Hyperreflexia, and Memory impairment

Diseases related with Hyperreflexia and Memory impairment

In the following list you will find some of the most common rare diseases related to Hyperreflexia and Memory impairment that can help you solving undiagnosed cases.

Top matches:

Autosomal spastic paraplegia type 72 is a rare, genetic, pure hereditary spastic paraplegia disorder characterized by early childhood onset of slowly progressive crural spastic paraparesis presenting with spastic gait, mild stiffness at rest, hyperreflexia (in lower limbs), extensor plantar responses and, in some, mild postural tremor, pes cavus, sphincter disturbances and sensory loss at ankles.

AUTOSOMAL SPASTIC PARAPLEGIA TYPE 72 Is also known as spg72

Related symptoms:

  • Pain
  • Spasticity
  • Hyperreflexia
  • Tremor
  • Babinski sign


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOSOMAL SPASTIC PARAPLEGIA TYPE 72

A substantial minority of degenerative dementias, perhaps 10%, lack the distinctive pathologic features that allow subclassification as Alzheimer disease (see {104300}) or other forms of dementia. In perhaps half of these cases of nonspecific dementia, there is a positive family history of dementia, with an apparent autosomal dominant mode of inheritance.See also frontotemporal lobe dementia (FLDEM ), which maps to chromosome 17 and is caused by mutation in the microtubule-associated protein tau gene (MAPT ).

FRONTOTEMPORAL DEMENTIA, CHROMOSOME 3-LINKED; FTD3 Is also known as dem|dementia, familial nonspecific|dmt1

Related symptoms:

  • Hyperreflexia
  • Gait disturbance
  • Dystonia
  • Cerebral atrophy
  • Babinski sign


SOURCES: OMIM MESH MENDELIAN

More info about FRONTOTEMPORAL DEMENTIA, CHROMOSOME 3-LINKED; FTD3

Spinocerebellar ataxia type 28 (SCA28) is a very rare subtype of type I autosomal dominant cerebellar ataxia (ADCA type I; see this term). It is characterized by juvenile onset, slowly progressive cerebellar ataxia due to Purkinje cell degeneration.

SPINOCEREBELLAR ATAXIA TYPE 28 Is also known as sca28

Related symptoms:

  • Ataxia
  • Nystagmus
  • Spasticity
  • Ptosis
  • Cognitive impairment


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about SPINOCEREBELLAR ATAXIA TYPE 28

Other less relevant matches:

Huntington disease-like 2 (HDL2) is a severe neurodegenerative disorder considered part of the neuroacanthocytosis syndromes (see this term) characterized by a triad of movement, psychiatric, and cognitive abnormalities.

HUNTINGTON DISEASE-LIKE 2 Is also known as hdl2

Related symptoms:

  • Seizures
  • Ataxia
  • Hyperreflexia
  • Dysarthria
  • Gait disturbance


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about HUNTINGTON DISEASE-LIKE 2

Related symptoms:

  • Ataxia
  • Nystagmus
  • Cognitive impairment
  • Hyperreflexia
  • Dysarthria


SOURCES: OMIM MENDELIAN

More info about SPINOCEREBELLAR ATAXIA 14; SCA14

Hereditary spastic ataxia comprises a heterogeneous group of progressive neurodegenerative disorders characterized by lower-limb spasticity and generalized ataxia with dysarthria, impaired ocular movements, and gait disturbance. Spastic ataxia-1 (SPAX1) is an autosomal dominant form of the disorder with linkage to chromosome 12p13 (summary by Meijer et al., 2002). Genetic Heterogeneity of Spastic AtaxiaSee also SPAX2 (OMIM ), caused by mutation in the KIF1C gene (OMIM ) on chromosome 17p13; SPAX3 (OMIM ), caused by rearrangements of the MARS2 gene (OMIM ) on chromosome 2q33; SPAX4 (OMIM ), caused by mutation in the MTPAP gene (OMIM ) on chromosome 10p11; SPAX5 (OMIM ), caused by mutation in the AFG3L2 gene (OMIM ) on chromosome 18p11; SPAX6 (OMIM ), caused by mutation in the SACS gene (OMIM ) on chromosome 13q12; SPAX7 (OMIM ); and SPAX8 (OMIM ), caused by mutation in the NKX6-2 gene (OMIM ) on chromosome 8q21.

Related symptoms:

  • Ataxia
  • Spasticity
  • Ptosis
  • Hyperreflexia
  • Dysarthria


SOURCES: OMIM MENDELIAN

More info about SPASTIC ATAXIA 1, AUTOSOMAL DOMINANT; SPAX1

Behavioral variant of frontotemporal dementia (bv-FTD) is a form of frontotemporal dementia (FTD; see this term), characterized by progressive behavioral impairment and a decline in executive function with frontal lobe-predominant atrophy.

BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA Is also known as bv-ftd

Related symptoms:

  • Hyperreflexia
  • Gait disturbance
  • Behavioral abnormality
  • Aggressive behavior
  • Mental deterioration


SOURCES: ORPHANET MENDELIAN

More info about BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA

ALZHEIMER DISEASE 3; AD Is also known as alzheimer disease, familial, 3|alzheimer disease 3, early-onset

Related symptoms:

  • Seizures
  • Ataxia
  • Spasticity
  • Cognitive impairment
  • Dysarthria


SOURCES: OMIM MENDELIAN

More info about ALZHEIMER DISEASE 3; AD

AUTOSOMAL DOMINANT SPASTIC ATAXIA TYPE 1 Is also known as spax1

Related symptoms:

  • Seizures
  • Ptosis
  • Hyperreflexia
  • Tremor
  • Dysphagia


SOURCES: ORPHANET MENDELIAN

More info about AUTOSOMAL DOMINANT SPASTIC ATAXIA TYPE 1

Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia is a rare autosomal dominant disease characterized by a complex phenotype including progressive dementia, apraxia, apathy, impaired balance, parkinsonism, spasticity and epilepsy.

HEREDITARY DIFFUSE LEUKOENCEPHALOPATHY WITH AXONAL SPHEROIDS AND PIGMENTED GLIA Is also known as dementia, familial, neumann type|adult-onset leukoencephalopathy with axonal spheroids and pigmented glia|fpsg|familial progressive subcortical gliosis|leukoencephalopathy with neuroaxonal spheroids, autosomal dominant|pold|alsp|pigmentary orthochromatic

Related symptoms:

  • Seizures
  • Ataxia
  • Spasticity
  • Cognitive impairment
  • Hyperreflexia


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about HEREDITARY DIFFUSE LEUKOENCEPHALOPATHY WITH AXONAL SPHEROIDS AND PIGMENTED GLIA

Top 5 symptoms//phenotypes associated to Hyperreflexia and Memory impairment

Symptoms // Phenotype % cases
Gait disturbance Common - Between 50% and 80% cases
Dystonia Common - Between 50% and 80% cases
Dysphagia Common - Between 50% and 80% cases
Rigidity Common - Between 50% and 80% cases
Ataxia Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Hyperreflexia and Memory impairment. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Personality changes Babinski sign Dysarthria Spasticity Seizures Frontotemporal dementia Dementia Mental deterioration Behavioral abnormality Mutism Depressivity Neuronal loss in central nervous system Spastic gait Cognitive impairment Spastic paraplegia Tremor Cerebral cortical atrophy Alzheimer disease Slow saccadic eye movements Inappropriate behavior Abnormality of extrapyramidal motor function Astrocytosis Dysgraphia Parkinsonism Ptosis Dyscalculia Abnormality of the cerebral white matter Apathy Hypertonia Pes cavus Difficulty walking Paraplegia Myoclonus Impaired vibratory sensation

Rare Symptoms - Less than 30% cases

Abnormality of eye movement Primitive reflex Shuffling gait Delusions Gait ataxia Ophthalmoplegia Abnormality of movement Neurofibrillary tangles Head tremor Leukoencephalopathy Bradykinesia Limb ataxia Chorea Neurodegeneration Lower limb hyperreflexia Leg muscle stiffness Spastic ataxia Irritability Supranuclear gaze palsy Cerebellar atrophy Nystagmus Psychosis Muscle stiffness Impaired vibration sensation at ankles Dysphasia Cerebral atrophy Aggressive behavior Abnormal pyramidal sign Lack of insight Brain atrophy Stereotypy Confusion Restlessness Disinhibition Apraxia Frontal release signs Loss of speech Perseveration Hyperorality Senile plaques Spastic tetraparesis Limb apraxia Spastic paraparesis Tetraparesis Paraparesis Headache Emotional blunting EEG with continuous slow activity Lewy bodies Collectionism Anarthria Agnosia Pain Optic ataxia Peripheral demyelination Diffuse leukoencephalopathy Restless legs Vegetative state CNS demyelination Insomnia Atrophy/Degeneration affecting the brainstem Decreased number of peripheral myelinated nerve fibers Leukodystrophy Progressive neurologic deterioration Frontotemporal cerebral atrophy Gliosis Lower limb spasticity Postural instability Hypoplasia of the corpus callosum Ventriculomegaly Jerky head movements Abnormality of the cerebrospinal fluid Impaired proprioception Spastic dysarthria Abnormal eyelid morphology Impaired vibration sensation in the lower limbs Generalized amyotrophy Abulia Falls Restrictive behavior Ophthalmoparesis Hallucinations Involuntary movements Anxiety Weight loss Dysmetric saccades Kinetic tremor Limb dystonia Gaze-evoked nystagmus Frontal cortical atrophy Acanthocytosis Orofacial dyskinesia Global brain atrophy Urinary incontinence Abnormality of higher mental function Upper limb spasticity Urinary bladder sphincter dysfunction Toe walking Postural tremor Action tremor Functional motor deficit Abnormal brain FDG positron emission tomography Facial myokymia Upper motor neuron dysfunction Dyslexia Echolalia Thickened nuchal skin fold Fasciculations Poor speech Generalized tonic-clonic seizures Skeletal muscle atrophy Scanning speech Caudate atrophy Myokymia Focal dystonia Progressive cerebellar ataxia Abnormal cerebellum morphology Dysmetria Attention deficit hyperactivity disorder Abnormality of the cerebrum Abnormal corpus striatum morphology Frontal lobe dementia


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Neuroblastoma and Osteoarthritis, related diseases and genetic alterations Fever and Vesicoureteral reflux, related diseases and genetic alterations