Leukemia, and Atrial fibrillation

Diseases related with Leukemia and Atrial fibrillation

In the following list you will find some of the most common rare diseases related to Leukemia and Atrial fibrillation that can help you solving undiagnosed cases.

Top matches:

Cutis marmorata telangiectatica congenita (CMTC) is a congenital localized or generalized vascular anomaly characterized by a persistent cutis marmorata pattern with a marbled bluish to deep purple appearance, spider nevus-like telangiectasia, phlebectasia and, occasionally, ulceration and atrophy of the affected skin.

CUTIS MARMORATA TELANGIECTATICA CONGENITA Is also known as megalencephaly-cutis marmorata telangiectatica congenita|cmtc|mcmtc|megalencephaly-capillary malformation syndrome|macrocephaly-cutis marmorata telangiectatica congenita|mcm|macrocephaly-capillary malformation

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Scoliosis


SOURCES: OMIM ORPHANET MENDELIAN

More info about CUTIS MARMORATA TELANGIECTATICA CONGENITA

Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by uncoordinated atrial activation with consequent deterioration of atrial mechanical function. It is the most common sustained cardiac rhythm disturbance, and its prevalence increases as the population ages. An estimated 70,000 strokes each year are caused by atrial fibrillation (summary by Oberti et al., 2004).For a discussion of genetic heterogeneity of atrial fibrillation, see {608583}.

Related symptoms:

  • Cardiomyopathy
  • Abnormal heart morphology
  • Tachycardia
  • Atrial fibrillation
  • Supraventricular tachycardia


SOURCES: OMIM MENDELIAN

More info about ATRIAL FIBRILLATION, FAMILIAL, 15; ATFB15

MN antigens reside on GYPA, one of the most abundant red-cell glycoproteins. The M and N antigens are 2 autosomal codominant antigens encoded by the first 5 amino acids of GYPA and include 3 O-linked glycans as part of the epitope. M and N differ at amino acids 1 and 5, where M is ser-ser-thr-thr-gly, and N is leu-ser-thr-thr-glu. M is the ancestral GYPA allele and is common in all human populations and Old World apes. GYPA, glycophorin B (GYPB ), and glycophorin E (GYPE ) are closely linked on chromosome 4q31. The N terminus of GYPB is essentially identical to that of GYPA except that it always expresses the N antigen, denoted 'N' or N-prime. Antigens of the Ss blood group (OMIM ) reside on GYPB, and recombination and gene conversion between GYPA, GYPB, and GYPE lead to hybrid glycophorin molecules and generation of low-incidence antigens. Thus, the MN and Ss blood groups are together referred to as the MNSs or MNS blood group system. The U antigen refers to a short extracellular sequence in GYPB located near the membrane. Recombination results in 3 glycophorin-null phenotypes: En(a-) cells lack GYPA due to recombination between GYPA and GYPB; GYPB-negative (S-s-U-) cells lack GYPB due to recombination in GYPB; and M(k) cells (M-N-S-s-U-) lack both GYPA and GYPB due to recombination between GYPA and GYPE. Individuals with glycophorin-null phenotypes have decreased sialic acid content and increased resistance to malarial infection (see {611162}). GYPA and GYPB are not essential for red-cell development or survival, and GYPA- and GYPB-null phenotypes are not associated with anemia or altered red-cell function (review by Cooling, 2015).

BLOOD GROUP, MN; MN Is also known as mn blood group

Related symptoms:

  • Neoplasm
  • Anemia
  • Leukemia


SOURCES: OMIM MENDELIAN

More info about BLOOD GROUP, MN; MN

Other less relevant matches:

Noonan syndrome (NS) is an autosomal dominant disorder characterized by short stature, facial dysmorphism, and a wide spectrum of congenital heart defects. The distinctive facial features consist of a broad forehead, hypertelorism, downslanting palpebral fissures, a high-arched palate, and low-set, posteriorly rotated ears. Cardiac involvement is present in up to 90% of patients. Pulmonic stenosis and hypertrophic cardiomyopathy are the most common forms of cardiac disease, but a variety of other lesions are also observed. Additional relatively frequent features include multiple skeletal defects (chest and spine deformities), webbed neck, mental retardation, cryptorchidism, and bleeding diathesis (summary by Tartaglia et al., 2002). Genetic Heterogeneity of Noonan SyndromeSee also NS3 (OMIM ), caused by mutation in the KRAS gene (OMIM ); NS4 (OMIM ), caused by mutation in the SOS1 gene (OMIM ); NS5 (OMIM ), caused by mutation in the RAF1 gene (OMIM ); NS6 (OMIM ), caused by mutation in the NRAS gene (OMIM ); NS7 (OMIM ), caused by mutation in the BRAF gene (OMIM ); NS8 (OMIM ), caused by mutation in the RIT1 gene (OMIM ); NS9 (OMIM ), caused by mutation in the SOS2 gene (OMIM ); and NS10 (OMIM ), caused by mutation in the LZTR1 gene (OMIM ).See also NS2 (OMIM ) for a possible autosomal recessive form of NS; Noonan syndrome-like disorder with loose anagen hair-1 (NSLH1 ), caused by mutation in the SHOC2 gene (OMIM ); Noonan syndrome-like disorder with loose anagen hair-2 (NSLH2 ), caused by mutation in the PPP1CB gene (OMIM ); and Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL ), caused by mutation in the CBL gene (OMIM ).Mutations in the neurofibromin gene (NF1 ), which is the site of mutations causing classic neurofibromatosis type I (NF1 ), have been found in neurofibromatosis-Noonan syndrome (NFNS ).

NOONAN SYNDROME 1; NS1 Is also known as female pseudo-turner syndrome|male turner syndrome|noonan syndrome|turner phenotype with normal karyotype

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Microcephaly


SOURCES: OMIM MENDELIAN

More info about NOONAN SYNDROME 1; NS1

Warfarin is a widely prescribed anticoagulant for the prevention of thromboembolic diseases for subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement (Yuan et al., 2005). The dose requirement is highly variable, both interindividually and interethnically.Variation in the VKORC1 gene is believed to be the most important individual predictor of warfarin dose, accounting for about 30% of the variance observed in dosing (Ross et al., 2010).

COUMARIN RESISTANCE Is also known as coumarin, poor metabolism of|warfarin resistance

Related symptoms:

  • Abnormality of metabolism/homeostasis
  • Atrial fibrillation
  • Abnormality of blood and blood-forming tissues
  • Deep venous thrombosis


SOURCES: OMIM MENDELIAN

More info about COUMARIN RESISTANCE

Related symptoms:

  • Atrial septal defect
  • Atrial fibrillation
  • Bradycardia


SOURCES: OMIM MESH MENDELIAN

More info about ATRIAL SEPTAL DEFECT 6; ASD6

Emery-Dreifuss muscular dystrophy is a genetically heterogeneous muscular disease that presents with muscular dystrophy, joint contractures, and cardiomyopathy with conduction defects (summary by Liang et al., 2011).For a discussion of genetic heterogeneity of EDMD, see {310300}.

Related symptoms:

  • Muscle weakness
  • Flexion contracture
  • Cardiomyopathy
  • Arrhythmia
  • Proximal muscle weakness


SOURCES: OMIM MENDELIAN

More info about EMERY-DREIFUSS MUSCULAR DYSTROPHY 7, AUTOSOMAL DOMINANT; EDMD7

Holt-Oram syndrome is an autosomal dominant disorder characterized by abnormalities of the upper limbs and shoulder girdle, associated with a congenital heart lesion. The typical combination is considered to be a triphalangeal thumb with a secundum atrial septal defect (ASD), but there is a great range in the severity of both the heart and skeletal lesions (summary by Hurst et al., 1991).

HOLT-ORAM SYNDROME; HOS Is also known as atriodigital dysplasia|heart-hand syndrome|hos1

Related symptoms:

  • Intellectual disability
  • Short stature
  • Failure to thrive
  • Micrognathia
  • Cleft palate


SOURCES: OMIM MENDELIAN

More info about HOLT-ORAM SYNDROME; HOS

Atrial fibrillation is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997).For a discussion of genetic heterogeneity of familial atrial fibrillation, see ATFB1 (OMIM ).

Related symptoms:

  • Stroke
  • Atrial fibrillation
  • Thromboembolic stroke


SOURCES: OMIM MENDELIAN

More info about ATRIAL FIBRILLATION, FAMILIAL, 11; ATFB11

Atrial fibrillation is the most common sustained cardiac rhythm disturbance, affecting more than 2 million Americans, with an overall prevalence of 0.89%. The prevalence increases rapidly with age, to 2.3% between the ages of 40 and 60 years, and to 5.9% over the age of 65. The most dreaded complication is thromboembolic stroke (Brugada et al., 1997).For a discussion of genetic heterogeneity of atrial fibrillation, see {608583}.

Related symptoms:

  • Stroke
  • Atrial fibrillation
  • Palpitations
  • Paroxysmal atrial fibrillation
  • Thromboembolic stroke


SOURCES: MESH OMIM MENDELIAN

More info about ATRIAL FIBRILLATION, FAMILIAL, 4; ATFB4

Top 5 symptoms//phenotypes associated to Leukemia and Atrial fibrillation

Symptoms // Phenotype % cases
Abnormal heart morphology Uncommon - Between 30% and 50% cases
Intellectual disability Uncommon - Between 30% and 50% cases
Depressed nasal bridge Uncommon - Between 30% and 50% cases
Abnormality of cardiovascular system morphology Uncommon - Between 30% and 50% cases
Atrial flutter Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Leukemia and Atrial fibrillation. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Cardiomyopathy Stroke Ventricular septal defect Patent ductus arteriosus Bradycardia Micrognathia Atrial septal defect Neoplasm

Rare Symptoms - Less than 30% cases

Abnormality of blood and blood-forming tissues Thrombocytopenia Polydactyly Arnold-Chiari malformation Vomiting Postnatal growth retardation Pectus excavatum Broad forehead Arnold-Chiari type I malformation Abnormal cardiac septum morphology Clinodactyly Anemia Short stature Seizures Bruising susceptibility Arrhythmia Low-set ears Failure to thrive Hernia Hypertelorism Epicanthus Thromboembolic stroke Growth delay Downslanted palpebral fissures Frontal bossing Syndactyly Edema Coarctation of aorta Global developmental delay Cognitive impairment Hypoplastic aortic arch Lymphangioma Amegakaryocytic thrombocytopenia Superior pectus carinatum Optic disc hypoplasia Muscle weakness Juvenile myelomonocytic leukemia Reduced factor XII activity Neurofibrosarcoma Panuveitis Loose anagen hair Deep venous thrombosis Pectus excavatum of inferior sternum Abnormality of metabolism/homeostasis Postductal coarctation of the aorta Preductal coarctation of the aorta Gonadal neoplasm Reduced factor XIII activity Multiple lentigines Nasogastric tube feeding Asymmetry of the thorax Neurofibromas Schwannoma Radial deviation of finger Amblyopia Lymphedema Plagiocephaly Azoospermia Bicuspid aortic valve Poor suck Pterygium Elevated alkaline phosphatase Failure to thrive in infancy Patent foramen ovale Myelodysplasia Cubitus valgus Abnormality of the coagulation cascade Synovitis Leukocytosis Abnormality of color vision Proximal muscle weakness Cystic hygroma Male infertility Abnormality of the vertebral column Neuroblastoma Gonadal dysgenesis Malignant hyperthermia Drusen Nonimmune hydrops fetalis Restrictive cardiomyopathy Shield chest Flexion contracture Gastrointestinal hemorrhage Muscular dystrophy Total anomalous pulmonary venous return Short humerus Oligodactyly Absent radius Thoracic scoliosis Short clavicles Heart block Truncus arteriosus Down-sloping shoulders Secundum atrial septal defect Allergy Ecchymosis Complete atrioventricular canal defect Anomalous pulmonary venous return Phocomelia Hematemesis Absent thumb Small thenar eminence Abnormality of the carpal bones Partial duplication of thumb phalanx Aplasia of the ulna Short digit Mesoaxial polydactyly Aplasia of the pectoralis major muscle Tibial torsion Lactose intolerance Patellar subluxation Quadricuspid aortic valve Palpitations Paroxysmal atrial fibrillation Permanent atrial fibrillation Atrioventricular canal defect Limited elbow extension Progressive muscle weakness Epistaxis Neck muscle weakness Proximal amyotrophy Cleft palate Hypertension Fatigue Abnormality of the skeletal system Respiratory distress Diarrhea Hepatosplenomegaly Nausea Asthma Clumsiness Abnormality of the cardiovascular system Mitral valve prolapse Short thumb Petechiae Triphalangeal thumb Hypoplastic left heart Right bundle branch block Bundle branch block Menorrhagia Hypoplasia of the ulna Bowing of the legs Atrioventricular block Abnormal vertebral morphology Hypoplasia of the radius Eosinophilia Aortic regurgitation Finger clinodactyly Horseshoe kidney Aortic valve stenosis Left ventricular hypertrophy Gastroesophageal reflux Primary amenorrhea Aplasia/Hypoplasia of the skin Shock Cutaneous syndactyly Cutis laxa Hemangioma Ischemic stroke Reduced bone mineral density Redundant skin Nephroblastoma Cutis marmorata Large for gestational age Cortical dysplasia Abnormality of digit Multiple cafe-au-lait spots Multicystic kidney dysplasia Telangiectasia of the skin Syringomyelia Nevus flammeus Severe postnatal growth retardation Severe failure to thrive Capillary hemangioma Megalencephaly Meningioma Varicose veins Large earlobe Abnormality of the lower limb Arteriovenous malformation Hemihypertrophy Purpura Telangiectasia Dilation of lateral ventricles Joint laxity Generalized hypotonia Scoliosis Muscular hypotonia Wide nasal bridge Intrauterine growth retardation Macrocephaly Ventriculomegaly Hydrocephalus Microphthalmia Hypothyroidism High forehead Deeply set eye Abnormality of the nervous system Finger syndactyly Postaxial hand polydactyly Toe syndactyly Smooth philtrum Oral cleft Joint hypermobility Polymicrogyria Postaxial polydactyly Thick vermilion border Retinal detachment Ascites Nevus Vesicoureteral reflux Abnormality of the skin Overgrowth Abnormality of the upper limb Cavum septum pellucidum Low posterior hairline Hypertrophic cardiomyopathy Congestive heart failure Intellectual disability, mild Splenomegaly Headache Dilatation Constipation Rod-cone dystrophy Posteriorly rotated ears Hypogonadism Abdominal pain Proptosis Polyhydramnios Kyphoscoliosis Low-set, posteriorly rotated ears Fever Sparse hair Hypotrichosis Pulmonic stenosis Facial asymmetry High, narrow palate Triangular face Abdominal distention Abnormal bleeding Dental malocclusion Webbed neck Wide intermamillary distance Amenorrhea Ventricular hypertrophy Short neck Myopia Arterial stenosis Cutis marmorata telangiectatica congenita Skin erosion Right aortic arch Asymmetric growth Perisylvian polymicrogyria Subcutaneous hemorrhage Short lower limbs Capillary malformation Facial hemangioma Hemimegalencephaly Leukocoria Progressive macrocephaly Displacement of the external urethral meatus Vascular ring Blue nevus Brachydactyly Tachycardia Supraventricular tachycardia Microcephaly Nystagmus Strabismus Sensorineural hearing impairment Abnormal facial shape Pain Cataract Cryptorchidism Ptosis High palate Feeding difficulties Premature atrial contractions


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