Hydrocephalus, and Eczema

Diseases related with Hydrocephalus and Eczema

In the following list you will find some of the most common rare diseases related to Hydrocephalus and Eczema that can help you solving undiagnosed cases.

Top matches:

Noonan syndrome-like disorder with loose anagen hair is characterized by facial features similar to those observed in Noonan syndrome (OMIM ), including hypertelorism, ptosis, downslanting palpebral fissures, low-set posteriorly angulated ears, and overfolded pinnae. In addition, patients display short stature, frequently with growth hormone (GH; see {139250}) deficiency; cognitive deficits; relative macrocephaly; small posterior fossa resulting in Chiari I malformation; hypernasal voice; cardiac defects, especially dysplasia of the mitral valve and septal defects; and ectodermal abnormalities, in which the most characteristic feature is the hair anomaly, including easily pluckable, sparse, thin, slow-growing hair (summary by Bertola et al., 2017). Genetic Heterogeneity of Noonan Syndrome-Like Disorder with Loose Anagen HairNSLH2 (OMIM ) is caused by mutation in the PPP1CB gene (OMIM ) on chromosome 2p23.

NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR 1; NSLH1 Is also known as tosti syndrome|nslh

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Hypertelorism


SOURCES: OMIM MENDELIAN

More info about NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR 1; NSLH1

The Loeys-Dietz syndrome (LDS) is an autosomal dominant aortic aneurysm syndrome with widespread systemic involvement. As defined by Loeys et al. (2006), the disorder is characterized by the triad of arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. Some patients have craniofacial involvement consisting of cleft palate, craniosynostosis, or hypertelorism. Bifid uvula may also be present. The natural history is characterized by aggressive arterial aneurysms and a high rate of pregnancy-related complications.LDS is also associated with immunologic-related disorders: approximately one-third of affected individuals exhibit food allergies, in contrast to a prevalence of 6 to 8% in the general population, and LDS patients have an increased prevalence of asthma, rhinitis, and eczema (summary by MacCarrick et al., 2014). NomenclatureIn initial reports, LDS patients, defined as those with mutations in TGFBR1 or TGFBR2, were stratified into 2 types, depending on severity of craniofacial features (type 1) or cutaneous features (type 2) (MacCarrick et al., 2014). Given that vascular disease is the major concern in LDS irrespective of the severity of systemic features, a revised nosology was proposed with sequential numbering corresponding to the gene mutant in each group (see below). Genetic Heterogeneity of Loeys-Dietz SyndromeLDS1 is caused by mutation in the TGFBR1 gene. LDS2 (OMIM ) is caused by mutation in the TGFBR2 gene (OMIM ). LDS3 (OMIM ), which is associated with early-onset osteoarthritis, is caused by mutation in the SMAD3 gene (OMIM ). LDS4 (OMIM ) is caused by mutation in the TGFB2 gene (OMIM ). LDS5 (OMIM ) is caused by mutation in the TGFB3 gene (OMIM ). ReviewsMacCarrick et al. (2014) provided a review of LDS, stating that there are no specific clinical criteria for the diagnosis, which is confirmed by molecular testing. They proposed that mutation in any of the 4 genes, TGFBR1, TGFBR2, SMAD3, or TGFB2, in combination with arterial aneurysm or dissection or a family history of documented LDS, should be sufficient to establish the diagnosis. The authors noted that rapidly progressive aortic aneurysmal disease is a distinct feature of LDS, and they discussed management strategies for cardiovascular issues as well as other complications of LDS.

LOEYS-DIETZ SYNDROME 1; LDS1 Is also known as aat5|aortic aneurysm, familial thoracic 5|loeys-dietz aortic aneurysm syndrome|furlong syndrome

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Scoliosis
  • Hypertelorism
  • Micrognathia


SOURCES: OMIM MENDELIAN

More info about LOEYS-DIETZ SYNDROME 1; LDS1

Deletion 2q37 or monosomy 2q37 is a chromosomal anomaly involving deletion of chromosome band 2q37 and manifests as three major clinical findings: developmental delay, skeletal malformations and facial dysmorphism.

2Q37 MICRODELETION SYNDROME Is also known as albright hereditary osteodystrophy-like syndrome|del(2)(q37)|monosomy 2q37-qter|brachydactyly-intellectual disability syndrome|albright hereditary osteodystrophy type 3|brachydactyly-mental retardation syndrome|bdmr|deletion 2q37-qter|deletion 2q37

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: ORPHANET MESH OMIM MENDELIAN

More info about 2Q37 MICRODELETION SYNDROME

Other less relevant matches:

Medium match DUBOWITZ SYNDROME

Dubowitz syndrome (DS) is a rare multiple congenital syndrome characterized primarly by growth retardation, microcephaly, distinctive facial dysmorphism, cutaneous eczema, a mild to severe intellectual deficit and genital abnormalities.

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Hearing impairment
  • Microcephaly


SOURCES: ORPHANET MENDELIAN

More info about DUBOWITZ SYNDROME

Noonan-like syndrome with loose anagen hair (NS/LAH) is a Noonan-related syndrome, characterized by facial anomalies suggestive of Noonan syndrome (see this term); a distinctive hair anomaly described as loose anagen hair syndrome (see this term); frequent congenital heart defects; distinctive skin features with darkly pigmented skin, keratosis pilaris, eczema or occasional neonatal ichtyosis (see this term); and short stature, often associated with a GH deficiency and psychomotor delays.

NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR Is also known as ns/lah|tosti syndrome

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR

Koolen-De Vries syndrome is characterized by moderate to severe intellectual disability, hypotonia, friendly demeanor, and highly distinctive facial features, including tall, broad forehead, long face, upslanting palpebral fissures, epicanthal folds, tubular nose with bulbous nasal tip, and large ears. More variable features include cardiac or genitourinary anomalies and seizures (summary by Koolen et al., 2012).

17Q21.31 MICRODELETION SYNDROME Is also known as del(17)(q21.31)|monosomy 17q21.31|chromosome 17q21.31 deletion syndrome|microdeletion 17q21.31 syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about 17Q21.31 MICRODELETION SYNDROME

VELOCARDIOFACIAL SYNDROME Is also known as chromosome 22q11.2 deletion syndrome|shprintzen vcf syndrome|vcf syndrome|vcfs

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM MENDELIAN

More info about VELOCARDIOFACIAL SYNDROME

DiGeorge syndrome (DGS) comprises hypocalcemia arising from parathyroid hypoplasia, thymic hypoplasia, and outflow tract defects of the heart. Disturbance of cervical neural crest migration into the derivatives of the pharyngeal arches and pouches can account for the phenotype. Most cases result from a deletion of chromosome 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR). Several genes are lost including the putative transcription factor TUPLE1 which is expressed in the appropriate distribution. This deletion may present with a variety of phenotypes: Shprintzen, or velocardiofacial, syndrome (VCFS ); conotruncal anomaly face (or Takao syndrome); and isolated outflow tract defects of the heart including tetralogy of Fallot, truncus arteriosus, and interrupted aortic arch. A collective acronym CATCH22 has been proposed for these differing presentations. A small number of cases of DGS have defects in other chromosomes, notably 10p13 (see {601362}). In the mouse, a transgenic Hox A3 (Hox 1.5) knockout produces a phenotype similar to DGS as do the teratogens retinoic acid and alcohol.

DIGEORGE SYNDROME; DGS Is also known as hypoplasia of thymus and parathyroids|chromosome 22q11.2 deletion syndrome|third and fourth pharyngeal pouch syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment


SOURCES: OMIM MENDELIAN

More info about DIGEORGE SYNDROME; DGS

22q11.2 deletion syndrome (DS) is a chromosomal anomaly which causes a congenital malformation disorder whose common features include cardiac defects, palatal anomalies, facial dysmorphism, developmental delay and immune deficiency.

22Q11.2 DELETION SYNDROME Is also known as monosomy 22q11|digeorge sequence|sedlackova syndrome|takao syndrome|velocardiofacial syndrome|shprintzen syndrome|conotruncal anomaly face syndrome|digeorge syndrome|catch 22|cayler cardiofacial syndrome|microdeletion 22q11.2|22q11ds

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Hearing impairment


SOURCES: ORPHANET MENDELIAN

More info about 22Q11.2 DELETION SYNDROME

Coffin-Siris syndrome is a multiple malformation syndrome characterized by mental retardation associated with coarse facial features, hypertrichosis, sparse scalp hair, and hypoplastic or absent fifth fingernails or toenails. Other more variable features may include poor overall growth, craniofacial abnormalities, spinal anomalies, and congenital heart defects (review by Vergano and Deardorff, 2014). Mutations in the ARID1B gene are the most common cause of Coffin-Siris syndrome (Wieczorek et al., 2013). Genetic Heterogeneity of Coffin-Siris SyndromeForms of Coffin-Siris syndrome have been shown to be caused by mutations in genes encoding subunits of the SWI/SNF complex, also known as the BAF complex, which functions as a chromatin remodeling factor. These include CSS2 (OMIM ), caused by mutation in the ARID1A gene (OMIM ); CSS3 (OMIM ), caused by mutation in the SMARCB1 gene (OMIM ); CSS4 (OMIM ), caused by mutation in the SMARCA4 gene (OMIM ); CSS5 (OMIM ), caused by mutation in the SMARCE1 gene (OMIM ); CSS6 (OMIM ), caused by mutation in the ARID2 gene (OMIM ); and CSS7 (OMIM ), caused by mutation in the DPF2 gene (OMIM ).A similar phenotype, Nicolaides-Baraitser syndrome (NCBRS ), is also caused by mutation in a subunit of this complex, i.e., SMARCA2 (OMIM ).

COFFIN-SIRIS SYNDROME 1; CSS1 Is also known as fifth digit syndrome|coffin-siris syndrome|mrd12|css|mental retardation, autosomal dominant 12

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Short stature
  • Generalized hypotonia


SOURCES: OMIM MENDELIAN

More info about COFFIN-SIRIS SYNDROME 1; CSS1

Top 5 symptoms//phenotypes associated to Hydrocephalus and Eczema

Symptoms // Phenotype % cases
Intellectual disability Very Common - Between 80% and 100% cases
Global developmental delay Very Common - Between 80% and 100% cases
Scoliosis Very Common - Between 80% and 100% cases
Short stature Very Common - Between 80% and 100% cases
Ptosis Common - Between 50% and 80% cases

Other less frequent symptoms

Patients with Hydrocephalus and Eczema. may also develop some of the following symptoms:

Common Symptoms - More than 50% cases

Atrial septal defect

Uncommon Symptoms - Between 30% and 50% cases

Hearing impairment

Common Symptoms - More than 50% cases

Hypertelorism

Uncommon Symptoms - Between 30% and 50% cases

Microcephaly

Common Symptoms - More than 50% cases

High palate

Uncommon Symptoms - Between 30% and 50% cases

Ventricular septal defect

Common Symptoms - More than 50% cases

Seizures

Uncommon Symptoms - Between 30% and 50% cases

Abnormality of cardiovascular system morphology

Common Symptoms - More than 50% cases

Strabismus

Uncommon Symptoms - Between 30% and 50% cases

Cleft palate

Common Symptoms - More than 50% cases

Hypospadias

Uncommon Symptoms - Between 30% and 50% cases

Patent ductus arteriosus

Common Symptoms - More than 50% cases

Attention deficit hyperactivity disorder

Uncommon Symptoms - Between 30% and 50% cases

Posteriorly rotated ears

Common Symptoms - More than 50% cases

Abnormal facial shape

Uncommon Symptoms - Between 30% and 50% cases

Nasal speech

Common Symptoms - More than 50% cases

Generalized hypotonia

Uncommon Symptoms - Between 30% and 50% cases

Umbilical hernia

Common Symptoms - More than 50% cases

Short neck

Uncommon Symptoms - Between 30% and 50% cases

Low-set ears Behavioral abnormality Bulbous nose Hypothyroidism Blepharophimosis Delayed speech and language development Cryptorchidism Micrognathia Inguinal hernia Cataract Hypoplasia of the corpus callosum Downslanted palpebral fissures Sparse scalp hair Abnormal heart morphology Hyperactivity Cognitive impairment Feeding difficulties in infancy Obesity Macrocephaly Arnold-Chiari malformation Conductive hearing impairment Craniosynostosis Hypoparathyroidism Brachydactyly Retrognathia Bicuspid aortic valve Pulmonic stenosis Feeding difficulties Failure to thrive Muscular hypotonia Hernia Tetralogy of Fallot Epicanthus Intrauterine growth retardation Joint laxity Recurrent infections Thrombocytopenia Hypocalcemia Hydronephrosis Abnormality of the skeletal system Neoplasm Ventriculomegaly Specific learning disability Prominent forehead High forehead Depressed nasal bridge Low posterior hairline Short philtrum High, narrow palate Autoimmunity Dilatation Low-set, posteriorly rotated ears Anemia Abnormality of the dentition Pectus excavatum Delayed skeletal maturation Laryngomalacia Narrow palpebral fissure Telecanthus Postnatal growth retardation Upslanted palpebral fissure Wide intermamillary distance Underdeveloped nasal alae Sacral dimple Small hand Joint hyperflexibility Anxiety Vomiting Aggressive behavior Depressivity Overfolded helix Bifid uvula Malar flattening Arachnodactyly Thin vermilion border Asthma Pes planus Meningocele Truncus arteriosus Seborrheic dermatitis Acne Aplasia of the uterus Vesicoureteral reflux Clinodactyly of the 5th finger Posterior embryotoxon Bipolar affective disorder Impaired T cell function Arthritis Growth hormone deficiency Schizophrenia Immunodeficiency Myopia Cholelithiasis Purpura Abnormality of the pinna Spina bifida

Rare Symptoms - Less than 30% cases

Abnormality of the head Rectal prolapse Cutis marmorata Growth delay Autoimmune hemolytic anemia Anal stenosis Autoimmune thrombocytopenia Submucous cleft hard palate Inflammation of the large intestine Intestinal malrotation Fever Hypoplastic toenails Broad thumb Chorea Psoriasiform dermatitis Protruding ear Wide mouth Dry skin Delayed eruption of teeth Choanal atresia Rheumatoid arthritis Low anterior hairline Hemolytic anemia Unilateral renal agenesis Spina bifida occulta Renal hypoplasia Renal dysplasia Abnormality of the fingernails Cleft lip Vitiligo Enlarged cisterna magna Tetany Failure to thrive in infancy Anal atresia Astigmatism Duodenal stenosis Narrow mouth Microphthalmia Sacral meningocele Right aortic arch Right aortic arch with mirror image branching Arteria lusoria Aplasia of the thymus Conotruncal defect Kyphosis Long philtrum Absent speech Retinal vascular tortuosity Hypoplasia of the thymus Platybasia Nystagmus Open mouth Macrotia Gastroesophageal reflux Hypoglycemia Hypotrichosis Carious teeth Joint hypermobility Myelomeningocele Juvenile rheumatoid arthritis Dandy-Walker malformation Long face Coarctation of aorta Hypotelorism Graves disease Interrupted aortic arch Perimembranous ventricular septal defect Thick lower lip vermilion Renal agenesis Amenorrhea Prominent nasal bridge Primary amenorrhea Joint dislocation Pain Spondylolisthesis Aortic aneurysm Pectus carinatum Broad forehead Broad nasal tip Dolichocephaly Short foot Thick vermilion border Wide nose Abnormality of the sternum Toe syndactyly Clinodactyly Mitral regurgitation Scarring Exotropia Sparse hair Anteverted nares Autistic behavior Myopathic facies Thin upper lip vermilion Coarse facial features Autism Multiple suture craniosynostosis Congenital diaphragmatic hernia Talipes equinovarus Loose anagen hair Obsessive-compulsive behavior Slow-growing hair Multicystic kidney dysplasia Dermal translucency Relative macrocephaly Pyloric stenosis Hyperpigmentation of the skin Arnold-Chiari type I malformation Long eyelashes Webbed neck Ichthyosis Frontal bossing Abnormal cardiac septum morphology Hypertrophic cardiomyopathy Polyhydramnios Mood swings Generalized hirsutism Recurrent hypoglycemia Neoplasm of the liver Coxa valga Tics Paranoia Congenital conductive hearing impairment Ectopic kidney Psychotic episodes Hemangioma Elevated alkaline phosphatase Precocious puberty Anonychia Accelerated skeletal maturation Partial agenesis of the corpus callosum Short 5th finger Central nervous system degeneration Vascular ring Velopharyngeal insufficiency Giant platelets Abnormality of digit Perineal fistula Dislocated radial head Turricephaly Generalized hypertrichosis Short sternum Basal ganglia calcification Hallucinations Lumbosacral hirsutism Hypoplastic fifth fingernail Short distal phalanx of the 5th finger Holoprosencephaly Prominent interphalangeal joints Abnormality of the hand Dysdiadochokinesis Apathy Severe expressive language delay Premature thelarche Hypoplasia of the brainstem Facial hypertrichosis Abnormality of the ear Intussusception Patellar hypoplasia Unilateral primary pulmonary dysgenesis Aplasia/Hypoplasia of the patella Anterior pituitary hypoplasia Hypotrichosis of the scalp Pulmonary artery atresia Abnormality of the endocrine system Echolalia Gastric ulcer Axonal loss Pierre-Robin sequence Delusions Hepatoblastoma Hearing abnormality Ectopic posterior pituitary Duodenal ulcer Unilateral lung agenesis Hypertrichosis Flexion contracture Tricuspid atresia Hand polydactyly Polycystic kidney dysplasia Hypopigmented skin patches Hypertensive crisis Abnormality of dental enamel Aganglionic megacolon Abnormal aortic arch morphology Abnormality of the tonsils Retinal arteriolar tortuosity Occipital myelomeningocele Gastrointestinal hemorrhage Visual impairment Respiratory distress Myalgia Glaucoma Constipation Agenesis of corpus callosum Abnormality of the thorax Chronic otitis media Intellectual disability, mild Bowel incontinence Foot polydactyly Hyperthyroidism Patellar dislocation Multiple renal cysts Abnormal eyelid morphology Varicose veins Atelectasis Chronic obstructive pulmonary disease Abnormality of the uterus Anorectal anomaly Corneal neovascularization Abnormal thrombocyte morphology Abnormal aortic valve morphology Abnormality of the pharynx Small earlobe Arrhinencephaly Abnormal pulmonary valve morphology Dysphasia Splenomegaly Optic atrophy Horseshoe kidney Iris coloboma Anterior segment developmental abnormality Decreased fetal movement Sclerocornea Cerebellar vermis hypoplasia Small nail Amblyopia Short palpebral fissure Polymicrogyria Femoral hernia Abnormal lung lobation Generalized tonic-clonic seizures Microtia Tall stature Abnormality of the kidney Preauricular skin tag Increased body weight Hypertonia Single transverse palmar crease Alcoholism Recurrent respiratory infections Synophrys Wide nasal bridge Type I truncus arteriosus Parathyroid agenesis Abdominal pain Parathyroid hypoplasia Decreased circulating parathyroid hormone level Respiratory tract infection Severe global developmental delay Confusion Perisylvian polymicrogyria Thick eyebrow Accommodative esotropia Esophoria Short distal phalanx of finger Vascular tortuosity Abnormality of the thymus Abnormality of the middle ear Hirsutism Abnormality of the skull Natal tooth Psychosis Stereotypy Self-injurious behavior Nephroblastoma Short metatarsal Short chin Bilateral single transverse palmar creases Aortic valve stenosis Short toe Sparse and thin eyebrow Short phalanx of finger Broad-based gait Supernumerary nipple Narrow forehead Short metacarpal Round face Sleep disturbance Highly arched eyebrow Downturned corners of mouth Short palm Finger syndactyly Deeply set eye Mild short stature Tracheomalacia Hyporeflexia Abnormality of skin pigmentation Aplasia/Hypoplasia of the corpus callosum Sandal gap Narrow face Wide anterior fontanel Chronic diarrhea Cutaneous photosensitivity Fine hair Sloping forehead Lymphoma Malabsorption Overweight Respiratory insufficiency Self-biting Pain insensitivity Abnormal aortic morphology Broad columella Subvalvular aortic stenosis Broad face Renal neoplasm Low hanging columella Brachycephaly Arrhythmia Delayed cranial suture closure Postaxial hand polydactyly Disproportionate tall stature Hallux valgus Ectopia lentis Microretrognathia Finger clinodactyly Joint contracture of the hand Osteoarthritis Blue sclerae Mitral valve prolapse Bruising susceptibility Aortic root aneurysm Facial asymmetry Camptodactyly Skeletal dysplasia Kyphoscoliosis Proptosis Small posterior fossa Deep palmar crease Megalencephaly Redundant skin Atrophic scars Rhinitis Midface retrusion Dural ectasia Sensorineural hearing impairment Biconvex vertebral bodies Bicuspid pulmonary valve Generalized arterial tortuosity Descending thoracic aorta aneurysm Pulmonary artery aneurysm Cystic medial necrosis Ascending aortic dissection Long thorax Unilateral ptosis Dilatation of the cerebral artery Arterial tortuosity Thoracic aortic aneurysm Ascending tubular aorta aneurysm Long toe Sagittal craniosynostosis High anterior hairline Narrow nose Soft skin Scaphocephaly Metatarsus adductus Aplasia/Hypoplasia of the thumb Peripheral demyelination Abnormality of the genital system Cortical dysplasia Impulsivity Sparse eyebrow Elbow dislocation Abnormality of the urinary system Abnormality of the genitourinary system Widely spaced teeth Narrow palate Heterotopia Status epilepticus Vertebral fusion Hip dysplasia Focal-onset seizure Otitis media Everted lower lip vermilion Cleft upper lip Oral cleft Poor speech Abnormality of the foot Hypermetropia Long fingers Slender finger Small for gestational age Broad chin Dysmetria Congenital cataract Mental deterioration Dementia Cerebellar atrophy Intellectual disability, severe Hypotrophy of the small hand muscles Abnormality of hair pigmentation Positional foot deformity Conspicuously happy disposition Prominent metopic ridge Pear-shaped nose Narrow palm Multifocal epileptiform discharges Expressive language delay Prominent fingertip pads Chronic infection Anteverted ears Abnormality of hair texture Glioma Hip dislocation Pallor Underdeveloped supraorbital ridges Thin skin Patent foramen ovale Deep philtrum Coarse hair Optic nerve hypoplasia Increased intracranial pressure Infantile muscular hypotonia Abnormal palate morphology Hoarse voice Cafe-au-lait spot Ventricular hypertrophy Aplasia/Hypoplasia of the eyebrow Cyanosis Short nose Cardiomyopathy Abnormality of thumb phalanx Abnormality of female external genitalia Abnormality of neutrophils Sparse lateral eyebrow Abnormality of the antihelix Acute lymphoblastic leukemia Right bundle branch block Abnormality of coagulation Intellectual disability, moderate Peripheral pulmonary artery stenosis Hypertension Motor delay Abnormality of the nasal bridge Broad fingertip Abnormal location of ears Superior pectus carinatum Abnormality of the intervertebral disk Abnormality of the pulmonary artery Thickened helices Abnormality of refraction Neurodevelopmental delay Redundant neck skin Abnormality of the testis Abnormally large globe Hypomagnesemia Fragile nails Hiatus hernia Abnormality of the elbow Broad neck Atopic dermatitis Freckling Short distal phalanx of the 5th toe


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