Fever, and Hematuria

Diseases related with Fever and Hematuria

In the following list you will find some of the most common rare diseases related to Fever and Hematuria that can help you solving undiagnosed cases.

Top matches:

Related symptoms:

  • Growth delay
  • Anemia
  • Hepatomegaly
  • Fever
  • Proteinuria


SOURCES: OMIM MESH MENDELIAN

More info about HEME OXYGENASE 1 DEFICIENCY; HMOX1D

Related symptoms:

  • Fever
  • Renal insufficiency
  • Proteinuria
  • Scarring
  • Stage 5 chronic kidney disease


SOURCES: OMIM ORPHANET MENDELIAN

More info about C3 GLOMERULONEPHRITIS

Immunodeficiency due to a classical component pathway complement deficiency is a primary immunodeficiency due to a deficiency in either complement components C1q, C1r, C1s, C2 or C4 characterized by increased susceptibility to bacterial infections, particularly with encapsulated bacteria, and increased risk for autoimmune disease. Most commonly, these include systemic lupus erythematosus (SLE), SLE-like disease, Henoch-Schonlein purpura, polymyositis and arthralgia. Disease severity is variable and dependent on the complement affected.

IMMUNODEFICIENCY DUE TO A CLASSICAL COMPONENT PATHWAY COMPLEMENT DEFICIENCY Is also known as immunodeficiency due to c1, c4, or c2 component complement deficiency|immunodeficiency due to an early component of complement deficiency

Related symptoms:

  • Pain
  • Cataract
  • Fever
  • Renal insufficiency
  • Immunodeficiency


SOURCES: OMIM ORPHANET MENDELIAN

More info about IMMUNODEFICIENCY DUE TO A CLASSICAL COMPONENT PATHWAY COMPLEMENT DEFICIENCY

Other less relevant matches:

Immunodeficiency with factor I anomaly is a rare, genetic, primary immunodeficiency disease characterized by increased susceptibility to recurrent, usually severe, infections (particularly by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumonia), typically manifesting as otitis, sinusitis, bronchitis, pneumonia, and/or meningitis. Autoimmune disease (e.g. systemic lupus erythematosus, glomerulonephritis) and atypical hemolytic uremic syndrome may be associated. Laboratory serum analysis reveals, in addition to diminished or undetectable complement factor I, variably decreased complement C3, complement factor B and complement factor H.

IMMUNODEFICIENCY WITH FACTOR I ANOMALY Is also known as complement component 3 inactivator deficiency|c3 inactivator deficiency

Related symptoms:

  • Fever
  • Renal insufficiency
  • Recurrent infections
  • Pneumonia
  • Recurrent respiratory infections


SOURCES: OMIM MESH ORPHANET MENDELIAN

More info about IMMUNODEFICIENCY WITH FACTOR I ANOMALY

Medium match NEPHROBLASTOMA

Nephroblastoma is the most frequent malignant renal tumor in children and is associated with an abnormal proliferation of cells that resemble the kidney cells of an embryo (metanephroma), leading to the term embryonal tumor.

NEPHROBLASTOMA Is also known as wilms tumor|nephroblastoma|renal embryonic tumor

Related symptoms:

  • Intellectual disability
  • Neoplasm
  • Hypertension
  • Fever
  • Renal insufficiency


SOURCES: OMIM ORPHANET MENDELIAN

More info about NEPHROBLASTOMA

The urofacial syndrome (UFS) is a rare autosomal recessive disease characterized by a severe and early-onset form of dysfunctional urinary voiding. Affected individuals usually present prenatally or in early childhood with grossly distorted renal tracts, comprising dysmorphic bladders and dilatation of the ureter and renal pelvis. They are at high risk of vesicoureteral reflux (VUR), with ascending bacterial infection leading to kidney damage, hypertension, and renal failure. One-third of UFS children also experience constipation or fecal soiling, suggesting that the pathophysiology of the syndrome encompasses a broader functional impairment of elimination. In addition, affected individuals have a characteristic facial grimace when trying to smile (summary by Daly et al., 2010). Genetic Heterogeneity of Urofacial SyndromeUrofacial syndrome-2 (UFS2 ) is caused by mutation in the LRIG2 gene (OMIM ) on chromosome 1p13.

UROFACIAL SYNDROME 1; UFS1 Is also known as facial palsy, partial, with urinary abnormalities|ochoa syndrome|hydronephrosis with peculiar facial expression|urofacial syndrome|inverted smile and occult neuropathic bladder|ufs

Related symptoms:

  • Abnormal facial shape
  • Pain
  • Cryptorchidism
  • Hypertension
  • Fever


SOURCES: OMIM MENDELIAN

More info about UROFACIAL SYNDROME 1; UFS1

Typical hemolytic uremic syndrome is characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells'). The vast majority of cases (90%) are sporadic, occur in children under 3 years of age, and are associated with epidemics of diarrhea caused by verotoxin-producing E. coli. The death rate is very low, about 30% of cases have renal sequelae, and there is usually no relapse of the disease. This form of HUS usually presents with a diarrhea prodrome (thus referred to as D+HUS) and has a good prognosis in most cases. In contrast, a subgroup of patients with HUS have an atypical presentation (aHUS or D-HUS) without a prodrome of enterocolitis and diarrhea and have a much poorer prognosis, with a tendency to relapse and frequent development of end-stage renal failure or death. These cases tend to be familial. Both autosomal recessive and autosomal dominant inheritance have been reported (Goodship et al., 1997; Taylor, 2001; Veyradier et al., 2003; Noris et al., 2003). Noris and Remuzzi (2009) provided a detailed review of atypical HUS. Genetic Heterogeneity of Atypical Hemolytic Uremic SyndromeAtypical HUS is a genetically heterogeneous condition. Susceptibility to the development of the disorder can be conferred by mutations in various components of or regulatory factors in the complement cascade system (Jozsi et al., 2008). See AHUS2 (OMIM ), AHUS3 (OMIM ), AHUS4 (OMIM ), AHUS5 (OMIM ), and AHUS6 (OMIM ). AHUS7 (see {615008}) is caused by mutation in the DGKE gene (OMIM ), which is not part of the complement cascade system.

HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1; AHUS1 Is also known as ahus, susceptibility to, 1

Related symptoms:

  • Seizures
  • Cognitive impairment
  • Anemia
  • Hypertension
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1; AHUS1

AMYLOIDOSIS, FAMILIAL VISCERAL Is also known as german type amyloidosis|amyloidosis, systemic nonneuropathic|amyloidosis viii|amyloidosis, familial renal|ostertag type amyloidosis

Related symptoms:

  • Hearing impairment
  • Neoplasm
  • Pain
  • Hypertension
  • Peripheral neuropathy


SOURCES: ORPHANET OMIM MENDELIAN

More info about AMYLOIDOSIS, FAMILIAL VISCERAL

Medium match MAJEED SYNDROME

Majeed syndrome is a rare genetic multisystemic disorder characterized by chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia, which may be accompanied by neutrophilic dermatosis.

MAJEED SYNDROME Is also known as chronic recurrent multifocal osteomyelitis-congenital dyserythropoietic anemia-neutrophilic dermatosis syndrome

Related symptoms:

  • Failure to thrive
  • Flexion contracture
  • Hepatomegaly
  • Fever
  • Edema


SOURCES: ORPHANET MENDELIAN

More info about MAJEED SYNDROME

Congenital thrombotic thrombocytopenic purpura is the hereditary form of thrombotic thrombocytopenic purpura (TTP; see this term) characterized by profound peripheral thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and single or multiple organ failure of variable severity.

CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA Is also known as congenital ttp|microangiopathic hemolytic anemia|thrombotic microangiopathy, familial|microangiopathic hemolytic anemia, congenital|congenital adamts-13 deficiency|upshaw factor, deficiency of|uss|thrombotic thrombocytopenic purpura, familial|familial ttp

Related symptoms:

  • Seizures
  • Pain
  • Anemia
  • Hypertension
  • Fever


SOURCES: OMIM ORPHANET MENDELIAN

More info about CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA

Top 5 symptoms//phenotypes associated to Fever and Hematuria

Symptoms // Phenotype % cases
Proteinuria Very Common - Between 80% and 100% cases
Renal insufficiency Common - Between 50% and 80% cases
Hypertension Uncommon - Between 30% and 50% cases
Nephropathy Uncommon - Between 30% and 50% cases
Glomerulonephritis Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Hematuria. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Skin rash Pain Microscopic hematuria Anemia Hemolytic-uremic syndrome Acute kidney injury Decreased serum complement factor I Purpura Stage 5 chronic kidney disease Abdominal pain Weight loss Hemolytic anemia Hepatomegaly Edema

Rare Symptoms - Less than 30% cases

Headache Schistocytosis Sepsis Recurrent urinary tract infections Splenomegaly Decreased serum complement factor H Pyelonephritis Decreased serum complement C3 Reticulocytosis Decreased serum complement factor B Glomerulopathy Neoplasm Microangiopathic hemolytic anemia Elevated serum creatinine Keratitis Pneumonia Hemiparesis Coma Thrombocytopenia Membranoproliferative glomerulonephritis IgA deposition in the glomerulus Macroscopic hematuria Mesangial hypercellularity Systemic lupus erythematosus Diarrhea Recurrent infections Increased blood urea nitrogen Arthralgia Meningitis Seizures Cardiomyopathy Optic neuropathy Failure to thrive Generalized amyloid deposition Renal amyloidosis Albuminuria Restrictive cardiomyopathy Enterocolitis Azotemia Complement deficiency Abnormal lactate dehydrogenase activity Drusen Papilledema Hepatosplenomegaly Paresthesia Glaucoma Amyloidosis Urticaria Abnormality of complement system Cholestasis Decreased level of thrombomodulin Anuria Hearing impairment Peripheral neuropathy Nephrotic syndrome Polyneuropathy Flexion contracture Growth delay Myalgia Abnormal bleeding Jaundice Abnormality of the kidney Pallor Paralysis Nausea and vomiting Confusion Nausea Increased serum lactate Vomiting Hyperbilirubinemia Personality changes Hyperkalemia Prolonged neonatal jaundice Autoimmune thrombocytopenia Preeclampsia Abnormal renal physiology Neonatal hyperbilirubinemia Arrhythmia Respiratory distress Cough Acne Papule Malabsorption Inflammatory abnormality of the skin Bone pain Increased bone mineral density Cachexia Increased susceptibility to fractures Metaphyseal irregularity Leukocytosis Fatigue Pustule Hypochromic microcytic anemia Synovitis Congenital hypoplastic anemia Abnormality of bone marrow cell morphology Chronic recurrent multifocal osteomyelitis Abnormal inflammatory response Tremor Pulmonary infiltrates Urinary retention Abnormality of blood and blood-forming tissues Recurrent sinusitis Sinusitis Vasculitis Recurrent bacterial infections Recurrent skin infections Chronic kidney disease Nephritis Septic arthritis Otitis media Recurrent streptococcus pneumoniae infections Tonsillitis Recurrent meningococcal disease Recurrent meningitis Glomerular deposits Recurrent Haemophilus influenzae infections Intellectual disability Recurrent otitis media Respiratory tract infection Overgrowth Cataract Asplenia Scarring Recurrent upper respiratory tract infections Abnormal retinal morphology Tubulointerstitial fibrosis Endocapillary hypercellularity Immunodeficiency Arthritis Erythema Autoimmunity Hepatitis Facial erythema Discoid lupus rash Loss of eyelashes Recurrent respiratory infections Lymphadenopathy Nephroblastoma Dysphasia Urethral obstruction Wolff-Parkinson-White syndrome Neurogenic bladder Facial grimacing Urethral stenosis Mild proteinuria Enuresis nocturna Urethral valve Dysuria Encopresis Abnormal facial expression Nocturnal lagophthalmos Cognitive impairment Abnormality of metabolism/homeostasis Hypertriglyceridemia Hyperlipidemia Enuresis Keratoconjunctivitis sicca Gonadal dysgenesis Cryptorchidism Aniridia Neoplasm of the lung Male pseudohermaphroditism Renal neoplasm Hemihypertrophy Neoplasm of the liver Abnormal facial shape Dilatation Hydroureter Constipation Hydronephrosis Vesicoureteral reflux Urinary incontinence Polydipsia Clubbing Polyuria Bloody diarrhea


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