Lymphoma, and Atopic dermatitis

Diseases related with Lymphoma and Atopic dermatitis

In the following list you will find some of the most common rare diseases related to Lymphoma and Atopic dermatitis that can help you solving undiagnosed cases.

Top matches:

IMD11B is an autosomal dominant disorder of immune dysfunction characterized by onset of moderate to severe atopic dermatitis in early childhood. Some patients may have recurrent infections and other variable immune abnormalities. Laboratory studies show defects in T-cell activation, increased IgE, and eosinophilia (summary by Ma et al., 2017).

IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B Is also known as atopic dermatitis, elevated ige, and eosinophilia

Related symptoms:

  • Recurrent infections
  • Pneumonia
  • Asthma
  • Lymphoma
  • Decreased antibody level in blood


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY 11B WITH ATOPIC DERMATITIS; IMD11B

Medium match PGM3-CDG

PGM3-CDG is a rare congenital disorder of glycosylation caused by mutations in the PGM3 gene and characterized by neonatal to childhood onset of recurrent bacterial and viral infections, inflammatory skin diseases, atopic dermatitis and atopic diatheses, and marked serum IgE elevation. Early neurologic impairment is evident including developmental delay, intellectual disability, ataxia, dysarthria, sensorineural hearing loss, myoclonus and seizures.

PGM3-CDG Is also known as cid due to pgm3 deficiency|immunodeficiency with hyper ige and cognitive impairment|pgm3-related congenital disorder of glycosylation|combined immunodeficiency due to pgm3 deficiency|immunodeficiency-vasculitis-myoclonus syndrome|ivms

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM ORPHANET MENDELIAN

More info about PGM3-CDG

Hyper-IgE recurrent infection syndrome is a primary immunodeficiency disorder characterized by chronic eczema, recurrent Staphylococcal infections, increased serum IgE, and eosinophilia. Patients have a distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures (Buckley et al., 1972; Grimbacher et al., 1999).

HYPER-IGE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT Is also known as hies, autosomal dominant|hyper-ige syndrome, autosomal dominant|job syndrome

Related symptoms:

  • Scoliosis
  • Hypertelorism
  • Strabismus
  • High palate
  • Wide nasal bridge


SOURCES: OMIM MENDELIAN

More info about HYPER-IGE RECURRENT INFECTION SYNDROME, AUTOSOMAL DOMINANT

Other less relevant matches:

Cardiofaciocutaneous (CFC) syndrome is a RASopathy characterized by craniofacial dysmorphology, congenital heart disease, dermatological abnormalities (most commonly hyperkeratotic skin and sparse, curly hair), growth retardation and intellectual disability.

CARDIOFACIOCUTANEOUS SYNDROME Is also known as cfcs|cfc syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about CARDIOFACIOCUTANEOUS SYNDROME

Immunodeficiency-55 is an autosomal recessive primary immunodeficiency characterized by intrauterine growth retardation, natural killer (NK) cell deficiency, and chronic neutropenia. Most patients also have postnatal growth retardation. Other clinical manifestations include mild facial dysmorphism, dry or eczematous skin, and recurrent infections with both viruses and bacteria. The disorder appears to result from a defect in DNA replication causing blockade of immune cell differentiation in the bone marrow, particularly affecting NK cells (summary by Cottineau et al., 2017).

COMBINED IMMUNODEFICIENCY DUE TO GINS1 DEFICIENCY Is also known as cid due to gins1 deficiency|combined immunodeficiency with intrauterine growth retardation-natural killer cell deficiency-neutropenia|combined immunodeficiency with intrauterine growth retardation-nk cell deficiency-neutropenia

Related symptoms:

  • Growth delay
  • Abnormal facial shape
  • Anemia
  • Intrauterine growth retardation
  • Blindness


SOURCES: OMIM ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY DUE TO GINS1 DEFICIENCY

Infantile-onset multisystem autoimmune disease-1 is characterized by early childhood onset of a spectrum of autoimmune disorders affecting multiple organs. Common manifestations include insulin-dependent diabetes mellitus and autoimmune enteropathy, or celiac disease, and autoimmune hematologic disorders. Other features include short stature and nonspecific dermatitis. More variable features include hypothyroidism, autoimmune arthritis, and delayed puberty. Some patients may show recurrent infections. The disorder results from an inborn error of cytokine signaling (summary by Flanagan et al., 2014 and Milner et al., 2015). Genetic Heterogeneity of Infantile-Onset Multisystem Autoimmune DiseaseSee also ADMIO2 (OMIM ), caused by mutation in the ZAP70 gene (OMIM ) on chromosome 2q12.

Related symptoms:

  • Short stature
  • Pain
  • Anemia
  • Abnormality of the dentition
  • Immunodeficiency


SOURCES: OMIM ORPHANET MENDELIAN

More info about STAT3-RELATED EARLY-ONSET MULTISYSTEM AUTOIMMUNE DISEASE

Familial myeloproliferative/lymphoproliferative neoplasms is an autosomal dominant cancer predisposition syndrome characterized by adult-onset of hematologic malignancies mainly affecting the myeloid line. Most patients present with myelodysplastic syndrome (MDS ) and/or acute myeloid leukemia (AML ). Rare lymphoid malignancies, including lymphoma, can also occur. Some mutation carriers, even if unaffected by a hematologic malignancy, may have evidence of immune dysregulation disorders, including asthma, eczema, or juvenile arthritis. The disorder shows incomplete penetrance (summary by Lewinsohn et al., 2016). Patients may show a favorable response to treatment with lenalidomide (summary by Polprasert et al., 2015).

Related symptoms:

  • Neoplasm
  • Anemia
  • Arthritis
  • Leukemia
  • Asthma


SOURCES: ORPHANET OMIM MENDELIAN

More info about DDX41-RELATED HEMATOLOGIC MALIGNANCY PREDISPOSITION SYNDROME

Combined immunodeficiency due to STK4 deficiency is a rare, genetic combined T and B cell immunodeficiency characterized by T- and B-cell lymphopenia, hypergammaglobulinemia and intermittent neutropenia. It presents with recurrent opportunistic viral, bacterial and fungal infections involving skin (cutaneous papillomatosis, molluscum contagiosum, skin abscesses, mucocutaneous candidiasis), upper and lower respiratory tract or septicemia. Other clinical features include autoimmune manifestations (autoimmune hemolytic anemia) and congenital heart defects (atrial septal defects, patent foramen ovale, mitral, triscupid and pulmonary valve insufficiency).

COMBINED IMMUNODEFICIENCY DUE TO STK4 DEFICIENCY Is also known as mst1 deficiency|cid due to stk4 deficiency|stk4 deficiency

Related symptoms:

  • Anemia
  • Atrial septal defect
  • Immunodeficiency
  • Lymphadenopathy
  • Hemolytic anemia


SOURCES: OMIM ORPHANET MENDELIAN

More info about COMBINED IMMUNODEFICIENCY DUE TO STK4 DEFICIENCY

Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006).For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see {600807}.

ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1 Is also known as as1|asrt1

Related symptoms:

  • Dyspnea
  • Cough
  • Asthma
  • Inflammatory abnormality of the skin
  • Wheezing


SOURCES: OMIM MENDELIAN

More info about ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1

Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002).For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see {600807}.

ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 2 Is also known as asrt2

Related symptoms:

  • Dyspnea
  • Cough
  • Asthma
  • Inflammatory abnormality of the skin
  • Wheezing


SOURCES: OMIM MENDELIAN

More info about ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 2

Top 5 symptoms//phenotypes associated to Lymphoma and Atopic dermatitis

Symptoms // Phenotype % cases
Inflammatory abnormality of the skin Very Common - Between 80% and 100% cases
Asthma Common - Between 50% and 80% cases
Recurrent infections Uncommon - Between 30% and 50% cases
Immunodeficiency Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Lymphoma and Atopic dermatitis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Eczema Lymphopenia Respiratory tract infection Hemolytic anemia Neutropenia Abnormality of the dentition Autoimmune hemolytic anemia Recurrent skin infections Lymphadenopathy Short stature Pneumonia Scoliosis High palate Cough Leukemia Erythema

Rare Symptoms - Less than 30% cases

Osteopenia Pruritus Coarse facial features Recurrent bacterial infections Prominent forehead Constipation Dysphagia Frontal bossing Joint hypermobility Atrial septal defect Chronic otitis media Ichthyosis Dyspnea Arthritis Erythroid dysplasia Myelodysplasia Abnormal intestine morphology Abnormal lung morphology Hypothyroidism Dry skin Chronic mucocutaneous candidiasis Thrombocytopenia Blindness Hypertelorism Neoplasm Growth delay Recurrent fungal infections Verrucae Strabismus Wheezing Abnormal facial shape Recurrent respiratory infections Colitis Ataxia Bronchiectasis Dysarthria Failure to thrive Gastroesophageal reflux Eosinophilia Hearing impairment T-cell lymphoma Leukopenia Intellectual disability Combined immunodeficiency Seizures Global developmental delay Abnormality of the skeletal system Generalized hypotonia Decreased antibody level in blood Curly hair Biparietal narrowing Generalized hyperpigmentation Long palpebral fissure Multiple cafe-au-lait spots Abnormal heart valve morphology Abnormality of the sternum Infantile spasms Neurofibromas Submucous cleft hard palate Alopecia of scalp Anal stenosis Woolly hair Gastrointestinal dysmotility Deep palmar crease Abnormality of refraction Abnormal myocardium morphology Delayed CNS myelination Abnormality of the testis Abnormality of the optic nerve Dystrophic fingernails Abnormal hair pattern Thick upper lip vermilion Short attention span Underdeveloped supraorbital ridges Abnormality of the gastrointestinal tract Abnormality of the ulna Premature skin wrinkling Hypoplasia of the zygomatic bone Absent eyelashes Enlarged kidney Arnold-Chiari type I malformation Abnormal eyelash morphology Aplasia/Hypoplasia of the eyebrow Poor appetite Neurodevelopmental delay Autoimmune neutropenia Hydroureter Abnormal palate morphology Palmoplantar hyperkeratosis Optic nerve hypoplasia Delayed gross motor development Abnormality of the genitourinary system Sleep apnea Hemangioma Aplasia/Hypoplasia of the corpus callosum Cutis laxa Relative macrocephaly Oculomotor apraxia Sparse eyelashes Narrow palate Abnormality of the nail Aspiration Cerebral visual impairment Hyperpigmentation of the skin Abnormality of vision Poor suck Malnutrition Ectropion Open bite Abnormal mitral valve morphology Absent eyebrow Obsessive-compulsive behavior Heart murmur Cubitus valgus Melanocytic nevus Pleural effusion Hyperextensible skin Scaling skin Sparse eyebrow Bilateral ptosis Failure to thrive in infancy Brittle hair Redundant skin Deep philtrum Large for gestational age Abnormality of hair texture Slow-growing hair Autoimmunity Recurrent ear infections Autoimmune thrombocytopenia Scleroderma Celiac disease Interstitial pulmonary abnormality Type I diabetes mellitus Delayed puberty Hepatosplenomegaly Interstitial pneumonitis Arthralgia Diabetes mellitus Pain Folliculitis Protein-losing enteropathy Osteosarcoma Severe intrauterine growth retardation Primary hypothyroidism Bone marrow hypocellularity Erythroderma Ventricular hypertrophy Pulmonary insufficiency Lymphoproliferative disorder Recurrent viral infections B-cell lymphoma Right ventricular hypertrophy Increased antibody level in blood Patent foramen ovale Chronic myelomonocytic leukemia Melanoma Monocytosis Refractory anemia Acute monocytic leukemia Immune dysregulation Acute myeloid leukemia Myeloid leukemia Systemic lupus erythematosus Ulcerative colitis Postnatal growth retardation Thickened helices Sparse or absent eyelashes Patchy alopecia Abnormal tricuspid valve morphology Abnormality of the optic disc Anterior creases of earlobe Frontal balding Endocarditis Increased nuchal translucency Multiple lentigines Hypoplasia of the frontal lobes Cavernous hemangioma Cafe-au-lait spot Excessive wrinkled skin Abnormality of the pulmonary artery Hyperextensibility of the finger joints Abnormal aortic valve morphology Subvalvular aortic stenosis Optic nerve dysplasia Generalized ichthyosis Respiratory failure Abnormality of the auditory canal Glaucoma Diarrhea Intrauterine growth retardation Oral aversion Multiple plantar creases Eyelid fasciculation Multiple palmar creases Inappropriate crying Laryngeal cleft Cutaneous T-cell lymphoma Morphological abnormality of the gastrointestinal tract Puberty and gonadal disorders Abnormal location of ears Abnormality of the hairline Hyperkeratosis pilaris Tongue thrusting Functional abnormality of the gastrointestinal tract Lymphedema Fine hair Thickened skin Impaired neutrophil chemotaxis Ptosis Cryptorchidism Cataract Muscular hypotonia Micrognathia Brachydactyly Nystagmus Squamous cell carcinoma of the vulva Feeding difficulties Anal canal squamous carcinoma Lung abscess Opportunistic infection Recurrent candida infections Recurrent Staphylococcus aureus infections Severe viral infections Onychomycosis Low-set ears Delayed speech and language development Eczematoid dermatitis Short neck Hypertonia Vomiting Cognitive impairment Intellectual disability, severe Edema Cardiomyopathy Hydrocephalus Anteverted nares Depressed nasal bridge Ventriculomegaly Ventricular septal defect Downslanted palpebral fissures Optic atrophy Macrocephaly Myopia Hepatomegaly Epicanthus Recurrent bacterial skin infections Hyporeflexia Behavioral abnormality Vasculitis Wide nose Abnormality of the nervous system Facial asymmetry Sensory impairment Skin rash Craniosynostosis Deeply set eye Narrow palpebral fissure Prominent nose Mandibular prognathia Osteoporosis Glomerulonephritis Severe combined immunodeficiency Allergic rhinitis Wide nasal bridge Membranoproliferative glomerulonephritis Vasculitis in the skin Recurrent fractures Otitis media Fractures of the long bones Myoclonus B lymphocytopenia Persistence of primary teeth Decrease in T cell count Red hair Increased IgE level Recurrent sinopulmonary infections Hemihypertrophy Recurrent bronchitis Thick lower lip vermilion Recurrent sinusitis Bronchitis Squamous cell carcinoma Urticaria Conductive hearing impairment Hemivertebrae Skin ulcer Sinusitis Congestive heart failure Splenomegaly Decreased body weight Falls Sleep disturbance High, narrow palate Hepatic steatosis Thick vermilion border Retinal dystrophy Bruising susceptibility Bulbous nose Long face Abdominal distention Peripheral axonal neuropathy Astigmatism Genu valgum Pulmonic stenosis Hypotrichosis Hypermetropia Abnormality of the cerebral white matter Palmoplantar keratoderma Abnormal bleeding Nail dystrophy Narrow forehead Open mouth Hemiparesis Myocardial infarction Cortical myoclonus Low posterior hairline Coarctation of aorta Cardiomegaly Abnormality of the cardiovascular system Full cheeks Progressive visual loss Growth hormone deficiency Webbed neck Dental malocclusion Premature birth Intestinal malrotation Vesicoureteral reflux Nevus Dolichocephaly Neurological speech impairment Kyphosis Abnormal heart morphology Cerebral cortical atrophy Hyperhidrosis Posteriorly rotated ears Alopecia Clinodactyly of the 5th finger Delayed skeletal maturation Inguinal hernia Encephalopathy Autism Pectus excavatum Depressivity Hernia Abnormality of cardiovascular system morphology Cerebral atrophy Malar flattening Long philtrum Short nose Hyperkeratosis Proptosis Sensorineural hearing impairment Abnormality of the eye Pectus carinatum Abnormal cardiac septum morphology Scarring Sparse hair Irritability Feeding difficulties in infancy Abnormality of the kidney Low-set, posteriorly rotated ears Polyhydramnios Telecanthus Hypertrophic cardiomyopathy Aggressive behavior Hydronephrosis EEG abnormality Umbilical hernia Macrotia High forehead Abnormality of skin pigmentation


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Intrauterine growth retardation and Hypoplasia of the corpus callosum, related diseases and genetic alterations Optic atrophy and Erythema, related diseases and genetic alterations