Hypertension, and Depressivity

Diseases related with Hypertension and Depressivity

In the following list you will find some of the most common rare diseases related to Hypertension and Depressivity that can help you solving undiagnosed cases.

Top matches:

Related symptoms:

  • Neoplasm
  • Hypertension
  • Abnormality of metabolism/homeostasis
  • Depressivity
  • Hypotension


SOURCES: MESH OMIM MENDELIAN

More info about DRUG METABOLISM, POOR, CYP2D6-RELATED

Corticosteroid-binding globulin deficiency is a rare, genetic, adrenal disease characterized by diminished corticosteroid-binding capacity associated with normal or low plasma corticosteroid-binding globulin concentration and reduced total plasma cortisol levels. Patients typically present chronic pain, fatigue and hypo/hypertension.

CORTICOSTEROID-BINDING GLOBULIN DEFICIENCY Is also known as transcortin deficiency|cbg deficiency

Related symptoms:

  • Pain
  • Hypertension
  • Fatigue
  • Abnormality of metabolism/homeostasis
  • Depressivity


SOURCES: OMIM ORPHANET MENDELIAN

More info about CORTICOSTEROID-BINDING GLOBULIN DEFICIENCY

ACTH-independent macronodular adrenal hyperplasia-2 is an autosomal dominant tumor susceptibility with syndromic incomplete penetrance, as a second hit to the ARMC5 gene is required to develop macronodular hyperplasia (Assie et al., 2013).

ACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2; AIMAH2 Is also known as primary macronodular adrenal hyperplasia

Related symptoms:

  • Neoplasm
  • Hypertension
  • Depressivity
  • Osteoporosis
  • Round face


SOURCES: OMIM MENDELIAN

More info about ACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 2; AIMAH2

Other less relevant matches:

PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 2; PPNAD2 Is also known as cushing syndrome, adrenal, due to ppnad2|pigmented micronodular adrenocortical disease, primary, 2

Related symptoms:

  • Hypertension
  • Kyphosis
  • Depressivity
  • Osteoporosis
  • Osteopenia


SOURCES: OMIM MENDELIAN

More info about PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 2; PPNAD2

Trimethylaminuria results from the abnormal presence of large amounts of volatile and malodorous trimethylamine within the body. This chemical, a tertiary aliphatic amine, is excreted in the urine, sweat (ichthyohidrosis), and breath, which take on the offensive odor of decaying fish (Mitchell, 1996).

TRIMETHYLAMINURIA; TMAU Is also known as fish-odor syndrome

Related symptoms:

  • Anemia
  • Hypertension
  • Splenomegaly
  • Depressivity
  • Hyperhidrosis


SOURCES: OMIM ORPHANET MENDELIAN

More info about TRIMETHYLAMINURIA; TMAU

Mutations in the AIP gene have been found predominantly in growth hormone (GH)-secreting adenomas, but have also been found in adrenocorticotropic hormone (ACTH)-secreting, thyroid hormone (TSH)-secreting, and prolactin (PRL)-secreting pituitary tumors.Pituitary adenomas are benign monoclonal neoplasms of the anterior pituitary gland, accounting for approximately 15% of intracranial tumors. Growth hormone (OMIM )-secreting adenomas, also known as somatotropinomas, which clinically result in acromegaly, comprise about 20% of all pituitary tumors and are the second most common hormone-secreting pituitary tumor after prolactin (OMIM )-secreting tumors, which account for 40 to 45% of pituitary tumors. ACTH-secreting tumors, which result in Cushing disease, and thyrotropin (TSHB )-secreting tumors are much less common. Nonsecreting pituitary tumors, which account for about 33%, can cause symptoms due to local compressive effects of tumor growth (Vierimaa et al., 2006; Georgitsi et al., 2007; Horvath and Stratakis, 2008).Acromegaly is characterized by coarse facial features, protruding jaw, and enlarged extremities (Vierimaa et al., 2006). Familial isolated somatotropinoma (FIS) is defined as the occurrence of at least 2 cases of acromegaly or gigantism in a family that does not exhibit features of other endocrine syndromes. FIS patients tend to have onset about 4 to 10 years earlier than patients with sporadic disease (Gadelha et al., 1999; Horvath and Stratakis, 2008).Cushing disease is characterized by central obesity, moon facies, diabetes, 'buffalo hump,' hypertension, fatigue, easy bruising, depression, and reproductive disorders. Cushing disease is associated with increased morbidity and mortality, mainly due to cardiovascular or cerebrovascular disease and infections (summary by Perez-Rivas et al., 2015).Familial isolated pituitary adenoma (FIPA) and pituitary adenoma predisposition (PAP) are terms referring to families in which 2 or more individuals develop pituitary tumors. Within a family, tumor types can be heterogeneous, with members of the same family having GH-secreting, prolactin-secreting, ACTH-secreting, or nonsecreting adenomas; in contrast, some families are homogeneous with regard to tumor type. Familial isolated somatotropinoma refers specifically to GH-secreting tumors and is usually associated with an acromegaly phenotype. Thus, FIS is a subset of FIPA or PAP (Toledo et al., 2007).Schlechte (2003) discussed prolactinoma in general terms as a clinical, diagnostic, and therapeutic problem. Genetic Heterogeneity of Pituitary AdenomasAlso see pituitary adenoma-2 (PITA2 ), caused by mutation in the GPR101 gene (OMIM ); pituitary adenoma-3 (PITA3 ), caused by somatic activating mutations in the GNAS1 gene (OMIM ); pituitary adenoma-4 (PITA4 ), caused by somatic mutation in the USP8 gene (OMIM ); and pituitary adenoma-5 (PITA5 ), caused by mutation in the CDH23 gene (OMIM ).Patients with the chromosome Xq26.3 microduplication syndrome (OMIM ) have growth hormone-secreting adenomas.Familial acromegaly can also occur in association with multiple endocrine neoplasia type I (MEN1 ), Carney complex (CNC1 ), and the McCune-Albright syndrome (OMIM ).Rostomyan et al. (2015) performed a retrospective analysis of 208 patients with pituitary gigantism due to pituitary adenoma or hyperplasia. Most patients (78.4%) were male, and the median onset of rapid growth was 13 years of age for boys and 11 years for girls. Of the 143 patients who consented to genetic testing, 29% had AIP mutations, and microduplication at Xq26.3 (XLAG ) was present in 2 familial isolated pituitary adenoma kindreds and in 10 sporadic patients. Rostomyan et al. (2015) noted that no genetic etiology was identified in more than 50% of the cases, and that the genetically unexplained cases showed more aggressive disease in terms of invasion, hormone levels, and lower control rates.

FAMILIAL ISOLATED PITUITARY ADENOMA Is also known as somatotropinoma, familial isolated|pagh1|somatotrophinoma, familial|ifs|isolated familial somatotropinoma|fipa|acromegaly due to pituitary adenoma 1|fis

Related symptoms:

  • Neoplasm
  • Hypertension
  • Fatigue
  • Cardiomyopathy
  • Headache


SOURCES: OMIM ORPHANET MENDELIAN

More info about FAMILIAL ISOLATED PITUITARY ADENOMA

Cushing syndrome is a clinical designation for the systemic signs and symptoms arising from excess cortisol production. Affected individuals typically show hypertension, impaired glucose tolerance, central obesity, osteoporosis, and sometimes depression. Corticotropin-independent Cushing syndrome results from autonomous cortisol production by the adrenal glands, often associated with adrenocortical tumors. Adrenocortical tumors are most common in adult females (summary by Cao et al., 2014; Sato et al., 2014).

PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 4; PPNAD4 Is also known as chromosome 19p13 duplication syndrome|cushing syndrome, adrenal, due to ppnad4

Related symptoms:

  • Muscle weakness
  • Hypertension
  • Obesity
  • Depressivity
  • Alopecia


SOURCES: OMIM MENDELIAN

More info about PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 4; PPNAD4

Primary pigmented micronodular adrenocortical disease is a form of ACTH-independent adrenal hyperplasia resulting in Cushing syndrome. It is usually seen as a manifestation of the Carney complex (CNC1 ), a multiple neoplasia syndrome. However, PPNAD can also occur in isolation (Groussin et al., 2002). Genetic Heterogeneity of Primary Pigmented Micronodular Adrenocortical DiseaseSee also PPNAD2 (OMIM ), caused by mutation in the PDE11A gene (OMIM ) on chromosome 2q31; PPNAD3 (OMIM ), caused by mutation in the PDE8B gene (OMIM ) on chromosome 5q13; and PPNAD4 (OMIM ), caused by a duplication on chromosome 19p13 that includes the PRKACA gene (OMIM ).

PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1; PPNAD1 Is also known as pigmented micronodular adrenocortical disease, primary, 1|cushing syndrome, adrenal, due to ppnad1|adrenocortical nodular dysplasia, primary

Related symptoms:

  • Neoplasm
  • Hypertension
  • Kyphosis
  • Obesity
  • Depressivity


SOURCES: OMIM MENDELIAN

More info about PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1; PPNAD1

Autosomal dominant dopa-responsive dystonia (DYT5a) is a rare neurometabolic disorder characterized by childhood-onset dystonia that shows a dramatic and sustained response to low doses of levodopa (L-dopa) and that may be associated with parkinsonism at an older age.

AUTOSOMAL DOMINANT DOPA-RESPONSIVE DYSTONIA Is also known as hpd with marked diurnal fluctuation|gtpch1-deficient dopa-responsive dystonia|gtpch1-deficient drd|dyt5a|hereditary progressive dystonia with marked diurnal fluctuation|autosomal dominant segawa syndrome

Related symptoms:

  • Intellectual disability
  • Hearing impairment
  • Scoliosis
  • Ataxia
  • Hypertension


SOURCES: ORPHANET MENDELIAN

More info about AUTOSOMAL DOMINANT DOPA-RESPONSIVE DYSTONIA

Fatal familial insomnia (FFI) is a very rare form of prion disease (see this term) characterized by subacute onset of insomnia showing as a reduced overall sleep time, autonomic dysfunction, and motor disturbances.

FATAL FAMILIAL INSOMNIA Is also known as insomnia, fatal familial

Related symptoms:

  • Seizures
  • Ataxia
  • Nystagmus
  • Spasticity
  • Hypertension


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about FATAL FAMILIAL INSOMNIA

Top 5 symptoms//phenotypes associated to Hypertension and Depressivity

Symptoms // Phenotype % cases
Increased circulating cortisol level Uncommon - Between 30% and 50% cases
Anxiety Uncommon - Between 30% and 50% cases
Neoplasm Uncommon - Between 30% and 50% cases
Osteoporosis Uncommon - Between 30% and 50% cases
Fatigue Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Hypertension and Depressivity. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Bruising susceptibility Adrenal hyperplasia Obesity Primary hypercortisolism Agitation Mental deterioration Osteopenia Abdominal obesity Moon facies Round face

Rare Symptoms - Less than 30% cases

Truncal obesity Dorsocervical fat pad Abnormality of metabolism/homeostasis Hypotension Tachycardia Paradoxical increased cortisol secretion on dexamethasone suppression test Pigmented micronodular adrenocortical disease Mood changes Decreased circulating ACTH level Hyperhidrosis Thin skin Gait ataxia Ataxia Kyphosis Macronodular adrenal hyperplasia Confusion Psychosis Striae distensae Postural tremor Nystagmus Torticollis Constipation Encephalopathy Cerebellar atrophy Dysphagia Tremor Fever Dysarthria Spasticity Brisk reflexes Seizures Impaired vibration sensation in the lower limbs Paresis of extensor muscles of the big toe Obsessive-compulsive behavior Transient hyperphenylalaninemia Rheumatoid arthritis Decreased CSF homovanillic acid Progressive flexion contractures Focal dystonia Generalized dystonia Dementia Lower limb hyperreflexia Limb dystonia Abnormality of the substantia nigra Abnormal autonomic nervous system physiology Myoclonus Stridor Delirium Hypersomnia Urinary retention Astrocytosis Central apnea Dysuria Bulbar signs Hypothermia Urinary bladder sphincter dysfunction Hyperventilation Insomnia Aphasia Impotence Apathy Weight loss Slurred speech Hyperkinesis Abnormality of extrapyramidal motor function Hallucinations Diplopia Progressive neurologic deterioration Neuronal loss in central nervous system Memory impairment Gliosis Coma Neurodegeneration Inability to walk Generalized tonic-clonic seizures Apnea Horizontal nystagmus Adrenocortical adenoma Bradykinesia Alzheimer disease Pituitary adenoma Prolactin excess Growth hormone excess Acanthosis nigricans Left ventricular hypertrophy Epidermal acanthosis Coarse facial features Headache Cardiomyopathy Trimethylaminuria Fish odor Body odor Recurrent pneumonia Menstrual irregularities Abnormality of the cardiovascular system Abnormal bleeding Neutropenia Splenomegaly Anemia Hyperglycemia Asthenia Increased muscle fatiguability Chronic pain Chronic fatigue Hepatic steatosis Pain Schizophrenia Neoplasm of the endocrine system Galactorrhea Parkinsonism Cerebral cortical atrophy Sleep disturbance Rigidity Hypothyroidism Pes cavus Babinski sign Talipes equinovarus Scoliosis Hearing impairment Intellectual disability Adrenocortical carcinoma Hypertrichosis Carcinoma Ecchymosis Pituitary prolactin cell adenoma Fragile skin Glucose intolerance Emotional lability Acne Increased body weight Hirsutism Proximal muscle weakness Diabetes mellitus Alopecia Muscle weakness Increased serum insulin-like growth factor 1 Prolactinoma Pituitary growth hormone cell adenoma Snoring


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Arthritis and Cyanosis, related diseases and genetic alterations Autoimmunity and Atrial septal defect, related diseases and genetic alterations Hyperreflexia and Arthritis, related diseases and genetic alterations Muscle weakness and Congenital cataract, related diseases and genetic alterations