Leukemia, and Myalgia

Diseases related with Leukemia and Myalgia

In the following list you will find some of the most common rare diseases related to Leukemia and Myalgia that can help you solving undiagnosed cases.

Top matches:

Related symptoms:

  • Hepatomegaly
  • Splenomegaly
  • Myalgia
  • Abnormality of the nervous system
  • Pruritus


SOURCES: ORPHANET OMIM MENDELIAN

More info about CHRONIC EOSINOPHILIC LEUKEMIA

Primary familial polycythemia is an inherited hematological disorder resulting from mutations in the erythropoietin (EPO) receptor and is characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production in the presence of low EPO levels.

PRIMARY FAMILIAL POLYCYTHEMIA Is also known as polycythemia, primary familial and congenital|primary familial and congenital polycythemia|familial erythrocytosis|erythrocytosis, autosomal dominant benign|pfcp|congenital polycythemia due to erythropoietin receptor mutation|congenital erythrocytosis due

Related symptoms:

  • Pain
  • Hypertension
  • Fatigue
  • Respiratory distress
  • Splenomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about PRIMARY FAMILIAL POLYCYTHEMIA

Other less relevant matches:

Mastocytosis, or mast cell disease, is a heterogeneous group of clinical disorders characterized by the abnormal accumulation of mast cells in various tissues, especially in the skin and hematopoietic organs. Mastocytosis usually appears in infancy or early adulthood. In most pediatric cases, the disease is limited to the skin, but it can be associated with systemic symptoms due to the release of mediators from mast cells, even when there is no systemic infiltration. It usually has a good prognosis, with substantial improvement or spontaneous resolution before puberty. In rare cases, the disease may remain active through adolescence as a systemic adult mastocytosis. Cutaneous mastocytosis is characterized by macules, papules, nodules, or diffuse infiltration of the skin, often associated with localized hyperpigmentation. Gentle rubbing of the lesions induces histamine release from mechanically activated mast cells, causing local wheals, erythema, and often pruritus, a phenomenon termed the 'Darier sign.' In contrast to childhood-onset mastocytosis, adult-onset mastocytosis often persists for the lifetime of the patient and is also more likely to be a severe and systemic disease involving numerous organs. In some cases, it is associated with a clonal hematologic non-mast-cell lineage disease, such as a myelodysplastic or myeloproliferative disorder. Adult-onset mastocytosis can also lead to the rare mast cell leukemia, which carries a high risk of mortality (summary by Bodemer et al., 2010 and Kambe et al., 2010).

MASTOCYTOSIS, CUTANEOUS; MASTC Is also known as mastocytosis, maculopapular cutaneous|mastocytosis, diffuse cutaneous|urticaria pigmentosa

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hypertension
  • Hepatomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about MASTOCYTOSIS, CUTANEOUS; MASTC

G6PD deficiency is the most common genetic cause of chronic and drug-, food-, or infection-induced hemolytic anemia. G6PD catalyzes the first reaction in the pentose phosphate pathway, which is the only NADPH-generation process in mature red cells; therefore, defense against oxidative damage is dependent on G6PD. Most G6PD-deficient patients are asymptomatic throughout their life, but G6PD deficiency can be life-threatening. The most common clinical manifestations of G6PD deficiency are neonatal jaundice and acute hemolytic anemia, which in most patients is triggered by an exogenous agent, e.g., primaquine or fava beans. Acute hemolysis is characterized by fatigue, back pain, anemia, and jaundice. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. The striking similarity between the areas where G6PD deficiency is common and Plasmodium falciparum malaria (see {611162}) is endemic provided evidence that G6PD deficiency confers resistance against malaria (summary by Cappellini and Fiorelli, 2008).

ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY Is also known as favism, susceptibility to

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Muscle weakness
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY

Dopamine beta-hydroxylase deficiency is an extremely rare genetic metabolic disorder characterized by autonomic dysregulation leading mainly to orthostatic hypotension.

DOPAMINE BETA-HYDROXYLASE DEFICIENCY Is also known as norepinephrine deficiency|noradrenaline deficiency

Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Muscular hypotonia
  • Pain
  • Ptosis


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about DOPAMINE BETA-HYDROXYLASE DEFICIENCY

Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations.

HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS Is also known as mac duffie syndrome|mac duffie hypocomplementemic urticarial vasculitis|anti-c1q vasculitis|mcduffie hypocomplementemic urticarial vasculitis|mcduffie syndrome

Related symptoms:

  • Seizures
  • Ataxia
  • Sensorineural hearing impairment
  • Pain
  • Peripheral neuropathy


SOURCES: ORPHANET MENDELIAN

More info about HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS

Autoinflammation, panniculitis, and dermatosis syndrome (AIPDS) is an autosomal recessive autoinflammatory disease characterized by neonatal onset of recurrent fever, erythematous rash with painful nodules, painful joints, and lipodystrophy. Additional features may include diarrhea, increased serum C-reactive protein, leukocytosis, and neutrophilia in the absence of any infection. Patients exhibit no overt primary immunodeficiency (Damgaard et al., 2016 and Zhou et al., 2016).

INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME Is also known as otulipenia|oras|otulin deficiency|otulin-related autoinflammatory syndrome

Related symptoms:

  • Failure to thrive
  • Fever
  • Diarrhea
  • Immunodeficiency
  • Arthralgia


SOURCES: ORPHANET OMIM MENDELIAN

More info about INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME

Familial cold autoinflammatory syndrome is characterized clinically by recurrent attacks of a maculopapular rash associated with arthralgias, myalgias, fever and chills, and swelling of the extremities after exposure to cold. Despite the first description of 'cold urticaria' (Kile and Rusk, 1940) the rash in most patients is nonpruritic and nonurticarial. Rarely, some patients may also develop late-onset renal amyloidosis (Hoffman et al., 2000).Overlapping syndromes also caused by mutation in the NLRP3 gene include Muckle-Wells syndrome (CAPS2 ), which has a high frequency of amyloidosis and late-onset sensorineural deafness, and chronic neurologic cutaneous and articular syndrome (CINCA, CAPS3; {607115}), which shows earlier onset and a more severe phenotype. Genetic Heterogeneity of Familial Cold Autoinflammatory SyndromeSee also FCAS2 (OMIM ), caused by mutation in the NLRP12 gene (OMIM ) on chromosome 19q13; FCAS3 (OMIM ), caused by mutation in the PLCG2 gene (OMIM ) on chromosome 16q23; and FCAS4 (OMIM ), caused by mutation in the NLRC4 gene (OMIM ) on chromosome 2p22.

FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1; FCAS1 Is also known as cold urticaria, familial|fcas|cold hypersensitivity|caps1|fcu|cold-induced autoinflammatory syndrome, familial|cryopyrin-associated periodic syndrome 1

Related symptoms:

  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain
  • Fever
  • Headache


SOURCES: OMIM MENDELIAN

More info about FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1; FCAS1

Complete deficiency of erythrocyte AMP deaminase is a clinically benign disorder (Ogasawara et al., 1987; Zydowo et al., 1989).

Related symptoms:

  • Pain
  • Fatigue
  • Myalgia


SOURCES: OMIM MENDELIAN

More info about ERYTHROCYTE AMP DEAMINASE DEFICIENCY

Top 5 symptoms//phenotypes associated to Leukemia and Myalgia

Symptoms // Phenotype % cases
Pain Common - Between 50% and 80% cases
Arthralgia Uncommon - Between 30% and 50% cases
Splenomegaly Uncommon - Between 30% and 50% cases
Skin rash Uncommon - Between 30% and 50% cases
Fatigue Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Leukemia and Myalgia. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Pruritus Hepatomegaly Lymphadenopathy Diarrhea Urticaria Leukocytosis Headache Abdominal pain Fever Hypertension

Rare Symptoms - Less than 30% cases

Vasculitis Nausea Nausea and vomiting Cirrhosis Ascites Amyloidosis Immunologic hypersensitivity Conjunctivitis Anemia Neoplasm Angioedema Hypotension Peripheral neuropathy Sensorineural hearing impairment Lymphoma Cough Mastocytosis Myeloproliferative disorder Vertigo Dyspnea Meningitis Seizures Venous thrombosis Abnormality of the nervous system Nonspherocytic hemolytic anemia Retrograde ejaculation Hemoglobinuria Nocturia Multiple myeloma Unconjugated hyperbilirubinemia Ataxia Recurrent hypoglycemia Intermittent hypothermia Muscular hypotonia Hypothermia Neonatal hypoglycemia Ptosis Orthostatic hypotension Blurred vision Epiphora Abnormal autonomic nervous system physiology Dehydration Syncope Fava bean-induced hemolytic anemia Hypoglycemia Vomiting Renal insufficiency Generalized hypotonia High palate Kernicterus Reduced tendon reflexes Arthritis Lipodystrophy Complement deficiency Episcleritis Obstructive lung disease Small vessel vasculitis Failure to thrive Immunodeficiency Scarring Joint swelling Uveitis Neutrophilia Panniculitis Hearing impairment Petechiae Episodic fever Chills Renal amyloidosis Inflammatory abnormality of the eye Irregular hyperpigmentation Proteinuria Anisocytosis Autoimmunity Hematuria Sensory neuropathy Recurrent bacterial infections Joint dislocation Cranial nerve paralysis Cerebral palsy Pleural effusion Hemoptysis Nephritis Hemiplegia/hemiparesis Emphysema Restrictive ventilatory defect Pericardial effusion Abnormal heart valve morphology Glomerulopathy Poikilocytosis Chronic leukemia Reticulocytosis Hepatosplenomegaly Edema Thrombocytopenia Arrhythmia Osteoporosis Weight loss Gastroesophageal reflux Erythema Increased red blood cell mass Papule Malabsorption Ichthyosis Tachycardia Recurrent fractures Sudden cardiac death Asthma Peripheral thrombosis Plethora Abnormal blistering of the skin Abnormal bleeding Eosinophilia Pulmonary infiltrates Restrictive cardiomyopathy Endocardial fibrosis Respiratory distress Stroke Epistaxis Increased hematocrit Myocardial infarction Cerebral hemorrhage Exertional dyspnea Polycythemia Thromboembolism Abnormal hemoglobin Increased hemoglobin Gastrointestinal hemorrhage Telangiectasia Hodgkin lymphoma Muscle weakness Abnormality of the gastric mucosa Dermatographic urticaria Cutaneous mastocytosis Anaphylactic shock Telangiectasia macularis eruptiva perstans Intellectual disability Jaundice Abnormal eosinophil morphology Pallor Hemolytic anemia Abnormality of the cardiovascular system Hyperbilirubinemia Back pain Osteomyelitis Prolonged neonatal jaundice Food intolerance Impaired temperature sensation Bone pain Loss of consciousness Bone marrow hypocellularity Osteolysis Leukopenia Shock Sarcoma Portal hypertension Hypermelanotic macule Asthenia Abnormality of blood and blood-forming tissues Acute leukemia Flushing Allergy Generalized osteosclerosis Hypersplenism Gastrointestinal stroma tumor Cold urticaria


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