Fever, and Jaundice

Diseases related with Fever and Jaundice

In the following list you will find some of the most common rare diseases related to Fever and Jaundice that can help you solving undiagnosed cases.

Top matches:

High match ROTOR SYNDROME

Rotor syndrome (RT) is a benign, inherited liver disorder characterized by chronic, predominantly conjugated, nonhemolytic hyperbilirubinemia with normal liver histology.

ROTOR SYNDROME Is also known as hyperbilirubinemia, rotor type

Related symptoms:

  • Fever
  • Abdominal pain
  • Jaundice
  • Conjugated hyperbilirubinemia
  • Abnormality of the gastric mucosa


SOURCES: ORPHANET MENDELIAN

More info about ROTOR SYNDROME

High match HEINZ BODY ANEMIA

This is a form of nonspherocytic hemolytic anemia of Dacie type I (in vitro autohemolysis is not corrected by added glucose). After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability.Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies; {208530}).

Related symptoms:

  • Anemia
  • Fever
  • Abnormality of metabolism/homeostasis
  • Jaundice
  • Hemolytic anemia


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about HEINZ BODY ANEMIA

Cholangiocarcinoma (CCA) is a biliary tract cancer (BTC, see this term) originating in the epithelium of the biliary tree, either intra or extra hepatic.

CHOLANGIOCARCINOMA Is also known as bile duct cancer|cca

Related symptoms:

  • Fever
  • Fatigue
  • Abdominal pain
  • Jaundice
  • Pruritus


SOURCES: ORPHANET MENDELIAN

More info about CHOLANGIOCARCINOMA

Other less relevant matches:

Dubin-Johnson syndrome (DJS) is a benign, inherited liver disorder characterized clinically by chronic, predominantly conjugated, hyperbilirubinemia and histopathologically by black-brown pigment deposition in parenchymal liver cells.

DUBIN-JOHNSON SYNDROME Is also known as hyperbilirubinemia ii|hblrdj|hyperbilirubinemia, dubin-johnson type|hyperbilirubinemia type 2|dubin-sprinz disease|sprinz-nelson syndrome

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Fatigue
  • Abdominal pain


SOURCES: OMIM ORPHANET MENDELIAN

More info about DUBIN-JOHNSON SYNDROME

Progressive familial intrahepatic cholestasis type 3 (PFIC3), a type of progressive familial intrahepatic cholestasis (PFIC, see this term), is a late-onset hereditary disorder in bile formation that is hepatocellular in origin. Onset may occur from infancy to young adulthood.

PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3 Is also known as cholestasis, progressive familial intrahepatic, with elevated serum gamma-glutamyltransferase|mdr3 deficiency|pfic3

Related symptoms:

  • Failure to thrive
  • Hypertension
  • Hepatomegaly
  • Fever
  • Diarrhea


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS TYPE 3

The Rotor type of hyperbilirubinemia is an autosomal recessive form of primary conjugated hyperbilirubinemia. It is similar to Dubin-Johnson syndrome (DJS ) in that affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. However, Rotor syndrome can be distinguished from DJS by a lack of hepatocyte pigment deposits, delayed plasma clearance of the unconjugated anionic dye bromsulfthalein, poor hepatic visualization on certain radiographic imaging studies, and prominent urinary excretion of coproporphyrin I (summary by van de Steeg et al., 2012).

HYPERBILIRUBINEMIA, ROTOR TYPE; HBLRR Is also known as rotor syndrome

Related symptoms:

  • Hepatomegaly
  • Fever
  • Fatigue
  • Abnormality of the skeletal system
  • Abdominal pain


SOURCES: OMIM MENDELIAN

More info about HYPERBILIRUBINEMIA, ROTOR TYPE; HBLRR

Medium match CIRRHOSIS, FAMILIAL

Related symptoms:

  • Hypertension
  • Fever
  • Jaundice
  • Abnormality of the liver
  • Lethargy


SOURCES: OMIM MENDELIAN

More info about CIRRHOSIS, FAMILIAL

HBV is a DNA virus that enters the liver via the bloodstream, and replication occurs only in liver tissue. Transmission occurs by percutaneous or mucosal exposure to infected blood or other body fluids. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma (HCC ) can be attributed to chronic HBV infection. Worldwide, 2 billion people have been infected with HBV, 360 million have chronic infection, and 600,000 die each year from HBV-related liver disease or HCC. However, there is marked geographic variability in HBV prevalence, with chronic infection affecting less than 2% of the populations of North America and western and northern Europe; between 2 and 7% of the populations of eastern and central Europe, the Amazon basin, the Middle East, and the Indian subcontinent; and more than 8% of the populations of Asia, sub-Saharan Africa, and the Pacific (Seeff and Hoofnagle, 2006; Shepard et al., 2006).

HEPATITIS B VIRUS, SUSCEPTIBILITY TO Is also known as hbv, susceptibility to

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Vomiting
  • Splenomegaly


SOURCES: OMIM MENDELIAN

More info about HEPATITIS B VIRUS, SUSCEPTIBILITY TO

G6PD deficiency is the most common genetic cause of chronic and drug-, food-, or infection-induced hemolytic anemia. G6PD catalyzes the first reaction in the pentose phosphate pathway, which is the only NADPH-generation process in mature red cells; therefore, defense against oxidative damage is dependent on G6PD. Most G6PD-deficient patients are asymptomatic throughout their life, but G6PD deficiency can be life-threatening. The most common clinical manifestations of G6PD deficiency are neonatal jaundice and acute hemolytic anemia, which in most patients is triggered by an exogenous agent, e.g., primaquine or fava beans. Acute hemolysis is characterized by fatigue, back pain, anemia, and jaundice. Increased unconjugated bilirubin, lactate dehydrogenase, and reticulocytosis are markers of the disorder. The striking similarity between the areas where G6PD deficiency is common and Plasmodium falciparum malaria (see {611162}) is endemic provided evidence that G6PD deficiency confers resistance against malaria (summary by Cappellini and Fiorelli, 2008).

ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY Is also known as favism, susceptibility to

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Muscle weakness
  • Pain
  • Anemia


SOURCES: OMIM MENDELIAN

More info about ANEMIA, NONSPHEROCYTIC HEMOLYTIC, DUE TO G6PD DEFICIENCY

A rare, autosomal recessive genetic syndrome caused by mutations in the RAB27A gene. It is characterized by hypopigmentation of the skin, hair and eyes, recurrent infections, neutropenia, and immune system abnormalities. Patients are prone to develop hemophagocytic lymphohistiocytosis.

GRISCELLI SYNDROME TYPE 2 Is also known as hypopigmentation-immunodeficiency with or without neurologic impairment syndrome|griscelli-pruni√Čras syndrome type 2

Related symptoms:

  • Seizures
  • Hepatomegaly
  • Fever
  • Hypertonia
  • Splenomegaly


SOURCES: ORPHANET MENDELIAN

More info about GRISCELLI SYNDROME TYPE 2

Top 5 symptoms//phenotypes associated to Fever and Jaundice

Symptoms // Phenotype % cases
Abdominal pain Uncommon - Between 30% and 50% cases
Hepatomegaly Uncommon - Between 30% and 50% cases
Fatigue Uncommon - Between 30% and 50% cases
Cirrhosis Uncommon - Between 30% and 50% cases
Abnormality of the gastric mucosa Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Jaundice. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Splenomegaly Conjugated hyperbilirubinemia Abnormality of the liver Pain Hyperbilirubinemia

Rare Symptoms - Less than 30% cases

Dark urine Hypertension Nonspherocytic hemolytic anemia Anemia Abnormality of coagulation Biliary tract abnormality Pruritus Abnormal urinary color Hemolytic anemia Reticulocytosis Hodgkin lymphoma Intellectual disability Prolonged neonatal jaundice Osteomyelitis Leukocytosis Myalgia Back pain Neoplasm Meningitis Muscle weakness Poikilocytosis Abnormality of the cardiovascular system Lymphoma Pallor Anisocytosis Lymphadenopathy Hemoglobinuria Pancytopenia Hemophagocytosis Pulmonary infiltrates Iris hypopigmentation Hypopigmentation of hair Petechiae Premature graying of hair Hyperlipidemia Neutropenia Unconjugated hyperbilirubinemia Acute hepatitis Nausea and vomiting Immunodeficiency Hypertonia Seizures Fava bean-induced hemolytic anemia Kernicterus Fulminant hepatitis Increased level of L-fucose in urine Membranous nephropathy Failure to thrive Cholestasis Hepatic failure Malabsorption Elevated hepatic transaminase Hepatosplenomegaly Diarrhea Intermittent jaundice Intrahepatic cholestasis Biliary tract neoplasm Acholic stools Anorexia Heinz body anemia Asplenia Abnormal heart valve morphology Abnormality of metabolism/homeostasis Portal hypertension Bile duct proliferation Chronic infection Vomiting Membranoproliferative glomerulonephritis Hepatocellular carcinoma Glomerulonephritis Hepatitis Nausea Carcinoma Increased level of propylene glycol in blood Portal fibrosis Micronodular cirrhosis Esophageal varix Pulmonary arterial hypertension Abdominal distention Lethargy Abnormality of skin pigmentation Abnormality of the skeletal system Partial albinism


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