Fever, and Skin rash

Diseases related with Fever and Skin rash

In the following list you will find some of the most common rare diseases related to Fever and Skin rash that can help you solving undiagnosed cases.


Top matches:

Medium match PYOGENIC BACTERIAL INFECTIONS DUE TO MYD88 DEFICIENCY


Pyogenic bacterial infection due to MyD88 deficiency is a primary immunodeficiency characterized by increased susceptibility to pyogenic bacterial infections, including invasive pneumococcal, invasive staphylococcal and pseudomonas disease.

PYOGENIC BACTERIAL INFECTIONS DUE TO MYD88 DEFICIENCY Is also known as myd88 deficiency|pyogenic bacterial infections, recurrent, due to myd88 deficiency|recurrent pyogenic bacterial infections due to myd88 deficiency

Related symptoms:

  • Fever
  • Immunodeficiency
  • Recurrent bacterial skin infections


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about PYOGENIC BACTERIAL INFECTIONS DUE TO MYD88 DEFICIENCY

Medium match PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1


Psoriasis (psoriasis vulgaris; PV) is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age (summary by Matthews et al., 1996).Generalized pustular psoriasis (GPP) is a life-threatening disease characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels of C-reactive protein (OMIM ) (summary by Marrakchi et al., 2011). GPP often presents in patients with existing or prior psoriasis vulgaris; however, GPP can develop without a history of PV (Sugiura et al., 2013). Palmoplantar pustulosis and acrodermatitis continua of Hallopeau represent acral forms of pustular psoriasis that have historically been grouped with GPP (summary by Setta-Kaffetzi et al., 2013).Nestle et al. (2009) provided a detailed review of the pathogenesis and genetics of psoriasis. Genetic Heterogeneity of Psoriasis and Psoriasis SusceptibilityPSORS2 (OMIM ) is caused by mutation in the CARD14 gene (OMIM ) on chromosome 17q25, and PSORS14 (OMIM ) is caused by mutation in the IL36RN gene (OMIM ) on chromosome 2q14.Psoriasis susceptibility loci include PSORS1 on 6p21.3; PSORS3 (OMIM ) on 4q; PSORS4 on 1q21; PSORS5 (OMIM ) on 3q21; PSORS6 (OMIM ) on 19p; PSORS7 (OMIM ) on 1p; PSORS8 (OMIM ) on 16q; PSORS9 (OMIM ) on 4q31; PSORS10 (OMIM ) on 18p11; PSORS11 (OMIM ) on 5q31-q33; PSORS12 (OMIM ) on 20q13; PSORS13 (OMIM ), conferred by variation in the TRAF3IP2 gene (OMIM ) on 6q21; and PSORS15 (OMIM ), conferred by variation in the AP1S3 gene (OMIM ) on 2q36.An additional putative psoriasis candidate locus has been reported on 20p (Nair et al., 1997).

Related symptoms:

  • Fever
  • Arthritis
  • Skin rash
  • Scaling skin
  • Psoriasiform dermatitis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 1, SUSCEPTIBILITY TO; PSORS1

Medium match PRIMARY IMMUNODEFICIENCY WITH POST-MEASLES-MUMPS-RUBELLA VACCINE VIRAL INFECTION


Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection is a rare primary immunodeficiency due to a defect in innate immunity disorder characterized by selective susceptibility to viral infections, particularly after systemic challenge with live viral vaccines, such as the measles, mumps and rubella (MMR) vaccine. Patients present severe, potentially fatal, manifestations to viral illness, including encephalitis, hepatitis and pneumonitis.

PRIMARY IMMUNODEFICIENCY WITH POST-MEASLES-MUMPS-RUBELLA VACCINE VIRAL INFECTION Is also known as primary immunodeficiency with post-mmr vaccine viral infection

Related symptoms:

  • Seizures
  • Fever
  • Skin rash
  • Hepatitis
  • Lymphopenia


SOURCES: OMIM ORPHANET MENDELIAN

More info about PRIMARY IMMUNODEFICIENCY WITH POST-MEASLES-MUMPS-RUBELLA VACCINE VIRAL INFECTION

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Other less relevant matches:

Medium match HEME OXYGENASE 1 DEFICIENCY; HMOX1D


Related symptoms:

  • Growth delay
  • Anemia
  • Hepatomegaly
  • Fever
  • Proteinuria


SOURCES: OMIM MESH MENDELIAN

More info about HEME OXYGENASE 1 DEFICIENCY; HMOX1D

Medium match RECURRENT NEISSERIA INFECTIONS DUE TO FACTOR D DEFICIENCY


Recurrent Neisseria infections due to factor D deficiency is a rare, genetic, primary immunodeficiency disorder characterized by an increased susceptibility to Neisseria bacterial infections, resulting from complement factor D deficiency, typically manifesting as recurrent respiratory infections, recurrent meningitis and/or septicemia. Patients typically present fever, purpuric rash, arthralgia, myalgia and undetectable complement factor D plasma concentrations.

RECURRENT NEISSERIA INFECTIONS DUE TO FACTOR D DEFICIENCY Is also known as factor d deficiency

Related symptoms:

  • Fever
  • Vomiting
  • Diarrhea
  • Recurrent infections
  • Respiratory tract infection


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about RECURRENT NEISSERIA INFECTIONS DUE TO FACTOR D DEFICIENCY

Medium match MAJEED SYNDROME; MJDS


MAJEED SYNDROME; MJDS Is also known as chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia, and neutrophilic dermatosis

Related symptoms:

  • Growth delay
  • Anemia
  • Flexion contracture
  • Fever
  • Delayed skeletal maturation


SOURCES: OMIM MENDELIAN

More info about MAJEED SYNDROME; MJDS

Medium match X-LINKED MENDELIAN SUSCEPTIBILITY TO MYCOBACTERIAL DISEASES DUE TO CYBB DEFICIENCY


Autosomal recessive cytochrome b-positive chronic granulomatous disease (CGD) type III is a immunodeficiency disorder characterized by recurrent pyogenic infections and granulomatous inflammation resulting from loss of phagocyte superoxide production (summary by Matute et al., 2009).For a general phenotypic description and a discussion of genetic heterogeneity of chronic granulomatous disease, see the well-established X-linked recessive cytochrome b-negative form (CGD ).

X-LINKED MENDELIAN SUSCEPTIBILITY TO MYCOBACTERIAL DISEASES DUE TO CYBB DEFICIENCY Is also known as granulomatous disease, chronic, due to ncf4 deficiency|cgd, autosomal recessive cytochrome b-positive, type iii|x-linked msmd due to cybb deficiency

Related symptoms:

  • Fever
  • Diarrhea
  • Immunodeficiency
  • Skin rash
  • Eczema


SOURCES: OMIM ORPHANET MENDELIAN

More info about X-LINKED MENDELIAN SUSCEPTIBILITY TO MYCOBACTERIAL DISEASES DUE TO CYBB DEFICIENCY

Medium match INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME


Autoinflammation, panniculitis, and dermatosis syndrome (AIPDS) is an autosomal recessive autoinflammatory disease characterized by neonatal onset of recurrent fever, erythematous rash with painful nodules, painful joints, and lipodystrophy. Additional features may include diarrhea, increased serum C-reactive protein, leukocytosis, and neutrophilia in the absence of any infection. Patients exhibit no overt primary immunodeficiency (Damgaard et al., 2016 and Zhou et al., 2016).

INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME Is also known as otulipenia|oras|otulin deficiency|otulin-related autoinflammatory syndrome

Related symptoms:

  • Failure to thrive
  • Fever
  • Diarrhea
  • Immunodeficiency
  • Arthralgia


SOURCES: ORPHANET OMIM MENDELIAN

More info about INFANTILE-ONSET PERIODIC FEVER-PANNICULITIS-DERMATOSIS SYNDROME

Medium match HEREDITARY PEDIATRIC BEHÇET-LIKE DISEASE


Familial Behcet-like autoinflammatory syndrome is an autosomal dominant disorder characterized by ulceration of mucosal surfaces, particularly in the oral and genital areas. Additional more variable features include skin rash, uveitis, and polyarthritis. Symptoms become apparent in the first or second decades. The disorder results from inappropriate activation of inflammatory cytokines; treatment with tumor necrosis factor (TNF ) inhibitors may be beneficial (summary by Zhou et al., 2016).

HEREDITARY PEDIATRIC BEHÇET-LIKE DISEASE Is also known as behÇet-like disease due to haploinsufficiency of a20|behÇet-like disease due to ha20

Related symptoms:

  • Neoplasm
  • Anemia
  • Thrombocytopenia
  • Skin rash
  • Hemolytic anemia


SOURCES: ORPHANET OMIM MENDELIAN

More info about HEREDITARY PEDIATRIC BEHÇET-LIKE DISEASE

Medium match FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1; FCAS1


Familial cold autoinflammatory syndrome is characterized clinically by recurrent attacks of a maculopapular rash associated with arthralgias, myalgias, fever and chills, and swelling of the extremities after exposure to cold. Despite the first description of 'cold urticaria' (Kile and Rusk, 1940) the rash in most patients is nonpruritic and nonurticarial. Rarely, some patients may also develop late-onset renal amyloidosis (Hoffman et al., 2000).Overlapping syndromes also caused by mutation in the NLRP3 gene include Muckle-Wells syndrome (CAPS2 ), which has a high frequency of amyloidosis and late-onset sensorineural deafness, and chronic neurologic cutaneous and articular syndrome (CINCA, CAPS3; {607115}), which shows earlier onset and a more severe phenotype. Genetic Heterogeneity of Familial Cold Autoinflammatory SyndromeSee also FCAS2 (OMIM ), caused by mutation in the NLRP12 gene (OMIM ) on chromosome 19q13; FCAS3 (OMIM ), caused by mutation in the PLCG2 gene (OMIM ) on chromosome 16q23; and FCAS4 (OMIM ), caused by mutation in the NLRC4 gene (OMIM ) on chromosome 2p22.

FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1; FCAS1 Is also known as cold urticaria, familial|fcas|cold hypersensitivity|caps1|fcu|cold-induced autoinflammatory syndrome, familial|cryopyrin-associated periodic syndrome 1

Related symptoms:

  • Hearing impairment
  • Sensorineural hearing impairment
  • Pain
  • Fever
  • Headache


SOURCES: OMIM MENDELIAN

More info about FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 1; FCAS1

Top 5 symptoms//phenotypes associated to Fever and Skin rash

Symptoms // Phenotype % cases
Arthralgia Uncommon - Between 30% and 50% cases
Diarrhea Uncommon - Between 30% and 50% cases
Anemia Uncommon - Between 30% and 50% cases
Immunodeficiency Uncommon - Between 30% and 50% cases
Episodic fever Uncommon - Between 30% and 50% cases
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Other less frequent symptoms

Patients with Fever and Skin rash. may also develop some of the following symptoms:

Rare Symptoms - Less than 30% cases


Colitis Hemolytic anemia Leukocytosis Growth delay Lymphopenia Recurrent bacterial infections Myalgia Low-grade fever Psoriasiform dermatitis Vasculitis Lipodystrophy Failure to thrive Perianal rash Lymphadenopathy Joint swelling Perioral eczema Neutrophilia Panniculitis Thrombocytopenia Recurrent aphthous stomatitis Neoplasm Scarring Antinuclear antibody positivity Inflammation of the large intestine Headache Renal amyloidosis Angioedema Chills Amyloidosis Petechiae Urticaria Conjunctivitis Nausea Pain Autoimmune thrombocytopenia Sensorineural hearing impairment Hearing impairment Genital ulcers Lupus anticoagulant Polyarticular arthritis Anterior uveitis Oral ulcer Uveitis Recurrent sinusitis Anemia of inadequate production Sinusitis Seizures Hematuria Proteinuria Hepatomegaly Pericardial effusion Hyponatremia Encephalitis Hepatitis Onychomadesis Vomiting Palmoplantar pustulosis Nail pits Acute monocytic leukemia Pustule Scaling skin Arthritis Recurrent bacterial skin infections Asplenia Recurrent infections Eczema Hepatosplenomegaly Chronic recurrent multifocal osteomyelitis Congenital hypoplastic anemia Decreased mean corpuscular volume Microcytic anemia Osteomyelitis Bone pain Inflammatory abnormality of the skin Delayed skeletal maturation Respiratory tract infection Flexion contracture Recurrent bacterial meningitis Complement deficiency Shock Purpura Meningitis Cough Cold urticaria



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