Hyperreflexia, and Amyotrophic lateral sclerosis

Diseases related with Hyperreflexia and Amyotrophic lateral sclerosis

In the following list you will find some of the most common rare diseases related to Hyperreflexia and Amyotrophic lateral sclerosis that can help you solving undiagnosed cases.

Top matches:

Related symptoms:

  • Muscle weakness
  • Spasticity
  • Hyperreflexia
  • Paralysis
  • Lower limb spasticity


SOURCES: OMIM MENDELIAN

More info about AMYOTROPHIC LATERAL SCLEROSIS 16, JUVENILE; ALS16

Childhood- and adolescent-onset forms of familial ALS (see ALS1, {105400}) carry the designation 'juvenile ALS.' Several forms of autosomal recessive juvenile ALS have been identified; see ALS2 (OMIM ) and ALS5 (OMIM ).

AMYOTROPHIC LATERAL SCLEROSIS TYPE 4 Is also known as als4|neuronopathy, distal hereditary motor, with pyramidal features|distal hereditary motor neuropathy with upper motor neuron signs|dhmn with upper motor neuron signs

Related symptoms:

  • Peripheral neuropathy
  • Hyperreflexia
  • Skeletal muscle atrophy
  • Gait disturbance
  • Babinski sign


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about AMYOTROPHIC LATERAL SCLEROSIS TYPE 4

Related symptoms:

  • Spasticity
  • Cognitive impairment
  • Hyperreflexia
  • Dysarthria
  • Dysphagia


SOURCES: OMIM MENDELIAN

More info about AMYOTROPHIC LATERAL SCLEROSIS, SUSCEPTIBILITY TO, 24; ALS24

Other less relevant matches:

Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production.

PRIMARY LATERAL SCLEROSIS Is also known as pls, adult|adult-onset primary lateral sclerosis|adult-onset pls|pls|plsa

Related symptoms:

  • Muscle weakness
  • Spasticity
  • Peripheral neuropathy
  • Hyperreflexia
  • Dysarthria


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about PRIMARY LATERAL SCLEROSIS

Juvenile amyotrophic lateral sclerosis (JALS) is a very rare severe motor neuron disease characterized by progressive upper and lower motor neuron degeneration causing facial spasticity, dysarthria, and gait disorders with onset before 25 years of age.

JUVENILE AMYOTROPHIC LATERAL SCLEROSIS Is also known as jals|juvenile lou gehrig disease|juvenile charcot disease

Related symptoms:

  • Spasticity
  • Hyperreflexia
  • Dysarthria
  • Skeletal muscle atrophy
  • Gait disturbance


SOURCES: ORPHANET MENDELIAN

More info about JUVENILE AMYOTROPHIC LATERAL SCLEROSIS

Autosomal recessive juvenile amyotrophic lateral sclerosis-5 is a neurodegenerative disorder characterized by onset of upper and lower motor neuron signs before age 25. Affected individuals have progressive spasticity of limb and facial muscles associated with distal amyotrophy. The disorder is slowly progressive, with cases of prolonged survival of more than 3 decades (summary by Orlacchio et al., 2010).For a phenotypic description and a discussion of genetic heterogeneity of amyotrophic lateral sclerosis (ALS), see ALS1 (OMIM ).

Related symptoms:

  • Muscle weakness
  • Spasticity
  • Cognitive impairment
  • Hyperreflexia
  • Dysarthria


SOURCES: OMIM MESH MENDELIAN

More info about AMYOTROPHIC LATERAL SCLEROSIS 5, JUVENILE; ALS5

AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 17 Is also known as silver spastic paraplegia syndrome|silver syndrome|spastic paraplegia-amyotrophy of hands and feet|spg17|spastic paraplegia with amyotrophy of hands and feet

Related symptoms:

  • Muscle weakness
  • Spasticity
  • Peripheral neuropathy
  • Hyperreflexia
  • Skeletal muscle atrophy


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA TYPE 17

Frontotemporal dementia and/or amyotrophic lateral sclerosis-4 is an autosomal dominant neurodegenerative disorder characterized by adult or late adult onset of cognitive impairment, behavioral abnormalities, and speech apraxia and/or upper and lower motor neuron signs. The phenotype is highly variable (summary by Freischmidt et al., 2015).For a discussion of genetic heterogeneity of FTDALS, see FTDALS1 (OMIM ).

Related symptoms:

  • Cognitive impairment
  • Hyperreflexia
  • Dysarthria
  • Skeletal muscle atrophy
  • Dysphagia


SOURCES: OMIM MENDELIAN

More info about FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 4; FTDALS4

Frontotemporal dementia and/or amyotrophic lateral sclerosis-3 is an autosomal dominant neurodegenerative disorder characterized by adult or late adult onset of cognitive impairment, behavioral abnormalities, and speech apraxia and/or upper and lower motor neuron signs. Some patients may also develop Paget disease of bone. The phenotype is highly variable, even within families (summary by Rea et al., 2014).For a discussion of genetic heterogeneity of FTDALS, see FTDALS1 (OMIM ).

Related symptoms:

  • Muscle weakness
  • Cognitive impairment
  • Hyperreflexia
  • Dysarthria
  • Skeletal muscle atrophy


SOURCES: OMIM MENDELIAN

More info about FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 3; FTDALS3

ALS17 is an adult-onset progressive neurodegenerative disorder with predominantly lower motor neuron involvement, manifest as muscle weakness and wasting of the upper and lower limbs, bulbar signs, and respiratory insufficiency (summary by Cox et al., 2010).

AMYOTROPHIC LATERAL SCLEROSIS 17; ALS17 Is also known as amyotrophic lateral sclerosis, chmp2b-related

Related symptoms:

  • Muscle weakness
  • Dysarthria
  • Skeletal muscle atrophy
  • Dysphagia
  • Respiratory insufficiency


SOURCES: MESH OMIM MENDELIAN

More info about AMYOTROPHIC LATERAL SCLEROSIS 17; ALS17

Top 5 symptoms//phenotypes associated to Hyperreflexia and Amyotrophic lateral sclerosis

Symptoms // Phenotype % cases
Abnormal lower motor neuron morphology Common - Between 50% and 80% cases
Skeletal muscle atrophy Common - Between 50% and 80% cases
Dysarthria Common - Between 50% and 80% cases
Muscle weakness Common - Between 50% and 80% cases
Babinski sign Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Hyperreflexia and Amyotrophic lateral sclerosis. may also develop some of the following symptoms:

Common Symptoms - More than 50% cases

Spasticity

Uncommon Symptoms - Between 30% and 50% cases

Dysphagia Fasciculations Spastic gait Abnormal upper motor neuron morphology Cognitive impairment Dementia Frontotemporal dementia Lower limb muscle weakness Hyporeflexia Bulbar signs Abnormal pyramidal sign Distal muscle weakness Bulbar palsy Peripheral neuropathy Gait disturbance

Rare Symptoms - Less than 30% cases

Respiratory insufficiency due to muscle weakness Distal amyotrophy Personality changes Spastic paraparesis Paraparesis Apathy Spastic dysarthria Language impairment Mutism Apraxia Cerebral cortical atrophy Speech apraxia Tetraparesis Pes cavus Lower limb spasticity Difficulty walking Disinhibition Spastic paraplegia Sensory impairment Brisk reflexes Respiratory insufficiency Hand muscle atrophy Thenar muscle atrophy Knee pain Hip pain Ankle weakness Lower limb hypertonia Thenar muscle weakness Hand muscle weakness Abnormality of the foot musculature Tongue atrophy Motor axonal neuropathy Impaired vibration sensation in the lower limbs First dorsal interossei muscle weakness First dorsal interossei muscle atrophy Abnormal motor nerve conduction velocity Tongue fasciculations Neurodegeneration Respiratory failure Areflexia Echolalia Progressive muscle weakness Irritability Behavioral abnormality Alzheimer disease Limb hypertonia Hypoplasia of the corpus callosum Postural tremor Pallor of dorsal columns of the spinal cord Spastic tetraparesis Muscle stiffness Clumsiness Peripheral axonal neuropathy Confusion Absent speech Diffuse axonal swelling Abnormal nerve conduction velocity Peripheral axonal degeneration Degeneration of anterior horn cells Axonal loss Axonal degeneration Clonus Limb muscle weakness Paralysis Degeneration of the lateral corticospinal tracts Sensory neuropathy Spinal muscular atrophy Hypertonia Foot dorsiflexor weakness Split hand Small hand Distal sensory impairment Paraplegia Abnormality of the foot Pes planus Tremor EMG abnormality Decreased number of large peripheral myelinated nerve fibers Progressive spasticity Pseudobulbar behavioral symptoms Abnormality of the bladder Decreased muscle mass Slurred speech Hyperkinesis Motor neuron atrophy


If you liked this article maybe you will also find interesting the following in-depth articles about other rare diseases, like Feeding difficulties and Thin skin, related diseases and genetic alterations Optic atrophy and Severe global developmental delay, related diseases and genetic alterations