Hypertension, and Prostate cancer

Diseases related with Hypertension and Prostate cancer

In the following list you will find some of the most common rare diseases related to Hypertension and Prostate cancer that can help you solving undiagnosed cases.

Top matches:

Low match ALKAPTONURIA

Alkaptonuria is a metabolic disease characterized by the accumulation of homogentisic acid (HGA) and its oxidized product, benzoquinone acetic acid (BQA), in various tissues (e.g. cartilage, connective tissue) and body fluids (urine, sweat), causing urine to darken when exposed to air as well as grey-blue coloration of the sclera and ear helix (ochronosis), and a disabling joint disease involving both the axial and peripheral joints (ochronotic arthropathy).

ALKAPTONURIA Is also known as homogentisic acid oxidase deficiency|hereditary ochronosis

Related symptoms:

  • Pain
  • Cognitive impairment
  • Hypertension
  • Kyphosis
  • Abnormality of metabolism/homeostasis


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about ALKAPTONURIA

Granulomatosis with polyangiitis is a small-vessel necrotizing vasculitis characterised by the association of inflammation of the vessel wall and peri- and extravascular granulomatosis.

GRANULOMATOSIS WITH POLYANGIITIS Is also known as wegener granulomatosis, formerly|gpa|wg, formerly

Related symptoms:

  • Seizures
  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain
  • Visual impairment


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about GRANULOMATOSIS WITH POLYANGIITIS

Von Hippel-Lindau disease (VHL) is a familial cancer predisposition syndrome associated with a variety of malignant and benign neoplasms, most frequently retinal, cerebellar, and spinal hemangioblastoma, renal cell carcinoma (RCC), and pheochromocytoma.

VON HIPPEL-LINDAU DISEASE Is also known as familial cerebelloretinal angiomatosis|von hippel-lindau syndrome|lindau disease|vhl

Related symptoms:

  • Hearing impairment
  • Ataxia
  • Nystagmus
  • Neoplasm
  • Sensorineural hearing impairment


SOURCES: ORPHANET MENDELIAN

More info about VON HIPPEL-LINDAU DISEASE

Other less relevant matches:

Low match CYSTIC FIBROSIS

Cystic fibrosis (CF) is a genetic disorder characterized by the production of sweat with a high salt content and mucus secretions with an abnormal viscosity.

CYSTIC FIBROSIS Is also known as mucoviscidosis|cf

Related symptoms:

  • Growth delay
  • Neoplasm
  • Failure to thrive
  • Pain
  • Hypertension


SOURCES: ORPHANET OMIM MENDELIAN

More info about CYSTIC FIBROSIS

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign neoplasms, most frequently retinal, cerebellar, and spinal hemangioblastoma, renal cell carcinoma (RCC), pheochromocytoma, and pancreatic tumors.Neumann and Wiestler (1991) classified VHL as type 1 (without pheochromocytoma) and type 2 (with pheochromocytoma). Brauch et al. (1995) further subdivided VHL type 2 into type 2A (with pheochromocytoma) and type 2B (with pheochromocytoma and renal cell carcinoma). Hoffman et al. (2001) noted that VHL type 2C refers to patients with isolated pheochromocytoma without hemangioblastoma or renal cell carcinoma. McNeill et al. (2009) proposed that patients with VHL syndrome caused by large VHL deletions that include the HSPC300 gene (C3ORF10 ) have a specific subtype of VHL syndrome characterized by protection from renal cell carcinoma, which the authors proposed be named VHL type 1B.Nordstrom-O'Brien et al. (2010) provided a review of the genetics of von Hippel-Lindau disease.

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Sensorineural hearing impairment
  • Pain
  • Hypertension


SOURCES: OMIM MENDELIAN

More info about VON HIPPEL-LINDAU SYNDROME; VHL

Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH ) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).'Although HH was initially considered to be a monogenic disorder, the presence of marked locus heterogeneity, incomplete penetrance within pedigrees, and variable expressivity of pathogenic alleles, together with evidence for mutations in multiple genes in some affected individuals, resulted in a conceptual shift from monogenicity to an oligogenic framework in which a limited number of genes contribute pathogenic alleles to the genetic network responsible for the neuroendocrine control of human reproduction (Sykiotis et al., 2010). Genetic Heterogeneity of Hypogonadotropic Hypogonadism with or without AnosmiaOther forms of autosomal hypogonadotropic hypogonadism with or without anosmia include HH3 (OMIM ), caused by mutation in the PROKR2 gene (OMIM ); HH4 (OMIM ), caused by mutation in the PROK2 gene (OMIM ); HH5 (OMIM ), caused by mutation in the CHD7 gene (OMIM ); HH6 (OMIM ), caused by mutation in the FGF8 gene (OMIM ); HH7 (OMIM ), caused by mutation in the GNRHR gene (OMIM ); HH8 (OMIM ), caused by mutation in the KISS1R gene (OMIM ); HH9 (OMIM ), caused by mutation in the NELF gene (OMIM ); HH10 (OMIM ), caused by mutation in the TAC3 gene (OMIM ); HH11 (OMIM ), caused by mutation in the TACR3 gene (OMIM ); HH12 (OMIM ), caused by mutation in the GNRH1 gene (OMIM ); HH13 (OMIM ), caused by mutation in the KISS1 gene (OMIM ); HH14 (OMIM ), caused by mutation in the WDR11 gene (OMIM ); HH15 (OMIM ), caused by mutation in the HS6ST1 gene (OMIM ); HH16 (OMIM ), caused by mutation in the SEMA3A gene (OMIM ); HH17 (OMIM ), caused by mutation in the SPRY4 gene (OMIM ); HH18 (OMIM ), caused by mutation in the IL17RD gene (OMIM ); HH19 (OMIM ), caused by mutation in the DUSP6 gene (OMIM ); HH20 (OMIM ), caused by mutation in the FGF17 gene (OMIM ); HH21 (OMIM ), caused by mutation in the FLRT3 gene (OMIM ); HH22 (OMIM ), caused by mutation in the FEZF1 gene (OMIM ); HH23 (OMIM ), caused by mutation in the LHB gene (OMIM ); and HH24 (OMIM ), caused by mutation in the FSHB gene (OMIM ).There is also an X-linked form of the disorder (HH1 ), caused by mutation in the KAL1 gene (OMIM ).There is evidence that mutation in 2 or more of these genes can work in combination (oligogenicity) to produce GnRH-deficient conditions (summary by Chan, 2011). Sykiotis et al. (2010), for example, demonstrated that of patients with an identifiable coding sequence mutation in 1 of 8 genes responsible for isolated GnRH deficiency, 11% carried mutations in at least one other of these genes as well.To assess oligogenicity in hypogonadotropic hypogonadism, Miraoui et al. (2013) analyzed 350 HH probands of European descent for mutation in 17 HH-associated genes. Mutations were identified in 124 (35%) of the probands, and 24 (19%) of the mutation-positive probands carried at least 2 mutant alleles from different genes. Miraoui et al. (2013) noted that 23 of the 24 oligogenic cases involved at least 1 gene associated with the fibroblast growth factor (FGF) network (see {601513}).Dode et al. (2006) stated that loss-of-function mutations in the KAL1 (OMIM ) and FGFR1 genes account for approximately 20% of all cases of Kallmann syndrome and that mutations in the PROKR2 and PROK2 genes account for an additional 10%.Gurbuz et al. (2012) reviewed all causative mutations detected in multiplex families with normosmic hypogonadotropic hypogonadism over a 7-year period in Turkey. Mutations that segregated with disease were identified in 17 (77.2%) of 22 families studied, including mutations of the GNRHR gene in 7 (31.8%) of the families, TACR3 in 6 (27.2%), KISSR in 2 (9%), TAC3 in 1 (4.5%), and KISS1 in 1 (4.5%). Inheritance was autosomal recessive in all 17 families.Valdes-Socin et al. (2014) reviewed the reproductive, neurodevelopmental, and genetic aspects of hypogonadotropic hypogonadism in human pathology.

HYPOGONADOTROPIC HYPOGONADISM 2 WITH OR WITHOUT ANOSMIA; HH2 Is also known as kallmann syndrome 2|kal2

Related symptoms:

  • Intellectual disability
  • Short stature
  • Hearing impairment
  • Neoplasm
  • Sensorineural hearing impairment


SOURCES: OMIM MENDELIAN

More info about HYPOGONADOTROPIC HYPOGONADISM 2 WITH OR WITHOUT ANOSMIA; HH2

Low match LYNCH SYNDROME

LYNCH SYNDROME Is also known as coca2|colon cancer, familial nonpolyposis, type 2|fcc2

Related symptoms:

  • Seizures
  • Neoplasm
  • Muscular hypotonia
  • Flexion contracture
  • Visual impairment


SOURCES: ORPHANET OMIM MENDELIAN

More info about LYNCH SYNDROME

Floating-Harbor syndrome is a genetic developmental disorder characterized by facial dysmorphism, short stature with delayed bone age, and expressive language delay.

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about FLOATING-HARBOR SYNDROME

Familial prostate cancer (FPC) is a malignant tumor of the prostate with an early onset. FPC is either asymptomatic or causes mictionary symptoms, erectile dysfunction, bone pain, venous compression and infectious or inflammatory syndrome (for the metastatic forms). It is also characterized by familial antecedents.

FAMILIAL PROSTATE CANCER Is also known as prca1

Related symptoms:

  • Neoplasm
  • Prostate cancer


SOURCES: ORPHANET OMIM MENDELIAN

More info about FAMILIAL PROSTATE CANCER

PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY Is also known as pcbc|capb

Related symptoms:

  • Prostate cancer
  • Neoplasm of the central nervous system


SOURCES: OMIM MENDELIAN

More info about PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY

Top 5 symptoms//phenotypes associated to Hypertension and Prostate cancer

Symptoms // Phenotype % cases
Neoplasm Common - Between 50% and 80% cases
Hearing impairment Uncommon - Between 30% and 50% cases
Sensorineural hearing impairment Uncommon - Between 30% and 50% cases
Pain Uncommon - Between 30% and 50% cases
Arthritis Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Hypertension and Prostate cancer. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Dilatation Visual loss Visual impairment Abdominal pain Seizures Neoplasm of the pancreas Gait disturbance Nausea and vomiting Malabsorption Carcinoma Myocardial infarction Neurological speech impairment

Rare Symptoms - Less than 30% cases

Increased intracranial pressure Gastrointestinal hemorrhage Constipation Sensory neuropathy Paresthesia Hemiplegia/hemiparesis Cough Dysarthria Capillary hemangioma Dyskinesia Hydronephrosis Weight loss Migraine Retinal detachment Recurrent respiratory infections Arrhythmia Hydrocephalus Otitis media Anxiety Abnormality of the pancreas Vomiting Pheochromocytoma Pancreatic cysts Chronic obstructive pulmonary disease Papillary cystadenoma of the epididymis Retinal capillary hemangioma Hemoptysis Wheezing Growth delay Pulmonary fibrosis Sinusitis Intestinal obstruction Multiple renal cysts Gastroesophageal reflux Clubbing Pancreatitis Abnormality of the liver Renal cell carcinoma Delayed puberty Headache Nephrocalcinosis Respiratory distress Exocrine pancreatic insufficiency Intellectual disability Cognitive impairment Prostatitis Cryptorchidism Abnormality of cardiovascular system morphology Abnormality of the nose Clinodactyly Coarctation of aorta Pancreatic adenocarcinoma Arthralgia Epididymal cyst Fatigue Joint stiffness Short stature Agenesis of corpus callosum Hypogonadism Hepatocellular carcinoma Pituitary adenoma Micropenis Ovarian neoplasm Neuroblastoma Intestinal polyposis Dysgraphia Osteopenia Amaurosis fugax Glioblastoma multiforme Cleft palate Neoplasm of the skeletal system Urinary tract neoplasm Cardiac diverticulum Neoplasm of the rectum Retinal neovascularization Cerebellar hemangioblastoma Abnormality of creatine metabolism Pulmonary capillary hemangiomatosis Benign neoplasm of the central nervous system Leiomyosarcoma Hemangioblastoma Neoplasm of the thyroid gland Spinal hemangioblastoma Secondary hyperaldosteronism Neoplasm of the ear Agnosia Abnormality of the nervous system Colon cancer Breast carcinoma Visual field defect Microphallus Hypertonia Hypogonadotrophic hypogonadism Holoprosencephaly Adrenal pheochromocytoma Muscular hypotonia Bimanual synkinesia Anosmia Choroidal neovascularization Behavioral abnormality Gonadotropin deficiency Hyposmia Reduced number of teeth Posterior uveitis Unilateral renal agenesis Hypopituitarism Ectrodactyly Gynecomastia Depressivity Cleft lip Attention deficit hyperactivity disorder Coloboma Basal cell carcinoma Thromboembolism Hallucinations Cleft upper lip Memory impairment Oral cleft Iris coloboma Choanal atresia Abnormal pyramidal sign Vesicoureteral reflux Irritability Renal agenesis Developmental regression Amenorrhea Hypotelorism Primary amenorrhea Flexion contracture Intellectual disability, mild Global developmental delay Abnormality of the fingernails Short clavicles Proportionate short stature Celiac disease High pitched voice Preauricular pit Impulsivity Language impairment Trigonocephaly Abnormality of the voice Nasal speech Abnormality of the hand Finger clinodactyly Lipoma Generalized hirsutism Short thumb Long eyelashes Broad thumb Recurrent otitis media Short palpebral fissure Low posterior hairline Interphalangeal joint contracture of finger Apraxia Hypoplasia of penis Microdontia Sprengel anomaly Cone-shaped epiphyses of the phalanges of the hand Dental malocclusion Expressive language delay Mesocardia Generalized cerebral atrophy/hypoplasia Abnormal soft palate morphology Broad fingertip Curved fingers Enlarged naris Congenital posterior urethral valve Congenital pseudoarthrosis of the clavicle Pseudoarthrosis Persistent left superior vena cava Varicocele Short upper lip Short columella Spinal dysraphism Stiff neck Tethered cord Broad columella Hyperextensibility of the finger joints Speech apraxia Enlarged joints 11 pairs of ribs Villous atrophy Enuresis Short attention span Abnormality of the clavicle Underdeveloped nasal alae Prominent nose Microcephaly Abnormality of the dentition Hypothyroidism Hyperactivity Upslanted palpebral fissure Posteriorly rotated ears Babinski sign Clinodactyly of the 5th finger Delayed skeletal maturation Inguinal hernia Abnormal heart morphology Hypospadias Paraganglioma Atrial septal defect Kyphoscoliosis Short neck Abnormality of the skeletal system Intrauterine growth retardation Wide nasal bridge Brachydactyly Hyperreflexia Delayed speech and language development High palate Low-set ears Abnormal facial shape Strabismus Micrognathia Mandibular prognathia Umbilical hernia Broad nasal tip Small for gestational age Triangular face Hypoplasia of the maxilla Small hand Downturned corners of mouth Hirsutism Bulbous nose Thin vermilion border Smooth philtrum Joint hyperflexibility Poor speech Hypermetropia Prominent nasal bridge Thin upper lip vermilion Short philtrum Camptodactyly of finger Craniosynostosis Wide mouth Postnatal growth retardation Feeding difficulties in infancy Intellectual disability, moderate Telecanthus Joint laxity Aggressive behavior Conductive hearing impairment Deeply set eye Carcinoid tumor Chronic pancreatitis Neoplasm of the endocrine system Epistaxis Cranial nerve paralysis Purpura Conjunctivitis Vasculitis Meningitis Hoarse voice Skin ulcer Diplopia Subcutaneous nodule Chest pain Hemiplegia Nephropathy Hematuria Papule Stroke Skin rash Retinopathy Autoimmunity Paralysis Proteinuria Myalgia Venous thrombosis Glomerulonephritis Proptosis Tracheal stenosis Periorbital edema Elevated C-reactive protein level Inflammatory abnormality of the eye Nasal obstruction Recurrent corneal erosions Abnormality of the hypothalamus-pituitary axis Cerebral ischemia Concave nasal ridge Angina pectoris Myositis Pleural effusion Gangrene Pulmonary infiltrates Pericarditis Glomerulopathy Elevated erythrocyte sedimentation rate Petechiae Restrictive ventilatory defect Diabetes insipidus Stridor Chronic otitis media Dyspnea Renal insufficiency Ocular pain Atherosclerosis Hyperparathyroidism Vertebral fusion Abnormality of the ear Aortic aneurysm Back pain Abnormality of the urinary system Growth abnormality Abnormality of vision Reduced bone mineral density Joint dislocation Abnormal joint morphology Aminoaciduria Abnormality of the nail Nephrolithiasis Osteoarthritis Blue sclerae Aciduria Abnormality of skin pigmentation Abnormality of the eye Abnormality of metabolism/homeostasis Kyphosis Abnormal heart valve morphology Arthropathy Cardiomyopathy Coronary artery calcification Respiratory insufficiency Fever Peripheral neuropathy Ochronosis Pigmentation of the sclera Tendonitis Intervertebral disk calcification Thickened Achilles tendon Tendon rupture Cartilage destruction Irregular hyperpigmentation Calcification of cartilage Intervertebral disc degeneration Mitral valve calcification Aortic valve calcification Dark urine Chronic pain Low back pain Hearing abnormality Ankylosis Joint swelling Rhinorrhea Subglottic stenosis Facial paralysis Biliary cirrhosis Meconium ileus Productive cough Obstructive lung disease Secretory diarrhea Chronic infection Nasal polyposis Rectal prolapse Pneumothorax Ileus Allergy Obstructive azoospermia Cor pulmonale Chronic lung disease Bronchitis Male infertility Steatorrhea Malnutrition Emphysema Portal hypertension Hypercalciuria Tachypnea Recurrent bronchopulmonary infections Absent vas deferens Recurrent pneumonia Tinnitus Renal neoplasm Hyperaldosteronism Papilledema Subarachnoid hemorrhage Polycythemia Hamartoma Neurofibromas Hypercalcemia Hypokalemia Hemangioma Elevated sweat chloride Progressive visual loss Nevus Renal cyst Vertigo Blindness Edema Microscopic nephrocalcinosis Echogenic fetal bowel Cellular metachromasia Biliary tract obstruction Azoospermia Insulin resistance Pleuritis Nystagmus Arteriovenous malformation Telangiectasia of the skin Aplasia/Hypoplasia of the cerebellum Polycystic kidney dysplasia Multicystic kidney dysplasia Abnormality of the kidney Glaucoma Hyperhidrosis Cataract Ataxia Abnormality of the retinal vasculature Recurrent intrapulmonary hemorrhage Scleritis Increased inflammatory response Arteritis Episcleritis Abnormal oral cavity morphology Ureteral stenosis Endocarditis Neuritis Granulomatosis Abnormality of the cerebral vasculature Visceral angiomatosis Bronchiectasis Respiratory tract infection Abnormal lung morphology Dehydration Decreased antibody level in blood Asthma Abdominal distention Cirrhosis Nausea Infertility Scarring Elevated hepatic transaminase Abnormality of the lymphatic system Respiratory failure Diabetes mellitus Recurrent infections Immunodeficiency Diarrhea Hepatomegaly Failure to thrive Neoplasm of the middle ear Vascular neoplasm Neuroendocrine neoplasm Neoplasm of the central nervous system


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