Fever, and Pruritus
Diseases related with Fever and Pruritus
In the following list you will find some of the most common rare diseases related to Fever and Pruritus that can help you solving undiagnosed cases.
Pyogenic bacterial infection due to MyD88 deficiency is a primary immunodeficiency characterized by increased susceptibility to pyogenic bacterial infections, including invasive pneumococcal, invasive staphylococcal and pseudomonas disease.
PYOGENIC BACTERIAL INFECTIONS DUE TO MYD88 DEFICIENCY Is also known as myd88 deficiency|pyogenic bacterial infections, recurrent, due to myd88 deficiency|recurrent pyogenic bacterial infections due to myd88 deficiencyRelated symptoms:
- Recurrent bacterial skin infections
More info about PYOGENIC BACTERIAL INFECTIONS DUE TO MYD88 DEFICIENCY
Medium match CHOLANGIOCARCINOMA
Cholangiocarcinoma (CCA) is a biliary tract cancer (BTC, see this term) originating in the epithelium of the biliary tree, either intra or extra hepatic.
CHOLANGIOCARCINOMA Is also known as bile duct cancer|ccaRelated symptoms:
- Abdominal pain
More info about CHOLANGIOCARCINOMA
Medium match PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3
Progressive familial intrahepatic cholestasis type 3 (PFIC3), a type of progressive familial intrahepatic cholestasis (PFIC, see this term), is a late-onset hereditary disorder in bile formation that is hepatocellular in origin. Onset may occur from infancy to young adulthood.
PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3 Is also known as cholestasis, progressive familial intrahepatic, with elevated serum gamma-glutamyltransferase|mdr3 deficiency|pfic3Related symptoms:
- Failure to thrive
More info about PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3
Other less relevant matches:
PLCG2-associated antibody deficiency and immune dysregulation is a rare, hereditary, immune deficiency with skin involvement characterized by early-onset cold urticaria after generalized exposure to cold air or evaporative cooling and not after contact with cold objects. Additional immunologic abnormalities are often present - antibody deficiency, recurrent infections, autoimmune disease and symptomatic allergic disease.
PLCG2-ASSOCIATED ANTIBODY DEFICIENCY AND IMMUNE DYSREGULATION Is also known as facu|familial cold urticaria with common variable immunodeficiency|antibody deficiency and immune dysregulation, plcg2-associated|plaid|familial atypical cold urticariaRelated symptoms:
- Recurrent infections
More info about PLCG2-ASSOCIATED ANTIBODY DEFICIENCY AND IMMUNE DYSREGULATION
Medium match CAROLI DISEASE
Medium match FAMILIAL COLD URTICARIA
Familial cold urticaria (FCAS) is the mildest form of cryopyrin-associated periodic syndrome (CAPS; see this term) and is characterized by recurrent episodes of urticaria-like skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia.
FAMILIAL COLD URTICARIA Is also known as fcas|familial cold autoinflammatory syndrome|fcuRelated symptoms:
- Sensorineural hearing impairment
More info about FAMILIAL COLD URTICARIA
Medium match DENGUE FEVER
Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).
DENGUE FEVER Is also known as df|dengue virus infectionRelated symptoms:
More info about DENGUE FEVER
Medium match LYMPHOMA, HODGKIN, CLASSIC; CHL
Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).
LYMPHOMA, HODGKIN, CLASSIC; CHL Is also known as hodgkin diseaseRelated symptoms:
- Peripheral neuropathy
More info about LYMPHOMA, HODGKIN, CLASSIC; CHL
Medium match AICARDI-GOUTIERES SYNDROME 3; AGS3
Aicardi-Goutieres syndrome is an autosomal recessive disorder characterized by onset of encephalopathy in the first year of life following normal early development. Affected infants typically show extreme irritability, intermittent unexplained fever, chilblains, progressive microcephaly, spasticity, dystonia, and profound psychomotor retardation. Laboratory studies show lymphocytosis and raised titers of alpha-interferon in the cerebrospinal fluid. Brain imaging may show white matter abnormalities, intracerebral calcifications, and cerebral atrophy. Many patients die in childhood (summary by Vogt et al., 2013).For a general phenotypic description and a discussion of genetic heterogeneity of Aicardi-Goutieres syndrome, see AGS1 (OMIM ).Related symptoms:
- Global developmental delay
- Generalized hypotonia
More info about AICARDI-GOUTIERES SYNDROME 3; AGS3
Medium match SÉZARY SYNDROME
Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells).
SÉZARY SYNDROME Is also known as sÉzary lymphomaRelated symptoms:
- Abnormal facial shape
- Peripheral neuropathy
More info about SÉZARY SYNDROME
Top 5 symptoms//phenotypes associated to Fever and Pruritus
|Symptoms // Phenotype||% cases|
|Hepatomegaly||Uncommon - Between 30% and 50% cases|
|Abdominal pain||Uncommon - Between 30% and 50% cases|
|Arthralgia||Uncommon - Between 30% and 50% cases|
|Hepatosplenomegaly||Uncommon - Between 30% and 50% cases|
|Splenomegaly||Uncommon - Between 30% and 50% cases|
Other less frequent symptoms
Patients with Fever and Pruritus. may also develop some of the following symptoms:
Uncommon Symptoms - Between 30% and 50% casesSkin rash Pain Fatigue
Rare Symptoms - Less than 30% casesThrombocytopenia Portal hypertension Urticaria Immunodeficiency Lymphoma Erythema Ascites Nausea and vomiting Headache Hyperhidrosis Cholestasis Weight loss Neoplasm Lymphadenopathy Peripheral neuropathy Anorexia Elevated hepatic transaminase Diarrhea Jaundice Hypertension Hyperreflexia Dystonia Hypoplasia of the corpus callosum Osteolysis Cerebral atrophy Encephalopathy Muscular hypotonia of the trunk Bone marrow hypocellularity Generalized hypotonia Spasticity Nystagmus Microcephaly Global developmental delay Seizures Polyclonal elevation of IgM Impaired lymphocyte transformation with phytohemagglutinin Monoclonal immunoglobulin M proteinemia Hodgkin lymphoma Cellular immunodeficiency Poor appetite Hemoptysis Lung adenocarcinoma Poor head control Irritability Hypotrichosis Abnormal immunoglobulin level Abnormal lymphocyte morphology T-cell lymphoma Lichenification Abnormality of the pleura Gangrene Irregular hyperpigmentation Erythroderma Ectropion Neoplasm of the skin Thickened skin Abnormality of the face Palmoplantar keratoderma Dry skin Nail dystrophy Severe global developmental delay Alopecia Edema Tremor Skeletal muscle atrophy Abnormal facial shape CSF lymphocytic pleiocytosis Lymphocytosis Hemiplegia Muscle stiffness Leukodystrophy Progressive microcephaly Cerebral calcification Delayed myelination Abnormality of the cerebral white matter Bone pain Petechiae Migraine Syncope Renal cyst Abnormality of the kidney Dilatation Vomiting Cold urticaria Angioedema Chills Allergic rhinitis Immune dysregulation Vitiligo Hashimoto thyroiditis Asthma Episodic fever Autoimmunity Recurrent infections Portal fibrosis Bile duct proliferation Intrahepatic cholestasis Hepatic failure Cirrhosis Malabsorption Failure to thrive Biliary tract neoplasm Acholic stools Recurrent bacterial skin infections Polycystic kidney dysplasia Esophageal varix Chest pain Hypotension Leukemia Cough Respiratory insufficiency Ataxia Hypoproteinemia Flushing Cardiorespiratory arrest Gingival bleeding Cerebral hemorrhage Shock Leukopenia Epistaxis Gastrointestinal hemorrhage Cholangitis Bruising susceptibility Lethargy Dysesthesia Polydipsia Conjunctivitis Dehydration Arthritis Myalgia Sensorineural hearing impairment Cholangiocarcinoma Liver abscess Epigastric pain Cutaneous T-cell lymphoma
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