Fever, and Hepatocellular carcinoma

Diseases related with Fever and Hepatocellular carcinoma

In the following list you will find some of the most common rare diseases related to Fever and Hepatocellular carcinoma that can help you solving undiagnosed cases.

Top matches:

HBV is a DNA virus that enters the liver via the bloodstream, and replication occurs only in liver tissue. Transmission occurs by percutaneous or mucosal exposure to infected blood or other body fluids. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma (HCC ) can be attributed to chronic HBV infection. Worldwide, 2 billion people have been infected with HBV, 360 million have chronic infection, and 600,000 die each year from HBV-related liver disease or HCC. However, there is marked geographic variability in HBV prevalence, with chronic infection affecting less than 2% of the populations of North America and western and northern Europe; between 2 and 7% of the populations of eastern and central Europe, the Amazon basin, the Middle East, and the Indian subcontinent; and more than 8% of the populations of Asia, sub-Saharan Africa, and the Pacific (Seeff and Hoofnagle, 2006; Shepard et al., 2006).

HEPATITIS B VIRUS, SUSCEPTIBILITY TO Is also known as hbv, susceptibility to

Related symptoms:

  • Pain
  • Hepatomegaly
  • Fever
  • Vomiting
  • Splenomegaly


SOURCES: OMIM MENDELIAN

More info about HEPATITIS B VIRUS, SUSCEPTIBILITY TO

Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava.

Related symptoms:

  • Neoplasm
  • Pain
  • Hypertension
  • Hepatomegaly
  • Fever


SOURCES: MESH OMIM ORPHANET MENDELIAN

More info about BUDD-CHIARI SYNDROME

HIGM is a rare immunodeficiency characterized by normal or elevated serum IgM levels associated with markedly decreased IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections and an increased susceptibility to opportunistic infections. Patients with X-linked HIGM also tend to have neutropenia, as well as a high rate of gastrointestinal and central nervous system infections, often resulting in severe liver disease and/or neurodegeneration (summary by Levy et al., 1997). Genetic Heterogeneity of Immunodeficiency with Hyper-IgMOther forms of HIGM include HIGM2 (OMIM ), which results from mutation in the AICDA gene (OMIM ), HIGM3 (OMIM ), which results from mutation in the CD40 gene (OMIM ), and HIGM5 (OMIM ), which results from mutation in the UNG gene (OMIM ). See also HIGM4 (OMIM ).

IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 1; HIGM1 Is also known as hyper-igm immunodeficiency, x-linked|hyper-igm syndrome 1|ihis|hyper-igm syndrome|xhim|imd3|higm|immunodeficiency 3

Related symptoms:

  • Seizures
  • Global developmental delay
  • Failure to thrive
  • Cognitive impairment
  • Anemia


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY WITH HYPER-IGM, TYPE 1; HIGM1

Other less relevant matches:

Variegate porphyria is a form of acute hepatic porphyria (see this term) characterized by the occurrence of neuro-visceral attacks with or without the presence of cutaneous lesions.

PORPHYRIA VARIEGATA Is also known as variegate porphyria|ppox deficiency|porphyria, south african type|protoporphyrinogen oxidase deficiency|vp

Related symptoms:

  • Intellectual disability
  • Seizures
  • Short stature
  • Growth delay
  • Nystagmus


SOURCES: OMIM ORPHANET MESH MENDELIAN

More info about PORPHYRIA VARIEGATA

Primary sclerosing cholangitis (PSC) is a rare, slowly progressive liver disease characterized by inflammation and destruction of the intra- and/or extra-hepatic bile ducts that lead to cholestasis, liver fibrosis, liver cirrhosis and ultimately liver failure.

PRIMARY SCLEROSING CHOLANGITIS Is also known as psc

Related symptoms:

  • Pain
  • Hypertension
  • Hepatomegaly
  • Fever
  • Fatigue


SOURCES: ORPHANET OMIM MENDELIAN

More info about PRIMARY SCLEROSING CHOLANGITIS

Gaucher disease type 2 is the acute neurological form of Gaucher disease (GD; see this term). It is characterized by early-onset and severe neurological involvement of the brainstem, associated with an organomegaly and generally leading to death before the age of 2.

GAUCHER DISEASE TYPE 2 Is also known as infantile cerebral gaucher disease|acute neuronopathic gaucher disease

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Microcephaly
  • Scoliosis


SOURCES: ORPHANET MENDELIAN

More info about GAUCHER DISEASE TYPE 2

Medium match NEPHROBLASTOMA

Nephroblastoma is the most frequent malignant renal tumor in children and is associated with an abnormal proliferation of cells that resemble the kidney cells of an embryo (metanephroma), leading to the term embryonal tumor.

NEPHROBLASTOMA Is also known as wilms tumor|nephroblastoma|renal embryonic tumor

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Hypertension
  • Fever
  • Renal insufficiency


SOURCES: OMIM ORPHANET MENDELIAN

More info about NEPHROBLASTOMA

Rhabdoid tumor predisposition syndrome-2 is an autosomal dominant cancer predisposition syndrome characterized by the onset in infancy, childhood, or young adulthood of various poorly differentiated tumors. Classically, tumors that arise in the central nervous system are referred to as atypical teratoid/rhabdoid tumors, whereas those arising in the kidney or other extracranial sites are referred to as malignant rhabdoid tumors. Tumors may also present as small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), also known as malignant rhabdoid tumor of the ovary (MRTO). All of these tumors are highly aggressive and often fatal (summary by Foulkes et al., 2014).See also RTPS1 (OMIM ), which is caused by mutation in the SMARCB1 gene (OMIM ) on chromosome 22q11.

Related symptoms:

  • Neoplasm
  • Pain
  • Anemia
  • Hypertension
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about RHABDOID TUMOR PREDISPOSITION SYNDROME 2; RTPS2

Beta-thalassemia (BT) major is a severe early-onset form of BT (see this term) characterized by severe anemia requiring regular red blood cell transfusions.

BETA-THALASSEMIA MAJOR Is also known as cooley anemia|mediterranean anemia

Related symptoms:

  • Hearing impairment
  • Muscle weakness
  • Cataract
  • Anemia
  • Feeding difficulties


SOURCES: ORPHANET MENDELIAN

More info about BETA-THALASSEMIA MAJOR

Cholangiocarcinoma (CCA) is a biliary tract cancer (BTC, see this term) originating in the epithelium of the biliary tree, either intra or extra hepatic.

CHOLANGIOCARCINOMA Is also known as bile duct cancer|cca

Related symptoms:

  • Fever
  • Fatigue
  • Abdominal pain
  • Jaundice
  • Pruritus


SOURCES: ORPHANET MENDELIAN

More info about CHOLANGIOCARCINOMA

Top 5 symptoms//phenotypes associated to Fever and Hepatocellular carcinoma

Symptoms // Phenotype % cases
Abdominal pain Common - Between 50% and 80% cases
Hepatomegaly Common - Between 50% and 80% cases
Jaundice Common - Between 50% and 80% cases
Pain Uncommon - Between 30% and 50% cases
Cirrhosis Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Hepatocellular carcinoma. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Hypertension Weight loss Splenomegaly Carcinoma Nausea Elevated hepatic transaminase Neoplasm of the liver Neoplasm Anemia Diarrhea Seizures Depressivity Fatigue Portal hypertension Ascites Thrombocytopenia Cholelithiasis Scarring Vomiting Abnormality of the liver Lymphadenopathy

Rare Symptoms - Less than 30% cases

Aspiration Renal neoplasm Sclerosing cholangitis Cholangiocarcinoma Pallor Nephroblastoma Hematuria Intellectual disability Irritability Muscle weakness Nausea and vomiting Dyspnea Abnormality of the thorax Arrhythmia Congestive heart failure Renal insufficiency Encephalopathy Osteoporosis Osteopenia Hepatosplenomegaly Pruritus Cholestasis Pulmonary arterial hypertension Increased serum ferritin Neutropenia Anorexia Histiocytosis Cholangitis Anxiety Acute hepatic failure Global developmental delay Autoimmunity Malabsorption Dark urine Failure to thrive Hepatitis Cardiorespiratory arrest Ectropion Hyponatremia Clubbing Petechiae Akinesia Bilateral ptosis Heart murmur Athetosis Menorrhagia Opisthotonus Intracranial hemorrhage Abnormality of coagulation Exertional dyspnea Interstitial pulmonary abnormality Epileptic spasms Venous thrombosis Adrenal insufficiency Microcytic anemia Fetal akinesia sequence Aspiration pneumonia Hypoparathyroidism Abnormality of the skull Hypokinesia Limb hypertonia Protuberant abdomen Atrophy/Degeneration affecting the brainstem Poor eye contact Congenital ichthyosiform erythroderma Bulbar palsy Hyperammonemia Poor suck Cataract Leukopenia Epistaxis Acholic stools Abnormality of eye movement Malar prominence Hepatic failure Pulmonary hypoplasia Generalized myoclonic seizures Abnormal bleeding Syncope Brain atrophy Abnormality of the skin Cyanosis Decreased fetal movement Pancytopenia Monochromacy Hypersplenism Oculomotor apraxia Cardiac arrest Skin ulcer Osteolysis Hyperbilirubinemia Knee flexion contracture Hypocalcemia Elbow flexion contracture Abnormality of the hypothalamus-pituitary axis Progressive neurologic deterioration Bone pain Progressive microcephaly Hydrops fetalis Abnormal hemoglobin Thickened skin Decreased body weight Purpura Genu valgum Paresthesia Gonadal dysgenesis Visual impairment Male pseudohermaphroditism Neoplasm of the lung Depressed nasal bridge Cardiomyopathy Aniridia Abnormality of the dentition Respiratory insufficiency Overgrowth EEG with temporal sharp waves Slowed horizontal saccades Cardiac valve calcification Abnormal platelet aggregation Hematological neoplasm Hemihypertrophy Hydrocephalus Upslanted palpebral fissure Poor appetite Hearing impairment Internal hemorrhage Embryonal neoplasm Neoplasm of the central nervous system Teratoma Oculomotor nerve palsy Ovarian neoplasm Headache Hypercalcemia Hemiplegia Sarcoma Cerebral palsy Cranial nerve paralysis Subcutaneous nodule Decreased beta-glucocerebrosidase protein and activity Erlenmeyer flask deformity of the femurs Feeding difficulties Nonimmune hydrops fetalis Abnormality of the spleen Hypoxemia Abnormality of the larynx Multiple myeloma Congenital nonbullous ichthyosiform erythroderma Supranuclear gaze palsy Slow saccadic eye movements Avascular necrosis of the capital femoral epiphysis Arthralgia Trismus Bulbar signs Hypomagnesemia Nyctalopia Delayed puberty Skeletal dysplasia Restrictive deficit on pulmonary function testing CSF pleocytosis Hypothyroidism Diabetes mellitus Orthopnea Laryngeal stridor Lethargy Giant cell hepatitis Intestinal bleeding Spontaneous hematomas Generalized osteosclerosis Subcutaneous hemorrhage Abducens palsy Axial dystonia Hemophagocytosis Eclabion Abnormal pattern of respiration Ophthalmoplegia Spasticity Corneal opacity Stomatitis Impaired Ig class switch recombination Decreased T cell activation Increased IgM level Dysgammaglobulinemia Chronic hepatitis IgM deficiency Agammaglobulinemia Enlarged tonsils Gingivitis Recurrent lower respiratory tract infections IgG deficiency IgA deficiency Encephalitis Leukoencephalopathy Absence of lymph node germinal center Agranulocytosis Chronic diarrhea Constipation Tetraplegia Hypopigmentation of the skin Tachycardia Confusion Paralysis Abnormality of the kidney Clinodactyly Opportunistic infection Abnormality of the skeletal system Peripheral neuropathy Nystagmus Growth delay Short stature Impaired memory B cell generation IgE deficiency Recurrent bacterial infections Involuntary movements Psychosis Gastrointestinal hemorrhage Hypercoagulability Varicose veins Thromboembolism Polycythemia Intestinal obstruction Myocardial infarction Stroke Peritonitis Fulminant hepatitis Acute hepatitis Membranous nephropathy Chronic infection Membranoproliferative glomerulonephritis Glomerulonephritis Esophageal varix Cholecystitis Clumsiness Hemolytic anemia Choreoathetosis Recurrent otitis media Otitis media Decreased antibody level in blood Sepsis Neurodegeneration Recurrent infections Gastrointestinal infarctions Immunodeficiency Dysarthria Cognitive impairment Hepatic vein thrombosis Reduced protein C activity Budd-Chiari syndrome Portal vein thrombosis Abnormal blistering of the skin Cutaneous photosensitivity Cough Microcephaly Motor delay Flexion contracture Abnormal facial shape Strabismus Ataxia Scoliosis Generalized hypotonia Dysphagia Adenocarcinoma of the large intestine Dilated superficial abdominal veins Recurrent systemic pyogenic infections Neoplasm of the gallbladder Abnormal large intestine physiology Spider hemangioma Intrauterine growth retardation Respiratory distress Elevated alkaline phosphatase of hepatic origin Gastroesophageal reflux Feeding difficulties in infancy Developmental regression Apnea Rigidity Hypoglycemia Umbilical hernia Polyhydramnios Edema Myoclonus Dementia Recurrent respiratory infections Delayed skeletal maturation Kyphosis Dystonia Hypertonia Polyclonal elevation of IgM Palmar telangiectasia Hypertrichosis Insomnia Type I diabetes mellitus Hepatic fibrosis Porphyrinuria Premature adrenarche Motor polyneuropathy Visual hallucinations Restlessness Hypoalbuminemia Fragile skin Milia Agitation Chronic kidney disease Hypopigmented skin patches Hallucinations Thin skin Pancreatitis Pleural effusion Abnormal biliary tract morphology Prolonged prothrombin time Chronic hepatic failure Vitamin K deficiency Vitamin A deficiency Vitamin E deficiency Abnormal eosinophil morphology Vitamin D deficiency Cholestatic liver disease Inflammation of the large intestine Ulcerative colitis Uveitis Thyroiditis Amyloidosis Celiac disease Abnormality of the thyroid gland Generalized amyotrophy Biliary tract neoplasm


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