Fever, and Pruritus

Diseases related with Fever and Pruritus

In the following list you will find some of the most common rare diseases related to Fever and Pruritus that can help you solving undiagnosed cases.

Top matches:

Pyogenic bacterial infection due to MyD88 deficiency is a primary immunodeficiency characterized by increased susceptibility to pyogenic bacterial infections, including invasive pneumococcal, invasive staphylococcal and pseudomonas disease.

PYOGENIC BACTERIAL INFECTIONS DUE TO MYD88 DEFICIENCY Is also known as myd88 deficiency|pyogenic bacterial infections, recurrent, due to myd88 deficiency|recurrent pyogenic bacterial infections due to myd88 deficiency

Related symptoms:

  • Fever
  • Immunodeficiency
  • Recurrent bacterial skin infections


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about PYOGENIC BACTERIAL INFECTIONS DUE TO MYD88 DEFICIENCY

Medium match CHOLANGIOCARCINOMA

Cholangiocarcinoma (CCA) is a biliary tract cancer (BTC, see this term) originating in the epithelium of the biliary tree, either intra or extra hepatic.

CHOLANGIOCARCINOMA Is also known as bile duct cancer|cca

Related symptoms:

  • Fever
  • Fatigue
  • Abdominal pain
  • Jaundice
  • Pruritus


SOURCES: ORPHANET MENDELIAN

More info about CHOLANGIOCARCINOMA

Progressive familial intrahepatic cholestasis type 3 (PFIC3), a type of progressive familial intrahepatic cholestasis (PFIC, see this term), is a late-onset hereditary disorder in bile formation that is hepatocellular in origin. Onset may occur from infancy to young adulthood.

PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3 Is also known as cholestasis, progressive familial intrahepatic, with elevated serum gamma-glutamyltransferase|mdr3 deficiency|pfic3

Related symptoms:

  • Failure to thrive
  • Hypertension
  • Hepatomegaly
  • Fever
  • Diarrhea


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3

Other less relevant matches:

PLCG2-associated antibody deficiency and immune dysregulation is a rare, hereditary, immune deficiency with skin involvement characterized by early-onset cold urticaria after generalized exposure to cold air or evaporative cooling and not after contact with cold objects. Additional immunologic abnormalities are often present - antibody deficiency, recurrent infections, autoimmune disease and symptomatic allergic disease.

PLCG2-ASSOCIATED ANTIBODY DEFICIENCY AND IMMUNE DYSREGULATION Is also known as facu|familial cold urticaria with common variable immunodeficiency|antibody deficiency and immune dysregulation, plcg2-associated|plaid|familial atypical cold urticaria

Related symptoms:

  • Pain
  • Fever
  • Recurrent infections
  • Arthralgia
  • Erythema


SOURCES: OMIM ORPHANET MENDELIAN

More info about PLCG2-ASSOCIATED ANTIBODY DEFICIENCY AND IMMUNE DYSREGULATION

Medium match CAROLI DISEASE

Caroli disease (CD) is a rare congenital liver disease characterized by non-obstructive cystic dilatations of the intra-hepatic and rarely extra-hepatic bile ducts.

Related symptoms:

  • Pain
  • Hypertension
  • Hepatomegaly
  • Fever
  • Vomiting


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about CAROLI DISEASE

Familial cold urticaria (FCAS) is the mildest form of cryopyrin-associated periodic syndrome (CAPS; see this term) and is characterized by recurrent episodes of urticaria-like skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia.

FAMILIAL COLD URTICARIA Is also known as fcas|familial cold autoinflammatory syndrome|fcu

Related symptoms:

  • Sensorineural hearing impairment
  • Fever
  • Fatigue
  • Headache
  • Hyperhidrosis


SOURCES: ORPHANET MENDELIAN

More info about FAMILIAL COLD URTICARIA

Medium match DENGUE FEVER

Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).

DENGUE FEVER Is also known as df|dengue virus infection

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Diarrhea
  • Headache


SOURCES: OMIM ORPHANET MENDELIAN

More info about DENGUE FEVER

Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).

LYMPHOMA, HODGKIN, CLASSIC; CHL Is also known as hodgkin disease

Related symptoms:

  • Ataxia
  • Neoplasm
  • Peripheral neuropathy
  • Hepatomegaly
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about LYMPHOMA, HODGKIN, CLASSIC; CHL

Aicardi-Goutieres syndrome is an autosomal recessive disorder characterized by onset of encephalopathy in the first year of life following normal early development. Affected infants typically show extreme irritability, intermittent unexplained fever, chilblains, progressive microcephaly, spasticity, dystonia, and profound psychomotor retardation. Laboratory studies show lymphocytosis and raised titers of alpha-interferon in the cerebrospinal fluid. Brain imaging may show white matter abnormalities, intracerebral calcifications, and cerebral atrophy. Many patients die in childhood (summary by Vogt et al., 2013).For a general phenotypic description and a discussion of genetic heterogeneity of Aicardi-Goutieres syndrome, see AGS1 (OMIM ).

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly
  • Nystagmus


SOURCES: MESH OMIM MENDELIAN

More info about AICARDI-GOUTIERES SYNDROME 3; AGS3

Medium match SÉZARY SYNDROME

Sézary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma characterized by a triad of erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells).

SÉZARY SYNDROME Is also known as sÉzary lymphoma

Related symptoms:

  • Neoplasm
  • Abnormal facial shape
  • Peripheral neuropathy
  • Hepatomegaly
  • Fever


SOURCES: MESH ORPHANET MENDELIAN

More info about SÉZARY SYNDROME

Top 5 symptoms//phenotypes associated to Fever and Pruritus

Symptoms // Phenotype % cases
Hepatomegaly Uncommon - Between 30% and 50% cases
Abdominal pain Uncommon - Between 30% and 50% cases
Arthralgia Uncommon - Between 30% and 50% cases
Hepatosplenomegaly Uncommon - Between 30% and 50% cases
Splenomegaly Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Pruritus. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Skin rash Pain Fatigue

Rare Symptoms - Less than 30% cases

Thrombocytopenia Portal hypertension Urticaria Immunodeficiency Lymphoma Erythema Ascites Nausea and vomiting Headache Hyperhidrosis Cholestasis Weight loss Neoplasm Lymphadenopathy Peripheral neuropathy Anorexia Elevated hepatic transaminase Diarrhea Jaundice Hypertension Hyperreflexia Dystonia Hypoplasia of the corpus callosum Osteolysis Cerebral atrophy Encephalopathy Muscular hypotonia of the trunk Bone marrow hypocellularity Generalized hypotonia Spasticity Nystagmus Microcephaly Global developmental delay Seizures Polyclonal elevation of IgM Impaired lymphocyte transformation with phytohemagglutinin Monoclonal immunoglobulin M proteinemia Hodgkin lymphoma Cellular immunodeficiency Poor appetite Hemoptysis Lung adenocarcinoma Poor head control Irritability Hypotrichosis Abnormal immunoglobulin level Abnormal lymphocyte morphology T-cell lymphoma Lichenification Abnormality of the pleura Gangrene Irregular hyperpigmentation Erythroderma Ectropion Neoplasm of the skin Thickened skin Abnormality of the face Palmoplantar keratoderma Dry skin Nail dystrophy Severe global developmental delay Alopecia Edema Tremor Skeletal muscle atrophy Abnormal facial shape CSF lymphocytic pleiocytosis Lymphocytosis Hemiplegia Muscle stiffness Leukodystrophy Progressive microcephaly Cerebral calcification Delayed myelination Abnormality of the cerebral white matter Bone pain Petechiae Migraine Syncope Renal cyst Abnormality of the kidney Dilatation Vomiting Cold urticaria Angioedema Chills Allergic rhinitis Immune dysregulation Vitiligo Hashimoto thyroiditis Asthma Episodic fever Autoimmunity Recurrent infections Portal fibrosis Bile duct proliferation Intrahepatic cholestasis Hepatic failure Cirrhosis Malabsorption Failure to thrive Biliary tract neoplasm Acholic stools Recurrent bacterial skin infections Polycystic kidney dysplasia Esophageal varix Chest pain Hypotension Leukemia Cough Respiratory insufficiency Ataxia Hypoproteinemia Flushing Cardiorespiratory arrest Gingival bleeding Cerebral hemorrhage Shock Leukopenia Epistaxis Gastrointestinal hemorrhage Cholangitis Bruising susceptibility Lethargy Dysesthesia Polydipsia Conjunctivitis Dehydration Arthritis Myalgia Sensorineural hearing impairment Cholangiocarcinoma Liver abscess Epigastric pain Cutaneous T-cell lymphoma


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