Immunodeficiency, and Hepatocellular carcinoma

Diseases related with Immunodeficiency and Hepatocellular carcinoma

In the following list you will find some of the most common rare diseases related to Immunodeficiency and Hepatocellular carcinoma that can help you solving undiagnosed cases.

Top matches:

HCV, which is principally transmitted by blood, infects about 3% of the world's population. HCV infection causes acute hepatitis, which is self-resolving in 20 to 50% of cases but does not confer permanent immunity. In 50 to 80% of cases, HCV infection becomes chronic and results in chronic hepatitis, cirrhosis, and hepatocellular carcinoma. As a result, HCV infection is a leading killer worldwide and the most common cause of liver failure in the U.S. HCV is opportunistic in individuals infected with human immunodeficiency virus (HIV; see {609423}), approximately 25% of whom are coinfected with HCV. HCV infection is also associated with cryoglobulinemia (see {123550}), a B-lymphocyte proliferative disorder (Pawlotsky, 2004; Chisari (2005); Pileri et al., 1998).

HEPATITIS C VIRUS, SUSCEPTIBILITY TO Is also known as hcv, susceptibility to

Related symptoms:

  • Immunodeficiency
  • Carcinoma
  • Cirrhosis
  • Hepatic failure
  • Hepatitis


SOURCES: OMIM MENDELIAN

More info about HEPATITIS C VIRUS, SUSCEPTIBILITY TO

HIGM is a rare immunodeficiency characterized by normal or elevated serum IgM levels associated with markedly decreased IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections and an increased susceptibility to opportunistic infections. Patients with X-linked HIGM also tend to have neutropenia, as well as a high rate of gastrointestinal and central nervous system infections, often resulting in severe liver disease and/or neurodegeneration (summary by Levy et al., 1997). Genetic Heterogeneity of Immunodeficiency with Hyper-IgMOther forms of HIGM include HIGM2 (OMIM ), which results from mutation in the AICDA gene (OMIM ), HIGM3 (OMIM ), which results from mutation in the CD40 gene (OMIM ), and HIGM5 (OMIM ), which results from mutation in the UNG gene (OMIM ). See also HIGM4 (OMIM ).

IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 1; HIGM1 Is also known as hyper-igm immunodeficiency, x-linked|hyper-igm syndrome 1|ihis|hyper-igm syndrome|xhim|imd3|higm|immunodeficiency 3

Related symptoms:

  • Seizures
  • Global developmental delay
  • Failure to thrive
  • Cognitive impairment
  • Anemia


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 1; HIGM1

Ataxia-telangiectasia is the association of severe combined immunodeficiency (affecting mainly the humoral immune response) with progressive cerebellar ataxia. It is characterised by neurological signs, telangiectasias, increased susceptibility to infections and a higher risk of cancer.

ATAXIA-TELANGIECTASIA Is also known as at1|louis-bar syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Microcephaly
  • Scoliosis


SOURCES: ORPHANET OMIM MENDELIAN

More info about ATAXIA-TELANGIECTASIA

Other less relevant matches:

The concept of mucosa-associated lymphoid tissue (MALT) lymphomas was introduced by Isaacson and Wright (1983). MALT lymphomas are now recognized as a distinct subtype of non-Hodgkin lymphoma (OMIM ). B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) are the most common form of lymphoma arising in extranodal sites, in most cases arising in the gastric mucosa (Isaacson and Spencer, 1995).

LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TYPE Is also known as malt lymphoma|gastric lymphoma, primary

Related symptoms:

  • Neoplasm
  • Immunodeficiency
  • Lymphoma
  • Hodgkin lymphoma
  • Gastric ulcer


SOURCES: OMIM ORPHANET MENDELIAN

More info about LYMPHOMA, MUCOSA-ASSOCIATED LYMPHOID TYPE

PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 4 Is also known as pfic4|tjp2 deficit

Related symptoms:

  • Neoplasm
  • Hypertension
  • Jaundice
  • Carcinoma
  • Abnormality of the liver


SOURCES: ORPHANET OMIM MENDELIAN

More info about PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 4

IMMUNODEFICIENCY, COMMON VARIABLE, 2; CVID2 Is also known as antibody deficiency due to taci defect|hypogammaglobulinemia due to taci deficiency

Related symptoms:

  • Neoplasm
  • Hepatomegaly
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY, COMMON VARIABLE, 2; CVID2

IMMUNODEFICIENCY, COMMON VARIABLE, 6; CVID6 Is also known as antibody deficiency due to cd81 defect

Related symptoms:

  • Hepatomegaly
  • Renal insufficiency
  • Immunodeficiency
  • Thrombocytopenia
  • Recurrent respiratory infections


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY, COMMON VARIABLE, 6; CVID6

Related symptoms:

  • Short stature
  • Neoplasm
  • Failure to thrive
  • Hepatomegaly
  • Diarrhea


SOURCES: OMIM MENDELIAN

More info about CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC, 2; PFIC2

HBV is a DNA virus that enters the liver via the bloodstream, and replication occurs only in liver tissue. Transmission occurs by percutaneous or mucosal exposure to infected blood or other body fluids. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma (HCC ) can be attributed to chronic HBV infection. Worldwide, 2 billion people have been infected with HBV, 360 million have chronic infection, and 600,000 die each year from HBV-related liver disease or HCC. However, there is marked geographic variability in HBV prevalence, with chronic infection affecting less than 2% of the populations of North America and western and northern Europe; between 2 and 7% of the populations of eastern and central Europe, the Amazon basin, the Middle East, and the Indian subcontinent; and more than 8% of the populations of Asia, sub-Saharan Africa, and the Pacific (Seeff and Hoofnagle, 2006; Shepard et al., 2006).

HEPATITIS B VIRUS, SUSCEPTIBILITY TO Is also known as hbv, susceptibility to

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Vomiting
  • Splenomegaly


SOURCES: OMIM MENDELIAN

More info about HEPATITIS B VIRUS, SUSCEPTIBILITY TO

Common variable immunodeficiency (CVID) comprises a heterogeneous group of diseases characterized by a significant hypogammaglobulinemia of unknown cause, failure to produce specific antibodies after immunizations and susceptibility to bacterial infections, predominantly caused by encapsulated bacteria.

COMMON VARIABLE IMMUNODEFICIENCY Is also known as primary antibody deficiency|cvid|antibody deficiency due to icos defect|idiopathic immunoglobulin deficiency|primary hypogammaglobulinemia

Related symptoms:

  • Hepatomegaly
  • Diarrhea
  • Splenomegaly
  • Immunodeficiency
  • Recurrent infections


SOURCES: ORPHANET OMIM MENDELIAN

More info about COMMON VARIABLE IMMUNODEFICIENCY

Top 5 symptoms//phenotypes associated to Immunodeficiency and Hepatocellular carcinoma

Symptoms // Phenotype % cases
Carcinoma Common - Between 50% and 80% cases
Hepatomegaly Common - Between 50% and 80% cases
Decreased antibody level in blood Uncommon - Between 30% and 50% cases
Abnormality of the liver Uncommon - Between 30% and 50% cases
Splenomegaly Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Immunodeficiency and Hepatocellular carcinoma. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Neoplasm Hepatitis Lymphoma IgA deficiency Recurrent bacterial infections Diarrhea Recurrent infections Cirrhosis IgG deficiency Autoimmunity Otitis media Bronchiectasis IgM deficiency Recurrent pneumonia Failure to thrive Recurrent bronchitis Chronic hepatitis Recurrent respiratory infections Recurrent otitis media

Rare Symptoms - Less than 30% cases

Lymphopenia IgE deficiency Sinusitis Hodgkin lymphoma Short stature Acute hepatitis Glomerulonephritis Purpura Seizures Arthralgia Impaired T cell function Pneumonia Recurrent sinusitis Conjunctivitis Elevated hepatic transaminase Jaundice Intermittent jaundice Cholestasis Intrahepatic cholestasis Choreoathetosis Dysarthria Neutropenia Lymphoproliferative disorder Hemolytic anemia Thrombocytopenia Hepatic failure Fever Recurrent lower respiratory tract infections Anemia Cognitive impairment Gastric lymphoma Gastric ulcer Chromosome breakage Hypertension Defective B cell differentiation Interosseus muscle atrophy Decreased/absent ankle reflexes Renal neoplasm Severe combined immunodeficiency B-cell lymphoma Conjunctival telangiectasia Immunoglobulin IgG2 deficiency Chronic myelogenous leukemia Hypoplasia of the thymus Abnormality of chromosome stability Abnormal spermatogenesis Cellular immunodeficiency Elevated alpha-fetoprotein Chronic lymphatic leukemia Decreased proportion of CD4-positive T cells Female hypogonadism Abnormality of the testis Absent Achilles reflex Increased sensitivity to ionizing radiation Spinocerebellar tract degeneration Aplasia/Hypoplasia of the thymus Mucosal telangiectasiae Non-Hodgkin lymphoma Progressive spinal muscular atrophy Neoplasm of the breast Skin rash Portal hypertension Chronic otitis media Fulminant hepatitis Brachycephaly Anal atresia Lymphadenopathy Vasculitis Abnormal intestine morphology Failure to thrive in infancy Emphysema Chronic infection Restrictive ventilatory defect Bronchitis Autoimmune thrombocytopenia B lymphocytopenia Gastrointestinal stroma tumor Recurrent infection of the gastrointestinal tract Humoral immunodeficiency Autoimmune neutropenia Membranous nephropathy Dark urine Acute hepatic failure Pruritus Biliary atresia Meningitis Thyroiditis Recurrent sinopulmonary infections Follicular hyperplasia Gastrointestinal carcinoma Renal insufficiency Proteinuria Coma Membranoproliferative glomerulonephritis Elevated alkaline phosphatase Conjugated hyperbilirubinemia Fat malabsorption Giant cell hepatitis Pain Vomiting Abdominal pain Nausea Acute lymphoblastic leukemia Abnormality of the hair Hypopigmentation of hair Strabismus Agranulocytosis Opportunistic infection Impaired memory B cell generation Intellectual disability Microcephaly Scoliosis Ataxia Nystagmus Muscle weakness Absence of lymph node germinal center Spasticity Flexion contracture Peripheral neuropathy Skeletal muscle atrophy Tremor Gait disturbance Cerebellar atrophy Dystonia Enlarged tonsils Impaired Ig class switch recombination Diabetes mellitus Leukoencephalopathy Cryoglobulinemia Global developmental delay Weight loss Neurodegeneration Sepsis Clumsiness Involuntary movements Chronic diarrhea Encephalitis Decreased T cell activation Gingivitis Agammaglobulinemia Cholangitis Stomatitis Dysgammaglobulinemia Increased IgM level Sclerosing cholangitis Cholangiocarcinoma Myoclonus Gait ataxia Prematurely aged appearance Athetosis Truncal ataxia Oculomotor apraxia Reduced tendon reflexes Cerebral palsy Breast carcinoma Slurred speech Polycystic ovaries Spinal muscular atrophy Glucose intolerance Cafe-au-lait spot Combined immunodeficiency Premature graying of hair Resting tremor Aplasia/Hypoplasia of the skin Multiple cafe-au-lait spots Telangiectasia of the skin Abnormality of the immune system Myeloid leukemia Abnormal vertebral morphology Limb ataxia Difficulty walking Unsteady gait Anxiety Respiratory tract infection Distal muscle weakness Leukemia Neurological speech impairment Delayed puberty Abnormality of eye movement Abnormality of movement Distal amyotrophy Telangiectasia Polyneuropathy Abnormal cerebellum morphology Progressive cerebellar ataxia Chorea Apraxia Type II diabetes mellitus Pancytopenia Intention tremor Posterior pharyngeal cleft


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