Fever, and Encephalitis

Diseases related with Fever and Encephalitis

In the following list you will find some of the most common rare diseases related to Fever and Encephalitis that can help you solving undiagnosed cases.

Top matches:

WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)).

WEST NILE VIRUS, SUSCEPTIBILITY TO Is also known as wnv, susceptibility to

Related symptoms:

  • Pain
  • Fever
  • Fatigue
  • Headache
  • Arthralgia


SOURCES: OMIM MENDELIAN

More info about WEST NILE VIRUS, SUSCEPTIBILITY TO

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 7; IIAE7 Is also known as herpes simplex encephalitis, susceptibility to, 5

Related symptoms:

  • Seizures
  • Fever
  • Headache
  • Rigidity
  • Confusion


SOURCES: OMIM MENDELIAN

More info about ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 7; IIAE7

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 8; IIAE8 Is also known as herpes simplex encephalitis, susceptibility to, 6

Related symptoms:

  • Seizures
  • Cognitive impairment
  • Fever
  • Edema
  • Immunodeficiency


SOURCES: OMIM MENDELIAN

More info about ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 8; IIAE8

Other less relevant matches:

Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection is a rare primary immunodeficiency due to a defect in innate immunity disorder characterized by selective susceptibility to viral infections, particularly after systemic challenge with live viral vaccines, such as the measles, mumps and rubella (MMR) vaccine. Patients present severe, potentially fatal, manifestations to viral illness, including encephalitis, hepatitis and pneumonitis.

PRIMARY IMMUNODEFICIENCY WITH POST-MEASLES-MUMPS-RUBELLA VACCINE VIRAL INFECTION Is also known as primary immunodeficiency with post-mmr vaccine viral infection

Related symptoms:

  • Seizures
  • Fever
  • Skin rash
  • Hepatitis
  • Lymphopenia


SOURCES: OMIM ORPHANET MENDELIAN

More info about PRIMARY IMMUNODEFICIENCY WITH POST-MEASLES-MUMPS-RUBELLA VACCINE VIRAL INFECTION

Herpes simplex encephalitis (HSE) is a severe viral infection of the central nervous system (CNS) resulting most commonly from infection with HSV-1 and occasionally by HSV-2. The disease peaks in childhood between 3 months and 3 years of age, although later onset can also occur, and affected individuals usually have neurologic sequelae, including seizures and cognitive or motor impairment. Some individuals may have recurrences of an acute episode of HSE; however, patients have no clear susceptibility to infection to other viruses. The virus gains entry to the CNS through a neuronal route via the trigeminal or olfactory nerves, not via the blood. Replication of this enveloped double-stranded DNA (dsDNA) virus involves the production and accumulation of RNA species, including dsRNA, which are recognized by the intracellular TLR3 signaling pathway. The susceptibility to HSV in particular appears to result from impaired TLR3-dependent interferon production by nonhematopoietic cells that reside within the CNS (review by Zhang et al., 2013; summary by Mork et al., 2015).For a general phenotypic description of herpes simplex encephalitis and a discussion of genetic heterogeneity of acute infection-induced encephalopathy, see {610551}.

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2 Is also known as herpes simplex encephalitis, susceptibility to, 2

Related symptoms:

  • Intellectual disability
  • Seizures
  • Cognitive impairment
  • Fever
  • Vomiting


SOURCES: OMIM MENDELIAN

More info about ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED (HERPES-SPECIFIC), SUSCEPTIBILITY TO, 2; IIAE2

Immunodeficiency-44 is an autosomal recessive primary immunodeficiency characterized by increased susceptibility to viral infections and adverse multisystemic reaction to vaccination in some patients. Affected individuals appear to have defects in mitochondrial fission and fusion (summary by Shahni et al., 2015).

Related symptoms:

  • Seizures
  • Spasticity
  • Visual impairment
  • Fever
  • Immunodeficiency


SOURCES: OMIM MENDELIAN

More info about IMMUNODEFICIENCY 44; IMD44

Familial acute necrotizing encephalopathy or ADANE is a potentially fatal neurological disease characterised by neuropathological lesions principally involving the brainstem, thalamus and putamen.

FAMILIAL ACUTE NECROTIZING ENCEPHALOPATHY Is also known as adane|recurrent acute necrotizing encephalopathy|ane|encephalopathy, acute necrotizing, susceptibility to

Related symptoms:

  • Intellectual disability
  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Spasticity


SOURCES: OMIM ORPHANET MENDELIAN

More info about FAMILIAL ACUTE NECROTIZING ENCEPHALOPATHY

X-linked lymphoproliferative disease is a hereditary immunodeficiency characterized, in the majority of cases, by an inadequate immune response to infection with the Epstein-Barr virus (EBV).

X-LINKED LYMPHOPROLIFERATIVE DISEASE Is also known as xlpd|duncan disease|xlp|immunodeficiency 5|infectious mononucleosis, severe, susceptibility to|purtilo syndrome|imd5|ebvs|lymphoproliferative disease, x-linked|epstein-barr virus infection, familial fatal|lyp|ebv infection, severe, susceptibility to|immun

Related symptoms:

  • Seizures
  • Neoplasm
  • Anemia
  • Hepatomegaly
  • Fever


SOURCES: ORPHANET OMIM MENDELIAN

More info about X-LINKED LYMPHOPROLIFERATIVE DISEASE

Familial hemophagocytic lymphohistiocytosis-2 (FHL2) is an autosomal recessive disorder of immune dysregulation with onset in infancy or early childhood. It is characterized clinically by fever, edema, hepatosplenomegaly, and liver dysfunction. Neurologic impairment, seizures, and ataxia are frequent. Laboratory studies show pancytopenia, coagulation abnormalities, hypofibrinogenemia, and hypertriglyceridemia. There is increased production of cytokines, such as gamma-interferon (IFNG ) and TNF-alpha (OMIM ), by hyperactivation and proliferation of T cells and macrophages. Activity of cytotoxic T cells and NK cells is reduced, consistent with a defect in cellular cytotoxicity. Bone marrow, lymph nodes, spleen, and liver show features of hemophagocytosis. Chemotherapy and/or immunosuppressant therapy may result in symptomatic remission, but the disorder is fatal without bone marrow transplantation (summary by Dufourcq-Lagelouse et al., 1999, Stepp et al., 1999, and Molleran Lee et al., 2004).For a general phenotypic description and a discussion of genetic heterogeneity of FHL, see {267700}.

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 2; FHL2 Is also known as hplh2|hlh2

Related symptoms:

  • Seizures
  • Global developmental delay
  • Generalized hypotonia
  • Ataxia
  • Failure to thrive


SOURCES: OMIM MENDELIAN

More info about HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 2; FHL2

Vanishing white matter leukodystrophy is an autosomal recessive neurologic disorder characterized by variable neurologic features, including progressive cerebellar ataxia, spasticity, and cognitive impairment associated with white matter lesions on brain imaging. The age at onset can range from early infancy to adulthood. Rapid neurologic deterioration can occur following minor head trauma. Female mutation carriers may develop ovarian failure, manifest as primary amenorrhea or as secondary amenorrhea lasting more than 6 months, associated with elevated gonadotropin levels at age less than 40 years (summary by Van der Knaap et al., 1998 and Schiffmann et al., 1997).

LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER; VWM Is also known as cach|cle|childhood ataxia with central nervous system hypomyelinization|cree leukoencephalopathy|vanishing white matter leukodystrophy

Related symptoms:

  • Seizures
  • Generalized hypotonia
  • Ataxia
  • Muscle weakness
  • Muscular hypotonia


SOURCES: ORPHANET OMIM MENDELIAN

More info about LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTER; VWM

Top 5 symptoms//phenotypes associated to Fever and Encephalitis

Symptoms // Phenotype % cases
Seizures Very Common - Between 80% and 100% cases
Meningitis Uncommon - Between 30% and 50% cases
Hemiparesis Uncommon - Between 30% and 50% cases
Vomiting Uncommon - Between 30% and 50% cases
Encephalopathy Uncommon - Between 30% and 50% cases

Other less frequent symptoms

Patients with Fever and Encephalitis. may also develop some of the following symptoms:

Uncommon Symptoms - Between 30% and 50% cases

Lethargy Mental deterioration Coma Immunodeficiency Confusion Cognitive impairment Gliosis Spasticity Ataxia Headache Generalized hypotonia

Rare Symptoms - Less than 30% cases

Immune dysregulation Anemia Hypertonia Visual impairment Pneumonia Diarrhea Gait disturbance Tetraplegia Hepatosplenomegaly Intellectual disability EEG abnormality Hepatomegaly Splenomegaly Rigidity Thrombocytopenia Edema Increased CSF protein Cerebral edema Memory impairment Herpes simplex encephalitis Lymphadenopathy Hyponatremia Pancytopenia Increased total bilirubin Muscle weakness Hypofibrinogenemia CSF pleocytosis Muscular hypotonia Delayed speech and language development Pain Hemophagocytosis Decreased liver function Fulminant hepatitis Global developmental delay Failure to thrive Jaundice Elevated hepatic transaminase Irritability Hypertriglyceridemia Diplopia Leukopenia Prolonged prothrombin time Increased intracranial pressure Peripheral neuropathy Hemiplegia Abnormality of coagulation Increased serum ferritin Papilledema Hypoproteinemia Generalized edema Hypoalbuminemia Peripheral demyelination Hyperreflexia Hyperventilation CNS hypomyelination Premature ovarian insufficiency Personality changes Emotional lability Axonal degeneration Secondary amenorrhea Progressive encephalopathy Delusions Spastic paraparesis CNS demyelination Cerebral hypomyelination Primary gonadal insufficiency Diffuse leukoencephalopathy Rapid neurologic deterioration Spastic hemiparesis Cessation of head growth Leukoencephalopathy Paraparesis Dysarthria Abnormality of the cerebral white matter Macrocephaly Optic atrophy Blindness Cerebral atrophy Dementia Developmental regression Distal muscle weakness Unsteady gait Muscle stiffness Progressive cerebellar ataxia Amenorrhea Pharyngitis Primary amenorrhea Progressive neurologic deterioration Spastic gait Leukodystrophy Reduced natural killer cell activity Sarcoma Non-Hodgkin lymphoma Myoclonus Foot dorsiflexor weakness Hallucinations Spastic tetraplegia Polyneuropathy Cough Pallor Opsoclonus Stomatitis Abnormality of mitochondrial metabolism Shock Cerebral visual impairment Chorea Metabolic acidosis Acidosis Severe viral infection Abnormal posturing Homonymous hemianopia CNS infection Encephalomalacia Hemianopia Recurrent infections Pericardial effusion Lymphopenia Hepatitis Skin rash Obesity Nuchal rigidity Paralysis Arthralgia Fatigue Severe vision loss Abducens palsy Burkitt lymphoma IgG deficiency Hepatic necrosis Pure red cell aplasia Dysgammaglobulinemia Increased IgM level Chorioretinitis Granulomatosis Hepatic encephalopathy Histiocytosis Lymphocytosis Cellular immunodeficiency Recurrent pharyngitis Aplastic anemia B-cell lymphoma Agammaglobulinemia Hodgkin lymphoma Acute encephalopathy Respiratory failure Abnormal muscle tone Necrotizing encephalopathy Polyneuritis Acute necrotizing encephalopathy Neoplasm Dilatation Falls Increased antibody level in blood Hepatic failure Lymphoma Decreased antibody level in blood Bronchiectasis Vasculitis Bone marrow hypocellularity Decreased circulating progesterone


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