Hypertension, and Pallor

Diseases related with Hypertension and Pallor

In the following list you will find some of the most common rare diseases related to Hypertension and Pallor that can help you solving undiagnosed cases.

Top matches:

Medium match PITUITARY APOPLEXY

The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.

Related symptoms:

  • Ptosis
  • Hypertension
  • Fever
  • Fatigue
  • Headache


SOURCES: MESH ORPHANET MENDELIAN

More info about PITUITARY APOPLEXY

Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia is an inborn error of folate metabolism due to deficiency of methylenetetrahydrofolate dehydrogenase-1. Manifestations may include hemolytic uremic syndrome, macrocytosis, epilepsy, hearing loss, retinopathy, mild mental retardation, lymphopenia involving all subsets, and low T-cell receptor excision circles. Folinic acid supplementation is an effective treatment (summary by Ramakrishnan et al., 2016).

COMBINED IMMUNODEFICIENCY AND MEGALOBLASTIC ANEMIA WITH OR WITHOUT HYPERHOMOCYSTEINEMIA; CIMAH Is also known as methylenetetrahydrofolate dehydrogenase 1 deficiency

Related symptoms:

  • Intellectual disability
  • Seizures
  • Hearing impairment
  • Sensorineural hearing impairment
  • Anemia


SOURCES: OMIM MENDELIAN

More info about COMBINED IMMUNODEFICIENCY AND MEGALOBLASTIC ANEMIA WITH OR WITHOUT HYPERHOMOCYSTEINEMIA; CIMAH

Congenital thrombotic thrombocytopenic purpura is the hereditary form of thrombotic thrombocytopenic purpura (TTP; see this term) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and single or multiple organ failure of variable severity.

CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA Is also known as congenital ttp|microangiopathic hemolytic anemia|thrombotic microangiopathy, familial|microangiopathic hemolytic anemia, congenital|congenital adamts-13 deficiency|upshaw factor, deficiency of|uss|thrombotic thrombocytopenic purpura, familial|familial ttp

Related symptoms:

  • Seizures
  • Pain
  • Anemia
  • Hypertension
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA

Other less relevant matches:

DENYS-DRASH SYNDROME; DDS Is also known as nephropathy, wilms tumor, and genital anomalies|drash syndrome|wilms tumor and pseudo- or true hermaphroditism

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Nystagmus
  • Neoplasm
  • Cleft palate


SOURCES: OMIM MENDELIAN

More info about DENYS-DRASH SYNDROME; DDS

A rare adenoma of the anterior lobe of the pituitary gland that produces thyrotropin. It is usually associated with goiter and hyperthyroidism.

TSH-SECRETING PITUITARY ADENOMA Is also known as thyrotroph adenoma|pituitary thyrotrophic adenoma|thyroid stimulating hormone-secreting pituitary adenoma|tsh-oma

Related symptoms:

  • Seizures
  • Ptosis
  • Hypertension
  • Tremor
  • Fatigue


SOURCES: ORPHANET MENDELIAN

More info about TSH-SECRETING PITUITARY ADENOMA

Hereditary paraganglioma-pheochromocytomas (PGL/PCC) are rare neuroendocrine tumors represented by paragangliomas (occurring in any paraganglia from the skull base to the pelvic floor) and pheochromocytomas (adrenal medullary paragangliomas; see this term).

HEREDITARY PHEOCHROMOCYTOMA-PARAGANGLIOMA Is also known as familial pheochromocytoma-paraganglioma

Related symptoms:

  • Tremor
  • Fatigue
  • Congestive heart failure
  • Weight loss
  • Conductive hearing impairment


SOURCES: ORPHANET MENDELIAN

More info about HEREDITARY PHEOCHROMOCYTOMA-PARAGANGLIOMA

Medium match PHEOCHROMOCYTOMA

Pheochromocytomas are catecholamine-secreting tumors that usually arise within the adrenal medulla. Approximately 10% arise in extraadrenal sympathetic ganglia, and are referred to as 'paragangliomas.' Approximately 10% are malignant, and approximately 10% are hereditary (Maher and Eng, 2002; Dluhy, 2002).Bolande (1974) introduced the concept and designation of the neurocristopathies, and identified 'simple,' including pheochromocytoma and medullary carcinoma of the thyroid, and 'complex' neurocristopathies and neurocristopathic syndromes, including NF1 and MEN2.Knudson and Strong (1972) applied Knudson's 2-mutation theory to pheochromocytoma (see discussion in {180200}) and concluded that it fits.Maher and Eng (2002) reviewed the clinical entities and genes associated with pheochromocytoma.

PHEOCHROMOCYTOMA Is also known as pheochromocytoma, susceptibility to

Related symptoms:

  • Neoplasm
  • Hypertension
  • Tremor
  • Fatigue
  • Congestive heart failure


SOURCES: ORPHANET OMIM MENDELIAN

More info about PHEOCHROMOCYTOMA

Alport syndrome is an inherited disorder of the basement membrane, resulting in progressive renal failure due to glomerulonephropathy, variable sensorineural hearing loss, and variable ocular anomalies (review by Kashtan, 1999).Alport syndrome is a genetically heterogeneous disorder, with all forms resulting from mutations in genes encoding type IV collagen, which is a major structural component of the basement membrane. Approximately 85% of cases of Alport syndrome are X-linked and about 15% are autosomal recessive (OMIM ); autosomal dominant inheritance (OMIM ) is rare (Kashtan, 1999).See also benign familial hematuria (BFH ), a phenotypically similar, but milder disorder.Alport syndrome is also a feature of 2 contiguous gene deletion syndromes involving the COL4A5 gene: Alport syndrome and diffuse leiomyomatosis (OMIM ) and Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis (AMME ).

ALPORT SYNDROME, X-LINKED; ATS Is also known as nephropathy and deafness, x-linked

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Sensorineural hearing impairment
  • Cataract
  • Hypertension


SOURCES: ORPHANET OMIM MENDELIAN

More info about ALPORT SYNDROME, X-LINKED; ATS

Medium match CADASIL

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary cerebrovascular disorder characterized by mid-adult onset of recurrent subcortical ischemic stroke and cognitive impairment progressing to dementia in addition to migraines with aura and mood disturbances seen in about a third of patients.

CADASIL Is also known as dementia, hereditary multi-infarct type|cadasil|cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy|casil|hereditary multi-infarct dementia

Related symptoms:

  • Seizures
  • Hearing impairment
  • Ataxia
  • Sensorineural hearing impairment
  • Muscle weakness


SOURCES: OMIM ORPHANET MENDELIAN

More info about CADASIL

ARTERIAL TORTUOSITY SYNDROME; ATS Is also known as arterial tortuosity

Related symptoms:

  • Intellectual disability
  • Seizures
  • Generalized hypotonia
  • Scoliosis
  • Hypertelorism


SOURCES: OMIM MENDELIAN

More info about ARTERIAL TORTUOSITY SYNDROME; ATS

Top 5 symptoms//phenotypes associated to Hypertension and Pallor

Symptoms // Phenotype % cases
Fatigue Common - Between 50% and 80% cases
Headache Common - Between 50% and 80% cases
Vomiting Common - Between 50% and 80% cases
Proteinuria Uncommon - Between 30% and 50% cases
Tremor Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Hypertension and Pallor. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Weight loss Seizures Fever Hearing impairment Intellectual disability Hematuria Nausea Cerebral hemorrhage Sensorineural hearing impairment Glomerulosclerosis Vertigo Palpitations Retinopathy Bitemporal hemianopia Congestive heart failure Renal insufficiency Adrenocorticotropic hormone deficiency Ptosis Aniridia Confusion Impotence Coma Hypotension Diplopia Growth hormone excess Cranial nerve paralysis Nausea and vomiting

Rare Symptoms - Less than 30% cases

Progressive visual loss Neoplasm Nephrotic syndrome Gynecomastia Easy fatigability Male hypogonadism Oculomotor nerve palsy Abnormal renal physiology Secondary growth hormone deficiency Decreased fertility in females Hypogonadotrophic hypogonadism Hernia Edema Glomerulopathy Delayed puberty Osteopenia Hyperhidrosis Osteoporosis Stage 5 chronic kidney disease Blindness Amenorrhea Sudden loss of visual acuity Congenital diaphragmatic hernia Decreased female libido Dysphonia Decreased circulating ACTH level Paraganglioma of head and neck Hypertensive retinopathy Panic attack Hypertension associated with pheochromocytoma Episodic hyperhidrosis Extraadrenal pheochromocytoma Elevated urinary epinephrine Elevated urinary dopamine Pulsatile tinnitus Elevated urinary norepinephrine Positive regitine blocking test Paroxysmal vertigo Congenital cataract Dysphagia Stroke Recurrent pneumonia Episodic paroxysmal anxiety Adrenal pheochromocytoma Female hypogonadism Conductive hearing impairment Adrenocorticotropin deficient adrenal insufficiency Decreased fertility in males Cranial nerve VI palsy Fourth cranial nerve palsy Internal ophthalmoplegia Abnormality of hair density Chest pain Recurrent paroxysmal headache Personality changes Hypercalcemia Episodic abdominal pain Flushing Paraganglioma Sinus tachycardia Cranial nerve compression Microscopic hematuria Vocal cord paralysis Glomerulonephritis Hemiparesis Pituitary hypothyroidism Bilateral sensorineural hearing impairment Photophobia Blurred vision Thrombocytopenia Galactorrhea Respiratory distress Pain Abnormality of the kidney Hemolytic-uremic syndrome Anemia Hypoglycemia Recurrent infections Prolactin excess Leukopenia Reduced visual acuity Migraine Impaired pain sensation Sensory neuropathy Amyloidosis Bulbar palsy Scotoma Tetraplegia Aphasia Brain atrophy Apathy Hemiplegia Urinary incontinence Abnormality of the skin Spastic tetraparesis Abnormal electroretinogram Memory impairment Peripheral demyelination Bradykinesia Abnormality of extrapyramidal motor function Leukoencephalopathy Psychosis Inability to walk Shock Atherosclerosis Myocardial infarction Truncal ataxia Tetraparesis Generalized tonic-clonic seizures Dysmetria Muscle weakness Hyperreflexia Peripheral neuropathy Visual impairment Delayed speech and language development Cognitive impairment Spasticity Ataxia Gait disturbance Cylindruria Morphological abnormality of the semicircular canal Lentiglobus Anterior lenticonus Diffuse leiomyomatosis Diffuse glomerular basement membrane lamellation Neoplasm of the colon Dysarthria Myopathy Lower limb muscle weakness EEG abnormality Abnormality of eye movement Attention deficit hyperactivity disorder Developmental regression Abnormality of the eye Mental deterioration Facial palsy Cerebral cortical atrophy Hypertonia Dementia Babinski sign Elevated serum creatine phosphokinase Visual loss Encephalopathy Depressivity Behavioral abnormality Optic neuropathy Stroke-like episode Abnormality of visual evoked potentials Aortic valve stenosis Hyperextensible skin Ischemic stroke Cutis laxa Aortic regurgitation Short chin Increased body weight Telangiectasia Heart murmur Thin skin Ventricular hypertrophy Convex nasal ridge Bruising susceptibility Long face Arachnodactyly Pulmonic stenosis Hyperinsulinemia Hyperglycemia Scarring Abnormal thrombosis Telangiectases of the cheeks Curved fingers Generalized arterial tortuosity Soft, doughy skin Dyspareunia Arterial tortuosity Rectal prolapse Bladder diverticulum Epiphora Hiatus hernia Soft skin Pulmonary artery stenosis Tracheomalacia Aortic root aneurysm Keratoconus Atrophic scars Pectus carinatum Blepharophimosis Transient ischemic attack Subcutaneous hemorrhage Abulia Subcortical dementia Retinal arteriolar tortuosity Focal sensory seizure Diffuse leukoencephalopathy Amaurosis fugax Mania Nonarteritic anterior ischemic optic neuropathy Perseveration Pseudobulbar paralysis Abnormality of nervous system morphology Migraine with aura Lenticonus Cerebral ischemia Varicose veins Recurrent subcortical infarcts Scintillating scotoma Joint laxity Downslanted palpebral fissures Umbilical hernia Macrotia Respiratory failure Inguinal hernia Pectus excavatum Dilatation Long philtrum Macrocephaly Subdural hemorrhage High palate Flexion contracture Muscular hypotonia Micrognathia Hypertelorism Scoliosis Generalized hypotonia Uterine neoplasm Edema of the lower limbs Thickening of the glomerular basement membrane Ovarian gonadoblastoma Septic arthritis Decreased methylcobalamin Hypogonadism Thiamine-responsive megaloblastic anemia Diarrhea Gonadal tissue inappropriate for external genitalia or chromosomal sex True hermaphroditism Asthenia Anuria Streak ovary Low-grade fever Uterus didelphys Ambiguous genitalia, female Diffuse mesangial sclerosis Infertility Folate deficiency Gonadoblastoma Severe combined immunodeficiency Macrocytic anemia Thrombocytosis Abnormality of the menstrual cycle Supraventricular arrhythmia Hemianopia Menstrual irregularities Increased circulating gonadotropin level Anisocytosis Hyperthyroidism Pericardial effusion Hypokalemia Antinuclear antibody positivity Goiter Ventricular arrhythmia Megaloblastic anemia Ambiguous genitalia, male Male pseudohermaphroditism Lymphopenia Hyperbilirubinemia Nystagmus Schistocytosis Microangiopathic hemolytic anemia Increased blood urea nitrogen Bloody diarrhea Neonatal hyperbilirubinemia Preeclampsia Respiratory insufficiency Elevated serum creatinine Purpura Reticulocytosis Autoimmune thrombocytopenia Acute kidney injury Prolonged neonatal jaundice Cleft palate Increased serum lactate Gonadal dysgenesis Jaundice Arrhythmia Focal segmental glomerulosclerosis Nephroblastoma Abdominal pain Abnormality of the genital system Primary amenorrhea Ambiguous genitalia Abnormal bleeding Paralysis Abdominal distention Nephropathy Skin rash Lethargy Hemolytic anemia Micropenis Combined immunodeficiency Recurrent urinary tract infections Macroscopic hematuria Raynaud phenomenon Cataract Episodic hypertension Renal artery stenosis Albuminuria Pheochromocytoma Neoplasm of the endocrine system Hemangioma Midface retrusion Cafe-au-lait spot Tachycardia Growth hormone deficiency Carcinoma Arachnoid hemangiomatosis Hypergonadotropic hypogonadism Myopia Dyspnea Hypopituitarism Hyperkalemia Periorbital edema Elliptocytosis Abdominal situs inversus Foam cells Corneal erosion Tubulointerstitial nephritis Hypoparathyroidism Dry skin Macular dystrophy Nephritis Chronic kidney disease Tinnitus Corneal dystrophy Subcutaneous nodule Ichthyosis Hyponatremia Increased circulating cortisol level Increased thyroid-stimulating hormone level Metabolic acidosis Heteronymous hemianopia Acidosis Abnormal visual field test Arthritis Autoimmunity Enlarged pituitary gland Euthyroid hyperthyroxinemia Pneumonia Abnormality of the pituitary gland Periodic hypokalemic paresis Erectile abnormalities Decreased antibody level in blood Pancytopenia Central adrenal insufficiency Thyroid crisis Immunodeficiency Oligomenorrhea Elevated calcitonin Retinal capillary hemangioma Pituitary adenoma Excessive daytime somnolence Central diabetes insipidus Normochromic anemia Abnormality of the cerebrospinal fluid Mydriasis Intellectual disability, mild Prolactin deficiency Trigeminal neuralgia Abnormal kinetic perimetry test Thunderclap headache Abnormal caudate nucleus morphology Abnormal static automated perimetry test Renal cell carcinoma Aortic tortuosity


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