Leukemia, and Stage 5 chronic kidney disease

Diseases related with Leukemia and Stage 5 chronic kidney disease

In the following list you will find some of the most common rare diseases related to Leukemia and Stage 5 chronic kidney disease that can help you solving undiagnosed cases.

Top matches:

ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH MCP/CD46 ANOMALY Is also known as ahus with mcp/cd46 anomaly|hemolytic-uremic syndrome without diarrhea with mcp/cd46 anomaly|ahus, susceptibility to, 2|atypical hus with mcp/cd46 anomaly|d-hus with mcp/cd46 anomaly

Related symptoms:

  • Hypertension
  • Renal insufficiency
  • Thrombocytopenia
  • Proteinuria
  • Stage 5 chronic kidney disease


SOURCES: OMIM ORPHANET MENDELIAN

More info about ATYPICAL HEMOLYTIC-UREMIC SYNDROME WITH MCP/CD46 ANOMALY

Schimke immuno-osseous dysplasia (SIOD) is a multisystem disorder characterized by spondyloepiphyseal dysplasia and disproportionate short stature, facial dysmorphism, T-cell immunodeficiency, and glomerulonephritis with nephrotic syndrome.

SCHIMKE IMMUNO-OSSEOUS DYSPLASIA Is also known as immunoosseous dysplasia, schimke type|schimke syndrome|spondyloepiphyseal dysplasia-nephrotic syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Scoliosis
  • Growth delay


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about SCHIMKE IMMUNO-OSSEOUS DYSPLASIA

Macrothrombocytopenia with or without granulocyte inclusions, nephritis, or sensorineural hearing loss was previously thought to be comprised of 4 distinct entities with overlapping features: Fechtner syndrome, May-Hegglin anomaly, Epstein syndrome, and Sebastian syndrome. Fechtner syndrome was characterized by the triad of thrombocytopenia, giant platelets, and Dohle body-like inclusions in peripheral blood leukocytes, with the additional Alport syndrome (OMIM )-like features of nephritis, hearing loss, and eye abnormalities, predominantly cataracts (Peterson et al., 1985). May-Hegglin anomaly was characterized by the triad of thrombocytopenia, giant platelets, and Dohle body-like inclusions in peripheral blood leukocytes. Epstein syndrome was characterized by thrombocytopenia, deafness, and nephritis, and lacked leukocyte inclusion bodies on classic staining of peripheral blood smears. Sebastian syndrome was similar to May-Hegglin anomaly, but had a different ultrastructural appearance of the leukocyte inclusions. Seri et al. (2003) suggested that these 4 disorders were not distinct entities, but rather represented a single disorder with a continuous clinical spectrum because variable phenotypic expression is observed not only between families but also within families having the same MYH9 mutation. In addition, Balduini et al. (2011) noted that all patients present leukocyte inclusion bodies, although of variable size. Seri et al. (2003) proposed the term 'MYH9-related disease' for the disorder; however, an isolated form of nonsyndromic deafness (DFNA17 ) is also caused by mutation in the MYH9 gene.

MACROTHROMBOCYTOPENIA AND GRANULOCYTE INCLUSIONS WITH OR WITHOUT NEPHRITIS OR SENSORINEURAL HEARING LOSS; MATINS Is also known as may-hegglin anomaly|apsm, formerly|macrothrombocytopenia, nephritis, and deafness|fechtner syndrome|alport syndrome with macrothrombocytopenia, formerly|macrothrombocytopenia with dispersed leukocytic inclusions|bleeding disorder, platelet-type, 6|macroth

Related symptoms:

  • Hearing impairment
  • Sensorineural hearing impairment
  • Cataract
  • Gait disturbance
  • Renal insufficiency


SOURCES: ORPHANET OMIM MENDELIAN

More info about MACROTHROMBOCYTOPENIA AND GRANULOCYTE INCLUSIONS WITH OR WITHOUT NEPHRITIS OR SENSORINEURAL HEARING LOSS; MATINS

Other less relevant matches:

COMPLEMENT COMPONENT 2 DEFICIENCY; C2D Is also known as c2 deficiency

Related symptoms:

  • Hypertension
  • Renal insufficiency
  • Immunodeficiency
  • Recurrent infections
  • Arthralgia


SOURCES: OMIM MENDELIAN

More info about COMPLEMENT COMPONENT 2 DEFICIENCY; C2D

Muckle-Wells syndrome (MWS) is characterized by episodic skin rash, arthralgias, and fever associated with late-onset sensorineural deafness and renal amyloidosis (Dode et al., 2002).See also familial cold-induced autoinflammatory syndrome-1 (FCAS1, CAPS1; {120100}), an allelic disorder with overlapping clinical features.

MUCKLE-WELLS SYNDROME; MWS Is also known as caps2|uda syndrome|urticaria-deafness-amyloidosis syndrome|cryopyrin-associated periodic syndrome 2

Related symptoms:

  • Seizures
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about MUCKLE-WELLS SYNDROME; MWS

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency disease characterized by microthrombocytopenia, eczema, infections and an increased risk for autoimmune manifestations and malignancies.

WISKOTT-ALDRICH SYNDROME Is also known as aldrich syndrome|imd2|immunodeficiency 2|eczema-thrombocytopenia-immunodeficiency syndrome|was|was1|wiskott-aldrich syndrome 1

Related symptoms:

  • Neoplasm
  • Anemia
  • Peripheral neuropathy
  • Fever
  • Fatigue


SOURCES: OMIM ORPHANET MENDELIAN

More info about WISKOTT-ALDRICH SYNDROME

NPHS14 is an autosomal recessive syndromic form of steroid-resistant nephrotic syndrome with multisystemic manifestations. Most affected individuals present in infancy or early childhood with progressive renal dysfunction associated with focal segmental glomerulosclerosis (FSGS) and resulting in end-stage renal disease within a few years. Other infants present with primary adrenal insufficiency. Some patients present in utero with fetal hydrops and fetal demise. Additional features of the disorder can include ichthyosis, acanthosis, adrenal insufficiency, immunodeficiency, and neurologic defects (summary by Prasad et al., 2017 and Lovric et al., 2017).For a discussion of genetic heterogeneity of nephrotic syndrome and FSGS, see NPHS1 (OMIM ).

FAMILIAL STEROID-RESISTANT NEPHROTIC SYNDROME WITH ADRENAL INSUFFICIENCY Is also known as primary adrenal insufficiency-steroid-resistant nephrotic syndrome due to sgpl1 deficiency

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Hearing impairment
  • Microcephaly


SOURCES: ORPHANET OMIM MENDELIAN

More info about FAMILIAL STEROID-RESISTANT NEPHROTIC SYNDROME WITH ADRENAL INSUFFICIENCY

Syndromic recessive X-linked ichthyosis (RXLI) refers to the cases of RXLI (see this term) that are associated with extracutaneous manifestations as part of a syndrome.

SYNDROMIC RECESSIVE X-LINKED ICHTHYOSIS Is also known as recessive x-linked ichthyosis with extracutaneous manifestations|syndromic rxli

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Cryptorchidism


SOURCES: ORPHANET MENDELIAN

More info about SYNDROMIC RECESSIVE X-LINKED ICHTHYOSIS

Autoimmune lymphoproliferative syndrome (ALPS) is a rare, inherited disorder characterized by non-malignant lymphoproliferation, multilineage cytopenias, and a lifelong increased risk of Hodgkin's and non-Hodgkin's lymphoma.

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME Is also known as alps|autoimmune lymphoproliferative syndrome, type i, autosomal dominant|fas deficiency|canale-smith syndrome

Related symptoms:

  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Edema
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME

Alport syndrome is an inherited disorder of the basement membrane, resulting in progressive renal failure due to glomerulonephropathy, variable sensorineural hearing loss, and variable ocular anomalies (review by Kashtan, 1999).Alport syndrome is a genetically heterogeneous disorder, with all forms resulting from mutations in genes encoding type IV collagen, which is a major structural component of the basement membrane. Approximately 85% of cases of Alport syndrome are X-linked and about 15% are autosomal recessive (OMIM ); autosomal dominant inheritance (OMIM ) is rare (Kashtan, 1999).See also benign familial hematuria (BFH ), a phenotypically similar, but milder disorder.Alport syndrome is also a feature of 2 contiguous gene deletion syndromes involving the COL4A5 gene: Alport syndrome and diffuse leiomyomatosis (OMIM ) and Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis (AMME ).

ALPORT SYNDROME, X-LINKED; ATS Is also known as nephropathy and deafness, x-linked

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Sensorineural hearing impairment
  • Cataract
  • Hypertension


SOURCES: ORPHANET OMIM MENDELIAN

More info about ALPORT SYNDROME, X-LINKED; ATS

Top 5 symptoms//phenotypes associated to Leukemia and Stage 5 chronic kidney disease

Symptoms // Phenotype % cases
Renal insufficiency Very Common - Between 80% and 100% cases
Thrombocytopenia Common - Between 50% and 80% cases
Proteinuria Common - Between 50% and 80% cases
Ichthyosis Uncommon - Between 30% and 50% cases
Nephrotic syndrome Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Leukemia and Stage 5 chronic kidney disease. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Immunodeficiency Recurrent infections Anemia Vasculitis Autoimmunity Seizures Sensorineural hearing impairment Hypertension Glomerulonephritis Hematuria Hearing impairment Glomerulopathy Nephropathy Focal segmental glomerulosclerosis Nephritis Microscopic hematuria Arthritis Glomerulosclerosis Purpura Chronic kidney disease Lymphoma Diarrhea Fatigue Lymphadenopathy Urticaria Edema Intellectual disability Lymphopenia Fever

Rare Symptoms - Less than 30% cases

Antinuclear antibody positivity Congenital cataract Retinopathy Hypogonadism Conjunctivitis Cryptorchidism Global developmental delay Reduced delayed hypersensitivity Combined immunodeficiency Increased IgA level Acute leukemia Steroid-resistant nephrotic syndrome Hodgkin lymphoma Cataract Bruising susceptibility Membranoproliferative glomerulonephritis Bilateral sensorineural hearing impairment Hepatosplenomegaly Epistaxis Prolonged bleeding time Petechiae Arthralgia Hemolytic anemia Skin rash Dyspnea Splenomegaly Peripheral neuropathy Neoplasm Rheumatoid arthritis Iron deficiency anemia Meningitis Developmental regression Short stature Hypothyroidism Neutropenia Headache Pneumonia Corneal opacity Vomiting Myopia Specific anti-polysaccharide antibody deficiency Oral bleeding Reduced lymphocyte surface expression of CD43 Generalized hypotonia Microcephaly Ataxia Strabismus Elevated serum creatinine Ptosis Abnormal delayed hypersensitivity skin test Acute kidney injury Hemolytic-uremic syndrome Micropenis Portal hypertension Hypocalcemia Primary hypothyroidism Primary adrenal insufficiency Adrenal insufficiency Focal impaired awareness seizure Hypoalbuminemia Recurrent bacterial infections Hypertriglyceridemia Chronic leukemia Epidermal acanthosis Focal-onset seizure Hepatic failure Mental deterioration Abnormality of the nervous system Hypoglycemia Absent microvilli on the surface of peripheral blood lymphocytes Microdontia Recurrent intrapulmonary hemorrhage Gingival bleeding Hypoplasia of the thymus Chronic obstructive pulmonary disease Hematochezia Microangiopathic hemolytic anemia Recurrent lower respiratory tract infections Blepharitis Monoclonal immunoglobulin M proteinemia Recurrent ear infections Microcytic anemia Cellulitis Scoliosis Keratitis Hyperostosis Inflammation of the large intestine IgM deficiency Increased IgE level Diffuse mesangial sclerosis Internal hemorrhage Large vessel vasculitis Increased blood urea nitrogen Congenital thrombocytopenia Abnormal platelet morphology Decreased mean platelet volume Abnormal platelet function Abnormal eosinophil morphology Abnormality of the menstrual cycle Generalized lymphadenopathy Bloody diarrhea Spontaneous hematomas Melena Hematemesis Anuria Interstitial pneumonitis Small vessel vasculitis Absent testis Congenital nephrotic syndrome Photophobia Tinnitus Corneal dystrophy Leukopenia Subcutaneous nodule Dry skin Pallor Weight loss Hypoparathyroidism Midface retrusion Dysphagia Intermediate uveitis Increased proportion of HLA DR+ T cells Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells Smooth muscle antibody positivity Macular dystrophy Edema of the lower limbs Decreased lymphocyte apoptosis Uterine neoplasm Morphological abnormality of the semicircular canal Lentiglobus Anterior lenticonus Diffuse leiomyomatosis Diffuse glomerular basement membrane lamellation Neoplasm of the colon Lenticonus Tubulointerstitial nephritis Thickening of the glomerular basement membrane Macroscopic hematuria Periorbital edema Elliptocytosis Abdominal situs inversus Foam cells Corneal erosion Antineutrophil antibody positivity Platelet antibody positive Intracranial hemorrhage Abdominal wall defect Eosinophilia Hepatitis Carcinoma Hepatomegaly Testicular seminoma Abnormality of the stomach Abnormality of the abdominal wall Basal cell carcinoma Dysphasia Unilateral renal agenesis Lissencephaly Hypohidrosis Attention deficit hyperactivity disorder Autism Hyperkeratosis Increased antibody level in blood Autoimmune hemolytic anemia Coombs-positive hemolytic anemia Antiphospholipid antibody positivity Rheumatoid factor positive Cervical lymphadenopathy Increased IgG level Autoimmune neutropenia Increased IgM level Follicular hyperplasia Chronic noninfectious lymphadenopathy Autoimmune thrombocytopenia Lymphocytosis Extramedullary hematopoiesis Chronic lymphatic leukemia Generalized edema Multiple myeloma Hepatocellular carcinoma Uveitis Chronic otitis media Chronic diarrhea Sarcoma Cellular immunodeficiency Abnormality of skin pigmentation Multiple lentigines Mucopolysacchariduria Hypoplasia of the capital femoral epiphysis Arteriosclerosis Right ventricular cardiomyopathy Dentinogenesis imperfecta Increased thyroid-stimulating hormone level Subvalvular aortic stenosis Precocious atherosclerosis Cerebral ischemia Villous atrophy Lymphoproliferative disorder B-cell lymphoma Shallow acetabular fossae Encephalomalacia Ovoid vertebral bodies Malabsorption Gastrointestinal hemorrhage Paraplegia Hip dislocation Spastic paraplegia Gait disturbance Platyspondyly Astigmatism Abnormal T cell morphology Lateral displacement of the femoral head Nephrosclerosis Anterior pituitary dysgenesis Premature arteriosclerosis Moyamoya phenomenon Abnormal immunoglobulin level Disproportionate short-trunk short stature Thoracic kyphosis Scarring Waddling gait Reduced bone mineral density Azoospermia Hyperlipidemia Atherosclerosis Opacification of the corneal stroma Bone marrow hypocellularity Abnormality of epiphysis morphology Premature birth Heterotopia Abnormal form of the vertebral bodies Abnormal lung morphology Fine hair Intellectual disability, profound Lumbar hyperlordosis Coarse hair Encephalitis Transient ischemic attack High pitched voice Abnormality of the vasculature Protuberant abdomen Bulbous nose Multiple cafe-au-lait spots Steatorrhea Hypermelanotic macule Emphysema Migraine Abnormal cerebellum morphology Spondyloepiphyseal dysplasia Melanocytic nevus Gliosis Brain atrophy Epiphyseal dysplasia Stroke Myocardial infarction Recurrent upper respiratory tract infections Cystinuria Cognitive impairment Depressed nasal bridge Motor delay Rigors Renal amyloidosis Band keratopathy Chills Recurrent respiratory infections Recurrent aphthous stomatitis Papilledema Abnormality of the mouth Episodic fever Amyloidosis Progressive sensorineural hearing impairment Arrhythmia Abnormal facial shape Leukocytosis Specific learning disability Skin ulcer Sinusitis Decreased testicular size Recurrent otitis media Pancytopenia Eczema Otitis media Respiratory tract infection Sudden cardiac death Chest pain Abnormal bleeding Sepsis Growth delay Cough Elevated erythrocyte sedimentation rate Intrauterine growth retardation Spastic gait Giant platelets Abnormality of the kidney Moderate proteinuria Leukocyte inclusion bodies Bifid clitoris Exstrophy Bladder exstrophy Macrothrombocytopenia Osteopenia Abnormal thrombosis Impaired platelet aggregation Ecchymosis Single umbilical artery Hyperlordosis Menorrhagia Thin upper lip vermilion Dementia Short neck Abnormality of the skeletal system Abnormality of the skin Coma Cardiomyopathy Cerebellar atrophy Myalgia Abdominal pain Congestive heart failure Systemic lupus erythematosus Pain Vasculitis in the skin Discoid lupus rash Angioedema Abnormality of the dentition Kyphosis Fatigable weakness Cylindruria


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