Fever, and Limb muscle weakness

Diseases related with Fever and Limb muscle weakness

In the following list you will find some of the most common rare diseases related to Fever and Limb muscle weakness that can help you solving undiagnosed cases.

Top matches:

Related symptoms:

  • Peripheral neuropathy
  • Fever
  • Skeletal muscle atrophy
  • Lower limb muscle weakness


SOURCES: OMIM MESH MENDELIAN

More info about NEUROPATHY, PAINFUL

Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is an inflammatory neuropathy belonging to the clinical spectrum of Guillain-Barré syndrome (GBS; see this term).

ACUTE INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY Is also known as guillain-barrÉ syndrome, acute inflammatory demyelinating polyradiculoneuropathic form|aidp|acute inflammatory polyneuropathy|acute idiopathic demyelinating polyneuropathy|gbs, acute inflammatory demyelinating polyradiculoneuropathic form

Related symptoms:

  • Generalized hypotonia
  • Hyporeflexia
  • Gait ataxia
  • Unsteady gait
  • Drooling


SOURCES: ORPHANET MENDELIAN

More info about ACUTE INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY

Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. Rare menstrual cycle-dependent febrile episodes have been reported, some of which have shown a luteal-phase-dependent pattern (summary by Jiang et al., 2012).

Related symptoms:

  • Ataxia
  • Fever
  • Tremor
  • Myalgia
  • Lower limb muscle weakness


SOURCES: OMIM MENDELIAN

More info about PERIODIC FEVER, MENSTRUAL CYCLE-DEPENDENT

Other less relevant matches:

Autosomal dominant intermediate Charcot-Marie-Tooth disease type E is a rare hereditary motor and sensory neuropathy disorder characterized by the typical CMT phenotype (slowly progressive distal muscle weakness and atrophy in upper and lower limbs, distal sensory loss in extremities, reduced or absent deep tendon reflexes and foot deformities) associated with focal segmental glomerulosclerosis (manifesting with proteinuria and progression to end-stage renal disease). Mild or moderate sensorineural hearing loss may also been associated. Nerve biopsy reveals both axonal and demyelinating changes and nerve conduction velocities vary from the demyelinating to axonal range (typically between 25-50m/sec.

AUTOSOMAL DOMINANT INTERMEDIATE CHARCOT-MARIE-TOOTH DISEASE TYPE E Is also known as cmtdie|charcot-marie-tooth disease-nephropathy syndrome|charcot-marie-tooth neuropathy with focal segmental glomerulonephritis

Related symptoms:

  • Hearing impairment
  • Sensorineural hearing impairment
  • Muscle weakness
  • Fever
  • Skeletal muscle atrophy


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOSOMAL DOMINANT INTERMEDIATE CHARCOT-MARIE-TOOTH DISEASE TYPE E

Autosomal recessive spinocerebellar ataxia-21 is a neurologic disorder characterized by onset of cerebellar ataxia associated with cerebellar atrophy in early childhood. Affected individuals also have recurrent episodes of liver failure in the first decade, resulting in chronic liver fibrosis, as well as later onset of a peripheral neuropathy. Mild learning disabilities may also occur (summary by Schmidt et al., 2015).

ACUTE INFANTILE LIVER FAILURE-CEREBELLAR ATAXIA-PERIPHERAL SENSORY MOTOR NEUROPATHY SYNDROME Is also known as spinocerebellar ataxia, autosomal recessive 21, with hepatopathy|autosomal recessive spinocerebellar ataxia type 21|scar21

Related symptoms:

  • Intellectual disability
  • Global developmental delay
  • Ataxia
  • Muscle weakness
  • Spasticity


SOURCES: ORPHANET OMIM MENDELIAN

More info about ACUTE INFANTILE LIVER FAILURE-CEREBELLAR ATAXIA-PERIPHERAL SENSORY MOTOR NEUROPATHY SYNDROME

The myopathic form of carnitine palmitoyltransferase II (CPT II) deficiency, an inherited metabolic disorder that affects mitochondrial oxidation of long chain fatty acids (LCFA), is the most common and the least severe form of CPT II deficiency (see this term).

CARNITINE PALMITOYL TRANSFERASE II DEFICIENCY, MYOPATHIC FORM Is also known as cpt2, adult-onset form|cpt2 deficiency, late-onset|carnitine palmitoyl transferase deficiency type 2, myopathic form|cptii, myopathic form|carnitine palmitoyl transferase ii deficiency, adult-onset form|carnitine palmitoyl transferase deficiency type 2, a

Related symptoms:

  • Muscle weakness
  • Pain
  • Spasticity
  • Visual impairment
  • Fever


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about CARNITINE PALMITOYL TRANSFERASE II DEFICIENCY, MYOPATHIC FORM

Familial acute necrotizing encephalopathy or ADANE is a potentially fatal neurological disease characterised by neuropathological lesions principally involving the brainstem, thalamus and putamen.

FAMILIAL ACUTE NECROTIZING ENCEPHALOPATHY Is also known as adane|recurrent acute necrotizing encephalopathy|ane|encephalopathy, acute necrotizing, susceptibility to

Related symptoms:

  • Intellectual disability
  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Spasticity


SOURCES: OMIM ORPHANET MENDELIAN

More info about FAMILIAL ACUTE NECROTIZING ENCEPHALOPATHY

X-linked Charcot-Marie-Tooth disease type 1 is a rare, genetic, peripheral sensorimotor neuropathy characterized by an X-linked dominant inheritance pattern and the childhood-onset (within the first decade in males) of progressive, distal, moderate to severe muscle weakness and atrophy in lower extremities and intrinsic hand muscles, pes cavus, bilateral foot drop, reduced or absent tendon reflexes, as well as mild to moderate sensory impairment in lower extremities. Females tend to have milder manifestations or may be asymptomatic. Sensorineural deafness and central nervous system involvement have also been reported.

X-LINKED CHARCOT-MARIE-TOOTH DISEASE TYPE 1 Is also known as cmt2, formerly|cmt1x|charcot-marie-tooth peroneal muscular atrophy, x-linked|cmtx1|cmtx|charcot-marie-tooth neuropathy, x-linked, 1|hereditary motor and sensory neuropathy, x-linked|hmsn, x-linked

Related symptoms:

  • Hearing impairment
  • Scoliosis
  • Ataxia
  • Nystagmus
  • Sensorineural hearing impairment


SOURCES: OMIM ORPHANET MENDELIAN

More info about X-LINKED CHARCOT-MARIE-TOOTH DISEASE TYPE 1

Medium match RIGID SPINE SYNDROME

Rigid spine syndrome (RSS) is a slowly progressive childhood-onset congenital muscular dystrophy (see this term) characterized by contractures of the spinal extensor muscles associated with abnormal posture (limitation of neck and trunk flexure), progressive scoliosis of the spine, early marked cervico-axial muscle weakness with relatively preserved strength and function of the extremities and progressive respiratory insufficiency.

RIGID SPINE SYNDROME Is also known as minicore myopathy, severe classic form|mdrs1|desmin-related myopathy with mallory bodies|multiminicore disease, severe classic form|myopathy, sepn1-related|rigid spine syndrome|muscular dystrophy, congenital, eichsfeld type|rigid spine congenital muscular

Related symptoms:

  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Scoliosis
  • Failure to thrive


SOURCES: OMIM ORPHANET MENDELIAN

More info about RIGID SPINE SYNDROME

Vasculitis due to ADA2 deficiency is a rare, genetic, systemic and rheumatologic disease due to adenosine deaminase-2 inactivating mutations, combining variable features of autoinflammation, vasculitis, and a mild immunodeficiency. Variable clinical presentation includes chronic or recurrent systemic inflammation with fever, livedo reticularis or racemosa, early-onset ischemic or hemorrhagic strokes, peripheral neuropathy, abdominal pain, hepatosplenomegaly, portal hypertension, cutaneous polyarteritis nodosa, variable cytopenia and immunoglobulin deficiency.

VASCULITIS DUE TO ADA2 DEFICIENCY Is also known as ada2 deficiency|vasculitis due to dada2

Related symptoms:

  • Ataxia
  • Pain
  • Anemia
  • Hypertension
  • Peripheral neuropathy


SOURCES: OMIM ORPHANET MENDELIAN

More info about VASCULITIS DUE TO ADA2 DEFICIENCY

Top 5 symptoms//phenotypes associated to Fever and Limb muscle weakness

Symptoms // Phenotype % cases
Muscle weakness Uncommon - Between 30% and 50% cases
Hyporeflexia Uncommon - Between 30% and 50% cases
Skeletal muscle atrophy Uncommon - Between 30% and 50% cases
Ataxia Uncommon - Between 30% and 50% cases
Peripheral neuropathy Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Limb muscle weakness. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Foot dorsiflexor weakness Lower limb muscle weakness Spasticity Onion bulb formation Motor delay Generalized hypotonia Distal muscle weakness Frequent falls Hepatomegaly Tremor Myalgia Distal sensory impairment

Rare Symptoms - Less than 30% cases

Splenomegaly Abnormality of the liver Hepatosplenomegaly Intellectual disability Cerebellar atrophy Global developmental delay Intention tremor Hyperreflexia Optic atrophy Proximal muscle weakness Sensorimotor neuropathy Cough Aphasia Abnormality of the cerebral white matter Hypertension Flexion contracture Scoliosis Rigidity Pain Pneumonia Gait disturbance Severe vision loss Distal lower limb amyotrophy Respiratory failure Visual impairment Distal upper limb amyotrophy Myopathy Axonal loss Sensory impairment Hearing impairment Sensorineural hearing impairment Areflexia Pes cavus Falls Distal amyotrophy Distal lower limb muscle weakness Gait ataxia High pitched voice Granulocytopenia Immune dysregulation Facial palsy Antiphospholipid antibody positivity Apnea Hyperlordosis Muscular dystrophy Arthrogryposis multiplex congenita Generalized muscle weakness Waddling gait Increased variability in muscle fiber diameter Spinal rigidity Ventricular hypertrophy Progressive muscle weakness Elbow flexion contracture Panniculitis Nasal speech Gowers sign Erythema nodosum Congenital muscular dystrophy Generalized amyotrophy Poor head control Edema Neonatal hypotonia Peripheral axonal degeneration Hyperventilation Upper limb undergrowth Hand tremor Excessive daytime somnolence Achilles tendon contracture Spinocerebellar tract degeneration Absent Achilles reflex Abnormality of peripheral nerve conduction Pseudobulbar paralysis Abnormal nerve conduction velocity Motor aphasia Congestive heart failure Short stature Failure to thrive Muscular hypotonia High palate Retinal arterial occlusion Lupus anticoagulant Pure red cell aplasia Respiratory insufficiency Cardiomyopathy Neck muscle weakness Hip contracture Right ventricular hypertrophy Hypoventilation Lymphadenopathy Headache Dilatation Abdominal pain Elevated hepatic transaminase Arthritis Skin rash Stroke Papule Ophthalmoplegia Paraplegia Combined immunodeficiency Decreased number of peripheral myelinated nerve fibers Agitation Decreased antibody level in blood Pancytopenia Hemiparesis Leukocytosis Cerebral hemorrhage Cutis marmorata Hemiplegia Ischemic stroke Leukopenia Purpura Immunodeficiency Anemia Malignant hyperthermia Raynaud phenomenon Hypercoagulability Thoracolumbar scoliosis Vasculitis Cor pulmonale Restrictive deficit on pulmonary function testing Abnormality of the rib cage Axial muscle weakness Respiratory arrest Reduced vital capacity Peroneal muscle atrophy Muscle fiber necrosis Cardiac conduction abnormality Nocturnal hypoventilation Orthopnea Crackles Minicore myopathy Hamstring contractures Limited neck flexion Abnormality of skeletal morphology Type 1 and type 2 muscle fiber minicore regions Thrombocytosis Elevated erythrocyte sedimentation rate Abnormality on pulmonary function testing Impaired pain sensation Dysarthria Pathologic fracture Renal insufficiency Progressive cerebellar ataxia Hepatic fibrosis Cerebellar vermis atrophy Progressive gait ataxia Acute hepatic failure Saccadic smooth pursuit Dysmetric saccades Generalized limb muscle atrophy Stuttering Fatigue Arrhythmia Paresthesia Elevated serum creatine phosphokinase Muscle cramps Hypertriglyceridemia Insulin resistance Muscle stiffness Hypocalcemia Pancreatitis Hyperkalemia Abnormality of the musculature Rhabdomyolysis Hepatic failure Reduced visual acuity Ketosis Increased circulating cortisol level Unsteady gait Drooling Episodic fever EMG: neuropathic changes Dysesthesia Acute demyelinating polyneuropathy Sleepy facial expression Impaired oropharyngeal swallow response Migraine Hepatitis Recurrent spontaneous abortion Intellectual disability, mild Proteinuria Stage 5 chronic kidney disease Split hand Glomerulosclerosis Glomerulonephritis Nephritis Hammertoe Steppage gait Focal segmental glomerulosclerosis Mild proteinuria Talipes equinovarus Myoglobinuria Hyperphosphatemia Lower limb hyperreflexia Abnormal cerebellum morphology Dysphagia Respiratory distress Kyphosis Babinski sign Difficulty walking Abnormality of the nervous system Abnormality of the foot Dysmetria Peripheral axonal neuropathy Sensory neuropathy Peripheral demyelination Acute necrotizing encephalopathy Tetraparesis Limb ataxia Paraparesis Cranial nerve paralysis Incoordination Dysdiadochokinesis Language impairment Toe walking Decreased motor nerve conduction velocity Axonal degeneration Nystagmus Polyneuritis Ketonuria Polyneuropathy Exercise-induced myalgia Hyperlipoproteinemia Recurrent myoglobinuria Recurrent pancreatitis Seizures Vomiting Diarrhea Hypertonia Encephalopathy Pallor Coma Necrotizing encephalopathy Tetraplegia Gliosis Spastic tetraplegia Hallucinations Encephalitis Increased CSF protein Cerebral edema Abnormal posturing Abducens palsy Acute encephalopathy Abnormal muscle tone Central retinal artery occlusion


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