Hypertension, and Sudden cardiac death

Diseases related with Hypertension and Sudden cardiac death

In the following list you will find some of the most common rare diseases related to Hypertension and Sudden cardiac death that can help you solving undiagnosed cases.

Top matches:

Ventricular septal defect (VSD) is the most common form of congenital cardiovascular anomaly, occurring in nearly 50% of all infants with a congenital heart defect and accounting for 14% to 16% of cardiac defects that require invasive treatment within the first year of life. Congenital VSDs may occur alone or in combination with other cardiac malformations. Large VSDs that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death (summary by {2,3:Wang et al., 2011, 2011}).For a discussion of genetic heterogeneity of ventricular septal defect, see VSD1 (OMIM ).

Related symptoms:

  • Hypertension
  • Ventricular septal defect
  • Congestive heart failure
  • Abnormality of cardiovascular system morphology
  • Arrhythmia


SOURCES: OMIM MENDELIAN

More info about VENTRICULAR SEPTAL DEFECT 2; VSD2

Ventricular septal defect (VSD) is the most common form of congenital cardiovascular anomaly, occurring in nearly 50% of all infants with a congenital heart defect and accounting for 14 to 16% of cardiac defects that require invasive treatment within the first year of life. Congenital VSDs may occur alone or in combination with other cardiac malformations. Large VSDs that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death (summary by {3,4:Wang et al., 2011, 2011}).Other congenital cardiac defects caused by mutation in the GATA4 gene include atrial septal defect (ASD2 ), tetralogy of Fallot (see TOF, {187500}), and endocardial cushion defects (AVSD4 ). Genetic Heterogeneity of Ventricular Septal DefectVSD2 (OMIM ) is caused by mutation in the CITED2 gene (OMIM ) on chromosome 6q24; VSD3 (OMIM ) is caused by mutation in the NKX2-5 gene (OMIM ) on chromosome 5q34.Somatic mutations in the HAND1 gene (OMIM ) have been identified in tissue samples from patients with VSD.

Related symptoms:

  • Hypertension
  • Ventricular septal defect
  • Atrial septal defect
  • Congestive heart failure
  • Abnormality of cardiovascular system morphology


SOURCES: OMIM MENDELIAN

More info about VENTRICULAR SEPTAL DEFECT 1; VSD1

Related symptoms:

  • Hypertension
  • Cardiomyopathy
  • Congestive heart failure
  • Dyspnea
  • Hypertrophic cardiomyopathy


SOURCES: OMIM MESH MENDELIAN

More info about CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 15; CMH15

Other less relevant matches:

Ventricular septal defect (VSD) is the most common form of congenital cardiovascular anomaly, occurring in nearly 50% of all infants with a congenital heart defect and accounting for 14 to 16% of cardiac defects that require invasive treatment within the first year of life. Congenital VSDs may occur alone or in combination with other cardiac malformations. Large VSDs that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death (summary by {3,4:Wang et al., 2011, 2011}).Other congenital cardiac defects caused by mutation in the NKX2-5 gene include atrial septal defect with or without atrioventricular conduction defects (ASD7 ), tetralogy of Fallot (see TOF, {187500}), conotruncal malformations (see {217095}), and hypoplastic left heart syndrome (HLHS2 ).For a discussion of genetic heterogeneity of ventricular septal defect, see VSD1 (OMIM ).

Related symptoms:

  • Hypertension
  • Ventricular septal defect
  • Atrial septal defect
  • Congestive heart failure
  • Abnormality of cardiovascular system morphology


SOURCES: OMIM MENDELIAN

More info about VENTRICULAR SEPTAL DEFECT 3; VSD3

CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 8; CMH8 Is also known as cardiomyopathy, hypertrophic, mid-left ventricular chamber type, 1

Related symptoms:

  • Hypertension
  • Cardiomyopathy
  • Myopathy
  • Congestive heart failure
  • Hypertrophic cardiomyopathy


SOURCES: MESH OMIM MENDELIAN

More info about CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 8; CMH8

Brugada Syndrome 7Brugada syndrome is characterized by an ST segment elevation in the right precordial electrocardiogram leads (so-called type 1 ECG) and a high incidence of sudden death in patients with structurally normal hearts. The syndrome typically manifests during adulthood, with a mean age of sudden death of 41 +/- 15 years, but also occurs in infants and children (summary by Antzelevitch et al., 2005).For a discussion of genetic heterogeneity of Brugada syndrome, see BRGDA1 (OMIM ). Atrial Fibrillation 16Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinical setting, with a prevalence of 1% in the general population; prevalence increases with age and reaches more than 8% in the ninth decade of life. AF accounts for more than 15% of strokes, and is associated with worsening heart failure and increased mortality. More than 30% of cases of AF are considered to be 'lone AF,' unassociated with coronary artery disease, hypertension, valvular heart disease, hyperthyroidism, heart failure, or structural heart disease (summary by Wang et al., 2010).For a discussion of genetic heterogeneity of atrial fibrillation, see ATFB1 (OMIM ).

Related symptoms:

  • Neoplasm
  • Hypertension
  • Congestive heart failure
  • Arrhythmia
  • Sudden cardiac death


SOURCES: MESH OMIM MENDELIAN

More info about BRUGADA SYNDROME 7; BRGDA7

Related symptoms:

  • Hypertension
  • Osteoporosis
  • Diabetes mellitus
  • Stroke
  • Sudden cardiac death


SOURCES: OMIM MESH MENDELIAN

More info about CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2; ADCAD2

ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 11; ARVD11 Is also known as arvc11|arrhythmogenic right ventricular cardiomyopathy 11

Related symptoms:

  • Hypertension
  • Cardiomyopathy
  • Dilatation
  • Arrhythmia
  • Hyperkeratosis


SOURCES: MESH OMIM MENDELIAN

More info about ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 11; ARVD11

HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA Is also known as hofh

Related symptoms:

  • Hypertension
  • Dyspnea
  • Arthralgia
  • Hepatic steatosis
  • Sudden cardiac death


SOURCES: ORPHANET MENDELIAN

More info about HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

Primary pulmonary arterial hypertension is a rare, often fatal, progressive vascular lung disease characterized by increased pulmonary vascular resistance and sustained elevation of mean pulmonary arterial pressure, leading to right ventricular hypertrophy and right heart failure. Pathologic features include a narrowing and thickening of small pulmonary vessels and plexiform lesions. There is pulmonary vascular remodeling of all layers of pulmonary arterial vessels: intimal thickening, smooth muscle cell hypertrophy or hyperplasia, adventitial fibrosis, and occluded vessels by in situ thrombosis (summary by Machado et al., 2009 and Han et al., 2013).Heterozygous mutations in the BMPR2 gene are found in nearly 70% of families with heritable PPH and in 25% of patients with sporadic disease. The disease is more common in women (female:male ratio of 1.7:1). However, the penetrance of PPH1 is incomplete: only about 10 to 20% of individuals with BMPR2 mutations develop the disease during their lifetime, suggesting that development of the disorder is triggered by other genetic or environmental factors. Patients with PPH1 are less likely to respond to acute vasodilater testing and are unlikely to benefit from treatment with calcium channel blockade (summary by Machado et al., 2009 and Han et al., 2013). Genetic Heterogeneity of Primary Pulmonary HypertensionPPH2 (OMIM ) is caused by mutation in the SMAD9 gene (OMIM ) on chromosome 13q13; PPH3 (OMIM ) is caused by mutation in the CAV1 gene (OMIM ) on chromosome 7q31; and PPH4 (OMIM ) is caused by mutation in the KCNK3 gene (OMIM ) on chromosome 2p23.See {265400} for a possible autosomal recessive form of PPH.Primary pulmonary hypertension may also be found in association with hereditary hemorrhagic telangiectasia type 1 (HHT1 ), caused by mutation in the ENG gene (OMIM ), and HHT2 (OMIM ), caused by mutation in the ACVRL1 (ALK1) gene (OMIM ).

PULMONARY HYPERTENSION, PRIMARY, 1; PPH1 Is also known as pulmonary arterial hypertension|pht|pah

Related symptoms:

  • Pain
  • Hypertension
  • Hepatomegaly
  • Fatigue
  • Respiratory distress


SOURCES: OMIM ORPHANET MENDELIAN

More info about PULMONARY HYPERTENSION, PRIMARY, 1; PPH1

Top 5 symptoms//phenotypes associated to Hypertension and Sudden cardiac death

Symptoms // Phenotype % cases
Congestive heart failure Common - Between 50% and 80% cases
Arrhythmia Uncommon - Between 30% and 50% cases
Dyspnea Uncommon - Between 30% and 50% cases
Abnormality of cardiovascular system morphology Uncommon - Between 30% and 50% cases
Abnormal heart morphology Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Hypertension and Sudden cardiac death. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Cardiomyopathy Ventricular septal defect Palpitations

Rare Symptoms - Less than 30% cases

Ventricular hypertrophy Hypercholesterolemia Hyperlipidemia Myocardial infarction T-wave inversion Ventricular fibrillation Endocardial fibrosis Atrial septal defect Exertional dyspnea Hypertrophic cardiomyopathy Renal artery stenosis Abnormal internal carotid artery morphology Cough Left ventricular failure Recurrent respiratory infections Edema Increased LDL cholesterol concentration Respiratory distress Fatigue Hepatomegaly Pain Abnormal eye physiology Cerebral artery atherosclerosis Myocardial steatosis Supravalvular aortic stenosis Abnormal tendon morphology Aortic atherosclerosis Premature arteriosclerosis Abnormality of nervous system physiology Coronary artery aneurysm Calcification of the aorta Cirrhosis Premature coronary artery atherosclerosis Renal steatosis Tendon xanthomatosis Vertigo Epistaxis Ascites Edema of the lower limbs Pulmonary aterial intimal fibrosis Pulmonary arterial medial hypertrophy Arterial intimal fibrosis Elevated right atrial pressure Pulmonary capillary hemangiomatosis Hemangiomatosis Increased pulmonary vascular resistance Spontaneous, recurrent epistaxis Abnormal tricuspid valve morphology Right ventricular failure Abnormal thrombosis Right ventricular hypertrophy Chest pain Capillary hemangioma Acrocyanosis Hemoptysis Scleroderma Hoarse voice Telangiectasia Abnormal lung morphology Xanthomatosis Pulmonary arterial hypertension Cardiomegaly Cyanosis Hypotension Precocious atherosclerosis Right ventricular dilatation Angina pectoris Abnormal heart valve morphology Glucose intolerance Atherosclerosis Hypertriglyceridemia Type II diabetes mellitus Stroke Diabetes mellitus Osteoporosis ST segment elevation Atrial flutter Neoplasm of the lung Hyperthyroidism Atrioventricular block Dilatation Atrial fibrillation Neoplasm Left atrial enlargement Restrictive cardiomyopathy Left ventricular hypertrophy Myopathy Pulmonary artery stenosis Hypoplastic left heart Patent ductus arteriosus Abnormality of the mitochondrion Pulmonic stenosis Perimembranous ventricular septal defect Gout Hyperkeratosis Peripheral arterial stenosis Reduced ejection fraction Optic neuropathy Coronary artery atherosclerosis Heart murmur Mitral regurgitation Hepatic steatosis Arthralgia T-wave inversion in the right precordial leads Diffuse palmoplantar hyperkeratosis Abnormal T-wave Abnormal echocardiogram Right ventricular cardiomyopathy Woolly hair Dilated cardiomyopathy Left bundle branch block Abnormal EKG Right bundle branch block Bundle branch block Palmoplantar hyperkeratosis Ventricular arrhythmia Ventricular tachycardia Cardiac arrest Dehydration Syncope Palmoplantar keratoderma Tachycardia Pulmonary artery vasoconstriction


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