Fever, and Lower limb muscle weakness

Diseases related with Fever and Lower limb muscle weakness

In the following list you will find some of the most common rare diseases related to Fever and Lower limb muscle weakness that can help you solving undiagnosed cases.

Top matches:

Related symptoms:

  • Peripheral neuropathy
  • Fever
  • Skeletal muscle atrophy
  • Lower limb muscle weakness


SOURCES: OMIM MESH MENDELIAN

More info about NEUROPATHY, PAINFUL

Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is an inflammatory neuropathy belonging to the clinical spectrum of Guillain-Barré syndrome (GBS; see this term).

ACUTE INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY Is also known as guillain-barrÉ syndrome, acute inflammatory demyelinating polyradiculoneuropathic form|aidp|acute inflammatory polyneuropathy|acute idiopathic demyelinating polyneuropathy|gbs, acute inflammatory demyelinating polyradiculoneuropathic form

Related symptoms:

  • Generalized hypotonia
  • Hyporeflexia
  • Gait ataxia
  • Unsteady gait
  • Drooling


SOURCES: ORPHANET MENDELIAN

More info about ACUTE INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY

Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. Rare menstrual cycle-dependent febrile episodes have been reported, some of which have shown a luteal-phase-dependent pattern (summary by Jiang et al., 2012).

Related symptoms:

  • Ataxia
  • Fever
  • Tremor
  • Myalgia
  • Lower limb muscle weakness


SOURCES: OMIM MENDELIAN

More info about PERIODIC FEVER, MENSTRUAL CYCLE-DEPENDENT

Other less relevant matches:

Autosomal recessive spinocerebellar ataxia-21 is a neurologic disorder characterized by onset of cerebellar ataxia associated with cerebellar atrophy in early childhood. Affected individuals also have recurrent episodes of liver failure in the first decade, resulting in chronic liver fibrosis, as well as later onset of a peripheral neuropathy. Mild learning disabilities may also occur (summary by Schmidt et al., 2015).

ACUTE INFANTILE LIVER FAILURE-CEREBELLAR ATAXIA-PERIPHERAL SENSORY MOTOR NEUROPATHY SYNDROME Is also known as spinocerebellar ataxia, autosomal recessive 21, with hepatopathy|autosomal recessive spinocerebellar ataxia type 21|scar21

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Ataxia
  • Muscle weakness
  • Spasticity


SOURCES: ORPHANET OMIM MENDELIAN

More info about ACUTE INFANTILE LIVER FAILURE-CEREBELLAR ATAXIA-PERIPHERAL SENSORY MOTOR NEUROPATHY SYNDROME

The myopathic form of carnitine palmitoyltransferase II (CPT II) deficiency, an inherited metabolic disorder that affects mitochondrial oxidation of long chain fatty acids (LCFA), is the most common and the least severe form of CPT II deficiency (see this term).

CARNITINE PALMITOYL TRANSFERASE II DEFICIENCY, MYOPATHIC FORM Is also known as cpt2, adult-onset form|cpt2 deficiency, late-onset|carnitine palmitoyl transferase deficiency type 2, myopathic form|cptii, myopathic form|carnitine palmitoyl transferase ii deficiency, adult-onset form|carnitine palmitoyl transferase deficiency type 2, a

Related symptoms:

  • Muscle weakness
  • Pain
  • Spasticity
  • Visual impairment
  • Fever


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about CARNITINE PALMITOYL TRANSFERASE II DEFICIENCY, MYOPATHIC FORM

X-linked Charcot-Marie-Tooth disease type 1 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked dominant inheritance pattern and the childhood-onset (within the first decade in males) of progressive, distal, moderate to severe muscle weakness and atrophy in lower extremities and intrinsic hand muscles, pes cavus, bilateral foot drop, reduced or absent tendon reflexes, as well as mild to moderate sensory impairment in lower extremities. Females tend to have milder manifestations or may be asymptomatic. Sensorineural deafness and central nervous system involvement have also been reported.

X-LINKED CHARCOT-MARIE-TOOTH DISEASE TYPE 1 Is also known as cmt2, formerly|cmt1x|charcot-marie-tooth peroneal muscular atrophy, x-linked|cmtx1|cmtx|charcot-marie-tooth neuropathy, x-linked, 1|hereditary motor and sensory neuropathy, x-linked|hmsn, x-linked

Related symptoms:

  • Hearing impairment
  • Scoliosis
  • Ataxia
  • Nystagmus
  • Sensorineural hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about X-LINKED CHARCOT-MARIE-TOOTH DISEASE TYPE 1

Medium match CADASIL

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a hereditary cerebrovascular disorder characterized by mid-adult onset of recurrent subcortical ischemic stroke and cognitive impairment progressing to dementia in addition to migraines with aura and mood disturbances seen in about a third of patients.

CADASIL Is also known as dementia, hereditary multi-infarct type|cadasil|cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy|casil|hereditary multi-infarct dementia

Related symptoms:

  • Seizures
  • Hearing impairment
  • Ataxia
  • Sensorineural hearing impairment
  • Muscle weakness


SOURCES: OMIM ORPHANET MENDELIAN

More info about CADASIL

Autosomal dominant intermediate Charcot-Marie-Tooth disease type E is a rare hereditary motor and sensory neuropathy disorder characterized by the typical CMT phenotype (slowly progressive distal muscle weakness and atrophy in upper and lower limbs, distal sensory loss in extremities, reduced or absent deep tendon reflexes and foot deformities) associated with focal segmental glomerulosclerosis (manifesting with proteinuria and progression to end-stage renal disease). Mild or moderate sensorineural hearing loss may also been associated. Nerve biopsy reveals both axonal and demyelinating changes and nerve conduction velocities vary from the demyelinating to axonal range (typically between 25-50m/sec.

AUTOSOMAL DOMINANT INTERMEDIATE CHARCOT-MARIE-TOOTH DISEASE TYPE E Is also known as cmtdie|charcot-marie-tooth disease-nephropathy syndrome|charcot-marie-tooth neuropathy with focal segmental glomerulonephritis

Related symptoms:

  • Hearing impairment
  • Sensorineural hearing impairment
  • Muscle weakness
  • Fever
  • Skeletal muscle atrophy


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOSOMAL DOMINANT INTERMEDIATE CHARCOT-MARIE-TOOTH DISEASE TYPE E

Thyrotoxic periodic paralysis (TPP) is a rare neurological disease characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state.

THYROTOXIC PERIODIC PARALYSIS Is also known as thyrotoxic hypokalemic periodic paralysis

Related symptoms:

  • Muscle weakness
  • Hypertension
  • Hyperreflexia
  • Tremor
  • Obesity


SOURCES: OMIM ORPHANET MENDELIAN

More info about THYROTOXIC PERIODIC PARALYSIS

Familial acute necrotizing encephalopathy or ADANE is a potentially fatal neurological disease characterised by neuropathological lesions principally involving the brainstem, thalamus and putamen.

FAMILIAL ACUTE NECROTIZING ENCEPHALOPATHY Is also known as adane|recurrent acute necrotizing encephalopathy|ane|encephalopathy, acute necrotizing, susceptibility to

Related symptoms:

  • Intellectual disability
  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Spasticity


SOURCES: OMIM ORPHANET MENDELIAN

More info about FAMILIAL ACUTE NECROTIZING ENCEPHALOPATHY

Top 5 symptoms//phenotypes associated to Fever and Lower limb muscle weakness

Symptoms // Phenotype % cases
Muscle weakness Common - Between 50% and 80% cases
Ataxia Uncommon - Between 30% and 50% cases
Hyporeflexia Uncommon - Between 30% and 50% cases
Tremor Uncommon - Between 30% and 50% cases
Peripheral neuropathy Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Lower limb muscle weakness. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Skeletal muscle atrophy Hyperreflexia Spasticity Foot dorsiflexor weakness Hearing impairment Sensorineural hearing impairment Gait disturbance Distal muscle weakness Visual impairment Distal sensory impairment Tetraplegia Onion bulb formation Frequent falls

Rare Symptoms - Less than 30% cases

Muscle stiffness Myopathy Seizures Distal upper limb amyotrophy Pain Elevated serum creatine phosphokinase Muscle cramps Tetraparesis Pseudobulbar paralysis Vomiting Abnormality of peripheral nerve conduction Impaired pain sensation Hyperkalemia Babinski sign Sensory neuropathy Distal amyotrophy Falls Dysmetria Cranial nerve paralysis Pes cavus Areflexia Rhabdomyolysis Aphasia Dysphagia Dysarthria Axonal loss Distal lower limb amyotrophy Severe vision loss Hypertonia Hypertension Peripheral demyelination Motor delay Sensorimotor neuropathy Intellectual disability Intention tremor Sensory impairment Generalized hypotonia Encephalopathy Gait ataxia Cerebellar atrophy Distal lower limb muscle weakness Pallor Coma Migraine Myalgia Shock Subdural hemorrhage Spastic tetraparesis Scintillating scotoma Atherosclerosis Stage 5 chronic kidney disease Proteinuria Recurrent pneumonia Truncal ataxia Leukoencephalopathy Split hand Glomerulosclerosis Glomerulonephritis Hemiparesis Nephritis Myocardial infarction Hammertoe Nonarteritic anterior ischemic optic neuropathy Cerebral ischemia Recurrent subcortical infarcts Scotoma Varicose veins Migraine with aura Transient ischemic attack Abnormality of visual evoked potentials Optic neuropathy Abnormality of nervous system morphology Amyloidosis Bulbar palsy Perseveration Mania Cerebral hemorrhage Abnormal electroretinogram Personality changes Subcutaneous hemorrhage Amaurosis fugax Apathy Diffuse leukoencephalopathy Focal sensory seizure Hemiplegia Retinal arteriolar tortuosity Stroke-like episode Abulia Subcortical dementia Palpitations Steppage gait Rigidity Late-onset proximal muscle weakness Respiratory paralysis Episodic flaccid weakness Second degree atrioventricular block Thyrotoxicosis with diffuse goiter Episodic hypokalemia Decreased urinary potassium Transient hypophosphatemia Thyrotoxicosis with toxic single thyroid nodule Thyrotoxicosis with toxic multinodular goitre Diarrhea Pneumonia Cough Periodic hypokalemic paresis Polyneuropathy Gliosis Spastic tetraplegia Hallucinations Encephalitis Increased CSF protein Cerebral edema Abnormal posturing Abducens palsy Acute encephalopathy Abnormal muscle tone Necrotizing encephalopathy Polyneuritis Exercise-induced muscle fatigue Increased intramyocellular lipid droplets Focal segmental glomerulosclerosis Myotonia Mild proteinuria Obesity Constipation Hyperhidrosis Weight loss Proptosis Paralysis Tachycardia Abnormality of extrapyramidal motor function EMG abnormality Goiter Hypokalemia Ophthalmoparesis Ventricular fibrillation Shortened PR interval Mildly elevated creatine phosphokinase Prolonged QT interval Hyperthyroidism Thyroiditis Hashimoto thyroiditis Hypomagnesemia Heat intolerance Graves disease Urinary retention Periodic paralysis Abnormality of muscle fibers Postprandial hyperglycemia Impaired myocardial contractility Psychosis Delayed speech and language development Bradykinesia Hypocalcemia Dysmetric saccades Generalized limb muscle atrophy Stuttering Fatigue Renal insufficiency Arrhythmia Respiratory failure Proximal muscle weakness Hypertriglyceridemia Insulin resistance Pancreatitis Acute hepatic failure Abnormality of the musculature Myoglobinuria Ketosis Hyperphosphatemia Ketonuria Exercise-induced myalgia Hyperlipoproteinemia Recurrent myoglobinuria Recurrent pancreatitis Scoliosis Nystagmus Saccadic smooth pursuit Progressive gait ataxia Respiratory distress Global developmental delay Unsteady gait Drooling Episodic fever EMG: neuropathic changes Dysesthesia Acute demyelinating polyneuropathy Sleepy facial expression Impaired oropharyngeal swallow response Hepatitis Increased circulating cortisol level Recurrent spontaneous abortion Hepatomegaly Cerebellar vermis atrophy Optic atrophy Talipes equinovarus Intellectual disability, mild Splenomegaly Reduced visual acuity Hepatosplenomegaly Abnormality of the liver Paresthesia Hepatic failure Progressive cerebellar ataxia Hepatic fibrosis Flexion contracture Kyphosis Memory impairment Abnormality of the eye Behavioral abnormality Headache Depressivity Visual loss Dementia Cerebral cortical atrophy EEG abnormality Hypoglycemia Facial palsy Mental deterioration Developmental regression Motor aphasia Attention deficit hyperactivity disorder Stroke Generalized tonic-clonic seizures Abnormality of eye movement Confusion Vertigo Nausea Inability to walk Brain atrophy Urinary incontinence Abnormality of the skin Cognitive impairment Peripheral axonal degeneration Difficulty walking Toe walking Abnormality of the nervous system Abnormality of the cerebral white matter Limb muscle weakness Abnormality of the foot Peripheral axonal neuropathy Abnormal cerebellum morphology Limb ataxia Paraparesis Incoordination Dysdiadochokinesis Language impairment Decreased motor nerve conduction velocity Abnormal nerve conduction velocity Axonal degeneration Lower limb hyperreflexia Pathologic fracture Decreased number of peripheral myelinated nerve fibers Hyperventilation Upper limb undergrowth Hand tremor Excessive daytime somnolence Achilles tendon contracture Spinocerebellar tract degeneration Absent Achilles reflex Acute necrotizing encephalopathy


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