Frontal bossing, and Migraine

Diseases related with Frontal bossing and Migraine

In the following list you will find some of the most common rare diseases related to Frontal bossing and Migraine that can help you solving undiagnosed cases.

Top matches:

Congenital bile acid synthesis defect type 4 (BAS defect type 4) is an anomaly of bile acid synthesis (see this term) characterized by mild cholestatic liver disease, fat malabsorption and/or neurological disease.

CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE 4 Is also known as 2-methylacyl-coa racemase deficiency|amacr deficiency|basd4|alpha-methyl-acyl-coa racemase deficiency|liver disease-retinitis pigmentosa-polyneuropathy-epilepsy syndrome

Related symptoms:

  • Seizures
  • Global developmental delay
  • Ataxia
  • Cataract
  • Spasticity


SOURCES: OMIM ORPHANET MENDELIAN

More info about CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE 4

High match CINCA SYNDROME

Chronic Infantile Neurological, Cutaneous, and Articular (CINCA) syndrome is characterised by skin rash, joint involvement, chronic meningitis with granulocytes and, in some cases, sensorineural hearing loss and ocular signs.

CINCA SYNDROME Is also known as multisystem inflammatory disease, neonatal-onset|nomid syndrome|iomid syndrome|infantile-onset multisystem inflammatory disease|prieur-griscelli syndrome|neonatal-onset multisystem inflammatory disease|chronic neurologic cutaneous and articular syndrome|c

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Hearing impairment
  • Growth delay
  • Sensorineural hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about CINCA SYNDROME

Crouzon syndrome with acanthosis nigricans (CAN) is a very rare, clinically heterogeneous form of faciocraniostenosis with Crouzon-like features and premature synostosis of cranial sutures (Crouzon disease, see this term), associated with acanthosis nigricans (AN; see this term).

CROUZON SYNDROME-ACANTHOSIS NIGRICANS SYNDROME Is also known as crouzon-dermoskeletal syndrome|crouzonodermoskeletal syndrome

Related symptoms:

  • Short stature
  • Hypertelorism
  • Failure to thrive
  • Strabismus
  • Cleft palate


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about CROUZON SYNDROME-ACANTHOSIS NIGRICANS SYNDROME

Other less relevant matches:

High match ACROMEGALY

Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations.

Related symptoms:

  • Neoplasm
  • Hypertension
  • Fatigue
  • Frontal bossing
  • Abnormality of the dentition


SOURCES: ORPHANET MENDELIAN

More info about ACROMEGALY

Hyperimmunoglobinemia D with periodic fever (HIDS) is a rare autoinflammatory disease characterized by periodic attacks of fever and a systemic inflammatory reaction (cervical lymphadenopathy, abdominal pain, vomiting, diarrhea, arthralgias and skin signs).

HYPERIMMUNOGLOBULINEMIA D WITH PERIODIC FEVER Is also known as hyperimmunoglobinemia d with recurrent fever|hyper-igd syndrome|hyperimmunoglobulinemia d and periodic fever syndrome|partial mevalonate kinase deficiency|hids|periodic fever, dutch type|hyperimmunoglobulinemia d syndrome

Related symptoms:

  • Intellectual disability
  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly


SOURCES: OMIM ORPHANET MENDELIAN

More info about HYPERIMMUNOGLOBULINEMIA D WITH PERIODIC FEVER

Craniosynostosis, Boston type is a form of syndromic craniosynostosis, characterized by a highly variable craniosynostosis with frontal bossing, turribrachycephaly and cloverleaf skull anomaly. Hypoplasia of the supraorbital ridges, cleft palate, extra teeth and limb anomalies (triphalangeal thumb, 3-4 syndactyly of the hands, a short first metatarsal, middle phalangeal agenesis in the feet) have also been described. Associated problems include headache, poor vision, and seizures. Intelligence is normal.

CRANIOSYNOSTOSIS, BOSTON TYPE Is also known as csb|warman-mulliken-hayward syndrome|craniosynostosis, warman type|craniosynostosis, boston-type

Related symptoms:

  • Seizures
  • Brachydactyly
  • Myopia
  • Downslanted palpebral fissures
  • Frontal bossing


SOURCES: OMIM ORPHANET MENDELIAN

More info about CRANIOSYNOSTOSIS, BOSTON TYPE

JACKSON-WEISS SYNDROME; JWS Is also known as craniosynostosis, midfacial hypoplasia, and foot abnormalities

Related symptoms:

  • Intellectual disability
  • Hypertelorism
  • Strabismus
  • Cleft palate
  • Ptosis


SOURCES: MESH OMIM MENDELIAN

More info about JACKSON-WEISS SYNDROME; JWS

High match SCLEROSTEOSIS

Sclerosteosis is a very rare serious sclerosing hyperostosis syndrome characterized clinically by variable syndactyly and progressive skeletal overgrowth (particularly of the skull), resulting in distinctive facial features (mandibular overgrowth, frontal bossing, midfacial hypoplasia), cranial nerve entrapment causing facial palsy and deafness, and potentially lethal elevation of intracranial pressure.

SCLEROSTEOSIS Is also known as cortical hyperostosis-syndactyly syndrome|sost|cortical hyperostosis with syndactyly

Related symptoms:

  • Hearing impairment
  • Hypertelorism
  • Nystagmus
  • Strabismus
  • Sensorineural hearing impairment


SOURCES: ORPHANET OMIM MENDELIAN

More info about SCLEROSTEOSIS

Medium match CROUZON DISEASE

Crouzon disease is characterized by craniosynostosis and facial hypoplasia.

CROUZON DISEASE Is also known as crouzon craniofacial dysostosis|craniofacial dysostosis, type i|cfd1

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Hearing impairment
  • Hypertelorism


SOURCES: OMIM ORPHANET MENDELIAN

More info about CROUZON DISEASE

Camurati-Englemann disease (CED) is a rare, clinically variable bone dysplasia syndrome characterized by hyperostosis of the long bones, skull, spine and pelvis, associated with severe pain in the extremities, a wide-based waddling gait, joint contractures, muscle weakness and easy fatigability. Camurati-Englemann disease (CED) is a rare, clinically variable bone dysplasia syndrome characterized by hyperostosis of the long bones, skull, spine and pelvis, associated with severe pain in the extremities, a wide-based waddling gait, joint contractures, muscle weakness and easy fatigability.

CAMURATI-ENGELMANN DISEASE Is also known as diaphyseal dysplasia 1, progressive|engelmann disease|progressive diaphyseal dysplasia|dpd1|ced|pdd

Related symptoms:

  • Hearing impairment
  • Scoliosis
  • Ataxia
  • Muscle weakness
  • Abnormal facial shape


SOURCES: OMIM ORPHANET MENDELIAN

More info about CAMURATI-ENGELMANN DISEASE

Top 5 symptoms//phenotypes associated to Frontal bossing and Migraine

Symptoms // Phenotype % cases
Headache Common - Between 50% and 80% cases
Proptosis Common - Between 50% and 80% cases
Increased intracranial pressure Uncommon - Between 30% and 50% cases
Optic atrophy Uncommon - Between 30% and 50% cases
Mandibular prognathia Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Frontal bossing and Migraine. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Hypertelorism Hearing impairment Fatigue Strabismus Ptosis Midface retrusion Craniosynostosis Acanthosis nigricans Turricephaly Intellectual disability Seizures Hepatomegaly Visual impairment Depressivity Hypoplasia of the maxilla Convex nasal ridge Dental malocclusion Abnormal facial shape Hydrocephalus Splenomegaly Cloverleaf skull Craniofacial dysostosis Arthralgia Sensorineural hearing impairment Downslanted palpebral fissures Hepatosplenomegaly Vasculitis Ataxia Global developmental delay Elevated erythrocyte sedimentation rate Brachycephaly Malar flattening Brachydactyly

Rare Symptoms - Less than 30% cases

Respiratory insufficiency Hypogonadism Cleft palate Failure to thrive Short stature Inflammatory abnormality of the eye Paralysis Facial palsy Hyperactivity Amyloidosis Leukocytosis Urticaria Increased bone mineral density Conductive hearing impairment Renal insufficiency Brachyturricephaly Delayed puberty Tall stature Hypertrophic cardiomyopathy Sleep apnea Hyperhidrosis Kyphosis Abnormality of the dentition Neoplasm Bicoronal synostosis Abnormal sacrum morphology High forehead Choanal stenosis Cataract Abnormality of the skull Melanocytic nevus Arnold-Chiari malformation Abnormal palate morphology Choanal atresia Epidermal acanthosis Hyperostosis Abnormality of pelvic girdle bone morphology Purpura Uveitis Syndactyly Shallow orbits Vomiting Conjunctivitis Anemia Growth delay Nausea Coronal craniosynostosis Sensory neuropathy Apathy Trigonocephaly Anterior plagiocephaly Overgrowth Vertigo Rod-cone dystrophy Genu valgum Depressed nasal bridge Limitation of joint mobility Blindness Fever Papule Skin rash Arthritis Pain Lymphadenopathy Myalgia Flexion contracture Scoliosis Skeletal dysplasia Hypotelorism Fingernail dysplasia Cortically dense long tubular bones Abnormality of the skeletal system Craniofacial hyperostosis Unicoronal synostosis Metopic synostosis Narrow forehead Trigeminal neuralgia Cleft soft palate Facial palsy secondary to cranial hyperostosis Curved distal phalanges of the hand Sclerotic vertebral endplates Diaphyseal thickening Deviation of finger Sclerotic scapulae Esodeviation 2-3 finger syndactyly Increased number of teeth Abnormality of the nose Visual field defect Broad clavicles Triphalangeal thumb Wormian bones Hallux varus 2-3 toe syndactyly Abnormal cortical bone morphology Serositis Calcaneonavicular fusion Cerebellar hypoplasia Nystagmus Cognitive impairment Wide nasal bridge Hypermetropia Visual loss Myopia Finger syndactyly Esotropia Nail dysplasia Broad metatarsal Pharyngitis Abnormality of fibula morphology Cutaneous syndactyly Optic neuritis Dolichocephaly Symphalangism affecting the phalanges of the hand Broad hallux phalanx Cervical lymphadenopathy Anosmia Preaxial foot polydactyly Split foot Underdeveloped supraorbital ridges Constriction of peripheral visual field Broad hallux Abnormal cranial nerve morphology Short metatarsal Abnormality of the pinna Broad ribs Respiratory distress Short upper lip Prominent forehead Metaphyseal dysplasia Facial paralysis Abnormality of the ulna Raynaud phenomenon Gangrene Poor appetite Aplasia/Hypoplasia of the radius Abnormality of the vertebral column Reduced subcutaneous adipose tissue Abnormality of tibia morphology Cachexia Easy fatigability Tinnitus Leukopenia Coxa valga Bone marrow hypocellularity Bone pain Slender build Abnormality of femur morphology Anorexia Cranial nerve compression Abnormal subcutaneous fat tissue distribution Cortical thickening of long bone diaphyses Cortical sclerosis Craniofacial osteosclerosis Optic nerve compression Diaphyseal dysplasia Diaphyseal sclerosis Abnormality of the radius Extramedullary hematopoiesis Limb pain Cranial hyperostosis Sclerosis of skull base Lower limb pain Abnormal diaphysis morphology Urinary retention Abnormality of the humerus Otosclerosis Diplopia Lumbar hyperlordosis Cleft lip Keratitis Lambdoidal craniosynostosis Sagittal craniosynostosis Gonadoblastoma Papilledema Scaphocephaly Syringomyelia Gonadal dysgenesis Atresia of the external auditory canal Erysipelas Hypopigmented skin patches Torticollis Narrow palate Amblyopia Dental crowding Primary amenorrhea Amenorrhea Iris coloboma Abnormality of the cervical spine Abnormality of the nasopharynx Waddling gait Proximal muscle weakness Delayed eruption of teeth Carious teeth Muscular dystrophy Neurological speech impairment Hyperlordosis Feeding difficulties in infancy Abnormality of the nervous system Difficulty walking Dysgerminoma Pes planus Glaucoma Gait disturbance Skeletal muscle atrophy Muscle weakness Cartilaginous trachea Narrow internal auditory canal Multiple suture craniosynostosis Neutrophilia Abnormality of reproductive system physiology Porokeratosis Abnormal thrombocyte morphology Abnormal granulocyte morphology Retrobulbar optic neuritis Pseudopapilledema Abnormality of neutrophils Elevated C-reactive protein level Delayed closure of the anterior fontanelle Juvenile rheumatoid arthritis Posteriorly rotated ears Arthropathy Abnormal joint morphology Progressive sensorineural hearing impairment Reduced bone mineral density Joint dislocation Meningitis Premature birth Feeding difficulties Dry skin EEG abnormality Membranous nephropathy Broad forehead Anxiety Coarse facial features Macrotia Diabetes mellitus Hypertension Short uvula Proportionate short stature Hypopigmentation of the skin Aplasia/Hypoplasia of the cerebellum Glomerulonephritis Laryngomalacia Abnormality of the metacarpal bones Abnormal form of the vertebral bodies Short metacarpal Nevus Nausea and vomiting Edema Paresthesia Mental deterioration Cirrhosis Peripheral axonal neuropathy Unsteady gait Confusion Retinopathy Abnormality of the liver Irritability Photophobia Polyneuropathy Gait ataxia Encephalopathy Tremor Dysarthria Peripheral neuropathy Epicanthus Spasticity Distal sensory impairment Coma Macrocephaly Bilateral single transverse palmar creases Biliary tract abnormality Fat malabsorption Iris hypopigmentation Atrophy/Degeneration affecting the brainstem Agitation Spastic paraparesis Paraparesis Hypergonadotropic hypogonadism Sensory impairment Sensorimotor neuropathy Cholestasis Hemiparesis Intention tremor Status epilepticus Type II diabetes mellitus Pigmentary retinopathy Synophrys Long face Neuritis Nyctalopia Aciduria Gastrointestinal hemorrhage Sepsis Abdominal distention Retinal dystrophy Infertility Cough Erythema Eczema Pallor Postnatal growth retardation Abdominal pain Pneumonia Constipation Diarrhea Microcephaly Dehydration Optic disc pallor Cortical diaphyseal thickening of the upper limbs Poor coordination Increased IgA level Chills Recurrent aphthous stomatitis Peritonitis Large forehead Acrocyanosis Posterior subcapsular cataract Peripheral visual field loss Nephrotic syndrome Episodic fever Subcapsular cataract Colitis Hypermelanotic macule Intestinal obstruction Recurrent pneumonia Long eyelashes Generalized hypotonia Broad jaw Wide nose Generalized hirsutism Impotence Large hands Acne Growth abnormality Cerebral palsy Widely spaced teeth Abnormality of the fingernails Hoarse voice Spinal canal stenosis Thickened skin Mitral regurgitation Osteoarthritis Thick lower lip vermilion Full cheeks Macroglossia Tapered finger Generalized hyperpigmentation Palpebral edema Macrodactyly Pheochromocytoma Dysmenorrhea Pituitary prolactin cell adenoma Deep plantar creases Galactorrhea Hypersomnia Paraganglioma Long penis Anterior hypopituitarism Joint swelling Deep palmar crease Neoplasm of the endocrine system Dysuria Abnormality of the endocrine system Abnormal toenail morphology Broad foot Growth hormone excess Elevated aldolase level


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