Hypertension, and Skin rash

Diseases related with Hypertension and Skin rash

In the following list you will find some of the most common rare diseases related to Hypertension and Skin rash that can help you solving undiagnosed cases.

Top matches:

COMPLEMENT COMPONENT 2 DEFICIENCY; C2D Is also known as c2 deficiency

Related symptoms:

  • Hypertension
  • Renal insufficiency
  • Immunodeficiency
  • Recurrent infections
  • Arthralgia


SOURCES: OMIM MENDELIAN

More info about COMPLEMENT COMPONENT 2 DEFICIENCY; C2D

AMYLOIDOSIS, FAMILIAL VISCERAL Is also known as german type amyloidosis|amyloidosis, systemic nonneuropathic|amyloidosis viii|amyloidosis, familial renal|ostertag type amyloidosis

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Pain
  • Hypertension
  • Peripheral neuropathy


SOURCES: ORPHANET OMIM MENDELIAN

More info about AMYLOIDOSIS, FAMILIAL VISCERAL

Low match KAPOSI SARCOMA

Kaposi sarcoma (KS) is a rare human herpes virus 8 (HHV-8)-induced endothelial inflammatory neoplasm that develops is various clinically distinct settings, manifesting mostly as cutaneous lesions, or mucosal or visceral involvement.

KAPOSI SARCOMA Is also known as multiple idiopathic pigmented hemangiosarcoma, susceptibility to

Related symptoms:

  • Neoplasm
  • Hypertension
  • Fever
  • Fatigue
  • Edema


SOURCES: OMIM ORPHANET MENDELIAN

More info about KAPOSI SARCOMA

Other less relevant matches:

Related symptoms:

  • Scoliosis
  • High palate
  • Visual impairment
  • Hypertension
  • Myopia


SOURCES: OMIM MENDELIAN

More info about PSEUDOXANTHOMA ELASTICUM, FORME FRUSTE

Congenital thrombotic thrombocytopenic purpura is the hereditary form of thrombotic thrombocytopenic purpura (TTP; see this term) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and single or multiple organ failure of variable severity.

CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA Is also known as congenital ttp|microangiopathic hemolytic anemia|thrombotic microangiopathy, familial|microangiopathic hemolytic anemia, congenital|congenital adamts-13 deficiency|upshaw factor, deficiency of|uss|thrombotic thrombocytopenic purpura, familial|familial ttp

Related symptoms:

  • Seizures
  • Pain
  • Anemia
  • Hypertension
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA

Blau syndrome is characterized by the triad of granulomatous arthritis, uveitis, and dermatitis. First described in 1985, it was considered to be distinct from sarcoidosis due to the early age of onset and autosomal dominant inheritance pattern. Published reports of sporadic cases of children with 'early-onset sarcoidosis' (EOS) with granulomatous involvement of different organs, primarily affecting joints, eyes, and skin, were suspected to represent the same disorder because the patients' characteristics were nearly identical. Subsequently, identical NOD2 mutations were identified in patients with Blau syndrome as well as in patients diagnosed with EOS, confirming earlier suspicions that they represented the same disease (summary by Borzutzky et al., 2010). Unlike older children diagnosed with sarcoidosis, these patients have no apparent pulmonary involvement; however, the disease is progressive and may result in severe complications such as blindness and/or joint destruction (Shetty and Gedalia, 1998).

BLAU SYNDROME; BLAUS Is also known as arthrocutaneouveal granulomatosis|granulomatous inflammatory arthritis, dermatitis, and uveitis, familial|eos|jabs syndrome|granulomatosis, familial juvenile systemic|acug|sarcoidosis, early-onset|granulomatosis, familial, blau type

Related symptoms:

  • Hearing impairment
  • Failure to thrive
  • Cataract
  • Flexion contracture
  • Visual impairment


SOURCES: OMIM MENDELIAN

More info about BLAU SYNDROME; BLAUS

Mastocytosis, or mast cell disease, is a heterogeneous group of clinical disorders characterized by the abnormal accumulation of mast cells in various tissues, especially in the skin and hematopoietic organs. Mastocytosis usually appears in infancy or early adulthood. In most pediatric cases, the disease is limited to the skin, but it can be associated with systemic symptoms due to the release of mediators from mast cells, even when there is no systemic infiltration. It usually has a good prognosis, with substantial improvement or spontaneous resolution before puberty. In rare cases, the disease may remain active through adolescence as a systemic adult mastocytosis. Cutaneous mastocytosis is characterized by macules, papules, nodules, or diffuse infiltration of the skin, often associated with localized hyperpigmentation. Gentle rubbing of the lesions induces histamine release from mechanically activated mast cells, causing local wheals, erythema, and often pruritus, a phenomenon termed the 'Darier sign.' In contrast to childhood-onset mastocytosis, adult-onset mastocytosis often persists for the lifetime of the patient and is also more likely to be a severe and systemic disease involving numerous organs. In some cases, it is associated with a clonal hematologic non-mast-cell lineage disease, such as a myelodysplastic or myeloproliferative disorder. Adult-onset mastocytosis can also lead to the rare mast cell leukemia, which carries a high risk of mortality (summary by Bodemer et al., 2010 and Kambe et al., 2010).

MASTOCYTOSIS, CUTANEOUS; MASTC Is also known as mastocytosis, maculopapular cutaneous|mastocytosis, diffuse cutaneous|urticaria pigmentosa

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hypertension
  • Hepatomegaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about MASTOCYTOSIS, CUTANEOUS; MASTC

Vasculitis due to ADA2 deficiency is a rare, genetic, systemic and rheumatologic disease due to adenosine deaminase-2 inactivating mutations, combining variable features of autoinflammation, vasculitis, and a mild immunodeficiency. Variable clinical presentation includes chronic or recurrent systemic inflammation with fever, livedo reticularis or racemosa, early-onset ischemic or hemorrhagic strokes, peripheral neuropathy, abdominal pain, hepatosplenomegaly, portal hypertension, cutaneous polyarteritis nodosa, variable cytopenia and immunoglobulin deficiency.

VASCULITIS DUE TO ADA2 DEFICIENCY Is also known as ada2 deficiency|vasculitis due to dada2

Related symptoms:

  • Ataxia
  • Pain
  • Anemia
  • Hypertension
  • Peripheral neuropathy


SOURCES: OMIM ORPHANET MENDELIAN

More info about VASCULITIS DUE TO ADA2 DEFICIENCY

Low match BLAU SYNDROME

Blau syndrome (BS) is a rare systemic inflammatory disease characterized by early onset granulomatous arthritis, uveitis and skin rash. BS now refers to both the familial and sporadic (formerly early-onset sarcoidosis) form of the same disease. The proposed term pediatric granulomatous arthritis is currently questioned since it fails to represent the systemic nature of the disease.

Related symptoms:

  • Cataract
  • Anemia
  • Hypertension
  • Fever
  • Splenomegaly


SOURCES: ORPHANET MENDELIAN

More info about BLAU SYNDROME

Pseudoxanthoma elasticum (PXE) is an inherited connective tissue disorder characterized by progressive calcification and fragmentation of elastic fibers in the skin, retina, and arterial walls.

PSEUDOXANTHOMA ELASTICUM Is also known as pxe|gronblad-strandberg-touraine syndrome|gronblad-strandberg syndrome

Related symptoms:

  • Scoliosis
  • Growth delay
  • High palate
  • Visual impairment
  • Hypertension


SOURCES: ORPHANET OMIM MENDELIAN

More info about PSEUDOXANTHOMA ELASTICUM

Top 5 symptoms//phenotypes associated to Hypertension and Skin rash

Symptoms // Phenotype % cases
Fever Common - Between 50% and 80% cases
Papule Common - Between 50% and 80% cases
Edema Uncommon - Between 30% and 50% cases
Lymphadenopathy Uncommon - Between 30% and 50% cases
Gastrointestinal hemorrhage Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Hypertension and Skin rash. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Abdominal pain Splenomegaly Pain Anemia Vasculitis Fatigue Diarrhea Abnormality of the liver Immunodeficiency Visual impairment Arthralgia Renal insufficiency Hepatosplenomegaly Weight loss Glaucoma Arthritis Purpura Hepatomegaly Neoplasm Hypermelanotic macule Peripheral neuropathy Visual loss Headache

Rare Symptoms - Less than 30% cases

Myopia Intermittent claudication Retinal hemorrhage Arteriosclerosis Reduced visual acuity Angina pectoris Medial calcification of large arteries Angioid streaks of the fundus Cerebral hemorrhage Macular degeneration Premature occlusive vascular stenosis Medial calcification of medium-sized arteries Blue sclerae Mitral valve prolapse Peau d'orange Skin ulcer Thrombocytopenia Myalgia Retinopathy Erythema nodosum Cutis marmorata Ischemic stroke Stroke Dilatation Leukopenia Sudden cardiac death Ichthyosis Pruritus Erythema Large vessel vasculitis Arrhythmia Iridocyclitis Synovitis Abnormal cranial nerve morphology Joint swelling Scoliosis Subcutaneous nodule Camptodactyly of finger Blindness Cataract Hemiparesis Nausea Nausea and vomiting High palate Posterior uveitis Restrictive cardiomyopathy Nephropathy Leukemia Proteinuria Drusen Cardiomyopathy Sarcoma Abnormal retinal morphology Optic neuropathy Hematuria Glomerulonephritis Hearing impairment Rheumatoid arthritis Autoimmunity Urticaria Pulmonary arterial hypertension Limitation of joint mobility Recurrent infections Dry skin Facial palsy Photophobia Dyspnea Stage 5 chronic kidney disease Pericarditis Hyperpigmentation of the skin Aortic aneurysm Keratitis Xerostomia Abnormality of the optic nerve Abnormality of the retinal vasculature Abnormal salivary gland morphology Abnormal choroid morphology Polyarticular arthritis Clear cell renal cell carcinoma Retrobulbar optic neuritis Abnormal inflammatory response Central retinal artery occlusion Skin plaque Retinal arterial occlusion Hemiplegia Cutaneous mastocytosis Anaphylactic shock Chronic leukemia Telangiectasia macularis eruptiva perstans Ataxia Optic atrophy Elevated hepatic transaminase Ophthalmoplegia Paraplegia Decreased antibody level in blood Pancytopenia Foot dorsiflexor weakness Systemic lupus erythematosus Leukocytosis Lupus anticoagulant Agitation Combined immunodeficiency Aphasia Elevated erythrocyte sedimentation rate Thrombocytosis Raynaud phenomenon Hypercoagulability Immune dysregulation Granulocytopenia Antiphospholipid antibody positivity Intrauterine growth retardation Panniculitis Pure red cell aplasia Growth delay Scarring Congestive heart failure Metamorphopsia Abnormality of the cerebral vasculature Peripheral arterial stenosis Lack of skin elasticity Redundant neck skin Abnormal thrombocyte morphology Abnormal mitral valve morphology Pulmonary edema Arterial stenosis Excessive wrinkled skin Pulmonary insufficiency Ectopic calcification Choroidal neovascularization Abnormal endocardium morphology Renovascular hypertension Thickened nuchal skin fold Abnormality of connective tissue Civatte bodies Accelerated atherosclerosis Vascular calcification Subcutaneous calcification Arterial calcification Hyperkeratotic papule Localized skin lesion Generalized arterial calcification Peripapillary chorioretinal atrophy Subretinal fluid Erythematous papule Abnormal atrioventricular valve morphology Mitral stenosis Abnormality of the mouth Abnormality of cardiovascular system morphology Atherosclerosis Hypothyroidism Mastocytosis Small for gestational age Joint hyperflexibility Abnormality of skin pigmentation Bruising susceptibility Postural instability Abnormality of the skin Cerebral calcification Abnormality of the cardiovascular system Myocardial infarction Mitral regurgitation Nephrocalcinosis Cutis laxa Severe intrauterine growth retardation Hyperextensible skin Redundant skin Intracranial hemorrhage Abnormality of the thorax Acne Tricuspid regurgitation Hemiplegia/hemiparesis Coronary artery atherosclerosis Chorioretinal atrophy Multiple lipomas Telangiectasia of the skin Striae distensae Severe vision loss Dermatographic urticaria Gastrointestinal stroma tumor Abnormality of the gastric mucosa Acute kidney injury Pallor Paralysis Confusion Papilledema Hemolytic anemia Coma Abnormal bleeding Increased serum lactate Hyperbilirubinemia Personality changes Hyperkalemia Prolonged neonatal jaundice Autoimmune thrombocytopenia Jaundice Reticulocytosis Microscopic hematuria Elevated serum creatinine Preeclampsia Abnormal renal physiology Hemolytic-uremic syndrome Neonatal hyperbilirubinemia Bloody diarrhea Increased blood urea nitrogen Microangiopathic hemolytic anemia Schistocytosis Failure to thrive Abnormality of the kidney Albuminuria Flexion contracture Abnormality of the sternum Neoplasm by anatomical site Generalized lymphadenopathy Venous insufficiency Skin nodule Cellular immunodeficiency Kyphosis Abnormality of the spleen Lymphoproliferative disorder High, narrow palate Abnormality of the lower limb Abnormality of the gastrointestinal tract Macule Hemangioma Renal amyloidosis Neoplasm of the skin Lymphedema Abnormal lung morphology Calcification of falx cerebri Lymphoma Pneumonia Encephalopathy Yellow papule Seizures Generalized amyloid deposition Tremor Respiratory distress Vomiting Amyloidosis Camptodactyly Food intolerance Shock Tachycardia Recurrent fractures Ascites Antinuclear antibody positivity Asthma Hypotension Abnormal blistering of the skin Telangiectasia Bone pain Bone marrow hypocellularity Osteolysis Fatigable weakness Portal hypertension Membranoproliferative glomerulonephritis Loss of consciousness Abnormality of blood and blood-forming tissues Acute leukemia Flushing Allergy Generalized osteosclerosis Myeloproliferative disorder Hypersplenism Susceptibility to herpesvirus Immunologic hypersensitivity Asthenia Impaired temperature sensation Abnormal eosinophil morphology Cirrhosis Malabsorption Cholestasis Cystoid macular edema Eczema Inflammatory abnormality of the skin Nephrotic syndrome Polyneuropathy Hypercalcemia Increased antibody level in blood Abnormality of the ear Abnormal joint morphology Uveitis Macular edema Juvenile rheumatoid arthritis Paresthesia Abducens palsy Angioedema Flexion contracture of toe Granulomatosis Band keratopathy Anterior uveitis Iritis Panuveitis Tendonitis Intermittent generalized erythematous papular rash Nongranulomatous uveitis Osteoporosis Gastroesophageal reflux Vasculitis in the skin Discoid lupus rash Medial calcification of small arteries


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Arthritis and Microtia, related diseases and genetic alterations Arthritis and Overgrowth, related diseases and genetic alterations Edema and Muscular dystrophy, related diseases and genetic alterations Immunodeficiency and Atopic dermatitis, related diseases and genetic alterations Sensorineural hearing impairment and Limb-girdle muscular dystrophy, related diseases and genetic alterations Hearing impairment and Myelodysplasia, related diseases and genetic alterations