Hyperreflexia, and Glioma

Diseases related with Hyperreflexia and Glioma

In the following list you will find some of the most common rare diseases related to Hyperreflexia and Glioma that can help you solving undiagnosed cases.

Top matches:

A substantial minority of degenerative dementias, perhaps 10%, lack the distinctive pathologic features that allow subclassification as Alzheimer disease (see {104300}) or other forms of dementia. In perhaps half of these cases of nonspecific dementia, there is a positive family history of dementia, with an apparent autosomal dominant mode of inheritance.See also frontotemporal lobe dementia (FLDEM ), which maps to chromosome 17 and is caused by mutation in the microtubule-associated protein tau gene (MAPT ).

FRONTOTEMPORAL DEMENTIA, CHROMOSOME 3-LINKED; FTD3 Is also known as dem|dementia, familial nonspecific|dmt1

Related symptoms:

  • Hyperreflexia
  • Gait disturbance
  • Dystonia
  • Cerebral atrophy
  • Babinski sign


SOURCES: OMIM MESH MENDELIAN

More info about FRONTOTEMPORAL DEMENTIA, CHROMOSOME 3-LINKED; FTD3

PARKINSON DISEASE 6, AUTOSOMAL RECESSIVE EARLY-ONSET; PARK6 Is also known as parkinson disease 6, early-onset|park6

Related symptoms:

  • Pain
  • Cognitive impairment
  • Hyperreflexia
  • Tremor
  • Behavioral abnormality


SOURCES: OMIM MESH MENDELIAN

More info about PARKINSON DISEASE 6, AUTOSOMAL RECESSIVE EARLY-ONSET; PARK6

PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE; PARK2 Is also known as pdj|parkinson disease, juvenile, autosomal recessive|parkinsonism, early-onset, with diurnal fluctuation|epdf

Related symptoms:

  • Neoplasm
  • Peripheral neuropathy
  • Hyperreflexia
  • Tremor
  • Gait disturbance


SOURCES: OMIM MENDELIAN

More info about PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE; PARK2

Other less relevant matches:

Behavioral variant of frontotemporal dementia (bv-FTD) is a form of frontotemporal dementia (FTD; see this term), characterized by progressive behavioral impairment and a decline in executive function with frontal lobe-predominant atrophy.

BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA Is also known as bv-ftd

Related symptoms:

  • Hyperreflexia
  • Gait disturbance
  • Behavioral abnormality
  • Aggressive behavior
  • Mental deterioration


SOURCES: ORPHANET MENDELIAN

More info about BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA

Rapid-onset dystonia-parkinsonism (RDP) is a very rare movement disorder, characterized by the abrupt onset of parkinsonism and dystonia, often triggered by physical or psychological stress.

RAPID-ONSET DYSTONIA-PARKINSONISM Is also known as dyt12|dystonia-parkinsonism, rapid-onset|rdp|dystonia 12

Related symptoms:

  • Intellectual disability
  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Motor delay


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about RAPID-ONSET DYSTONIA-PARKINSONISM

Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia is a rare autosomal dominant disease characterized by a complex phenotype including progressive dementia, apraxia, apathy, impaired balance, parkinsonism, spasticity and epilepsy.

HEREDITARY DIFFUSE LEUKOENCEPHALOPATHY WITH AXONAL SPHEROIDS AND PIGMENTED GLIA Is also known as dementia, familial, neumann type|adult-onset leukoencephalopathy with axonal spheroids and pigmented glia|fpsg|familial progressive subcortical gliosis|leukoencephalopathy with neuroaxonal spheroids, autosomal dominant|pold|alsp|pigmentary orthochromatic

Related symptoms:

  • Seizures
  • Ataxia
  • Spasticity
  • Cognitive impairment
  • Hyperreflexia


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about HEREDITARY DIFFUSE LEUKOENCEPHALOPATHY WITH AXONAL SPHEROIDS AND PIGMENTED GLIA

HUNTINGTON DISEASE-LIKE 1 Is also known as early-onset prion disease with prominent psychiatric features|hln1|prion disease, early-onset, with prominent psychiatric features|hdl1|huntington-like neurodegenerative disorder 1|huntington-like neurodegenerative disorder, autosomal dominant

Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Nystagmus
  • Cognitive impairment


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about HUNTINGTON DISEASE-LIKE 1

Parkinson disease is the second most common neurogenic disorder after Alzheimer disease (AD ), affecting approximately 1% of the population over age 50. Clinical manifestations include resting tremor, muscular rigidity, bradykinesia, and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia (Polymeropoulos et al., 1996).For a general phenotypic description and a discussion of genetic heterogeneity of Parkinson disease, see {168600}.

PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARK1 Is also known as parkinson disease 1, autosomal dominant lewy body

Related symptoms:

  • Spasticity
  • Delayed speech and language development
  • Hyperreflexia
  • Dysarthria
  • Tremor


SOURCES: OMIM MESH MENDELIAN

More info about PARKINSON DISEASE 1, AUTOSOMAL DOMINANT; PARK1

Early infantile epileptic encephalopathy-14 is a severe neurologic disorder characterized by onset in the first 6 months of life of refractory focal seizures and arrest of psychomotor development. Ictal EEG shows discharges that arise randomly from various areas of both hemispheres and migrate from one brain region to another. The disorder presents as 'malignant migrating partial seizures of infancy' (MMPSI), a clinical designation (summary by Barcia et al., 2012).For a general phenotypic description and a discussion of genetic heterogeneity of EIEE, see EIEE1 (OMIM ).

MALIGNANT MIGRATING PARTIAL SEIZURES OF INFANCY Is also known as mmpei|malignant migrating partial epilepsy of infancy|mmpsi|migrating partial epilepsy of infancy|mpsi|mpei|migrating partial seizures of infancy

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about MALIGNANT MIGRATING PARTIAL SEIZURES OF INFANCY

SCA17 is an autosomal dominant neurologic disorder characterized by ataxia, pyramidal and extrapyramidal signs, cognitive impairments, psychosis, and seizures. Its clinical phenotype and inheritance pattern are similar to Huntington disease (HD ). Individuals with normal TBP alleles have between 25 and 44 repeats, whereas SCA17 patients have between 47 and 63 repeats. Reduced penetrance is seen with 45 to 46 repeats (summary by Gao et al. (2008)).For a general discussion of autosomal dominant of spinocerebellar ataxia, see SCA1 (OMIM ).

SPINOCEREBELLAR ATAXIA 17; SCA17 Is also known as hdl4|huntington disease-like 4

Related symptoms:

  • Intellectual disability
  • Seizures
  • Ataxia
  • Spasticity
  • Cognitive impairment


SOURCES: OMIM MENDELIAN

More info about SPINOCEREBELLAR ATAXIA 17; SCA17

Top 5 symptoms//phenotypes associated to Hyperreflexia and Glioma

Symptoms // Phenotype % cases
Gliosis Common - Between 50% and 80% cases
Neuronal loss in central nervous system Common - Between 50% and 80% cases
Rigidity Common - Between 50% and 80% cases
Dementia Common - Between 50% and 80% cases
Bradykinesia Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Hyperreflexia and Glioma. may also develop some of the following symptoms:

Common Symptoms - More than 50% cases

Depressivity

Uncommon Symptoms - Between 30% and 50% cases

Parkinsonism

Common Symptoms - More than 50% cases

Tremor

Uncommon Symptoms - Between 30% and 50% cases

Dystonia Gait disturbance Postural instability Mutism Seizures Personality changes Behavioral abnormality Aggressive behavior Ataxia Cognitive impairment Anxiety Myoclonus Mental deterioration Alzheimer disease Dysarthria Dysphagia Abnormal pyramidal sign Spasticity Memory impairment Cerebral cortical atrophy Dyskinesia Delusions Gait ataxia Encephalopathy Psychosis Resting tremor Lewy bodies Abnormality of extrapyramidal motor function Intellectual disability Cerebellar atrophy Generalized hypotonia Apraxia Restlessness Cerebral atrophy Frontotemporal dementia Urinary incontinence Astrocytosis Confusion Lack of insight Senile plaques Inappropriate behavior Frontal release signs Babinski sign

Rare Symptoms - Less than 30% cases

Dysmetria Loss of speech Involuntary movements Global brain atrophy Apathy Stereotypy Unsteady gait Inability to walk Progressive cerebellar ataxia Broad-based gait Progressive neurologic deterioration Hypokinesia Torticollis Focal dystonia Hallucinations Abnormality of eye movement Ventriculomegaly Hypoplasia of the corpus callosum Delayed speech and language development Shuffling gait Frontal lobe dementia Abnormal posturing Brain atrophy Chorea Urinary urgency Hypomimic face Abnormality of movement Disinhibition Abnormal cerebellum morphology Orthostatic hypotension Neurofibrillary tangles Dysgraphia Abnormality of the cerebral white matter Parkinsonism with favorable response to dopaminergic medication Abnormal autonomic nervous system physiology Hypotension Perseveration Hyperorality Dyscalculia Simultanapraxia Basal ganglia gliosis Jerky head movements Abnormal head movements Pontocerebellar atrophy Frequent falls Incoordination Abnormality of ocular smooth pursuit Jerky ocular pursuit movements Hyperactive deep tendon reflexes Slurred speech Abnormality of higher mental function Abnormal saccadic eye movements Abnormality of the shoulder Mania Sleep disturbance Abnormality of the basal ganglia Slow saccadic eye movements Mask-like facies Paranoia Poor fine motor coordination Epileptic spasms Positive Romberg sign Developmental stagnation Muscle fibrillation Clonus Progressive microcephaly Status epilepticus Hypsarrhythmia Cyanosis Epileptic encephalopathy Focal-onset seizure Delayed myelination Generalized myoclonic seizures Tetraplegia Developmental regression Apnea Flushing Muscular hypotonia of the trunk Alcoholism Gaze-evoked nystagmus Poor eye contact Central hypoventilation Micrographia Global developmental delay Diffuse cerebral atrophy Lower limb hyperreflexia Limb ataxia Multifocal seizures Intention tremor Microcephaly Absent speech Generalized-onset seizure Focal motor seizures Pneumonia Hypoventilation Pain Clumsiness Poor speech EEG with continuous slow activity Collectionism Abulia Frontotemporal cerebral atrophy Restrictive behavior Abnormal brain FDG positron emission tomography Upper motor neuron dysfunction Dyslexia Echolalia Thickened nuchal skin fold Dysphasia Fasciculations Generalized tonic-clonic seizures Orofacial dyskinesia Irritability Substantia nigra gliosis Cogwheel rigidity Olivopontocerebellar atrophy Sensory axonal neuropathy Impaired vibratory sensation Peripheral axonal neuropathy Respiratory failure Diabetes mellitus Peripheral neuropathy Neoplasm Akinesia Frontal cortical atrophy Emotional blunting Motor delay EEG abnormality Peripheral demyelination Weight loss Nystagmus Diffuse leukoencephalopathy Restless legs Vegetative state CNS demyelination Insomnia Atrophy/Degeneration affecting the brainstem Decreased number of peripheral myelinated nerve fibers Leukoencephalopathy Muscle stiffness Leukodystrophy Neurodegeneration Fever Difficulty walking Retrocollis Oculogyric crisis Personality disorder Craniofacial dystonia Weak voice Torsion dystonia Limb dystonia Emotional lability Dysphonia Drooling Intellectual disability, mild Hypertonia Impaired pursuit initiation and maintenance


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