Lymphoma, and Abnormal bleeding

Diseases related with Lymphoma and Abnormal bleeding

In the following list you will find some of the most common rare diseases related to Lymphoma and Abnormal bleeding that can help you solving undiagnosed cases.


Top matches:

Low match PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY; FPDMM


PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY; FPDMM Is also known as platelet disorder, aspirin-like|thrombocytopenia, familial, with propensity to acute myelogenous leukemia|fpd/aml

Related symptoms:

  • Anemia
  • Thrombocytopenia
  • Hernia
  • Hypospadias
  • Umbilical hernia


SOURCES: OMIM MENDELIAN

More info about PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY; FPDMM

Low match BURKITT LYMPHOMA


Burkitt lymphoma is a rare form of malignant mature B-cell non-Hodgkin lymphoma.

BURKITT LYMPHOMA Is also known as small non-cleaved cell lymphoma

Related symptoms:

  • Neoplasm
  • Immunodeficiency
  • Abdominal pain
  • Abnormality of the liver
  • Nausea and vomiting


SOURCES: OMIM ORPHANET MENDELIAN

More info about BURKITT LYMPHOMA

Low match EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2; EDSPD2


Related symptoms:

  • Scoliosis
  • Neoplasm
  • Fever
  • Inguinal hernia
  • Arthralgia


SOURCES: OMIM MENDELIAN

More info about EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2; EDSPD2

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Other less relevant matches:

Low match RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISEASE


RAS-associated autoimmune leukoproliferative disease (RALD) is a rare genetic disorder characterized by monocytosis, autoimmune cytopenias, lymphoproliferation, hepatosplenomegaly, and hypergammaglobulinemia.

RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISEASE Is also known as alps4|rald|autoimmune lymphoproliferative syndrome, type iv

Related symptoms:

  • Anemia
  • Hepatomegaly
  • Fever
  • Splenomegaly
  • Recurrent infections


SOURCES: ORPHANET OMIM MENDELIAN

More info about RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISEASE

Low match ESSENTIAL THROMBOCYTHEMIA


Essential thrombocythemia (ET) is a myeloproliferative neoplasm (MPN, see this term) characterized by a sustained elevation of platelet number (> 450 x 109/L) with a tendency for thrombosis and hemorrhage.

ESSENTIAL THROMBOCYTHEMIA Is also known as thrombocytosis 1|essential thrombocytosis|et

Related symptoms:

  • Pain
  • Hypertension
  • Hepatomegaly
  • Abnormality of the skeletal system
  • Respiratory distress


SOURCES: ORPHANET OMIM MENDELIAN

More info about ESSENTIAL THROMBOCYTHEMIA

Low match KAPOSI SARCOMA


Kaposi sarcoma (KS) is a rare human herpes virus 8 (HHV-8)-induced endothelial inflammatory neoplasm that develops is various clinically distinct settings, manifesting mostly as cutaneous lesions, or mucosal or visceral involvement.

KAPOSI SARCOMA Is also known as multiple idiopathic pigmented hemangiosarcoma, susceptibility to

Related symptoms:

  • Neoplasm
  • Hypertension
  • Fever
  • Fatigue
  • Edema


SOURCES: OMIM ORPHANET MENDELIAN

More info about KAPOSI SARCOMA

Low match AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME


Autoimmune lymphoproliferative syndrome (ALPS) is a rare, inherited disorder characterized by non-malignant lymphoproliferation, multilineage cytopenias, and a lifelong increased risk of Hodgkin's and non-Hodgkin's lymphoma.

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME Is also known as alps|autoimmune lymphoproliferative syndrome, type i, autosomal dominant|fas deficiency|canale-smith syndrome

Related symptoms:

  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Edema
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

Low match COMMON VARIABLE IMMUNODEFICIENCY


Common variable immunodeficiency (CVID) comprises a heterogeneous group of diseases characterized by a significant hypogammaglobulinemia of unknown cause, failure to produce specific antibodies after immunizations and susceptibility to bacterial infections, predominantly caused by encapsulated bacteria.

COMMON VARIABLE IMMUNODEFICIENCY Is also known as primary antibody deficiency|cvid|antibody deficiency due to icos defect|idiopathic immunoglobulin deficiency|primary hypogammaglobulinemia

Related symptoms:

  • Hepatomegaly
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency
  • Recurrent infections


SOURCES: ORPHANET OMIM MENDELIAN

More info about COMMON VARIABLE IMMUNODEFICIENCY

Low match DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 3; DKCA3


Dyskeratosis congenita is an inherited bone marrow failure syndrome classically characterized by the triad of mucosal leukoplakia, nail dysplasia, and abnormal skin pigmentation. Affected individuals have an increased risk of aplastic anemia and malignancy. Less common features include epiphora, premature gray hair, microcephaly, developmental delay, and pulmonary fibrosis, among others. The phenotype is highly variable. All affected individuals have shortened telomeres due to a defect in telomere maintenance (summary by Savage et al., 2008).For a discussion of genetic heterogeneity of dyskeratosis congenita, see DCKA1 (OMIM ).

Related symptoms:

  • Global developmental delay
  • Short stature
  • Hearing impairment
  • Microcephaly
  • Ataxia


SOURCES: OMIM MENDELIAN

More info about DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 3; DKCA3

Low match HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1


Zur Stadt et al. (2005) summarized the clinical features of hemophagocytic lymphohistiocytosis (HLH), a rare autosomal recessive disorder characterized by massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently central nervous system involvement. In FHL, the familial form of the disease, first episodes occur mostly during infancy, with a rapidly fatal outcome if untreated. Diagnostic criteria also include low fibrinogen and high triglyceride and ferritin levels. Chemoimmunotherapy based on corticosteroids, epipodophyllotoxins, and cyclosporin succeeds in controlling the disease in the majority of patients, although remission is rarely obtained (Henter et al., 2002). Most patients suffer an early death unless they are treated by hematopoietic stem cell transplantation (Durken et al., 1999). Genetic Heterogeneity of Familial Hemophagocytic LymphohistiocytosisFamilial hemophagocytic lymphohistiocytosis exhibits genetic heterogeneity. In some families, familial hemophagocytic lymphohistiocytosis has been found to be linked to chromosome 9q (HPLH1, FHL1). FHL2 (OMIM ) is caused by mutation in the PRF1 gene (OMIM ) on chromosome 10q22; FHL3 (OMIM ) is caused by mutation in the UNC13D gene (OMIM ) on chromosome 17q25; FHL4 (OMIM ) is caused by mutation in the syntaxin-11 gene (STX11 ) on chromosome 6q24; and FHL5 (OMIM ) is caused by mutation in the syntaxin-binding protein-2 (STXBP2 ), which is an interaction partner of STX11, on chromosome 19p13.Furthermore, before the identification of mutations in the RAG1 (OMIM ) and RAG2 (OMIM ) genes, both of which map to 11p, Omenn syndrome (familial reticuloendotheliosis with eosinophilia; {603554}) was not thought to be clearly distinct from other reported cases of hemophagocytic lymphohistiocytosis.

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1 Is also known as hemophagocytic reticulosis, familial|hlh1|hemophagocytic lymphohistiocytosis, familial|erythrophagocytic lymphohistiocytosis, familial|reticulosis, familial histiocytic|hplh1|fhl|fhlh|hplh|fel

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia
  • Neoplasm


SOURCES: OMIM MENDELIAN

More info about HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 1; FHL1

Top 5 symptoms//phenotypes associated to Lymphoma and Abnormal bleeding

Symptoms // Phenotype % cases
Anemia Uncommon - Between 30% and 50% cases
Lymphadenopathy Uncommon - Between 30% and 50% cases
Hepatomegaly Uncommon - Between 30% and 50% cases
Neoplasm Uncommon - Between 30% and 50% cases
Purpura Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Lymphoma and Abnormal bleeding. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases


Thrombocytopenia Splenomegaly Leukemia Hemolytic anemia Hepatosplenomegaly Abnormality of the liver Fever Immunodeficiency Vasculitis Hypertension Neutropenia Gastrointestinal hemorrhage Increased antibody level in blood Autoimmune thrombocytopenia Pancytopenia Lymphoproliferative disorder Acute leukemia Skin rash Recurrent infections Bruising susceptibility

Rare Symptoms - Less than 30% cases


Autoimmune neutropenia Autoimmune hemolytic anemia Recurrent respiratory infections Hodgkin lymphoma Leukopenia Lymphocytosis Follicular hyperplasia Decreased lymphocyte apoptosis Edema Abnormal intestine morphology Generalized edema Encephalopathy Pneumonia Abnormal lung morphology Cellular immunodeficiency Ataxia Global developmental delay Autoimmunity Eosinophilia Diarrhea Elevated hepatic transaminase Impaired platelet aggregation Prolonged bleeding time Abnormality of the spleen Abnormality of bone marrow cell morphology Irritability Arthralgia Umbilical hernia Myelodysplasia Increased VLDL cholesterol concentration Recurrent infection of the gastrointestinal tract Humoral immunodeficiency Posterior pharyngeal cleft Hypofibrinogenemia Short stature Hearing impairment Microcephaly Cryptorchidism T-cell lymphoma Growth delay Delayed speech and language development Intrauterine growth retardation Alopecia Cerebellar hypoplasia Osteoporosis Osteopenia Retinopathy Granulocytopenia Nail dystrophy Dry skin Abnormality of skin pigmentation Gastrointestinal stroma tumor Hemiplegia Impaired T cell function Plasmacytosis Anal atresia Decreased antibody level in blood Otitis media Recurrent otitis media Bronchiectasis Sinusitis Lymphopenia Recurrent pneumonia Recurrent bacterial infections Lipogranulomatosis Conjunctivitis Failure to thrive in infancy B lymphocytopenia Chronic otitis media Emphysema Restrictive ventilatory defect Bronchitis Recurrent sinusitis IgA deficiency IgG deficiency Polyneuritis CSF pleocytosis Increased total bilirubin IgM deficiency Recurrent bronchitis Nail dysplasia Partial albinism Pulmonary infiltrates Histiocytosis Tetraplegia Prolonged prothrombin time Sepsis Decreased HDL cholesterol concentration Prolonged partial thromboplastin time Hypoproteinemia Increased serum ferritin Gliosis Increased CSF protein Peripheral demyelination Severe combined immunodeficiency Hepatic failure Episodic fever Combined immunodeficiency Hypertriglyceridemia Abnormality of the coagulation cascade Albinism Hyponatremia Aspiration Meningitis Hyperbilirubinemia Increased intracranial pressure Encephalitis Coma Confusion Increased LDL cholesterol concentration Aseptic necrosis Hypoalbuminemia Cerebral calcification Fine hair Hyperpigmentation of the skin Bone marrow hypocellularity Hemophagocytosis Portal hypertension Epiphora Pulmonary fibrosis Premature graying of hair Interstitial pulmonary abnormality Oral leukoplakia Abnormality of the nervous system Aplastic anemia Esophageal stricture Phimosis Reticulated skin pigmentation Pulmonary hemorrhage Seizures Generalized hypotonia Failure to thrive Muscular hypotonia Hypertonia Brachycephaly Jaundice Iron deficiency anemia Intermediate uveitis Headache Gingival bleeding Premature loss of teeth Periodontitis Gingival recession Respiratory tract infection Cardiac arrest Recurrent upper respiratory tract infections Monocytosis Pain Abnormality of the skeletal system Respiratory distress Dyspnea Atrophic scars Paresthesia Vertigo Chest pain Myocardial infarction Venous thrombosis Leukocytosis Myeloid leukemia Pulmonary embolism Thrombocytosis Transient ischemic attack Acrocyanosis Fragile skin Nephroblastoma Abnormality of the cerebral vasculature Intestinal obstruction Hernia Hypospadias Epistaxis Acute myeloid leukemia Neuroblastoma Acute lymphoblastic leukemia Acute monocytic leukemia Refractory anemia Abdominal pain Nausea and vomiting Hyperuricemia Hyperextensible skin B-cell lymphoma Abnormality of the pancreas Abnormality of the ovary Decreased proportion of CD4-positive T cells Abnormality of the lymph nodes Burkitt lymphoma Increased lactate dehydrogenase activity Neoplasm of the oral cavity Scoliosis Inguinal hernia Joint hypermobility Osteoarthritis Gangrene Arterial thrombosis Increased proportion of HLA DR+ T cells Chronic noninfectious lymphadenopathy Hepatitis Urticaria Glomerulonephritis Petechiae Basal cell carcinoma Uveitis Hepatocellular carcinoma Antinuclear antibody positivity Multiple myeloma Chronic lymphatic leukemia Extramedullary hematopoiesis Increased IgA level Renal insufficiency Antiphospholipid antibody positivity Increased IgM level Reduced delayed hypersensitivity Increased IgG level Cervical lymphadenopathy Rheumatoid factor positive Coombs-positive hemolytic anemia Platelet antibody positive Antineutrophil antibody positivity Smooth muscle antibody positivity Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells Carcinoma Neoplasm by anatomical site Abnormal thrombocyte morphology Pulmonary arterial hypertension Myeloproliferative disorder Amaurosis fugax Myelofibrosis Bloody diarrhea Abnormal platelet morphology Decreased mean platelet volume Abnormal platelet aggregation Increased megakaryocyte count Fatigue Weight loss Papule Lymphedema Susceptibility to herpesvirus Neoplasm of the skin Hemangioma Sarcoma Hypermelanotic macule Abnormal retinal morphology Macule Abnormality of the gastrointestinal tract Abnormality of the lower limb Skin nodule Venous insufficiency Generalized lymphadenopathy Skin plaque Abnormal natural killer cell physiology



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