Hypertension, and Dysarthria

Diseases related with Hypertension and Dysarthria

In the following list you will find some of the most common rare diseases related to Hypertension and Dysarthria that can help you solving undiagnosed cases.

Top matches:

Fatal familial insomnia (FFI) is a very rare form of prion disease (see this term) characterized by subacute onset of insomnia showing as a reduced overall sleep time, autonomic dysfunction, and motor disturbances.

FATAL FAMILIAL INSOMNIA Is also known as insomnia, fatal familial

Related symptoms:

  • Seizures
  • Ataxia
  • Nystagmus
  • Spasticity
  • Hypertension


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about FATAL FAMILIAL INSOMNIA

Medium match CARASIL

CARASIL is a hereditary cerebral small vessel disease characterized by early-onset gait disturbances, premature scalp alopecia, ischemic stroke, acute mid to lower back pain and progressive cognitive disturbances leading to severe dementia.

CARASIL Is also known as cerebrovascular disease with thin skin, alopecia, and disc disease|subcortical vascular encephalopathy, progressive|maeda syndrome|cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy

Related symptoms:

  • Ataxia
  • Nystagmus
  • Pain
  • Spasticity
  • Cognitive impairment


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about CARASIL

Medium match SNEDDON SYNDROME

Sneddon's syndrome (SS) is a rare non-inflammatory thrombotic vasculopathy characterized by the combination of cerebrovascular disease with livedo racemosa.

SNEDDON SYNDROME Is also known as livedo reticularis-cerebrovascular accident syndrome|livedo racemosa-cerebrovascular accident syndrome|livedo reticularis and cerebrovascular accidents|ehrmann-sneddon syndrome

Related symptoms:

  • Seizures
  • Muscle weakness
  • Pain
  • Visual impairment
  • Motor delay


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about SNEDDON SYNDROME

Other less relevant matches:

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a rare neurodegenerative disorder characterized by adult-onset progressive intention tremor and gait ataxia.

FRAGILE X-ASSOCIATED TREMOR/ATAXIA SYNDROME Is also known as fxtas syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Hearing impairment
  • Ataxia


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about FRAGILE X-ASSOCIATED TREMOR/ATAXIA SYNDROME

Riboflavin transporter deficiency (RTD) is a progressive motor neuron disorder characterized by respiratory insufficiency, sensorineural deafness and progressive ponto-bulbar palsy.

RIBOFLAVIN TRANSPORTER DEFICIENCY Is also known as sensorineural hearing loss-pontobulbar palsy syndrome|brown-vialetto-van laere syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Ataxia
  • Muscle weakness
  • Muscular hypotonia


SOURCES: ORPHANET MENDELIAN

More info about RIBOFLAVIN TRANSPORTER DEFICIENCY

Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disorder characterized by maternally transmitted diabetes and sensorineural deafness.

MATERNALLY-INHERITED DIABETES AND DEAFNESS Is also known as ballinger-wallace syndrome|diabetes-deafness syndrome, maternally transmitted|mitochondrial diabetes|noninsulin-dependent diabetes mellitus with deafness|niddm with deafness|diabetes mellitus, type ii, with deafness|midd

Related symptoms:

  • Intellectual disability
  • Seizures
  • Hearing impairment
  • Ataxia
  • Sensorineural hearing impairment


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about MATERNALLY-INHERITED DIABETES AND DEAFNESS

Juvenile Huntington disease (JHD) is a form of Huntington disease (HD; see this term), characterized by onset of signs and symptoms before 20 years of age.

JUVENILE HUNTINGTON DISEASE Is also known as huntington chorea|jhd|juvenile huntington chorea

Related symptoms:

  • Seizures
  • Ataxia
  • Cognitive impairment
  • Anemia
  • Delayed speech and language development


SOURCES: OMIM ORPHANET MENDELIAN

More info about JUVENILE HUNTINGTON DISEASE

Hypermanganesemia with dystonia-1 is an autosomal recessive metabolic disorder characterized by increased serum manganese, motor neurodegeneration with extrapyramidal features, polycythemia, and hepatic dysfunction, which leads to cirrhosis in some cases. Intellectual function is preserved (summary by Tuschl et al., 2012 and Quadri et al., 2012). Genetic Heterogeneity of Hypermanganesemia With DystoniaSee also HMNDYT2 (OMIM ), caused by mutation in the SLC39A14 gene (OMIM ) on chromosome 8p21.

CIRRHOSIS-DYSTONIA-POLYCYTHEMIA-HYPERMANGANESEMIA SYNDROME Is also known as hmdpc|hypermanganesemia with dystonia, polycythemia, and cirrhosis

Related symptoms:

  • Microcephaly
  • Ataxia
  • Hypertension
  • Peripheral neuropathy
  • Hepatomegaly


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about CIRRHOSIS-DYSTONIA-POLYCYTHEMIA-HYPERMANGANESEMIA SYNDROME

Bilateral striopallidodentate calcinosis (BSPDC, also erroneously called Fahr disease) is characterized by the accumulation of calcium deposits in different brain regions, particularly the basal ganglia and dentate nucleus, and is often associated with neurodegeneration.

BILATERAL STRIOPALLIDODENTATE CALCINOSIS Is also known as cerebrovascular ferrocalcinosis|primary familial brain calcification|ferrocalcinosis, cerebrovascular|pfbc|bspdc|striopallidodentate calcinosis, bilateral|cerebral calcification, nonarteriosclerotic, idiopathic, adult-onset|basal ganglia calcification, id

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Microcephaly
  • Ataxia


SOURCES: ORPHANET OMIM MENDELIAN

More info about BILATERAL STRIOPALLIDODENTATE CALCINOSIS

Medium match CADASIL

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary cerebrovascular disorder characterized by mid-adult onset of recurrent subcortical ischemic stroke and cognitive impairment progressing to dementia in addition to migraines with aura and mood disturbances seen in about a third of patients.

CADASIL Is also known as dementia, hereditary multi-infarct type|cadasil|cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy|casil|hereditary multi-infarct dementia

Related symptoms:

  • Seizures
  • Hearing impairment
  • Ataxia
  • Sensorineural hearing impairment
  • Muscle weakness


SOURCES: OMIM ORPHANET MENDELIAN

More info about CADASIL

Top 5 symptoms//phenotypes associated to Hypertension and Dysarthria

Symptoms // Phenotype % cases
Ataxia Very Common - Between 80% and 100% cases
Seizures Common - Between 50% and 80% cases
Tremor Common - Between 50% and 80% cases
Dysphagia Common - Between 50% and 80% cases
Mental deterioration Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Hypertension and Dysarthria. may also develop some of the following symptoms:

Common Symptoms - More than 50% cases

Dementia

Uncommon Symptoms - Between 30% and 50% cases

Gait disturbance

Common Symptoms - More than 50% cases

Memory impairment

Uncommon Symptoms - Between 30% and 50% cases

Pain Cognitive impairment Bradykinesia Hyperreflexia Rigidity Dysmetria Depressivity Muscle weakness Encephalopathy Apathy Vertigo Visual impairment Neuronal loss in central nervous system Gliosis Intellectual disability Neurodegeneration Stroke Abnormality of movement Urinary incontinence Abnormality of extrapyramidal motor function Gait ataxia Slurred speech Cerebral cortical atrophy Aggressive behavior Myalgia Astrocytosis Delayed speech and language development Emotional lability Facial palsy Peripheral neuropathy Hearing impairment Hemiparesis Abnormality of the cerebral white matter Chorea Personality changes Headache Behavioral abnormality Dystonia Dysdiadochokinesis Nystagmus Spasticity Cerebellar atrophy Myoclonus Postural instability Abnormality of eye movement Confusion Progressive neurologic deterioration Anxiety Abnormal autonomic nervous system physiology Aphasia Brain atrophy Parkinsonism Abnormal cerebellum morphology

Rare Symptoms - Less than 30% cases

Hypertrophic cardiomyopathy Lower limb muscle weakness Progressive cerebellar ataxia Abnormality of the liver Hemiplegia Myocardial infarction Migraine Poor fine motor coordination Transient ischemic attack Ptosis Bulbar palsy Paralysis Developmental regression Subcortical dementia Diabetes mellitus Subcutaneous hemorrhage Action tremor Mask-like facies Psychosis Global developmental delay Paraparesis Obsessive-compulsive behavior Truncal ataxia Cranial nerve paralysis Sensorineural hearing impairment Spastic paraparesis Amaurosis fugax Schizophrenia Hyporeflexia Cardiomyopathy Bipolar affective disorder Cerebral ischemia Myopathy Irritability Hypertonia Motor delay Abnormal pyramidal sign Impotence Mania Tetraparesis Peripheral demyelination Unsteady gait Ophthalmoplegia Inability to walk Broad-based gait Coma Babinski sign Diplopia Hallucinations Hyperkinesis Ventriculomegaly Agitation Generalized tonic-clonic seizures Leukoencephalopathy Weight loss Microcephaly Type II diabetes mellitus Diffuse leukoencephalopathy Fever Hepatomegaly Pseudobulbar paralysis Fatigue Urinary bladder sphincter dysfunction Constipation Clumsiness Stroke-like episode Progressive encephalopathy Akinesia Steppage gait Abnormality of coagulation Echolalia Axonal loss Polycythemia Generalized dystonia Hepatic encephalopathy Prolonged prothrombin time Esophageal varix Hypomimic face Rheumatoid arthritis Abnormal myelination Limb dystonia Hyperglycinemia Portal hypertension Hypokinesia Abnormal involuntary eye movements Splenomegaly Jaundice Unconjugated hyperbilirubinemia Difficulty walking Elevated hepatic transaminase Oral motor hypotonia Frequent temper tantrums Cirrhosis Suicidal ideation Hepatic steatosis Neuronal loss in basal ganglia Polyneuropathy Gastrointestinal hemorrhage Decreased liver function Muscle fibrillation Sensorimotor neuropathy Paranoia Testicular atrophy Dilated fourth ventricle Chronic bronchitis Head tremor Hyperbilirubinemia Pneumonia Upper limb undergrowth Restlessness Cerebellar vermis atrophy Toe walking Bronchitis Micronodular cirrhosis Pseudohypoparathyroidism Vitamin E deficiency Nausea Atherosclerosis Spastic tetraparesis Recurrent pneumonia Abnormality of the skin Tetraplegia Sensory neuropathy Attention deficit hyperactivity disorder Abnormal electroretinogram Pallor Abnormality of the eye Hypoglycemia EEG abnormality Elevated serum creatine phosphokinase Visual loss Shock Cerebral hemorrhage Dense calcifications in the cerebellar dentate nucleus Perseveration Scintillating scotoma Nonarteritic anterior ischemic optic neuropathy Recurrent subcortical infarcts Abulia Retinal arteriolar tortuosity Focal sensory seizure Abnormality of nervous system morphology Scotoma Migraine with aura Varicose veins Abnormality of visual evoked potentials Optic neuropathy Impaired pain sensation Amyloidosis Vomiting Calcification of the small brain vessels Abnormal globus pallidus morphology Abnormality of divalent inorganic cation homeostasis Cerebral calcification Dyskinesia Neurological speech impairment Corneal opacity Thrombocytopenia Intrauterine growth retardation Abnormal transferrin saturation Muscle stiffness Copper accumulation in liver Increased total iron binding capacity Decreased serum ferritin Pica Abnormality of amino acid metabolism Abnormal basal ganglia MRI signal intensity Choreoathetosis Oral-pharyngeal dysphagia Pill-rolling tremor Orofacial dyskinesia Progressive choreoathetosis Micrographia Focal motor seizures Limb dysmetria Mood swings Alcoholism Focal dystonia Athetosis Calcinosis Abnormal lower motor neuron morphology Lewy bodies Frontotemporal dementia Basal ganglia calcification Abnormality of neuronal migration Incoordination Limb muscle weakness Involuntary movements Antiphospholipid antibody positivity Heart murmur Cutis marmorata Visual field defect Atrophic scars Thrombocytosis Acrocyanosis Arteriovenous malformation Peripheral arterial stenosis Facial paralysis Hemianopia Arterial stenosis Thromboembolic stroke Vascular skin abnormality Lupus anticoagulant Systemic lupus erythematosus Autism Hypothyroidism Proximal muscle weakness Distal sensory impairment Hypotension Intention tremor Limb ataxia Horizontal nystagmus Premature ovarian insufficiency Postural tremor Global brain atrophy Bowel incontinence Abnormality of the thyroid gland Intracranial hemorrhage Vasculitis Atrophy/Degeneration affecting the brainstem Snoring Hyperhidrosis Apnea Tachycardia Stridor Insomnia Hyperventilation Hypothermia Bulbar signs Dysuria Central apnea Urinary retention Hypersomnia Delirium Alopecia Nephropathy Osteoporosis Sparse hair Spastic gait Back pain Urinary urgency Gaze-evoked nystagmus Spastic ataxia Low back pain Arteriosclerosis Diffuse white matter abnormalities Knee pain Pseudobulbar signs Diffuse demyelination of the cerebral white matter Arteriosclerosis of small cerebral arteries Resting tremor Diffuse cerebral atrophy Generalized-onset seizure Vestibular dysfunction Abnormality of the kidney Retinopathy Malabsorption Retinal degeneration Pigmentary retinopathy Bilateral sensorineural hearing impairment Pancytopenia External ophthalmoplegia Ragged-red muscle fibers Constriction of peripheral visual field Aplasia/Hypoplasia of the cerebellum Hyperglycemia Bundle branch block Macular dystrophy Arrhythmia Abnormal retinal morphology Progressive sensorineural hearing impairment Glomerulopathy Retinal atrophy Abnormality of lipid metabolism Left bundle branch block Abnormal chorioretinal morphology Anemia Hyperactivity Arthritis Cough Infertility Falls Proteinuria Renal insufficiency Olivopontocerebellar atrophy Muscular hypotonia Disinhibition Kinetic tremor Dysesthesia Saccadic smooth pursuit Pollakisuria Abnormality of brainstem morphology Abnormal nerve conduction velocity Impaired distal vibration sensation Diffuse cerebellar atrophy Obsessive-compulsive trait Retrocollis Inertia Impaired tandem gait Skeletal muscle atrophy Congestive heart failure Respiratory insufficiency Hypogonadism Optic disc pallor Gynecomastia Progressive hearing impairment Sleep apnea Cachexia Diabetes insipidus Abnormality of color vision Iris hypopigmentation Abnormal cranial nerve morphology Abnormality of macular pigmentation Cataract Optic atrophy Subdural hemorrhage


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