Hypertension, and Depressivity
Diseases related with Hypertension and Depressivity
In the following list you will find some of the most common rare diseases related to Hypertension and Depressivity that can help you solving undiagnosed cases.
High match DRUG METABOLISM, POOR, CYP2D6-RELATED
- Abnormality of metabolism/homeostasis
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High match CORTICOSTEROID-BINDING GLOBULIN DEFICIENCY
Corticosteroid-binding globulin deficiency is a rare, genetic, adrenal disease characterized by diminished corticosteroid-binding capacity associated with normal or low plasma corticosteroid-binding globulin concentration and reduced total plasma cortisol levels. Patients typically present chronic pain, fatigue and hypo/hypertension.
CORTICOSTEROID-BINDING GLOBULIN DEFICIENCY Is also known as transcortin deficiency|cbg deficiencyRelated symptoms:
- Abnormality of metabolism/homeostasis
More info about CORTICOSTEROID-BINDING GLOBULIN DEFICIENCY
ACTH-independent macronodular adrenal hyperplasia-2 is an autosomal dominant tumor susceptibility with syndromic incomplete penetrance, as a second hit to the ARMC5 gene is required to develop macronodular hyperplasia (Assie et al., 2013).
ACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2; AIMAH2 Is also known as primary macronodular adrenal hyperplasiaRelated symptoms:
- Round face
More info about ACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2; AIMAH2
Other less relevant matches:
PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 2; PPNAD2 Is also known as cushing syndrome, adrenal, due to ppnad2|pigmented micronodular adrenocortical disease, primary, 2Related symptoms:
More info about PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 2; PPNAD2
Medium match TRIMETHYLAMINURIA; TMAU
Trimethylaminuria results from the abnormal presence of large amounts of volatile and malodorous trimethylamine within the body. This chemical, a tertiary aliphatic amine, is excreted in the urine, sweat (ichthyohidrosis), and breath, which take on the offensive odor of decaying fish (Mitchell, 1996).
TRIMETHYLAMINURIA; TMAU Is also known as fish-odor syndromeRelated symptoms:
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Medium match FAMILIAL ISOLATED PITUITARY ADENOMA
Mutations in the AIP gene have been found predominantly in growth hormone (GH)-secreting adenomas, but have also been found in adrenocorticotropic hormone (ACTH)-secreting, thyroid hormone (TSH)-secreting, and prolactin (PRL)-secreting pituitary tumors.Pituitary adenomas are benign monoclonal neoplasms of the anterior pituitary gland, accounting for approximately 15% of intracranial tumors. Growth hormone (OMIM )-secreting adenomas, also known as somatotropinomas, which clinically result in acromegaly, comprise about 20% of all pituitary tumors and are the second most common hormone-secreting pituitary tumor after prolactin (OMIM )-secreting tumors, which account for 40 to 45% of pituitary tumors. ACTH-secreting tumors, which result in Cushing disease, and thyrotropin (TSHB )-secreting tumors are much less common. Nonsecreting pituitary tumors, which account for about 33%, can cause symptoms due to local compressive effects of tumor growth (Vierimaa et al., 2006; Georgitsi et al., 2007; Horvath and Stratakis, 2008).Acromegaly is characterized by coarse facial features, protruding jaw, and enlarged extremities (Vierimaa et al., 2006). Familial isolated somatotropinoma (FIS) is defined as the occurrence of at least 2 cases of acromegaly or gigantism in a family that does not exhibit features of other endocrine syndromes. FIS patients tend to have onset about 4 to 10 years earlier than patients with sporadic disease (Gadelha et al., 1999; Horvath and Stratakis, 2008).Cushing disease is characterized by central obesity, moon facies, diabetes, 'buffalo hump,' hypertension, fatigue, easy bruising, depression, and reproductive disorders. Cushing disease is associated with increased morbidity and mortality, mainly due to cardiovascular or cerebrovascular disease and infections (summary by Perez-Rivas et al., 2015).Familial isolated pituitary adenoma (FIPA) and pituitary adenoma predisposition (PAP) are terms referring to families in which 2 or more individuals develop pituitary tumors. Within a family, tumor types can be heterogeneous, with members of the same family having GH-secreting, prolactin-secreting, ACTH-secreting, or nonsecreting adenomas; in contrast, some families are homogeneous with regard to tumor type. Familial isolated somatotropinoma refers specifically to GH-secreting tumors and is usually associated with an acromegaly phenotype. Thus, FIS is a subset of FIPA or PAP (Toledo et al., 2007).Schlechte (2003) discussed prolactinoma in general terms as a clinical, diagnostic, and therapeutic problem.
FAMILIAL ISOLATED PITUITARY ADENOMA Is also known as somatotropinoma, familial isolated|pagh1|somatotrophinoma, familial|ifs|isolated familial somatotropinoma|fipa|acromegaly due to pituitary adenoma 1|fisRelated symptoms:
More info about FAMILIAL ISOLATED PITUITARY ADENOMA
Cushing syndrome is a clinical designation for the systemic signs and symptoms arising from excess cortisol production. Affected individuals typically show hypertension, impaired glucose tolerance, central obesity, osteoporosis, and sometimes depression. Corticotropin-independent Cushing syndrome results from autonomous cortisol production by the adrenal glands, often associated with adrenocortical tumors. Adrenocortical tumors are most common in adult females (summary by Cao et al., 2014; Sato et al., 2014).
PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 4; PPNAD4 Is also known as chromosome 19p13 duplication syndrome|cushing syndrome, adrenal, due to ppnad4Related symptoms:
- Muscle weakness
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Primary pigmented micronodular adrenocortical disease is a form of ACTH-independent adrenal hyperplasia resulting in Cushing syndrome. It is usually seen as a manifestation of the Carney complex (CNC1 ), a multiple neoplasia syndrome. However, PPNAD can also occur in isolation (Groussin et al., 2002).
PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1; PPNAD1 Is also known as pigmented micronodular adrenocortical disease, primary, 1|cushing syndrome, adrenal, due to ppnad1|adrenocortical nodular dysplasia, primaryRelated symptoms:
More info about PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1; PPNAD1
Medium match AUTOSOMAL DOMINANT DOPA-RESPONSIVE DYSTONIA
Autosomal dominant dopa-responsive dystonia (DYT5a) is a rare neurometabolic disorder characterized by childhood-onset dystonia that shows a dramatic and sustained response to low doses of levodopa (L-dopa) and that may be associated with parkinsonism at an older age.
AUTOSOMAL DOMINANT DOPA-RESPONSIVE DYSTONIA Is also known as hpd with marked diurnal fluctuation|gtpch1-deficient dopa-responsive dystonia|gtpch1-deficient drd|dyt5a|hereditary progressive dystonia with marked diurnal fluctuation|autosomal dominant segawa syndromeRelated symptoms:
- Intellectual disability
- Hearing impairment
More info about AUTOSOMAL DOMINANT DOPA-RESPONSIVE DYSTONIA
Medium match FATAL FAMILIAL INSOMNIA
Fatal familial insomnia (FFI) is a very rare form of prion disease (see this term) characterized by subacute onset of insomnia showing as a reduced overall sleep time, autonomic dysfunction, and motor disturbances.
FATAL FAMILIAL INSOMNIA Is also known as insomnia, fatal familialRelated symptoms:
More info about FATAL FAMILIAL INSOMNIA
Top 5 symptoms//phenotypes associated to Hypertension and Depressivity
|Symptoms // Phenotype||% cases|
|Increased circulating cortisol level||Uncommon - Between 30% and 50% cases|
|Anxiety||Uncommon - Between 30% and 50% cases|
|Neoplasm||Uncommon - Between 30% and 50% cases|
|Osteoporosis||Uncommon - Between 30% and 50% cases|
|Fatigue||Uncommon - Between 30% and 50% cases|
Other less frequent symptoms
Patients with Hypertension and Depressivity. may also develop some of the following symptoms:
Uncommon Symptoms - Between 30% and 50% casesBruising susceptibility Adrenal hyperplasia Obesity Primary hypercortisolism Agitation Mental deterioration Osteopenia Abdominal obesity Moon facies Round face
Rare Symptoms - Less than 30% casesTruncal obesity Dorsocervical fat pad Abnormality of metabolism/homeostasis Hypotension Tachycardia Paradoxical increased cortisol secretion on dexamethasone suppression test Pigmented micronodular adrenocortical disease Mood changes Decreased circulating ACTH level Hyperhidrosis Thin skin Gait ataxia Ataxia Kyphosis Macronodular adrenal hyperplasia Confusion Psychosis Striae distensae Postural tremor Nystagmus Torticollis Constipation Encephalopathy Cerebellar atrophy Dysphagia Tremor Fever Dysarthria Spasticity Brisk reflexes Seizures Impaired vibration sensation in the lower limbs Paresis of extensor muscles of the big toe Obsessive-compulsive behavior Transient hyperphenylalaninemia Rheumatoid arthritis Decreased CSF homovanillic acid Progressive flexion contractures Focal dystonia Generalized dystonia Dementia Lower limb hyperreflexia Limb dystonia Abnormality of the substantia nigra Abnormal autonomic nervous system physiology Myoclonus Stridor Delirium Hypersomnia Urinary retention Astrocytosis Central apnea Dysuria Bulbar signs Hypothermia Urinary bladder sphincter dysfunction Hyperventilation Insomnia Aphasia Impotence Apathy Weight loss Slurred speech Hyperkinesis Abnormality of extrapyramidal motor function Hallucinations Diplopia Progressive neurologic deterioration Neuronal loss in central nervous system Memory impairment Gliosis Coma Neurodegeneration Inability to walk Generalized tonic-clonic seizures Apnea Horizontal nystagmus Adrenocortical adenoma Bradykinesia Alzheimer disease Pituitary adenoma Prolactin excess Growth hormone excess Acanthosis nigricans Left ventricular hypertrophy Epidermal acanthosis Coarse facial features Headache Cardiomyopathy Trimethylaminuria Fish odor Body odor Recurrent pneumonia Menstrual irregularities Abnormality of the cardiovascular system Abnormal bleeding Neutropenia Splenomegaly Anemia Hyperglycemia Asthenia Increased muscle fatiguability Chronic pain Chronic fatigue Hepatic steatosis Pain Schizophrenia Neoplasm of the endocrine system Galactorrhea Parkinsonism Cerebral cortical atrophy Sleep disturbance Rigidity Hypothyroidism Pes cavus Babinski sign Talipes equinovarus Scoliosis Hearing impairment Intellectual disability Adrenocortical carcinoma Hypertrichosis Carcinoma Ecchymosis Pituitary prolactin cell adenoma Fragile skin Glucose intolerance Emotional lability Acne Increased body weight Hirsutism Proximal muscle weakness Diabetes mellitus Alopecia Muscle weakness Increased serum insulin-like growth factor 1 Prolactinoma Pituitary growth hormone cell adenoma Snoring
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