Hyperreflexia, and Migraine

Diseases related with Hyperreflexia and Migraine

In the following list you will find some of the most common rare diseases related to Hyperreflexia and Migraine that can help you solving undiagnosed cases.

Top matches:

Dystonia-9 is an autosomal dominant neurologic disorder characterized by childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia. Most show some degree of cognitive impairment. Other variable features may include seizures, migraine headaches, and ataxia (summary by Weber et al., 2011).

PAROXYSMAL DYSTONIC CHOREATHETOSIS WITH EPISODIC ATAXIA AND SPASTICITY Is also known as dyt9|cse choreoathetosis, paroxysmal, with episodic ataxia|episodic choreoathetosis/spasticity|choreoathetosis, kinesigenic, with episodic ataxia and spasticity|choreoathetosis/spasticity, episodic

Related symptoms:

  • Intellectual disability
  • Seizures
  • Ataxia
  • Spasticity
  • Cognitive impairment


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about PAROXYSMAL DYSTONIC CHOREATHETOSIS WITH EPISODIC ATAXIA AND SPASTICITY

Paroxysmal exertion-induced dyskinesia (PED) is a form of paroxysmal dyskinesia (see this term), characterized by painless attacks of dystonia of the extremities triggered by prolonged physical activities.

PAROXYSMAL EXERTION-INDUCED DYSKINESIA Is also known as ped with or without epilepsy and/or hemolytic anemia|paroxysmal exertion-induced dystonia with or without epilepsy and/or hemolytic anemia|dyt18|dystonia 18|ped|paroxysmal exercise-induced dyskinesia with or without epilepsy and/or hemolytic anemia

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about PAROXYSMAL EXERTION-INDUCED DYSKINESIA

Spinocerebellar ataxia type 36 (SCA36) is a subtype of autosomal dominant cerebellar ataxia type 1 (ADCA type 1; see this term) characterized by gait and limb ataxia, lower limb spasticity, dysarthria, muscle fasiculations, tongue atrophy and hyperreflexia.

SPINOCEREBELLAR ATAXIA TYPE 36 Is also known as sca36|asidan

Related symptoms:

  • Hearing impairment
  • Ataxia
  • Nystagmus
  • Spasticity
  • Ptosis


SOURCES: OMIM ORPHANET MENDELIAN

More info about SPINOCEREBELLAR ATAXIA TYPE 36

Other less relevant matches:

Arnold-Chiari malformation type I is a central nervous system malformation characterized by caudal displacement of the cerebellar tonsils exceeding 5mm below the foramen magnum with or without syringomyelia. Symptoms vary in onset and severity and include suboccipital headache, neck pain, vertigo, tinnitus, ocular symptoms (diplopia, blurred vision, photofobia, nystagmus), lower cranial nerve signs, cerebellar ataxia, and spasticity. Some affected individuals can be asymptomatic.

ARNOLD-CHIARI MALFORMATION TYPE I Is also known as cm1|arnold-chiari malformation type 1|chiari malformation type 1|chiari malformation type i

Related symptoms:

  • Hearing impairment
  • Scoliosis
  • Ataxia
  • Nystagmus
  • Muscle weakness


SOURCES: OMIM ORPHANET MENDELIAN

More info about ARNOLD-CHIARI MALFORMATION TYPE I

Retinal vasculopathy and cerebral leukodystrophy (RVCL) is an inherited group of small vessel diseases comprised of cerebroretinal vasculopathy (CRV), hereditary vascular retinopathy (HRV) and hereditary endotheliopathy with retinopathy, nephropathy and stroke (HERNS; see these terms); all exhibiting progressive visual impairment as well as variable cerebral dysfunction.

RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS Is also known as retinopathy, vascular, with cerebral and renal involvement and raynaud and migraine phenomena|cerebroretinal vasculopathy, hereditary|crv|retinal vasculopathy and cerebral leukoencephalopathy|rvcl|rvcl-s

Related symptoms:

  • Seizures
  • Ataxia
  • Neoplasm
  • Pain
  • Visual impairment


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about RETINAL VASCULOPATHY WITH CEREBRAL LEUKOENCEPHALOPATHY AND SYSTEMIC MANIFESTATIONS

Medium match HARTNUP DISEASE

Hartnup disease is a rare metabolic disorder belonging to the neutral aminoacidurias and characterized by abnormal renal and gastrointestinal transport of neutral amino acids (tryptophan, alanine, asparagine, glutamine, histidine, isoleucine, leucine, phenylalanine, serine, threonine, tyrosine and valine).

HARTNUP DISEASE Is also known as aminoaciduria, hartnup type|hartnup disease|hartnup disorder

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about HARTNUP DISEASE

Medium match LEBER PLUS DISEASE

Leber `plus' disease describes patients with the clinical features of Leber's hereditary optic neuropathy (LHON; see term) in combination with other serious systemic or neurological abnormalities. These abnormalities include: postural tremor, motor disorder, multiple sclerosis-like syndrome, spinal cord disease, skeletal changes, Parkinsonism with dystonia, anarthria, dystonia, motor and sensory peripheral neuropathy, spasticity and mild encephalopathy. It is caused by maternally-inherited mitochondrial DNA (mtDNA) mutations.

LEBER PLUS DISEASE Is also known as lhon plus disease

Related symptoms:

  • Seizures
  • Global developmental delay
  • Hearing impairment
  • Ataxia
  • Muscle weakness


SOURCES: ORPHANET MENDELIAN

More info about LEBER PLUS DISEASE

Medium match NORRIE DISEASE

Norrie disease (ND) is a rare X-linked genetic vitreoretinal condition characterized by abnormal retinal development with congenital blindness. Common associated manifestations include sensorineural hearing loss and developmental delay, intellectual disability and/or behavioral disorders.

NORRIE DISEASE Is also known as episkopi blindness|norrie-warburg disease|atrophia bulborum hereditaria

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Hearing impairment
  • Microcephaly


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about NORRIE DISEASE

Medium match CADASIL

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary cerebrovascular disorder characterized by mid-adult onset of recurrent subcortical ischemic stroke and cognitive impairment progressing to dementia in addition to migraines with aura and mood disturbances seen in about a third of patients.

CADASIL Is also known as dementia, hereditary multi-infarct type|cadasil|cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy|casil|hereditary multi-infarct dementia

Related symptoms:

  • Seizures
  • Hearing impairment
  • Ataxia
  • Sensorineural hearing impairment
  • Muscle weakness


SOURCES: OMIM ORPHANET MENDELIAN

More info about CADASIL

Medium match BEHÇET DISEASE

Behçet's disease (BD) is a chronic, relapsing, multisystemic vasculitis characterized by mucocutaneous lesions, as well as articular, vascular, ocular and central nervous system manifestations.

BEHÇET DISEASE Is also known as bd|behcet disease

Related symptoms:

  • Seizures
  • Ataxia
  • Neoplasm
  • Pain
  • Cataract


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about BEHÇET DISEASE

Top 5 symptoms//phenotypes associated to Hyperreflexia and Migraine

Symptoms // Phenotype % cases
Ataxia Very Common - Between 80% and 100% cases
Seizures Common - Between 50% and 80% cases
Spasticity Common - Between 50% and 80% cases
Dysarthria Common - Between 50% and 80% cases
Gait disturbance Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Hyperreflexia and Migraine. may also develop some of the following symptoms:

Common Symptoms - More than 50% cases

Headache

Uncommon Symptoms - Between 30% and 50% cases

Vertigo Diplopia Babinski sign Hearing impairment Behavioral abnormality Nystagmus Hypertonia Muscle weakness Global developmental delay Intellectual disability Tremor Gait ataxia Confusion Pain Hemiparesis Visual impairment EEG abnormality Visual loss Paresthesia Cognitive impairment Dementia Urinary incontinence Dysmetria Abnormality of the eye Lower limb spasticity Cranial nerve paralysis Sensory impairment Photophobia Psychosis Irritability Generalized tonic-clonic seizures Memory impairment Blindness Abnormal pyramidal sign Dystonia Peripheral neuropathy Dysphagia Developmental regression Attention deficit hyperactivity disorder Mental deterioration Stroke Fever Episodic ataxia Myoclonus Neoplasm Retinopathy Muscular hypotonia

Rare Symptoms - Less than 30% cases

Olivopontocerebellar atrophy Encephalitis Myocardial infarction Glomerulopathy Blurred vision Fasciculations Progressive hearing impairment Truncal ataxia Scoliosis Parkinsonism Leukoencephalopathy Reduced visual acuity Vasculitis Hallucinations Abnormality of the nervous system Aseptic necrosis Cerebral ischemia Cirrhosis Depressivity Anxiety Lower limb hyperreflexia Malabsorption Increased intracranial pressure Lower limb muscle weakness Dilatation Abnormality of the retinal vasculature Abnormal blistering of the skin Nausea Unsteady gait Cough Diarrhea Raynaud phenomenon Telangiectasia Abnormality of eye movement Progressive visual loss Encephalopathy Optic neuropathy Abnormal retinal morphology Limb ataxia Hemiplegia Cerebral cortical atrophy Brain atrophy Microcephaly Hand tremor Aggressive behavior Glaucoma Paroxysmal dyskinesia Spastic paraparesis Generalized hypotonia Optic atrophy Choreoathetosis Paraplegia Dyskinesia Sensorineural hearing impairment Ptosis Clonus Involuntary movements Cataract Autism Delayed speech and language development Anterior chamber synechiae Vascular neoplasm Myopathy Neoplasm of the eye Uterine rupture Aplasia/Hypoplasia of the lens Abnormal cochlea morphology Failure to thrive Hypertension Abnormality of the skin Vomiting Elevated serum creatine phosphokinase Hypoglycemia Cryptorchidism Facial palsy Pallor Inability to walk Tetraplegia Sensory neuropathy Coma Diabetes mellitus Microphthalmia Malar flattening Intellectual disability, severe Macrotia Retinal dysplasia Retinopathy of prematurity Retinoblastoma Aplasia/Hypoplasia of the cerebellum Abnormal chorioretinal morphology Shallow anterior chamber Exudative vitreoretinopathy Narrow nasal bridge Remnants of the hyaloid vascular system Retinal fold Venous insufficiency Leukocoria Abnormality of immune system physiology Severe vision loss Hypoplasia of the iris Anterior synechiae of the anterior chamber Abnormal pupil morphology Abnormality of the vasculature Abnormality of the helix Sclerocornea Self-injurious behavior Erectile abnormalities Deeply set eye Posterior synechiae of the anterior chamber Abnormality of the diencephalon Vitreoretinopathy Corneal degeneration Corneal opacity Delayed puberty Retinal degeneration Thin vermilion border Abnormal vitreous humor morphology Retinal detachment Ectopia lentis Sleep disturbance Hypotelorism Intellectual disability, profound Stereotypy Opacification of the corneal stroma Intellectual disability, progressive Phthisis bulbi Cachexia Protruding ear Subcutaneous hemorrhage Peripheral demyelination Acne Gangrene Pulmonary infiltrates Pustule Uveitis Pulmonary embolism Hemoptysis Pericarditis Keratoconjunctivitis sicca Epiphora Inflammation of the large intestine Rheumatoid arthritis Abnormal myocardium morphology Pleural effusion Venous thrombosis Aortic regurgitation Pancreatitis Meningitis Anorexia Subcutaneous nodule Mitral regurgitation Gastrointestinal hemorrhage Chest pain Myositis Arterial thrombosis Nausea and vomiting Posterior uveitis Decreased level of D-mannose in urine Epididymitis Genital ulcers Panuveitis Superficial thrombophlebitis Orchitis Retrobulbar optic neuritis Iritis Increased inflammatory response Iridocyclitis Anterior uveitis Recurrent aphthous stomatitis Optic neuritis Chorioretinitis Immunologic hypersensitivity Erythema nodosum Thrombophlebitis Pleuritis Oral ulcer Endocarditis Alopecia areata Stomatitis Lymphadenopathy Papule Bradykinesia Scotoma Pseudobulbar paralysis Abnormality of nervous system morphology Migraine with aura Stroke-like episode Varicose veins Transient ischemic attack Abnormality of visual evoked potentials Impaired pain sensation Amyloidosis Bulbar palsy Aphasia Mania Cerebral hemorrhage Personality changes Apathy Abnormal electroretinogram Shock Atherosclerosis Spastic tetraparesis Recurrent pneumonia Tetraparesis Abnormality of extrapyramidal motor function Perseveration Elevated brain lactate level by MRS Autoimmunity Renal insufficiency Scarring Joint stiffness Erythema Arthritis Myalgia Arthralgia Dyspnea Weight loss Abdominal pain Alopecia Splenomegaly Amaurosis fugax Fatigue Subdural hemorrhage Scintillating scotoma Nonarteritic anterior ischemic optic neuropathy Recurrent subcortical infarcts Abulia Subcortical dementia Retinal arteriolar tortuosity Focal sensory seizure Diffuse leukoencephalopathy Growth delay Insomnia Marcus Gunn pupil Tongue fasciculations Arnold-Chiari malformation Spastic gait Progressive cerebellar ataxia Limb muscle weakness Hyperhidrosis Limb myoclonus Loss of Purkinje cells in the cerebellar vermis Tongue atrophy Head tremor Urinary urgency Slow saccadic eye movements Impaired smooth pursuit Cerebellar vermis atrophy Bowel incontinence Amyotrophic lateral sclerosis Dysdiadochokinesis Incoordination Intention tremor Tinnitus Syringomyelia Neurodegeneration Horner syndrome Fatigable weakness of swallowing muscles Distal peripheral sensory neuropathy Brain stem compression Adult onset sensorineural hearing impairment Small posterior fossa Basilar invagination Neck pain Recurrent paroxysmal headache Hyperacusis Arnold-Chiari type I malformation Cranial nerve compression Cervical C2/C3 vertebral fusion Basilar impression Central sleep apnea Stiff neck Dysesthesia Myelopathy Fused cervical vertebrae Vocal cord paralysis Neuronal loss in central nervous system Difficulty walking Enlarged sagittal diameter of the cervical canal Intellectual disability, mild Specific learning disability Focal-onset seizure Chorea Hemolytic anemia Falls Abnormality of movement Intellectual disability, moderate Cerebral atrophy Anemia Frequent falls Paroxysmal choreoathetosis Progressive spastic paraparesis Morphological abnormality of the pyramidal tract Progressive spastic paraplegia Brisk reflexes Paraparesis Dehydration Postural instability Spastic paraplegia Generalized-onset seizure Progressive microcephaly Cerebellar atrophy Migraine without aura Skeletal muscle atrophy Generalized tonic-clonic seizures without focal onset Hypoglycorrhachia Upper limb dysmetria Focal aware seizure Jerky head movements Paroxysmal dystonia Limb dysmetria Abnormality of the head Horizontal nystagmus Torsion dystonia Action tremor Reticulocytosis Hyperactive deep tendon reflexes Atonic seizures Impulsivity Focal impaired awareness seizure Slurred speech Absence seizures Areflexia of upper limbs Abnormality of the vestibulocochlear nerve Centrocecal scotoma Neutral hyperaminoaciduria Optic disc pallor Muscle cramps Polyneuropathy Lactic acidosis Ophthalmoplegia Abnormality of the cerebral white matter Pes cavus Arrhythmia Grasp reflex Torticollis Glabellar reflex Hyperphenylalaninemia Neural tube defect Glossitis Mood changes Abnormal urinary color Methylmalonic aciduria Bruxism Gingivitis Exotropia Ragged-red muscle fibers Irregular hyperpigmentation Gaze-evoked horizontal nystagmus Horizontal supranuclear gaze palsy Cervical spinal canal stenosis Motor tics Rapid neurologic deterioration Abnormal fundus morphology Abnormality of the spinal cord Leg muscle stiffness Decreased activity of mitochondrial complex I Vertical nystagmus Postural tremor Abnormality of brainstem morphology Abnormality of the basal ganglia Thoracic kyphosis Papilledema Ankle clonus Gaze-evoked nystagmus Impotence Abnormality of color vision Impaired vibratory sensation Delusions Emotional lability Anteriorly placed odontoid process Nephropathy Macular edema Chronic sinusitis Abnormality of the periventricular white matter Elevated erythrocyte sedimentation rate Leukodystrophy Sinusitis Apraxia Hematuria Proteinuria Micronodular cirrhosis Elevated hepatic transaminase Edema Functional abnormality of the inner ear Abnormality of the eleventh cranial nerve Abnormality of the twelfth cranial nerve Abnormality of the clivus Flat posterior fossa Small flat posterior fossa Abnormality of the musculature of the lower limbs Brain neoplasm Retinal hemorrhage Abnormality of vision Gastroesophageal reflux Hypopigmented skin patches Aminoaciduria Chronic diarrhea Inflammatory abnormality of the skin Cutaneous photosensitivity Aciduria Hepatic steatosis Skin rash Hydrocephalus Limb pain Strabismus Short stature Punctate vasculitis skin lesions Diminished ability to concentrate Progressive forgetfulness Focal white matter lesions Vasculitis in the skin Retinal exudate Central nervous system degeneration Hypopyon


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