Fever, and Epidermal acanthosis

Diseases related with Fever and Epidermal acanthosis

In the following list you will find some of the most common rare diseases related to Fever and Epidermal acanthosis that can help you solving undiagnosed cases.

Top matches:

The most common form of ichthyosis. It is an autosomal dominant inherited or acquired disorder characterized by scaling and desquamation of the skin.

ICHTHYOSIS VULGARIS Is also known as ichthyosis simplex

Related symptoms:

  • Fever
  • Hyperkeratosis
  • Ichthyosis
  • Asthma
  • Eczema


SOURCES: OMIM MESH MENDELIAN

More info about ICHTHYOSIS VULGARIS

Related symptoms:

  • Fever
  • Hyperkeratosis
  • Arthralgia
  • Arthritis
  • Ichthyosis


SOURCES: OMIM MENDELIAN

More info about PSORIASIS 2; PSORS2

Generalized pustular psoriasis is a severe inflammatory skin disease that can be life-threatening and that is characterized by recurrent episodes of high fever, fatigue, episodic erythematous cutaneous eruptions with sterile cutaneous pustules formation on various parts of the body, and neutrophil leukocytosis.

GENERALIZED PUSTULAR PSORIASIS Is also known as ditra|interleukin 36 receptor antagonist deficiency|acrodermatitis continua of hallopeau|generalized pustular psoriasis|psorp|gpp|palmoplantar pustulosis

Related symptoms:

  • Muscle weakness
  • Fever
  • Headache
  • Erythema
  • Skin rash


SOURCES: OMIM ORPHANET MENDELIAN

More info about GENERALIZED PUSTULAR PSORIASIS

Other less relevant matches:

Autoinflammation with arthritis and dyskeratosis is characterized by recurrent fever, widespread skin dyskeratosis, arthritis, elevated biologic markers of inflammation, and mild autoimmunity with a high transitional B-cell level (summary by Grandemange et al., 2016).

Related symptoms:

  • Growth delay
  • Failure to thrive
  • Anemia
  • Fever
  • Respiratory insufficiency


SOURCES: OMIM MENDELIAN

More info about AUTOINFLAMMATION WITH ARTHRITIS AND DYSKERATOSIS; AIADK

Sterile multifocal osteomyelitis with periostitis and pustulosis is a rare, severe, genetic autoinflammatory syndrome characterized by usually neonatal onset of generalized neutrophilic cutaneous pustulosis and severe, recurrent, multifocal, aseptic osteomyelitis with marked periostitis, typically affecting distal ribs, long bones and vertebral bodies. High levels of acute-phase reactants (with no fever associated) and onychosis are frequently observed additional features.

STERILE MULTIFOCAL OSTEOMYELITIS WITH PERIOSTITIS AND PUSTULOSIS Is also known as interleukin-1 receptor antagonist deficiency|interleukin 1 receptor antagonist deficiency|autoinflammatory disease due to interleukin-1 receptor antagonist deficiency|dira|ompp

Related symptoms:

  • Pain
  • Feeding difficulties
  • Hepatomegaly
  • Fever
  • Respiratory insufficiency


SOURCES: ORPHANET OMIM MENDELIAN

More info about STERILE MULTIFOCAL OSTEOMYELITIS WITH PERIOSTITIS AND PUSTULOSIS

Chronic mucocutaneous candidosis (CMC) refers to a group of heterogenous disorders characterized by persistent, debilitating and/or recurrent infections of the skin, nails, and mucus membranes, mainly with the fungal pathogen Candida albicans.

CHRONIC MUCOCUTANEOUS CANDIDIASIS Is also known as card9 immunodeficiency|candidiasis, familial chronic mucocutaneous, autosomal recessive|cmc

Related symptoms:

  • Seizures
  • Fever
  • Behavioral abnormality
  • Immunodeficiency
  • Headache


SOURCES: OMIM ORPHANET MENDELIAN

More info about CHRONIC MUCOCUTANEOUS CANDIDIASIS

Medium match H SYNDROME

H syndrome is a systemic inherited histiocytosis, with characteristic cutaneous findings accompanying systemic manifestations. H syndrome refers to the major clinical findings of hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height, and occasionally, hyperglycemia/diabetes mellitus. Due to overlapping clinical features, H syndrome is now considered to include pigmented hypertrichosis with insulin dependent diabetes mellitus syndrome (PHID), Faisalabad histiocytosis (FHC) and familial sinus histiocytosis with massive lymphadenopathy (FSHML).

H SYNDROME Is also known as sinus histiocytosis and massive lymphadenopathy|hjcd|shml|hyperpigmentation, cutaneous, with hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism with or without hearing loss|h syndrome|faisalabad histiocytosis|pigmented hypertrichosis wi

Related symptoms:

  • Global developmental delay
  • Short stature
  • Generalized hypotonia
  • Hearing impairment
  • Growth delay


SOURCES: MESH ORPHANET OMIM MENDELIAN

More info about H SYNDROME

Medium match PROTEUS SYNDROME

Proteus syndrome (PS) is a very rare and complex hamartomatous overgrowth disorder characterized by progressive overgrowth of the skeleton, skin, adipose, and central nervous systems.

PROTEUS SYNDROME Is also known as partial gigantism-nevi-hemihypertrophy-macrocephaly syndrome|gigantism, partial, of hands and feet, nevi, hemihypertrophy, and macrocephaly

Related symptoms:

  • Intellectual disability
  • Seizures
  • Scoliosis
  • Hypertelorism
  • Nystagmus


SOURCES: ORPHANET OMIM MESH MENDELIAN

More info about PROTEUS SYNDROME

Ectodermal dysplasia-syndactyly syndrome is a rare, genetic ectodermal dysplasia syndrome characterized by sparse to absent scalp hair, eyebrows, and eyelashes (with pili torti when present), widely spaced, conical-shaped teeth with peg-shaped, conical crowns and enamel hypoplasia and palmoplantar hyperkeratosis, associated with partial cutaneous syndactyly in hands and feet.

ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME Is also known as edss|edss1

Related symptoms:

  • Cognitive impairment
  • Syndactyly
  • Alopecia
  • Hyperhidrosis
  • Hyperkeratosis


SOURCES: ORPHANET OMIM MENDELIAN

More info about ECTODERMAL DYSPLASIA-SYNDACTYLY SYNDROME

Epidermolytic ichthyosis (EI) is a rare keratinopathic ichthyosis (KPI; see this term), that is characterized by a blistering phenotype at birth which progressively becomes hyperkeratotic.

AUTOSOMAL DOMINANT EPIDERMOLYTIC ICHTHYOSIS Is also known as bullous congenital ichthyosiform erythroderma of brock|epidermolytic ichthyosis|bie|bullous congenital ichthyosiform erythroderma|ehk|bullous erythroderma ichthyosiformis congenita of brocq|bcie|bullous ichthyosiform erythroderma|ichthyosis hystrix brocq

Related symptoms:

  • Growth delay
  • Hyperhidrosis
  • Hyperkeratosis
  • Weight loss
  • Erythema


SOURCES: OMIM ORPHANET MENDELIAN

More info about AUTOSOMAL DOMINANT EPIDERMOLYTIC ICHTHYOSIS

Top 5 symptoms//phenotypes associated to Fever and Epidermal acanthosis

Symptoms // Phenotype % cases
Hyperkeratosis Very Common - Between 80% and 100% cases
Ichthyosis Uncommon - Between 30% and 50% cases
Scaling skin Uncommon - Between 30% and 50% cases
Splenomegaly Uncommon - Between 30% and 50% cases
Psoriasiform dermatitis Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Epidermal acanthosis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Inflammatory abnormality of the skin Growth delay Leukocytosis Skin rash Erythema Headache Hyperhidrosis Heat intolerance

Rare Symptoms - Less than 30% cases

Osteolysis Hepatosplenomegaly Syndactyly Ptosis Hypertelorism Papule Hallux valgus Lipodystrophy Ectodermal dysplasia Palmoplantar keratoderma Pain Hepatomegaly Sepsis Meningitis Generalized hyperkeratosis Abnormality of dental enamel Confusion Fragile skin Overgrowth Alopecia Proptosis Palmoplantar hyperkeratosis Seizures Immunodeficiency Recurrent infections Lymphadenopathy Skin ulcer Abnormality of the nail Hypotrichosis Hyperostosis Anteverted nares Periostitis Varicose veins Respiratory insufficiency Anemia Failure to thrive Arthralgia Edema Pustule Osteomyelitis Arthritis Parakeratosis Eczema Lymphopenia Kyphosis Generalized hirsutism Abnormal vertebral morphology Hemangioma Venous thrombosis Retroperitoneal fibrosis Sinusitis Upper eyelid edema Lymphedema Abnormality of retinal pigmentation Thickened skin Subcutaneous nodule Seborrheic keratosis Abnormality of the metacarpal bones Reduced number of teeth Goiter Pericardial effusion Pulmonary embolism Generalized hyperpigmentation Ovarian neoplasm Hamartoma Multiple cafe-au-lait spots Snoring Multiple lipomas Neurofibromas Stiff skin Bilateral camptodactyly Disproportionate tall stature Decreased muscle mass Diabetes insipidus Melanocytic nevus Chorioretinal coloboma Cachexia Cervical lymphadenopathy Growth abnormality Abnormal form of the vertebral bodies Heterotopia Scoliosis Open mouth Macrotia Depressed nasal bridge Craniosynostosis Joint stiffness Intellectual disability, moderate Carcinoma Myopia Skeletal dysplasia Kyphoscoliosis Glaucoma Low-set ears Macrocephaly Abdominal pain Constipation Optic atrophy Clinodactyly of the 5th finger Visual loss Abnormality of cardiovascular system morphology Downslanted palpebral fissures Spinal canal stenosis Hip dislocation High myopia Abdominal distention Decreased antibody level in blood Intellectual disability Round face Nystagmus Nevus Gliosis Neoplasm Sudden cardiac death Renal cyst Dolichocephaly Polymicrogyria Long face Abnormality of skin pigmentation Strabismus Abnormal facial shape Facial asymmetry Carious teeth Cataract Finger syndactyly Myofibrillar myopathy Irregular hyperpigmentation Sparse scalp hair Absent eyebrow Hypoplastic toenails Coarse hair Widely spaced teeth Cutaneous syndactyly Sparse eyelashes Abnormality of the hair Sparse and thin eyebrow Hypoplasia of dental enamel Small nail Cutaneous finger syndactyly Cognitive impairment Mandibular hyperostosis Hypertrophy of skin of soles Depigmentation/hyperpigmentation of skin Connective tissue nevi Central heterochromia Neoplasm of the thymus Abnormal subcutaneous fat tissue distribution Retinal nonattachment Aplasia/Hypoplasia of the eyebrow Conical tooth Retinal hamartoma Cutaneous photosensitivity Hypernatremic dehydration Hypernatremia Congenital bullous ichthyosiform erythroderma Disseminated intravascular coagulation Poor appetite Congenital ichthyosiform erythroderma Skin vesicle Erythroderma Recurrent skin infections Dehydration Pili torti Abnormal blistering of the skin Weight loss 2-3 toe cutaneous syndactyly Epidermal hyperkeratosis Absent facial hair Palmar hyperkeratosis Patchy alopecia Hypoplasia of teeth Ridged nail Bronchogenic cyst Thymus hyperplasia Abnormal lung lobation Deep venous thrombosis Thin bony cortex Panniculitis Buphthalmos Arterial thrombosis Anisocytosis Hemihypertrophy Abnormality of the neck Lower limb asymmetry Arteriovenous malformation Meningioma Visceral angiomatosis Macroorchidism Abnormality of the wrist Abnormality of finger Spinal cord compression Capillary hemangioma Papilledema Exostoses Lipoma Neoplasm of the lung Long penis Thick nasal alae Nevus sebaceous Testicular neoplasm Facial hyperostosis Narrow internal auditory canal Sirenomelia Macrodactyly Portal vein thrombosis Calvarial hyperostosis Metatarsus valgus Epidermal nevus Lymphangioma Upper limb asymmetry Enlarged polycystic ovaries Keloids Nephrogenic diabetes insipidus Epibulbar dermoid Venous malformation Neoplasm of the central nervous system Thrombophlebitis Vascular skin abnormality Asymmetry of the thorax Asymmetric growth Episcleritis Lipoatrophy Facial telangiectasia Recurrent respiratory infections Recurrent urinary tract infections Hepatitis Abnormality of the skin Hematuria Pruritus Cough Feeding difficulties in infancy Abnormality of the eye Behavioral abnormality Abnormality of vision Onychomadesis Chronic recurrent multifocal osteomyelitis Cerebral vasculitis Low-grade fever Fetal distress Fused cervical vertebrae Stomatitis Thrombocytosis Joint swelling Abnormality of the fingernails Abnormality of the immune system Interstitial pulmonary abnormality Onychomycosis Hearing impairment Generalized hypotonia Short stature Global developmental delay Chronic oral candidiasis Broad nail Dyspareunia Abnormal lip morphology Abnormality of temperature regulation Abnormality of blood and blood-forming tissues Abnormal endocardium morphology Recurrent fungal infections Cheilitis Lichenification Abnormal vagina morphology Chronic mucocutaneous candidiasis Abnormal toenail morphology Abnormality of the mouth Hemoptysis Vertebral fusion Vasculitis Flexion contracture Nail dystrophy Palmoplantar pustulosis Asthenia Neutrophilia Chills Cholangitis Furrowed tongue Nail dysplasia Nausea Muscle weakness Oligoarthritis Diffuse skin atrophy Orthokeratosis Atopic dermatitis Rheumatoid arthritis Dermal atrophy Orthokeratotic hyperkeratosis Eczematoid dermatitis Allergic rhinitis Asthma Geographic tongue Diarrhea Osteopenia Antinuclear antibody positivity Respiratory distress Feeding difficulties Punctate keratitis Comedo Polyarticular arthritis Increased IgA level Corneal neovascularization Villous atrophy Follicular hyperkeratosis Uveitis Photophobia Keratoconjunctivitis sicca Thyroiditis Autoimmune hemolytic anemia Atrophic scars Keratitis Chronic diarrhea Hemolytic anemia Dry skin Autoimmunity Sensorineural hearing impairment Epicanthus Myelofibrosis Elbow flexion contracture Elevated erythrocyte sedimentation rate Increased antibody level in blood Hyperglycemia Stridor Sleep apnea Azoospermia Plagiocephaly Type I diabetes mellitus Hypergonadotropic hypogonadism Scleroderma Aspiration Gynecomastia Hyperpigmentation of the skin Gingival overgrowth Telangiectasia Bronchiectasis Primary amenorrhea Hypertrichosis Hypertriglyceridemia Microcytic anemia Polycythemia Epistaxis Histiocytosis Generalized lymphadenopathy Corneal arcus Hyperplasia of the maxilla Broad finger Pancreatic hypoplasia Abnormality of cardiovascular system physiology Chronic rhinitis Reticulocytopenia Skin nodule Episodic fever Nasal obstruction Recurrent pharyngitis Decreased serum testosterone level Communicating hydrocephalus Aspiration pneumonia Abnormal eyebrow morphology Enlarged kidney Exocrine pancreatic insufficiency Severe sensorineural hearing impairment Blue sclerae Cardiomegaly Hyperreflexia Patent ductus arteriosus Micropenis Diabetes mellitus Hypogonadism Posteriorly rotated ears Severe short stature Pneumonia Delayed skeletal maturation Abnormal heart morphology Clinodactyly Dyspnea Hernia Intellectual disability, mild Atrial septal defect Hydrocephalus Ventriculomegaly Ventricular septal defect Frontal bossing Wide nasal bridge Brachydactyly Hypothyroidism Pes planus Bilateral sensorineural hearing impairment Cleft upper lip Mitral valve prolapse Amenorrhea Decreased testicular size Wide intermamillary distance Growth hormone deficiency Full cheeks Recurrent fractures Polyneuropathy Flat face Abnormality of the foot Conductive hearing impairment Delayed puberty Malabsorption Pectus carinatum Retinopathy Abnormal cardiac septum morphology Apnea Abnormality of the kidney Camptodactyly Low-set, posteriorly rotated ears Conjunctival hamartoma


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