden cardiac death Sepsis Nephropathy Hemolytic anemia Cough Autoimmunity Proteinuria Sensory neuropathy Parkinsonism Hypergonadotropic hypogonadism Hypoplasia of olfactory tract Severe short stature Patent ductus arteriosus Microphthalmia Intrauterine growth retardation Hyperreflexia Cleft palate Abnormality of the subarachnoid space Reduced factor X activity Reduced prothrombin activity Juvenile myelomonocytic leukemia Reduced factor XII activity Reduced factor IX activity Upslanted palpebral fissure Abnormality of the mediastinum Arteritis Pulmonary lymphangiectasia Monocytosis Broad toe Prominent fingertip pads Chylothorax Hypochromic microcytic anemia Abnormality of the spleen Hydrocele testis Facial hypotonia Hypogonadism Diabetes mellitus Proximal placement of thumb Sloping forehead Spina bifida Abnormal vertebral morphology Insulin resistance Short thumb Telangiectasia Recurrent urinary tract infections Aganglionic megacolon Abnormality of the genital system Choanal atresia Short palpebral fissure Oligohydramnios Tetralogy of Fallot Weight loss Renal agenesis Anal atresia Facial asymmetry Toe syndactyly Hip dislocation Finger syndactyly Small for gestational age Abnormality of the liver Carcinoma Pes planus Hypothyroidism Abnormal eyebrow morphology Overfolded helix Brain atrophy Resting tremor Partial albinism Hypersplenism Progressive peripheral neuropathy Hemophagocytosis Spinocerebellar tract degeneration White hair Generalized hypopigmentation Fair hair Gingivitis Iris hypopigmentation Hypopigmentation of hair Sensory axonal neuropathy Recurrent bacterial skin infections Cerebral hemorrhage Albinism Decreased nerve conduction velocity Foot dorsiflexor weakness Amblyopia Hypertriglyceridemia Cutaneous photosensitivity Abnormality of extrapyramidal motor function Bradykinesia Peripheral demyelination Gastrointestinal hemorrhage Macular hypoplasia Oculogyric crisis Abnormality of the thorax Triangular face Cholelithiasis Bicuspid aortic valve Torticollis Bilateral single transverse palmar creases Aortic valve stenosis Hydrops fetalis Mitral regurgitation Cyanosis Hip dysplasia Wide intermamillary distance Esotropia Ascites Hypofibrinogenemia Highly arched eyebrow Broad forehead Joint laxity Myopathy Motor delay Cognitive impairment Generalized hypopigmentation of hair Recurrent systemic pyogenic infections Abnormality of multiple cell lineages in the bone marrow Giant melanosomes in melanocytes Recurrent cutaneous abscess formation Abnormal leukocyte morphology Oral aversion


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